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A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

artículo científico publicado en 2010

Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit

artículo científico publicado en 2011

Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms

artículo científico publicado en 2004

Brain acetylcholinesterase activity controls systemic cytokine levels through the cholinergic anti-inflammatory pathway

artículo científico publicado en 2008

Brain region-specific alterations in the gene expression of cytokines, immune cell markers and cholinergic system components during peripheral endotoxin-induced inflammation

artículo científico publicado en 2014

Central muscarinic cholinergic regulation of the systemic inflammatory response during endotoxemia

artículo científico publicado en 2006

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

artículo científico publicado en 2004

Galantamine alleviates inflammation and other obesity-associated complications in high-fat diet-fed mice.

artículo científico publicado en 2011

ISO-1 binding to the tautomerase active site of MIF inhibits its pro-inflammatory activity and increases survival in severe sepsis

artículo científico publicado en 2005

Identification of pigment epithelium-derived factor as an adipocyte-derived inflammatory factor

artículo científico publicado en 2012

Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling

artículo científico publicado en 2008

Nicotinic acetylcholine receptor alpha7 subunit is an essential regulator of inflammation

artículo científico publicado en 2003

Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

artículo científico publicado en 2003

Role of HMGB1 in apoptosis-mediated sepsis lethality

artículo científico publicado en 2006

Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis

artículo científico publicado en 2007

Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis

scientific journal article

Suppression of HMGB1 release by stearoyl lysophosphatidylcholine:an additional mechanism for its therapeutic effects in experimental sepsis

artículo científico publicado en 2005

Thyroxine is a potential endogenous antagonist of macrophage migration inhibitory factor (MIF) activity

artículo científico publicado en 2011

Transcutaneous vagus nerve stimulation reduces serum high mobility group box 1 levels and improves survival in murine sepsis

artículo científico publicado en 2007

Xanomeline suppresses excessive pro-inflammatory cytokine responses through neural signal-mediated pathways and improves survival in lethal inflammation

artículo científico publicado en 2014