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Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent <i>N</i>-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration

artículo científico publicado en 2021

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}- N -methylpyridine-2-carboxamide (AZD5305): A PARP1–DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs

artículo científico publicado en 2021

Discovery of a picomolar potency pharmacological corrector of the mutant CFTR chloride channel

scientific article published on 21 February 2020

Identification, Structure-Activity Relationship, and Biological Characterization of 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indoles as a Novel Class of CFTR Potentiators

scientific article published on 18 September 2020

Perspectives on natural product epigenetic modulators in chemical biology and medicine.

artículo científico publicado en 2013

SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

artículo científico publicado en 2010

The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.

artículo científico publicado en 2012

The design and synthesis of novel IBiox N-heterocyclic carbeneligands derived from substituted amino-indanols

scientific article published on 28 November 2011

The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.

artículo científico publicado en 2014

The discovery of indole full agonists of the neurotensin receptor 1 (NTSR1).

artículo científico publicado en 2014

Thienopyrimidinone Based Sirtuin-2 (SIRT2)-Selective Inhibitors Bind in the Ligand Induced Selectivity Pocket.

artículo científico publicado en 2017

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