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A Genomic Analysis Workflow for Colorectal Cancer Precision Oncology

scientific article published on 07 March 2019

A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer

artículo científico publicado en 2011

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

artículo científico publicado en 2016

Blockade of EGFR and MEK intercepts heterogeneous mechanisms of acquired resistance to anti-EGFR therapies in colorectal cancer.

artículo científico publicado en 2014

Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients.

artículo científico publicado en 2015

Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer

artículo científico publicado en 2012

Emergence of MET hyper-amplification at progression to MET and BRAF inhibition in colorectal cancer

artículo científico publicado en 2017

Erratum: Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

scientific article published on 01 July 2015

Increased detection sensitivity for KRAS mutations enhances the prediction of anti-EGFR monoclonal antibody resistance in metastatic colorectal cancer.

artículo científico publicado en 2011

Inhibition of MEK and PI3K/mTOR suppresses tumor growth but does not cause tumor regression in patient-derived xenografts of RAS-mutant colorectal carcinomas

artículo científico publicado en 2012

Molecular Landscape of Acquired Resistance to Targeted Therapy Combinations in BRAF-Mutant Colorectal Cancer

artículo científico publicado en 2016

The molecular landscape of colorectal cancer cell lines unveils clinically actionable kinase targets

artículo científico publicado en 2015

Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer

artículo científico publicado en 2015

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