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14-3-3 σ expression effects G2/M response to oxygen and correlates with ovarian cancer metastasis

artículo científico publicado en 2011

A Stepwise Integrated Approach to Personalized Risk Predictions in Stage III Colorectal Cancer

artículo científico publicado en 2016

A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers

artículo científico publicado en 2010

A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

artículo científico publicado en 2007

A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation

artículo científico publicado en 2014

A novel derivative of the natural agent deguelin for cancer chemoprevention and therapy

artículo científico publicado en 2008

A preclinical evaluation of the MEK inhibitor refametinib in HER2-positive breast cancer cell lines including those with acquired resistance to trastuzumab or lapatinib

artículo científico publicado en 2017

A preclinical evaluation of the PI3K alpha/delta dominant inhibitor BAY 80-6946 in HER2-positive breast cancer models with acquired resistance to the HER2-targeted therapies trastuzumab and lapatinib.

artículo científico publicado en 2014

A systems approach to analysis of molecular complexity in breast cancer

artículo científico publicado en 2009

AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

artículo científico publicado en 2009

Aberrations in translational regulation are associated with poor prognosis in hormone receptor-positive breast cancer

artículo científico publicado en 2012

Absence of thyroid transcription factor-1 expression is associated with poor survival in patients with advanced pulmonary adenocarcinoma treated with pemetrexed-based chemotherapy

artículo científico publicado en 2018

Adipose tissue derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor derived factors.

artículo científico publicado en 2011

Adipose tissue-derived stem cells differentiate into carcinoma-associated fibroblast-like cells under the influence of tumor-derived factors.

artículo científico publicado en 2010

Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression

artículo científico publicado en 2009

An efficient procedure for protein extraction from formalin-fixed, paraffin-embedded tissues for reverse phase protein arrays

artículo científico publicado en 2012

An insight into the molecular genetics of a uveal melanoma patient cohort

article

An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer

scientific article published on August 2008

An uncommon complication of vertebroplasty: the role of anticoagulation

scientific article published on 01 July 2019

Analysis of H3K4me3 and H3K27me3 bivalent promotors in HER2+ breast cancer cell lines reveals variations depending on estrogen receptor status and significantly correlates with gene expression

artículo científico publicado en 2020

Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer

artículo científico publicado en 2009

Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach

artículo científico publicado en 2017

BAYESIAN SPARSE GRAPHICAL MODELS FOR CLASSIFICATION WITH APPLICATION TO PROTEIN EXPRESSION DATA. ⬇️

artículo científico publicado en 2014

BCL-2 system analysis identifies high-risk colorectal cancer patients.

artículo científico publicado en 2016

BCL2 protein signalling determines acute responses to neoadjuvant chemoradiotherapy in rectal cancer.

artículo científico publicado en 2014

BRCA1 promoter methylation and clinical outcomes in ovarian cancer: an individual patient data meta-analysis

artículo científico publicado en 2020

BRCA1/2 mutation analysis in 41 ovarian cell lines reveals only one functionally deleterious BRCA1 mutation

artículo científico publicado en 2013

Biphasic metaplastic sarcomatoid carcinoma of the breast

artículo científico publicado en 2006

Breast carcinoma with neuroendocrine differentiation and myocardial metastases

artículo científico publicado en 2007

Brief report on the detection of the EGFR-T790M mutation in exhaled breath condensate from lung cancer patients

artículo científico publicado en 2018

CD10-/ALDH- cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell hierarchy.

artículo científico publicado en 2017

Challenges associated with systemic therapy for older patients with inoperable non-small cell lung cancer

scientific article published on 31 August 2020

Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics

artículo científico publicado en 2009

Clinical assessment of PTEN loss in endometrial carcinoma: immunohistochemistry outperforms gene sequencing

artículo científico publicado en 2012

Combination of variations in inflammation- and endoplasmic reticulum-associated genes as putative biomarker for bevacizumab response in KRAS wild-type colorectal cancer

artículo científico publicado en 2020

Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo

artículo científico publicado en 2010

Combined Src and aromatase inhibition impairs human breast cancer growth in vivo and bypass pathways are activated in AZD0530-resistant tumors

artículo científico publicado en 2009

Combined targeting EGFR and SRC as a potential novel therapeutic approach for the treatment of triple negative breast cancer

scientific article published on 28 January 2020

Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy

scientific article published in Nature Communications

Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis

artículo científico publicado en 2013

Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

artículo científico publicado en 2013

Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest

artículo científico publicado en 2011

DNA methylation in haematological malignancies: the role of decitabine

artículo científico publicado en 2003

Development of a personalized therapeutic strategy for ERBB-gene-mutated cancers.

