Lista de obras -

A Pilot Study of Thymosin .ALPHA.1 Therapy for Chronic Hepatitis B Patients ⬇️

artículo científico publicado el 1 de octubre de 2003

A long-term glycyrrhizin injection therapy reduces hepatocellular carcinogenesis rate in patients with interferon-resistant active chronic hepatitis C: a cohort study of 1249 patients.

artículo científico publicado en 2006

Adefovir dipivoxil for treatment of breakthrough hepatitis caused by lamivudine-resistant mutants of hepatitis B virus.

artículo científico publicado en 2004

Adequate timing of ribavirin reduction in patients with hemolysis during combination therapy of interferon and ribavirin for chronic hepatitis C.

artículo científico publicado en 2004

Anticarcinogenic impact of interferon on patients with chronic hepatitis C: a large-scale long-term study in a single center

artículo científico publicado en 2006

Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy.

artículo científico publicado en 2005

Association of amino acid substitution pattern in nonstructural protein 5A of hepatitis C virus genotype2a low viral load and response to interferon monotherapy.

artículo científico publicado en 2003

Benefit of lamivudine therapy and factors associated with clinical outcome in spontaneous severe acute exacerbation of chronic hepatitis B virus infection

artículo científico publicado en 2004

Clinical and pathological characteristics of the autoimmune hepatitis and primary biliary cirrhosis overlap syndrome

artículo científico publicado en 2004

Clinical and virological characteristics of untreated patients with chronic hepatitis C who develop serum alanine aminotransferase flare-up

artículo científico publicado en 2005

Clinical and virological features of non-breakthrough and severe exacerbation due to lamivudine-resistant hepatitis B virus mutants

artículo científico publicado en 2006

Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C.

artículo científico publicado en 2002

Clinical features of hepatitis B virus genotype A in Japanese patients.

artículo científico publicado en 2003

Consistently low hepatitis B virus DNA saves patients from hepatocellular carcinogenesis in HBV-related cirrhosis. A nested case-control study using 96 untreated patients

artículo científico publicado en 2003

Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3cm or less in diameter

artículo científico publicado en 2005

Determinants of serum ALT normalization after phlebotomy in patients with chronic hepatitis C infection

artículo científico publicado en 2005

Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis

artículo científico publicado en 2006

Early viral kinetics and treatment outcome in combination of high-dose interferon induction vs. pegylated interferon plus ribavirin for naive patients infected with hepatitis C virus of genotype 1b and high viral load.

artículo científico publicado en 2005

Effect of acute self-limited hepatitis C virus (HCV) superinfection on hepatitis B virus (HBV)-related cirrhosis. Virological features of HBV-HCV dual infection

artículo científico publicado en 2004

Efficacy of 6-month interferon therapy in chronic hepatitis B virus infection in Japan.

artículo científico publicado en 2004

Efficacy of interferon monotherapy in young adult patients with chronic hepatitis C virus infection.

artículo científico publicado en 2006

Efficacy of interferon monotherapy to 394 consecutive naive cases infected with hepatitis C virus genotype 2a in Japan: therapy efficacy as consequence of tripartite interaction of viral, host and interferon treatment-related factors

artículo científico publicado en 2002

Efficacy of interferon retreatment after relapse for chronic hepatitis C patients with biochemical response after first interferon therapy

artículo científico publicado en 2004

Efficacy of interferon therapy in elderly patients with chronic hepatitis C.

artículo científico publicado en 2006

Efficacy of lamivudine therapy and factors associated with emergence of resistance in chronic hepatitis B virus infection in Japan.

artículo científico publicado en 2003

Efficacy of lamivudine treatment in Japanese patients with hepatitis B virus-related cirrhosis

artículo científico publicado en 2004

Efficacy of prolonged interferon therapy for patients with chronic hepatitis C with HCV-genotype 1b and high virus load

artículo científico publicado en 2003

Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine.

artículo científico publicado en 2007

Factors contributing to ribavirin dose reduction due to anemia during interferon alfa2b and ribavirin combination therapy for chronic hepatitis C.

artículo científico publicado en 2004

Favorable efficacy of long-term lamivudine therapy in patients with chronic hepatitis B: an 8-year follow-up study.

artículo científico publicado en 2005

HBe antigen loss during lamivudine therapy is not caused by mutations in precore and core promoter genes in patients with chronic hepatitis B.

artículo científico publicado en 2003

Hepatitis B virus-related hepatocellular carcinogenesis and its prevention

artículo científico publicado en 2005

Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection

artículo científico publicado en 2004

Hepatocyte steatosis is an important predictor of response to interferon (IFN) monotherapy in Japanese patients infected with HCV genotype 2a: Virological features of IFN-resistant cases with hepatocyte steatosis

artículo científico publicado en 2005

High-dose interferon alpha-2b induction therapy in combination with ribavirin for Japanese patients infected with hepatitis C virus genotype 1b with a high baseline viral load.

