Lista de obras - Jacek Otlewski - Dominio Público Uruguay

A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells

artículo científico publicado en 2017

A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell Lines.

artículo científico publicado en 2016

A novel, stable, helical scaffold as an alternative binder - construction of phage display libraries

artículo científico publicado el 18 de septiembre de 2012

Amyloid-forming peptides selected proteolytically from phage display library

artículo científico publicado en 2003

Analysis of serine proteinase-inhibitor interaction by alanine shaving

artículo científico publicado en 2002

Anti-FGFR1 aptamer-tagged superparamagnetic conjugates for anticancer hyperthermia therapy

artículo científico publicado en 2017

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

artículo científico publicado en 2017

Aptamers: Molecules of great potential ⬇️

artículo científico publicado el 28 de abril de 2013

Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin

artículo científico publicado en 2003

Biophysical properties of the eukaryotic ribosomal stalk

artículo científico publicado en 2010

Bivalent peptides as models for multimeric targets of PDZ domains.

artículo científico publicado en 2007

Correction: Serwotka-Suszczak, A. M. et al. A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells. Int. J. Mol. Sci. 2017, 18, 401

artículo científico publicado en 2018

Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins

artículo científico publicado en 2019

Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling

scientific article published on 12 April 2019

Crystal structure of Vigna radiata cytokinin-specific binding protein in complex with zeatin

artículo científico publicado en 2006

Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants

artículo científico publicado en 2004

Current methods for the synthesis of homogeneous antibody-drug conjugates

artículo científico publicado en 2015

Cytokinin-induced structural adaptability of a Lupinus luteus PR-10 protein

artículo científico publicado en 2009

Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors.

artículo científico publicado en 2017

Degenerate specificity of PDZ domains from RhoA-specific nucleotide exchange factors PDZRhoGEF and LARG.

artículo científico publicado en 2008

Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1.

artículo científico publicado en 2017

Design and characteristics of a stable protein scaffold for specific binding based on variable lymphocyte receptor sequences ⬇️

artículo científico publicado el 18 de mayo de 2011

Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy

artículo científico publicado en 2016

Design of fully active FGF-1 variants with increased stability

artículo científico publicado en 2004

Design, expression and characterization of a highly stable tetratricopeptide-based protein scaffold for phage display application

artículo científico publicado en 2013

Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins.

artículo científico publicado en 2019

Dissecting the thermodynamics of GAP-RhoA interactions

artículo científico publicado en 2008

ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling.

artículo científico publicado en 2013

Efficient production and purification of extracellular domain of human FGFR-Fc fusion proteins from Chinese hamster ovary cells.

artículo científico publicado en 2014

Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity

artículo científico publicado en 2006

Expression, purification and catalytic activity of Lupinus luteus asparagine beta-amidohydrolase and its Escherichia coli homolog

artículo científico publicado en 2004

Expression, purification and crystallization of cysteine-rich human protein muskelin in Escherichia coli

artículo científico publicado en 2008

FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation

artículo científico publicado en 2012

FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1

scientific article published on 19 July 2018

FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1

artículo científico publicado en 2020

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

artículo científico publicado en 2020

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner

artículo científico publicado en 2020

Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein-protein interactions to protein stability.

artículo científico publicado en 2012

Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers

artículo científico publicado en 2018

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1.

artículo científico publicado en 2018

High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer

artículo científico publicado en 2017

High-Yield Site-Specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues.

artículo científico publicado en 2017

Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action

artículo científico publicado en 2005

Hydrogen bonds in human ubiquitin reflected in temperature coefficients of amide protons

artículo científico publicado en 2002

Identification of a peptide antagonist of the FGF1-FGFR1 signaling axis by phage display selection

artículo científico publicado en 2019

Identification of new FGF1 binding partners-Implications for its intracellular function

artículo científico publicado en 2016

Importance of alpha-helix N-capping motif in stabilization of betabetaalpha fold.

artículo científico publicado en 2003

Increased protein stability of FGF1 can compensate for its reduced affinity for heparin

artículo científico publicado en 2009

Instability restricts signaling of multiple fibroblast growth factors.

artículo científico publicado en 2015

Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions

artículo científico publicado en 2020

Longer action means better drug: tuning up protein therapeutics

artículo científico publicado en 2011

Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity

scientific article published on 15 August 2019

Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein

artículo científico publicado en 2002

NMR structures of two variants of bovine pancreatic trypsin inhibitor (BPTI) reveal unexpected influence of mutations on protein structure and stability

artículo científico publicado en 2002

Novel Method for Preparation of Site-Specific, Stoichiometric-Controlled Dual Warhead Conjugate of FGF2 via Dimerization Employing Sortase A-Mediated Ligation

artículo científico publicado en 2019

Novel peptide recognized by RhoA GTPase

artículo científico publicado en 2006

Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells

artículo científico publicado en 2022

Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1)

artículo científico publicado en 2014

PDZ domain from Dishevelled -- a specificity study

artículo científico publicado el 13 de junio de 2011

PDZ domains - common players in the cell signaling

artículo científico publicado en 2003

PDZ tandem of human syntenin: crystal structure and functional properties

artículo científico publicado en 2003

Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF.