artículo científico publicado en 2018

Differences in MEK inhibitor efficacy in molecularly characterized low-grade serous ovarian cancer cell lines

artículo científico publicado en 2016

Disease-free and overall survival after pathologic complete disease remission of cytologically proven inflammatory breast carcinoma axillary lymph node metastases after primary systemic chemotherapy

scientific article published on 01 March 2006

Dose-adjusting capecitabine minimizes adverse effects while maintaining efficacy: a retrospective review of capecitabine for metastatic breast cancer

artículo científico

Dynamic platelet function is markedly different in patients with cancer compared to healthy donors

scientific article published on 25 September 2018

Economic impact of 21-gene recurrence score testing on early-stage breast cancer in Ireland.

artículo científico publicado en 2015

Effects of HER family-targeting tyrosine kinase inhibitors on antibody-dependent cell-mediated cytotoxicity in HER2-expressing breast cancer

artículo científico publicado en 2020

Epidermal growth factor receptor and K-Ras mutations and resistance of lung cancer to insulin-like growth factor 1 receptor tyrosine kinase inhibitors

artículo científico publicado en 2012

Frequency, impact and a preclinical study of novel gene family mutations in HER2-positive breast cancer

article

Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGF-beta pathway signaling indicates response to primary chemotherapy

artículo científico publicado en 2010

Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer

artículo científico publicado en 2011

Genome-wide transcriptome profiling of homologous recombination DNA repair

artículo científico publicado en 2014

Genomic and Transcriptomic Characterisation of Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer

artículo científico publicado en 2020

Genomic profiling of a dedifferentiated mucosal melanoma following exposure to immunotherapy

scientific article published on 01 April 2020

Germline single nucleotide polymorphisms in ERBB3 and BARD1 genes result in a worse relapse free survival response for HER2-positive breast cancer patients treated with adjuvant based docetaxel, carboplatin and trastuzumab (TCH)

artículo científico publicado en 2018

Growth factor receptor/steroid receptor cross talk in trastuzumab-treated breast cancer

artículo científico publicado en 2014

HDAC4-regulated STAT1 activation mediates platinum resistance in ovarian cancer.

artículo científico publicado en 2011

HER2-family signalling mechanisms, clinical implications and targeting in breast cancer

artículo científico publicado en 2014

High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

artículo científico publicado en 2011

High-throughput oncogene mutation profiling shows demographic differences in BRAF mutation rates among melanoma patients.

artículo científico publicado en 2015

Homologous Recombination Deficiency (HRD) Score Predicts Response to Platinum-Containing Neoadjuvant Chemotherapy in Patients with Triple-Negative Breast Cancer.

artículo científico publicado en 2016

Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor-positive human breast cancer

artículo científico publicado en 2010

Identification and clinical impact of potentially actionable somatic oncogenic mutations in solid tumor samples

artículo científico publicado en 2020

Identification of remodeling and spacing factor 1 (rsf-1, HBXAP) at chromosome 11q13 as a putative oncogene in ovarian cancer

artículo científico publicado en 2006

Imaging differences in metaplastic and invasive ductal carcinomas of the breast

artículo científico publicado en 2007

Immune effects of bevacizumab: killing two birds with one stone

artículo científico publicado en 2014

Impact of somatic PI3K pathway and ERBB family mutations on pathological complete response (pCR) in HER2-positive breast cancer patients who received neoadjuvant HER2-targeted therapies.

artículo científico publicado en 2017

Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm

artículo científico publicado en 2017

Incidence and outcome of BRCA mutations in unselected patients with triple receptor-negative breast cancer

artículo científico publicado en 2011

Increased platelet reactivity in patients with late-stage metastatic cancer.

artículo científico publicado en 2013

Individualization of neoadjuvant therapy for breast cancer according to molecular tumor characteristics

scientific article published on 01 December 2005

Individualized molecular medicine: linking functional proteomics to select therapeutics targeting the PI3K pathway for specific patients

artículo científico publicado en 2008

Influence of DNA copy number and mRNA levels on the expression of breast cancer related proteins

artículo científico publicado en 2013

Integrative analysis of cyclin protein levels identifies cyclin b1 as a classifier and predictor of outcomes in breast cancer

artículo científico publicado en 2009

Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI 60 cancer cell line set

artículo científico publicado en 2010

Integrin-linked kinase has a critical role in ErbB2 mammary tumor progression: implications for human breast cancer.