artículo científico publicado en 2004

Histological improvements after a three-year lamivudine therapy in patients with chronic hepatitis B in whom YMDD mutants did not or did develop

artículo científico publicado en 2003

Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001.

artículo científico publicado en 2004

Influence of hepatitis C virus subtype on hepatocellular carcinogenesis: a multivariate analysis of a retrospective cohort of 593 patients with cirrhosis

artículo científico publicado en 2002

Inhibitory effect of branched-chain amino acid granules on progression of compensated liver cirrhosis due to hepatitis C virus

artículo científico publicado en 2008

Interferon for treatment of breakthrough infection with hepatitis B virus mutants developing during long-term lamivudine therapy

artículo científico publicado en 2002

Interferon lowers tumor recurrence rate after surgical resection or ablation of hepatocellular carcinoma: a pilot study of patients with hepatitis B virus-related cirrhosis.

artículo científico publicado en 2006

Interferon monotherapy for patients with chronic hepatitis C and normal serum aminotransferase levels at commencement of treatment.

artículo científico publicado en 2004

Interferon therapy for 2 years or longer reduces the incidence of hepatocarcinogenesis in patients with chronic hepatitis C viral infection.

artículo científico publicado en 2004

Interferon-alpha for reinfection with hepatitis C virus in two patients with chronic hepatitis C who had responded to previous therapies

artículo científico publicado en 2003

Lamivudine monotherapy for spontaneous severe acute exacerbation of chronic hepatitis B.

artículo científico publicado en 2005

Long-term clinical remission induced by corticosteroid withdrawal therapy (CSWT) in patients with chronic hepatitis B infection: a prospective randomized controlled trial--CSWT with and without follow-up interferon-alpha therapy

artículo científico publicado en 2002

Long-term follow-up of HBeAg-positive young adult Japanese patients treated with corticosteroid withdrawal therapy for chronic hepatitis B

scientific article published on 21 August 2006

Long-term follow-up of interferon monotherapy in 454 consecutive naive patients infected with hepatitis C virus: multi-course interferon therapy may reduce the risk of hepatocellular carcinoma and increase survival

artículo científico publicado en 2005

Long-term outcome after hepatitis B surface antigen seroclearance in patients with chronic hepatitis B.

artículo científico publicado en 2006

Long-term outcome after interferon therapy in elderly patients with chronic hepatitis C.

artículo científico publicado en 2007

Long-term outcome of HBV carriers with negative HBe antigen and normal aminotransferase.

artículo científico publicado en 2006

Long-term presence of HBV in the sera of chronic hepatitis B patients with HBsAg seroclearance.

artículo científico publicado en 2007

Long-term prognosis by lamivudine monotherapy for severe acute exacerbation in chronic hepatitis B infection: emergence of YMDD motif mutant and risk of breakthrough hepatitis -- an open-cohort study

artículo científico publicado en 2003

Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine.

artículo científico publicado en 2004

Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy

artículo científico publicado en 2002

Natural history of compensated cirrhosis in the Child-Pugh class A compared between 490 patients with hepatitis C and 167 with B virus infections.

artículo científico publicado en 2006

Origin of neovascular structure in an early stage of hepatocellular carcinoma: study of alpha-smooth muscle actin immunohistochemistry in serial thin sections of surgically resected cancer

artículo científico publicado en 2006

Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis

scientific article published on 01 July 2004

Persistence of acute infection with hepatitis B virus genotype A and treatment in Japan

artículo científico publicado en 2005

Precore wild-type hepatitis B virus with G1896 in the resolution of persistent hepatitis B virus infection.

artículo científico publicado en 2003

Prediction model of hepatocarcinogenesis for patients with hepatitis C virus-related cirrhosis. Validation with internal and external cohorts

artículo científico publicado en 2006

Predictive factors of virological non-response to interferon-ribavirin combination therapy for patients infected with hepatitis C virus of genotype 1b and high viral load.

artículo científico publicado en 2006

Randomized trial of prolonged interferon retreatment for chronic hepatitis C patients with HCV-genotype 1b and high virus load ⬇️

artículo científico publicado el 1 de abril de 2003

Randomized, controlled trial of natural interferon-alpha therapy for e-antigen-positive chronic hepatitis B patients

artículo científico publicado en 2002

Recurrence rate and prognosis of patients with hepatocellular carcinoma that developed after elimination of hepatitis C virus RNA by interferon therapy. A closed cohort study including matched control patients

artículo científico publicado en 2003

Serum levels of gamma-globulin and total bilirubin influence the prevalence of multiple extrahepatic complication in patients with hepatitis C virus infection

artículo científico publicado en 2003

Severe acute exacerbation of liver disease may reduce or delay emergence of YMDD motif mutants in long-term lamivudine therapy for hepatitis B e antigen-positive chronic hepatitis B.