artículo científico publicado en 2004

Protease resistant variants of FGF1 with prolonged biological activity.

artículo científico publicado en 2014

Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells

artículo científico publicado en 2021

Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule

artículo científico publicado en 2015

Selection and characterization of human antibody fragments specific for psoriasin - a cancer associated protein

artículo científico publicado en 2012

Selection of specific interactors from phage display library based on sea lamprey variable lymphocyte receptor sequences

artículo científico publicado en 2015

Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1)

artículo científico publicado en 2020

Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity

artículo científico publicado en 2018

Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential

artículo científico publicado en 2020

Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin

artículo científico publicado en 2003

Structural requirements of FGF-1 for receptor binding and translocation into cells

artículo científico publicado en 2006

Structure of a highly stable mutant of human fibroblast growth factor 1

scientific article published on 18 December 2008

Tailoring small proteins towards biomedical applications

artículo científico publicado en 2011

Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment

scientific article published on 20 December 2018

The DCX-domain tandems of doublecortin and doublecortin-like kinase

artículo científico publicado en 2003

The autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding

artículo científico publicado en 2017

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle

artículo científico publicado en 2004

The dimerization mechanism of LIS1 and its implication for proteins containing the LisH motif

artículo científico publicado en 2006

The high Zn(II) affinity of the tetracysteine tag affects its fluorescent labeling with biarsenicals

artículo científico publicado en 2010

The impact of Glu-->Ala and Glu-->Asp mutations on the crystallization properties of RhoGDI: the structure of RhoGDI at 1.3 A resolution

artículo científico publicado en 2002

The impact of Lys-->Arg surface mutations on the crystallization of the globular domain of RhoGDI

artículo científico publicado en 2004

The many faces of protease-protein inhibitor interaction

artículo científico publicado en 2005

The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF

scientific article published on 05 September 2006

The structure of the N-terminal domain of the product of the lissencephaly gene Lis1 and its functional implications

artículo científico publicado en 2004

Thermodynamics of single peptide bond cleavage in bovine pancreatic trypsin inhibitor (BPTI).

artículo científico publicado en 2002

Translocation of Exogenous FGF1 and FGF2 Protects the Cell against Apoptosis Independently of Receptor Activation

artículo científico publicado en 2018

Trypsin specificity as elucidated by LIE calculations, X-ray structures, and association constant measurements

artículo científico publicado en 2004

Tumor-specific hyperthermia with aptamer-tagged superparamagnetic nanoparticles.

artículo científico publicado en 2013

Lista de obras de Jacek Otlewski

A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells

A Novel Affibody-Auristatin E Conjugate With a Potent and Selective Activity Against HER2+ Cell Lines.

A novel, stable, helical scaffold as an alternative binder - construction of phage display libraries

Amyloid-forming peptides selected proteolytically from phage display library

Analysis of serine proteinase-inhibitor interaction by alanine shaving

Anti-FGFR1 aptamer-tagged superparamagnetic conjugates for anticancer hyperthermia therapy

Antibody-induced dimerization of FGFR1 promotes receptor endocytosis independently of its kinase activity

Aptamers: Molecules of great potential ⬇️

Assignment of 1H, 13C and 15N resonances of the N-terminal microtubule-binding domain of human doublecortin

Biophysical properties of the eukaryotic ribosomal stalk

Bivalent peptides as models for multimeric targets of PDZ domains.

Correction: Serwotka-Suszczak, A. M. et al. A Conjugate Based on Anti-HER2 Diaffibody and Auristatin E Targets HER2-Positive Cancer Cells. Int. J. Mol. Sci. 2017, 18, 401

Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins

Crosstalk between p38 and Erk 1/2 in Downregulation of FGF1-Induced Signaling

Crystal structure of Vigna radiata cytokinin-specific binding protein in complex with zeatin

Crystal structures of five bovine chymotrypsin complexes with P1 BPTI variants

Current methods for the synthesis of homogeneous antibody-drug conjugates

Cytokinin-induced structural adaptability of a Lupinus luteus PR-10 protein

Cytotoxic Conjugates of Fibroblast Growth Factor 2 (FGF2) with Monomethyl Auristatin E for Effective Killing of Cells Expressing FGF Receptors.

Degenerate specificity of PDZ domains from RhoA-specific nucleotide exchange factors PDZRhoGEF and LARG.

Design and In Vitro Evaluation of a Cytotoxic Conjugate Based on the Anti-HER2 Affibody Fused to the Fc Fragment of IgG1.

Design and characteristics of a stable protein scaffold for specific binding based on variable lymphocyte receptor sequences ⬇️

Design and characteristics of cytotoxic fibroblast growth factor 1 conjugate for fibroblast growth factor receptor-targeted cancer therapy

Design of fully active FGF-1 variants with increased stability

Design, expression and characterization of a highly stable tetratricopeptide-based protein scaffold for phage display application

Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins.