artículo científico publicado en 2010

Lack of familiarity with genetic testing among patients in Ireland with Cancer

artículo científico publicado en 2020

Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab

scientific article published on 24 May 2018

Loss of Phosphatase and Tensin homologue deleted on chromosome 10 engages ErbB3 and insulin-like growth factor-I receptor signaling to promote antiestrogen resistance in breast cancer

artículo científico publicado en 2009

Low number of examined lymph nodes in node-negative breast cancer patients is an adverse prognostic factor

artículo científico publicado en 2006

Lower dose capecitabine has a more favorable therapeutic index in metastatic breast cancer: retrospective analysis of patients treated at M. D. Anderson Cancer Center and a review of capecitabine toxicity in the literature

artículo científico publicado en 2005

Lysophosphatidic acid-induced transcriptional profile represents serous epithelial ovarian carcinoma and worsened prognosis

artículo científico publicado en 2009

Management of Unusual Histological Types of Breast Cancer ⬇️

artículo científico publicado el 23 de julio de 2012

Management of patients with systemic mastocytosis: review of M. D. Anderson Cancer Center experience

artículo científico publicado en 2004

Markers of MEK inhibitor resistance in low-grade serous ovarian cancer: EGFR is a potential therapeutic target

Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy.

artículo científico publicado en 2007

Mechanistic basis for overcoming platinum resistance using copper chelating agents

artículo científico publicado en 2012

Metaplastic sarcomatoid carcinoma of the breast with absent or minimal overt invasive carcinomatous component: a misnomer

artículo científico publicado en 2005

Modeling ductal carcinoma in situ: a HER2-Notch3 collaboration enables luminal filling.

artículo científico publicado en 2011

Molecular screening for breast cancer prevention, early detection, and treatment planning: combining biomarkers from DNA, RNA, and protein

artículo científico publicado en 2006

Molecular subclasses of breast cancer: how do we define them? The IMPAKT 2012 Working Group Statement.

artículo científico publicado en 2012

Molecular targeted therapy in ovarian cancer: what is on the horizon?

artículo científico publicado en 2011

Neoadjuvant crizotinib in advanced inflammatory myofibroblastic tumour with ALK gene rearrangement

artículo científico publicado en 2015

Neoadjuvant systemic therapy for breast cancer: an overview and review of recent clinical trials

artículo científico publicado en 2005

Network inference using steady-state data and Goldbeter-Koshland kinetics. [corrected]

artículo científico publicado en 2012

Network inference using steady-state data and Goldbeter–Koshland kinetics

artículo científico publicado en 2013

New approaches in the treatment of myelofibrosis

artículo científico publicado en 2005

Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

artículo científico publicado en 2011

Non-invasive genotyping and monitoring of tumor evolution in locally advanced rectal cancer (LARC) patients using circulating tumor DNA (ctDNA)

artículo científico publicado en 2018

Outcome after pathologic complete eradication of cytologically proven breast cancer axillary node metastases following primary chemotherapy

scientific article published on 01 December 2005

Outcome differences between patients with node-negative breast cancer classified according to the st. Gallen risk categories.

artículo científico publicado en 2009

Outcome of Colorectal Cancer Patients Treated with Combination Bevacizumab Therapy: A Pooled Retrospective Analysis of Three European Cohorts from the Angiopredict Initiative

artículo científico publicado en 2016

OvMark: a user-friendly system for the identification of prognostic biomarkers in publically available ovarian cancer gene expression datasets.

artículo científico publicado en 2014

Ovarian cancer

artículo científico publicado en 2009

Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead

artículo científico publicado en 2008

Overcoming resistance and restoring sensitivity to HER2-targeted therapies in breast cancer ⬇️

artículo científico publicado el 2 de agosto de 2012

PARP Inhibitors as P-glyoprotein Substrates.

artículo científico publicado en 2014

PI3K inhibition to overcome endocrine resistance in breast cancer

artículo científico publicado en 2017

PI3K pathway-directed therapeutic strategies in cancer.

