Lista de obras -

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

artículo científico publicado en 2005

1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity

artículo científico publicado en 2009

11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

artículo científico publicado en 2005

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity

artículo científico publicado en 2008

An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes

artículo científico publicado en 2012

Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist

artículo científico publicado en 2010

Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents

artículo científico publicado en 2007

ApoA-I mimetic peptides promote pre-β HDL formation in vivo causing remodeling of HDL and triglyceride accumulation at higher dose

artículo científico publicado en 2010

Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments

artículo científico publicado en 2010

Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss

artículo científico publicado en 2011

Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents

artículo científico publicado en 2007

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

artículo científico publicado en 2003

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

artículo científico publicado en 2002

Design and synthesis of (ant)-agonists that alter appetite and adiposity

artículo científico publicado en 2006

Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation

artículo científico publicado en 2010

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocorti

artículo científico publicado en 2005

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

artículo científico publicado en 2005

Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

artículo científico publicado en 2012

Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity

artículo científico publicado en 2010

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

artículo científico publicado en 2011

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

artículo científico publicado en 2010

Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality

artículo científico publicado en 2011

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists

artículo científico publicado en 2010

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

artículo científico publicado en 2010

Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.

artículo científico publicado en 2010

Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice

artículo científico publicado en 2005

Glucocorticoids, chronic stress, and obesity

artículo científico publicado en 2006

Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9 ⬇️

artículo científico publicado el 24 de enero de 2011

Lack of protection with a novel, selective melanocortin receptor subtype-4 agonist RY767 in a rat transient middle cerebral artery occlusion stroke model

artículo científico publicado en 2008

Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists

artículo científico publicado en 2007

Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

artículo científico publicado en 2002

Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity

artículo científico publicado en 2006

Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice

artículo científico publicado en 2004

Modulation of metabolic syndrome by fibroblast growth factor 19 (FGF19)?

artículo científico publicado en 2004

Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis ⬇️

artículo científico publicado el 28 de octubre de 2012

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia ⬇️

artículo científico publicado el 23 de octubre de 2011

Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation

artículo científico publicado en 2009

Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice ⬇️

artículo científico publicado el 8 de noviembre de 2011

Regulation of body weight and carcass composition by sibutramine in rats

artículo científico publicado en 2002

Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity

artículo científico publicado en 2010

Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat.

artículo científico publicado en 2005

Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists

artículo científico publicado en 2007

Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists

artículo científico publicado en 2005

Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists

artículo científico publicado en 2005

The mu-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist

artículo científico publicado en 2006

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

artículo científico publicado en 2002

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

artículo científico publicado en 2002

The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity

artículo científico publicado en 2008

The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species

artículo científico publicado en 2011

Utilizing HaloTag Technology to Track the Fate of PCSK9 from Intracellular vs. Extracellular Sources ⬇️

artículo científico publicado el 20 de septiembre de 2012

Validation of Human ApoB and ApoAI Immunoturbidity Assays for Non-human Primate Dyslipidemia and Atherosclerosis Research ⬇️

artículo científico publicado el 11 de marzo de 2011

Lista de obras de

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

1-Sulfonyl-4-acylpiperazines as selective cannabinoid-1 receptor (CB1R) inverse agonists for the treatment of obesity

11beta-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

2-Substituted piperazine-derived imidazole carboxamides as potent and selective CCK1R agonists for the treatment of obesity

An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes

Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist

Antiobesity efficacy of a novel cannabinoid-1 receptor inverse agonist, N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[[5-(trifluoromethyl)pyridin-2-yl]oxy]propanamide (MK-0364), in rodents

ApoA-I mimetic peptides promote pre-β HDL formation in vivo causing remodeling of HDL and triglyceride accumulation at higher dose

Body temperature as a mouse pharmacodynamic response to bombesin receptor subtype-3 agonists and other potential obesity treatments

Cannabinoid-1 receptor inhibition prevents the reduction of 24-hour energy expenditure with weight loss

Characterization of a novel and selective cannabinoid CB1 receptor inverse agonist, Imidazole 24b, in rodents

Chronic MCH-1 receptor modulation alters appetite, body weight and adiposity in rats

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

Design and synthesis of (ant)-agonists that alter appetite and adiposity

Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocorti

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity

Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists

Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.

Ghrelin neutralization by a ribonucleic acid-SPM ameliorates obesity in diet-induced obese mice

Glucocorticoids, chronic stress, and obesity

Improved efficacy for ezetimibe and rosuvastatin by attenuating the induction of PCSK9 ⬇️

Lack of protection with a novel, selective melanocortin receptor subtype-4 agonist RY767 in a rat transient middle cerebral artery occlusion stroke model

Lead optimization of 5,6-diarylpyridines as CB1 receptor inverse agonists

Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism

Melanocortin-4 receptor (MC4R) agonists for the treatment of obesity

Metabotropic glutamate receptor mGlu5 is a mediator of appetite and energy balance in rats and mice

Modulation of metabolic syndrome by fibroblast growth factor 19 (FGF19)?

Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis ⬇️

Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia ⬇️

Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation

Reconstituted HDL Elicits Marked Changes in Plasma Lipids Following Single-Dose Injection in C57Bl/6 Mice ⬇️

Regulation of body weight and carcass composition by sibutramine in rats

Regulation of energy homeostasis by bombesin receptor subtype-3: selective receptor agonists for the treatment of obesity

Structure-activity relationship of linear tetrapeptides Tic-DPhe-Arg-Trp-NH2 at the human melanocortin-4 receptor and effects on feeding behaviors in rat.

Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists

Synthesis and SAR of 5,6-diarylpyridines as human CB1 inverse agonists

Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists

The mu-opioid receptor subtype is required for the anorectic effect of an opioid receptor antagonist

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

The role of melanocortins in body weight regulation: opportunities for the treatment of obesity

The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity

The use of stable-isotopically labeled oleic acid to interrogate lipid assembly in vivo: assessing pharmacological effects in preclinical species

Utilizing HaloTag Technology to Track the Fate of PCSK9 from Intracellular vs. Extracellular Sources ⬇️

Validation of Human ApoB and ApoAI Immunoturbidity Assays for Non-human Primate Dyslipidemia and Atherosclerosis Research ⬇️