Lista de obras -

A novel in vivo receptor occupancy methodology for the glucocorticoid receptor: toward an improved understanding of lung pharmacokinetic/pharmacodynamic relationships.

artículo científico publicado en 2015

Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

artículo científico publicado en 2017

Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

scientific article published on 30 January 2019

C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats.

artículo científico publicado en 2009

Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

artículo científico publicado en 2019

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.

artículo científico publicado en 2017

Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

artículo científico publicado en 2015

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

artículo científico publicado en 2009

Drug-drug interactions of anti-infective drugs: utility of fluorescence cyp inhibition assays in drug discovery

artículo científico publicado en 2006

Exploring in silico prediction of the unbound brain-to-plasma drug concentration ratio: model validation, renewal, and interpretation

artículo científico publicado en 2014

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

artículo científico publicado en 2014

Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

artículo científico publicado en 2009

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

artículo científico publicado en 2011

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

artículo científico publicado en 2007

Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

artículo científico publicado en 2016

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods ⬇️

artículo científico publicado el 13 de diciembre de 2010

Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling

artículo científico publicado en 2020

Methodologies to assess brain drug delivery in lead optimization

artículo científico publicado en 2009

On the rate and extent of drug delivery to the brain.

artículo científico publicado en 2008

Pharmacokinetic considerations of nanodelivery to the brain: Using modeling and simulations to predict the outcome of liposomal formulations

artículo científico publicado en 2016

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

artículo científico publicado en 2018

Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator ⬇️

scientific article published on 29 January 2019

Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging

artículo científico publicado en 2019

Simultaneous determination of renal plasma flow and glomerular filtration rate in conscious mice using dual bolus injection

artículo científico publicado en 2013

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

artículo científico publicado en 2009

The brain slice method for studying drug distribution in the CNS

artículo científico publicado en 2013

Translational model to predict pulmonary pharmacokinetics and efficacy in man for inhaled bronchodilators

artículo científico publicado en 2017

Uncovering the regional localization of inhaled salmeterol retention in the lung

artículo científico publicado en 2018

Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling

scientific article published on 01 June 2019

Lista de obras de

A novel in vivo receptor occupancy methodology for the glucocorticoid receptor: toward an improved understanding of lung pharmacokinetic/pharmacodynamic relationships.

Benchmarking of Human Dose Prediction for Inhaled Medicines from Preclinical In Vivo Data

Building on the success of osimertinib: achieving CNS exposure in oncology drug discovery

C-peptide normalizes glomerular filtration rate in hyperfiltrating conscious diabetic rats.

Computational modeling of lung deposition of inhaled particles in chronic obstructive pulmonary disease (COPD) patients: identification of gaps in knowledge and data

Current Progress Toward a Better Understanding of Drug Disposition Within the Lungs: Summary Proceedings of the First Workshop on Drug Transporters in the Lungs.

Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds

Development of a high-throughput brain slice method for studying drug distribution in the central nervous system

Drug-drug interactions of anti-infective drugs: utility of fluorescence cyp inhibition assays in drug discovery

Exploring in silico prediction of the unbound brain-to-plasma drug concentration ratio: model validation, renewal, and interpretation

Identification of positron emission tomography (PET) tracer candidates by prediction of the target-bound fraction in the brain

Improved measurement of drug exposure in the brain using drug-specific correction for residual blood

In silico prediction of unbound brain-to-plasma concentration ratio using machine learning algorithms

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids

Lung Retention by Lysosomal Trapping of Inhaled Drugs Can Be Predicted In Vitro With Lung Slices

Measurement of Unbound Drug Exposure in Brain: Modeling of pH Partitioning Explains Diverging Results between the Brain Slice and Brain Homogenate Methods ⬇️

Mechanisms of a sustained anti-inflammatory drug response in alveolar macrophages unraveled with mathematical modeling

Methodologies to assess brain drug delivery in lead optimization

On the rate and extent of drug delivery to the brain.

Pharmacokinetic considerations of nanodelivery to the brain: Using modeling and simulations to predict the outcome of liposomal formulations

Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Accurately Predicts the Better Bronchodilatory Effect of Inhaled Versus Oral Salbutamol Dosage Forms

Pulmonary PET imaging confirms preferential lung target occupancy of an inhaled bronchodilator ⬇️

Revealing the Regional Localization and Differential Lung Retention of Inhaled Compounds by Mass Spectrometry Imaging

Simultaneous determination of renal plasma flow and glomerular filtration rate in conscious mice using dual bolus injection

Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids

The brain slice method for studying drug distribution in the CNS

Translational model to predict pulmonary pharmacokinetics and efficacy in man for inhaled bronchodilators

Uncovering the regional localization of inhaled salmeterol retention in the lung

Understanding the Influence of Nanocarrier-Mediated Brain Delivery on Therapeutic Performance Through Pharmacokinetic-Pharmacodynamic Modeling