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A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis

artículo científico publicado en 2006

A novel ring-substituted diindolylmethane,1,1-bis[3'-(5-methoxyindolyl)]-1-(p-t-butylphenyl) methane, inhibits extracellular signal-regulated kinase activation and induces apoptosis in acute myelogenous leukemia

artículo científico publicado en 2005

An organometallic protein kinase inhibitor pharmacologically activates p53 and induces apoptosis in human melanoma cells

artículo científico publicado en 2007

Development of a conditional in vivo model to evaluate the efficacy of small molecule inhibitors for the treatment of Raf-transformed hematopoietic cells

artículo científico publicado en 2005

Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression

artículo científico publicado en 2008

Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

artículo científico publicado en 2008

Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia

artículo científico publicado en 2006

PPARgamma-active triterpenoid CDDO enhances ATRA-induced differentiation in APL.

artículo científico publicado en 2007

Up-regulation of MDR1 and induction of doxorubicin resistance by histone deacetylase inhibitor depsipeptide (FK228) and ATRA in acute promyelocytic leukemia cells

artículo científico publicado en 2005