Lista de obras -

(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands

artículo científico publicado en 2015

3-Aminomethyl Derivatives of 2-Phenylimidazo[1,2-a]-pyridine as Positive Allosteric Modulators of GABAA Receptor with Potential Antipsychotic Activity.

artículo científico publicado en 2017

4-tert-Pentylphenoxyalkyl derivatives - Histamine H receptor ligands and monoamine oxidase B inhibitors

artículo científico publicado en 2018

7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists.

artículo científico publicado en 2012

Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.

artículo científico publicado en 2014

Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55

article

Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands

artículo científico publicado en 2017

Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.

artículo científico publicado en 2015

Design, synthesis, and biological evaluation of fluorinated imidazo[1,2-a]pyridine derivatives with potential antipsychotic activity

artículo científico publicado en 2016

Design, synthesis, and in vitro and in vivo characterization of 1-{4-[4-(substituted)piperazin-1-yl]butyl}guanidines and their piperidine analogues as histamine H3 receptor antagonists

artículo científico publicado en 2019

Development of novel cellular model for affinity studies of histamine H(4) receptor ligands

artículo científico publicado en 2013

Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies

scientific article published on 28 December 2018

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors ⬇️

artículo científico publicado en 2020

Fluorescent-labeled selective adenosine A2B receptor antagonist enables competition binding assay by flow cytometry

artículo científico publicado en 2018

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ⬇️

artículo científico publicado en 2012

Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate

artículo científico publicado en 2017

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats.

artículo científico publicado en 2016

Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay

artículo científico publicado en 2016

Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies

scientific article published on 02 February 2019

Novel naphthyloxy derivatives - Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation.

artículo científico publicado en 2018

Optimization and preclinical evaluation of novel histamine H3receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives

scientific article published on 10 November 2018

Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines

artículo científico publicado en 2022

Preclinical evaluation of 1,2,4-triazole-based compounds targeting voltage-gated sodium channels (VGSCs) as promising anticonvulsant drug candidates

scientific article published on 17 October 2019

Search for histamine H4 receptor ligands in the group of 4-methylpiperazino amide derivatives.

artículo científico publicado en 2010

Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.

artículo científico publicado en 2016

Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands

artículo científico publicado en 2019

Structural modifications in the distal, regulatory region of histamine H<sub>3</sub> receptor antagonists leading to the identification of a potent anti-obesity agent

artículo científico publicado en 2020

Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents.

artículo científico publicado en 2015

Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands.

artículo científico publicado en 2017

Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands

Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.

artículo científico publicado en 2011

Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones

artículo científico publicado en 2013

The Synthesis of 1,3,5-triazine Derivatives and JNJ7777120 Analogues with Histamine H4 Receptor Affinity and Their Interaction with PTEN Promoter

Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.

artículo científico publicado en 2018

Lista de obras de

(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands

3-Aminomethyl Derivatives of 2-Phenylimidazo[1,2-a]-pyridine as Positive Allosteric Modulators of GABAA Receptor with Potential Antipsychotic Activity.

4-tert-Pentylphenoxyalkyl derivatives - Histamine H receptor ligands and monoamine oxidase B inhibitors

7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists.

Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.

Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55

Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands

Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.

Design, synthesis, and biological evaluation of fluorinated imidazo[1,2-a]pyridine derivatives with potential antipsychotic activity

Design, synthesis, and in vitro and in vivo characterization of 1-{4-[4-(substituted)piperazin-1-yl]butyl}guanidines and their piperidine analogues as histamine H3 receptor antagonists

Development of novel cellular model for affinity studies of histamine H(4) receptor ligands

Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies

Dual Target Ligands with 4-tert-Butylphenoxy Scaffold as Histamine H3 Receptor Antagonists and Monoamine Oxidase B Inhibitors ⬇️

Fluorescent-labeled selective adenosine A2B receptor antagonist enables competition binding assay by flow cytometry

Magnolia Extract, Magnolol, and Metabolites: Activation of Cannabinoid CB2 Receptors and Blockade of the Related GPR55. ⬇️

Molecular mechanism of action and safety of 5-(3-chlorophenyl)-4-hexyl-2,4-dihydro-3H-1,2,4-triazole-3-thione - a novel anticonvulsant drug candidate

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats.

Novel Piperazine Arylideneimidazolones Inhibit the AcrAB-TolC Pump in Escherichia coli and Simultaneously Act as Fluorescent Membrane Probes in a Combined Real-Time Influx and Efflux Assay

Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies

Novel naphthyloxy derivatives - Potent histamine H3 receptor ligands. Synthesis and pharmacological evaluation.

Optimization and preclinical evaluation of novel histamine H3receptor ligands: Acetyl and propionyl phenoxyalkyl piperazine derivatives

Overcoming undesirable hERG affinity by incorporating fluorine atoms: A case of MAO-B inhibitors derived from 1 H-pyrrolo-[3,2-c]quinolines

Preclinical evaluation of 1,2,4-triazole-based compounds targeting voltage-gated sodium channels (VGSCs) as promising anticonvulsant drug candidates

Search for histamine H4 receptor ligands in the group of 4-methylpiperazino amide derivatives.

Similarities and differences in affinity and binding modes of tricyclic pyrimido- and pyrazinoxanthines at human and rat adenosine receptors.

Structural modifications and in vitro pharmacological evaluation of 4-pyridyl-piperazine derivatives as an active and selective histamine H3 receptor ligands

Structural modifications in the distal, regulatory region of histamine H<sub>3</sub> receptor antagonists leading to the identification of a potent anti-obesity agent

Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents.

Synthesis and biological activity of novel tert-amylphenoxyalkyl (homo)piperidine derivatives as histamine H3R ligands.

Synthesis and biological activity of novel tert-butyl and tert-pentylphenoxyalkyl piperazine derivatives as histamine H3R ligands

Synthesis and biological activity of tricyclic cycloalkylimidazo-, pyrimido- and diazepinopurinediones.

Synthesis, biological activity and molecular modelling studies of tricyclic alkylimidazo-, pyrimido- and diazepinopurinediones

The Synthesis of 1,3,5-triazine Derivatives and JNJ7777120 Analogues with Histamine H4 Receptor Affinity and Their Interaction with PTEN Promoter

Tricyclic xanthine derivatives containing a basic substituent: adenosine receptor affinity and drug-related properties.