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(R)-(3-amino-2-fluoropropyl) phosphinic acid (AZD3355), a novel GABAB receptor agonist, inhibits transient lower esophageal sphincter relaxation through a peripheral mode of action

artículo científico publicado en 2009

A modeling approach for compounds affecting body composition

artículo científico publicado en 2013

Corrigendum to 'Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development' Drug Discovery Today 23 (2018) 1733-1745

artículo científico publicado en 2018

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

artículo científico publicado en 2009

Discovery of (3-(4-(2-Oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone (AZD1979), a Melanin Concentrating Hormone Receptor 1 (MCHr1) Antagonist with Favorable Physicochemical Properties

artículo científico publicado en 2016

Discovery of agonists of cannabinoid receptor 1 with restricted central nervous system penetration aimed for treatment of gastroesophageal reflux disease

artículo científico publicado en 2012

Drug metabolism and pharmacokinetic strategies for oligonucleotide- and mRNA-based drug development

scientific article published on 28 May 2018

Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs

artículo científico publicado en 2016

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

artículo científico publicado en 2014

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

artículo científico publicado en 2011

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

artículo científico publicado en 2007

Integrating efficacy and safety: Telemetry and echocardiography in a pig model of myocardial infarction

scientific article published on 01 September 2019

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

artículo científico publicado en 2009

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