Dissecting the thermodynamics of GAP-RhoA interactions

ERK-mediated phosphorylation of fibroblast growth factor receptor 1 on Ser777 inhibits signaling.

Efficient production and purification of extracellular domain of human FGFR-Fc fusion proteins from Chinese hamster ovary cells.

Exploring the Sn binding pockets in gingipains by newly developed inhibitors: structure-based design, chemistry, and activity

Expression, purification and catalytic activity of Lupinus luteus asparagine beta-amidohydrolase and its Escherichia coli homolog

Expression, purification and crystallization of cysteine-rich human protein muskelin in Escherichia coli

FGF1-gold nanoparticle conjugates targeting FGFR efficiently decrease cell viability upon NIR irradiation

FGF2 Dual Warhead Conjugate with Monomethyl Auristatin E and α-Amanitin Displays a Cytotoxic Effect towards Cancer Cells Overproducing FGF Receptor 1

FGF2-Derived PeptibodyF2-MMAE Conjugate for Targeted Delivery of Cytotoxic Drugs into Cancer Cells Overexpressing FGFR1

FGFR1 clustering with engineered tetravalent antibody improves the efficiency and modifies the mechanism of receptor internalization

FHF1 is a bona fide fibroblast growth factor that activates cellular signaling in FGFR-dependent manner

Femtomolar Zn2+ affinity of LIM domain of PDLIM1 protein uncovers crucial contribution of protein-protein interactions to protein stability.

Generation of high-affinity, internalizing anti-FGFR2 single-chain variable antibody fragment fused with Fc for targeting gastrointestinal cancers

High Affinity Promotes Internalization of Engineered Antibodies Targeting FGFR1.

High-Affinity Internalizing Human scFv-Fc Antibody for Targeting FGFR1-Overexpressing Lung Cancer

High-Yield Site-Specific Conjugation of Fibroblast Growth Factor 1 with Monomethylauristatin E via Cysteine Flanked by Basic Residues.

Highly stable mutants of human fibroblast growth factor-1 exhibit prolonged biological action

Hydrogen bonds in human ubiquitin reflected in temperature coefficients of amide protons

Identification of a peptide antagonist of the FGF1-FGFR1 signaling axis by phage display selection

Identification of new FGF1 binding partners-Implications for its intracellular function

Importance of alpha-helix N-capping motif in stabilization of betabetaalpha fold.

Increased protein stability of FGF1 can compensate for its reduced affinity for heparin

Instability restricts signaling of multiple fibroblast growth factors.

Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions

Longer action means better drug: tuning up protein therapeutics

Low Stability of Integrin-Binding Deficient Mutant of FGF1 Restricts Its Biological Activity

Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein

NMR structures of two variants of bovine pancreatic trypsin inhibitor (BPTI) reveal unexpected influence of mutations on protein structure and stability

Novel Method for Preparation of Site-Specific, Stoichiometric-Controlled Dual Warhead Conjugate of FGF2 via Dimerization Employing Sortase A-Mediated Ligation

Novel peptide recognized by RhoA GTPase

Nuclear Localization Sequence of FGF1 Is Not Required for Its Intracellular Anti-Apoptotic Activity in Differentiated Cells

Nucleolin regulates phosphorylation and nuclear export of fibroblast growth factor 1 (FGF1)

PDZ domain from Dishevelled -- a specificity study

PDZ domains - common players in the cell signaling

PDZ tandem of human syntenin: crystal structure and functional properties

Preliminary crystallographic analysis of the complex of the human GTPase RhoA with the DH/PH tandem of PDZ-RhoGEF.

Protease resistant variants of FGF1 with prolonged biological activity.

Purification and In Vitro Evaluation of an Anti-HER2 Affibody-Monomethyl Auristatin E Conjugate in HER2-Positive Cancer Cells

Selection and Characterization of Single Chain Antibody Fragments Specific for Hsp90 as a Potential Cancer Targeting Molecule

Selection and characterization of human antibody fragments specific for psoriasin - a cancer associated protein

Selection of specific interactors from phage display library based on sea lamprey variable lymphocyte receptor sequences

Site-Specific, Stoichiometric-Controlled, PEGylated Conjugates of Fibroblast Growth Factor 2 (FGF2) with Hydrophilic Auristatin Y for Highly Selective Killing of Cancer Cells Overproducing Fibroblast Growth Factor Receptor 1 (FGFR1)

Specific Antibody Fragment Ligand Traps Blocking FGF1 Activity

Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic Potential

Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin

Structural requirements of FGF-1 for receptor binding and translocation into cells

Structure of a highly stable mutant of human fibroblast growth factor 1

Tailoring small proteins towards biomedical applications

Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment

The DCX-domain tandems of doublecortin and doublecortin-like kinase

The autoinhibitory function of D1 domain of FGFR1 goes beyond the inhibition of ligand binding

The crystal structure of RhoA in complex with the DH/PH fragment of PDZRhoGEF, an activator of the Ca(2+) sensitization pathway in smooth muscle

The dimerization mechanism of LIS1 and its implication for proteins containing the LisH motif