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A multi-center preclinical study of gadoxetate DCE-MRI in rats as a biomarker of drug induced inhibition of liver transporter function.

artículo científico publicado en 2018

Activation of peroxisome proliferator-activated receptor-alpha protects the heart from ischemia/reperfusion injury

artículo científico publicado en 2003

Albiglutide, a Long Lasting Glucagon-Like Peptide-1 Analog, Protects the Rat Heart against Ischemia/Reperfusion Injury: Evidence for Improving Cardiac Metabolic Efficiency ⬇️

artículo científico publicado el 26 de agosto de 2011

An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure

artículo científico publicado en 2012

Apoptosis signal-regulating kinase 1 inhibition attenuates cardiac hypertrophy and cardiorenal fibrosis induced by uremic toxins: Implications for cardiorenal syndrome

artículo científico publicado en 2017

Assessing the effects of LXR agonists on cellular cholesterol handling: a stable isotope tracer study

artículo científico publicado en 2006

Assessment of macrophage infiltration in a murine model of abdominal aortic aneurysm

artículo científico publicado en 2009

Atherosclerotic plaque inflammation varies between vascular sites and correlates with response to inhibition of lipoprotein-associated phospholipase A2.

artículo científico publicado en 2015

Cardioprotection Resulting from Glucagon-Like Peptide-1 Administration Involves Shifting Metabolic Substrate Utilization to Increase Energy Efficiency in the Rat Heart

artículo científico publicado en 2015

Cardioprotection by systemic dosing of thymosin beta four following ischemic myocardial injury

artículo científico publicado en 2013

Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

artículo científico publicado en 2013

Chronic inhibition of hypoxia-inducible factor prolyl 4-hydroxylase improves ventricular performance, remodeling, and vascularity after myocardial infarction in the rat.

artículo científico publicado en 2010

Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress.

artículo científico publicado en 2012

Differential uptake of ferumoxtran-10 and ferumoxytol, ultrasmall superparamagnetic iron oxide contrast agents in rabbit: critical determinants of atherosclerotic plaque labeling

scientific article published on 01 April 2005

Examining the relationship between exercise tolerance and isoproterenol-based cardiac reserve in murine models of heart failure

artículo científico publicado en 2013

Hepatic Phospholipidosis Is Associated with Altered Hepatobiliary Function as Assessed by Gadoxetate Dynamic Contrast-enhanced Magnetic Resonance Imaging

artículo científico publicado en 2015

In Vivo Imaging of Small Molecular Weight Peptides for Targeted Renal Drug Delivery: A Study in Normal and Polycystic Kidney Diseased Mice

artículo científico publicado en 2019

In vivo activation of peroxisome proliferator-activated receptor-delta protects the heart from ischemia/reperfusion injury in Zucker fatty rats

artículo científico publicado en 2008

In vivo serial assessment of aortic aneurysm formation in apolipoprotein E-deficient mice via MRI

scientific article published on 17 September 2008

Inhibition of Apoptosis Signal-Regulating Kinase 1 Attenuates Myocyte Hypertrophy and Fibroblast Collagen Synthesis

artículo científico publicado en 2017

Inhibition of FGF/FGFR autocrine signaling in mesothelioma with the FGF ligand trap, FP-1039/GSK3052230.

scientific article published on 20 May 2016

Inhibition of apoptosis signal-regulating kinase 1 ameliorates left ventricular dysfunction by reducing hypertrophy and fibrosis in a rat model of cardiorenal syndrome

scientific article published on 06 April 2020

Multimodal imaging approach to examine biodistribution kinetics of Cabotegravir (GSK1265744) long acting parenteral formulation in rat.

artículo científico publicado en 2017

Non invasive imaging assessment of the biodistribution of GSK2849330, an ADCC and CDC optimized anti HER3 mAb, and its role in tumor macrophage recruitment in human tumor-bearing mice

artículo científico publicado en 2017

Noninvasive assessment of ectopic uterine tissue development in rats using magnetic resonance imaging

artículo científico publicado en 2007

Normalization of skeletal muscle glycogen synthesis and glycolysis in rosiglitazone-treated Zucker fatty rats: an in vivo nuclear magnetic resonance study

artículo científico publicado en 2002

Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat

artículo científico publicado en 2013

PPARdelta activation normalizes cardiac substrate metabolism and reduces right ventricular hypertrophy in congestive heart failure

scientific article published on 01 July 2007

Pharmacological inhibition of C-C chemokine receptor 2 decreases macrophage infiltration in the aortic root of the human C-C chemokine receptor 2/apolipoprotein E-/- mouse: magnetic resonance imaging assessment

artículo científico publicado en 2009

RE: ASK1, a new target in treating cardiorenal syndrome (CRS)

artículo científico publicado en 2020

RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis

artículo científico publicado en 2020

RE: Inhibition of apoptosis signal-regulating kinase 1 might be a novel therapeutic target in the treatment of cardiorenal syndrome

scientific article published on 10 September 2020

Reduction of intramyocellular lipid following short-term rosiglitazone treatment in Zucker fatty rats: an in vivo nuclear magnetic resonance study

artículo científico publicado en 2003

Rosiglitazone treatment in Zucker diabetic Fatty rats is associated with ameliorated cardiac insulin resistance and protection from ischemia/reperfusion-induced myocardial injury

artículo científico publicado en 2005

Selective PPARdelta agonist treatment increases skeletal muscle lipid metabolism without altering mitochondrial energy coupling: an in vivo magnetic resonance spectroscopy study

scientific article published on 28 August 2007

Serial MRI characterization of the functional and morphological changes in mouse lung in response to cardiac remodeling following myocardial infarction ⬇️

artículo científico publicado el 10 de junio de 2011

Simultaneous assessment of left-ventricular infarction size, function and tissue viability in a murine model of myocardial infarction by cardiac manganese-enhanced magnetic resonance imaging (MEMRI).

artículo científico publicado en 2004

Soluble epoxide hydrolase inhibition does not prevent cardiac remodeling and dysfunction after aortic constriction in rats and mice

artículo científico publicado en 2013

Synthetic LXR agonists increase LDL in CETP species

artículo científico publicado en 2005

Technologies: preclinical imaging for drug development

artículo científico publicado en 2013

The use of micro-CT imaging to examine and illustrate fetal skeletal abnormalities in Dutch Belted rabbits and to prove concordance with Alizarin Red stained skeletal examination

artículo científico publicado en 2017

p38 MAPK Inhibitors Ameliorate Target Organ Damage in Hypertension: Part 2. Improved Renal Function as Assessed by Dynamic Contrast-Enhanced Magnetic Resonance Imaging ⬇️

artículo científico publicado el 15 de octubre de 2003

p38 MAPK inhibition reduces aortic ultrasmall superparamagnetic iron oxide uptake in a mouse model of atherosclerosis: MRI assessment

scientific article published on 27 December 2007

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