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3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers

artículo científico publicado en 2019

A functional analysis of 180 cancer cell lines reveals conserved intrinsic metabolic programs

artículo científico publicado en 2022

AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo

artículo científico publicado el 16 de julio de 2013

Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress

artículo científico publicado en 2015

Acetyl-coA synthetase 2 promotes acetate utilization and maintains cell growth under metabolic stress.

artículo científico publicado en 2014

Activity of the monocarboxylate transporter 1 inhibitor AZD3965 in small cell lung cancer

artículo científico publicado en 2013

Combined Inhibition of PI3Kβ and mTOR Inhibits Growth of PTEN-null Tumors

scientific article published on 10 August 2018

Inhibiting PI3Kβ with AZD8186 Regulates Key Metabolic Pathways in PTEN-Null Tumors

artículo científico publicado en 2017

Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

artículo científico publicado en 2016

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

artículo científico publicado en 2017

Inhibition of monocarboxylate transporter-1 (MCT1) by AZD3965 enhances radiosensitivity by reducing lactate transport

artículo científico publicado en 2014

Investigation of the role of Ras and other signaling kinases on the regulation of pyruvate dehydrogenase complex activity

Leptin, BMI, and a Metabolic Gene Expression Signature Associated with Clinical Outcome to VEGF Inhibition in Colorectal Cancer

artículo científico publicado en 2015

Pre-clinical pharmacology of AZD3965, a selective inhibitor of MCT1: DLBCL, NHL and Burkitt's lymphoma anti-tumor activity

artículo científico publicado en 2017

Quantitation of Endogenous Metabolites in Mouse Tumors Using Mass-Spectrometry Imaging

artículo científico publicado en 2018

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters

scientific article published in Scientific Reports

Targeted Metabolic Profiling of the Tg197 Mouse Model Reveals Itaconic Acid as a Marker of Rheumatoid Arthritis

artículo científico publicado en 2016

Targeted profiling of polar intracellular metabolites using ion-pair-high performance liquid chromatography and -ultra high performance liquid chromatography coupled to tandem mass spectrometry: applications to serum, urine and tissue extracts

artículo científico publicado en 2014

The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer

scientific article published on 07 January 2021