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A cofactor consumption screen identifies promising NfsB family nitroreductases for dinitrotoluene remediation

scientific article published on 07 August 2019

A gain-of-function positive-selection expression plasmid that enables high-efficiency cloning

artículo científico publicado en 2014

Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A.

artículo científico publicado en 2013

Engineering Escherichia coli NfsB To Activate a Hypoxia-Resistant Analogue of the PET Probe EF5 To Enable Non-Invasive Imaging during Enzyme Prodrug Therapy

artículo científico publicado en 2019

Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.

artículo científico publicado en 2017

Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues

artículo científico publicado en 2020

Mechanistic Understanding Enables the Rational Design of Salicylanilide Combination Therapies for Gram-Negative Infections

scientific article published on 15 September 2020

Mechanistic understanding enables the rational design of salicylanilide combination therapies for Gram-negative infections

artículo científico publicado en 2020

Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility

artículo científico

Rational design of an AKR1C3-resistant analog of PR-104 for enzyme-prodrug therapy

artículo científico publicado en 2016

Reduction of quinones and nitroaromatic compounds by Escherichia coli nitroreductase A (NfsA): Characterization of kinetics and substrate specificity

artículo científico publicado en 2016

Site-saturation mutagenesis by overlap extension PCR.

artículo científico publicado en 2014

The Flavin Reductase MsuE Is a Novel Nitroreductase that Can Efficiently Activate Two Promising Next-Generation Prodrugs for Gene-Directed Enzyme Prodrug Therapy

artículo científico publicado en 2013

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