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A Recurrent Activating Missense Mutation in Waldenström Macroglobulinemia Affects the DNA Binding of the ETS Transcription Factor SPI1 and Enhances Proliferation

scientific article published on 24 April 2019

Cotargeting signaling pathways driving survival and cell cycle circumvents resistance to Kit inhibitors in leukemia ⬇️

artículo científico publicado el 20 de marzo de 2012

Multiple functional domains of the oncoproteins Spi-1/PU.1 and TLS are involved in their opposite splicing effects in erythroleukemic cells

artículo científico publicado en 2004

Nebula--a web-server for advanced ChIP-seq data analysis

artículo científico publicado en 2012

Oncogenic kit triggers Shp2/Erk1/2 pathway to down-regulate the pro-apoptotic protein Bim and to promote apoptosis resistance in leukemic cells

artículo científico publicado en 2012

Regulation of the positive transcriptional effect of PLZF through a non-canonical EZH2 activity.

artículo científico publicado en 2018

Senescence is a Spi1-induced anti-proliferative mechanism in primary hematopoietic cells.

artículo científico publicado en 2017

Spi-1 and Fli-1 directly activate common target genes involved in ribosome biogenesis in Friend erythroleukemic cells.

artículo científico publicado en 2009

Spi-1/PU.1 activates transcription through clustered DNA occupancy in erythroleukemia

artículo científico publicado en 2012

Spi-1/PU.1 oncogene accelerates DNA replication fork elongation and promotes genetic instability in the absence of DNA breakage

artículo científico publicado en 2010

Spi-1/PU.1 oncoprotein affects splicing decisions in a promoter binding-dependent manner

scientific article published on 11 May 2006

Spi-1/PU.1 participates in erythroleukemogenesis by inhibiting apoptosis in cooperation with Epo signaling and by blocking erythroid differentiation

artículo científico publicado en 2007

The Spi1/PU.1 transcription factor accelerates replication fork progression by increasing PP1 phosphatase in leukemia

artículo científico publicado en 2017

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