artículo científico publicado en 2010

PIK3CA mutations associated with gene signature of low mTORC1 signaling and better outcomes in estrogen receptor-positive breast cancer

artículo científico publicado en 2010

PTEN loss is a context-dependent outcome determinant in obese and non-obese endometrioid endometrial cancer patients

artículo científico publicado en 2015

Patient demographics and management challenges in an Irish symptomatic breast cancer unit

scientific article published on 20 May 2020

Patterns of genomic loss of heterozygosity predict homologous recombination repair defects in epithelial ovarian cancer

artículo científico publicado en 2012

Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer

artículo científico publicado en 2012

Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer

artículo científico publicado en 2014

Pharmacodynamic markers of perifosine efficacy

artículo científico publicado en 2007

Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancer

artículo científico publicado en 2010

Point mutations of protein kinases and individualised cancer therapy

artículo científico publicado en 2006

Preclinical drug testing and clinical trial planning of palbociclib (CDK4/6 inhibitor) drug combination with a PI3K or MAPK inhibitor for colorectal cancer (CRC)

artículo científico publicado en 2019

Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro.

artículo científico publicado en 2018

Preclinical evaluation of a novel triple-acting PIM/PI3K/mTOR inhibitor, IBL-302, in breast cancer

artículo científico publicado en 2020

Prevalence of tumor BRCA1 and BRCA2 dysfunction in unselected patients with ovarian cancer

artículo científico publicado en 2020

Primary angiosarcomas of the breast

artículo científico publicado en 2007

Prognostic significance of occult axillary lymph node metastases after chemotherapy-induced pathologic complete response of cytologically proven axillary lymph node metastases from breast cancer.

artículo científico publicado en 2009

Proteomic and transcriptomic profiling reveals a link between the PI3K pathway and lower estrogen-receptor (ER) levels and activity in ER+ breast cancer

artículo científico publicado en 2010

Quantitative proteomic analysis in breast cancer

artículo científico publicado en 2011

RE: RNA Disruption Assay as a Biomarker of Pathological Complete Response in Neoadjuvant Trastuzumab-Treated Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer

artículo científico publicado en 2016

RPPAML/RIMS: a metadata format and an information management system for reverse phase protein arrays

artículo científico publicado en 2008

Rak functions as a tumor suppressor by regulating PTEN protein stability and function

artículo científico publicado en 2009

Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer

scientific journal article

Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer

artículo científico publicado en 2008

Reverse phase protein array: validation of a novel proteomic technology and utility for analysis of primary leukemia specimens and hematopoietic stem cells

artículo científico publicado en 2006

Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.

artículo científico publicado en 2011

S100β as a serum marker in endocrine resistant breast cancer

artículo científico publicado en 2017

Similar overall survival with reduced vs. standard dose bevacizumab monotherapy in progressive glioblastoma

scientific article published on 22 November 2019

Squamous Cell Carcinoma of the Breast

artículo científico publicado en 2005

Src promotes estrogen-dependent estrogen receptor alpha proteolysis in human breast cancer

artículo científico publicado en 2007

Subtype and pathway specific responses to anticancer compounds in breast cancer

artículo científico publicado en 2011

Systems analysis of protein signatures predicting Cetuximab responses in KRAS, NRAS, BRAF and PIK3CA wild-type patient-derived xenografts models of metastatic colorectal cancer

scientific article published on 23 July 2020

Systems biology analysis identifies molecular determinants of chemotherapy-induced diarrhoea

scientific article published on 17 December 2019

Targeting c-Met in triple negative breast cancer: preclinical studies using the c-Met inhibitor, Cpd A

artículo científico publicado en 2020

Targeting the epidermal growth factor receptor in epithelial ovarian cancer: current knowledge and future challenges.

artículo científico publicado en 2009

The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer

artículo científico publicado en 2014

The biology of ovarian cancer: new opportunities for translation

artículo científico publicado en 2009

The frequencies and clinical implications of mutations in 33 kinase-related genes in locally advanced rectal cancer: a pilot study.

artículo científico publicado en 2014

The impact of ERBB-family germline single nucleotide polymorphisms on survival response to adjuvant trastuzumab treatment in HER2-positive breast cancer

artículo científico publicado en 2016

The prognostic value of tumour regression grade following neoadjuvant chemoradiation therapy for rectal cancer

artículo científico publicado en 2014

Trends for Inflammatory Breast Cancer: Is Survival Improving?

artículo científico publicado en 2007

Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data

artículo científico publicado en 2018

Use of exhaled breath condensate (EBC) in the diagnosis of SARS-COV-2 (COVID-19)

artículo científico publicado en 2020

Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer.

artículo científico publicado en 2012

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