artículo científico publicado en 2004

Significance of hepatitis B virus DNA clearance and early prediction of hepatocellular carcinogenesis in patients with cirrhosis undergoing interferon therapy: long-term follow up of a pilot study

artículo científico publicado en 2005

Significance of multicentric cancer recurrence after potentially curative ablation of hepatocellular carcinoma: a longterm cohort study of 892 patients with viral cirrhosis.

artículo científico publicado en 2003

Significance of serum ribavirin concentration in combination therapy of interferon and ribavirin for chronic hepatitis C.

artículo científico publicado en 2005

Stepwise hook extension technique for radiofrequency ablation therapy of hepatocellular carcinoma

artículo científico publicado en 2002

Successful control of ruptured hepatocellular carcinoma with radiofrequency ablation.

artículo científico publicado en 2004

Sustained negativity for HCV-RNA over 24 or more months by long-term interferon therapy correlates with eradication of HCV in patients with hepatitis C virus genotype 1b and high viral load

artículo científico publicado en 2004

The influence of hepatitis B virus genotype on the development of lamivudine resistance during long-term treatment.

artículo científico publicado en 2003

Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy

artículo científico publicado en 2003

Usefulness of serum KL-6 for early diagnosis of idiopathic pulmonary fibrosis in patients with hepatitis C virus.

artículo científico publicado en 2003

Usefulness of the serum KL-6 assay in patients with hepatitis C virus

artículo científico publicado en 2005

Viral genotypes and response to interferon in patients with acute prolonged hepatitis B virus infection of adulthood in Japan

artículo científico publicado en 2002

Virological and biochemical relapse according to YMDD motif mutant type during long‐term lamivudine monotherapy ⬇️

artículo científico publicado el 1 de diciembre de 2003

Virological and biochemical relapse after discontinuation of lamivudine monotherapy for chronic hepatitis B in Japan: comparison with breakthrough hepatitis during long-term treatment

artículo científico publicado en 2005

Virological differences between patients infected with subtypes Ba and Bj of hepatitis B virus genotype B.

artículo científico publicado en 2005

Virological outcomes in patients infected chronically with hepatitis B virus genotype A in comparison with genotypes B and C.

artículo científico publicado en 2006

YMDD mutants in patients with chronic hepatitis B before treatment are not selected by lamivudine

artículo científico publicado en 2004

Lista de obras de

A Pilot Study of Thymosin .ALPHA.1 Therapy for Chronic Hepatitis B Patients ⬇️

A long-term glycyrrhizin injection therapy reduces hepatocellular carcinogenesis rate in patients with interferon-resistant active chronic hepatitis C: a cohort study of 1249 patients.

Adefovir dipivoxil for treatment of breakthrough hepatitis caused by lamivudine-resistant mutants of hepatitis B virus.

Adequate timing of ribavirin reduction in patients with hemolysis during combination therapy of interferon and ribavirin for chronic hepatitis C.

Anticarcinogenic impact of interferon on patients with chronic hepatitis C: a large-scale long-term study in a single center

Association of amino acid substitution pattern in core protein of hepatitis C virus genotype 1b high viral load and non-virological response to interferon-ribavirin combination therapy.

Association of amino acid substitution pattern in nonstructural protein 5A of hepatitis C virus genotype2a low viral load and response to interferon monotherapy.

Benefit of lamivudine therapy and factors associated with clinical outcome in spontaneous severe acute exacerbation of chronic hepatitis B virus infection

Clinical and pathological characteristics of the autoimmune hepatitis and primary biliary cirrhosis overlap syndrome

Clinical and virological characteristics of untreated patients with chronic hepatitis C who develop serum alanine aminotransferase flare-up

Clinical and virological features of non-breakthrough and severe exacerbation due to lamivudine-resistant hepatitis B virus mutants

Clinical characteristics of patients infected with hepatitis B virus genotypes A, B, and C.

Clinical features of hepatitis B virus genotype A in Japanese patients.

Consistently low hepatitis B virus DNA saves patients from hepatocellular carcinogenesis in HBV-related cirrhosis. A nested case-control study using 96 untreated patients

Cost-effectiveness of radiofrequency ablation and surgical therapy for small hepatocellular carcinoma of 3cm or less in diameter

Determinants of serum ALT normalization after phlebotomy in patients with chronic hepatitis C infection

Dysplastic nodules frequently develop into hepatocellular carcinoma in patients with chronic viral hepatitis and cirrhosis

Early viral kinetics and treatment outcome in combination of high-dose interferon induction vs. pegylated interferon plus ribavirin for naive patients infected with hepatitis C virus of genotype 1b and high viral load.

Effect of acute self-limited hepatitis C virus (HCV) superinfection on hepatitis B virus (HBV)-related cirrhosis. Virological features of HBV-HCV dual infection

Efficacy of 6-month interferon therapy in chronic hepatitis B virus infection in Japan.

Efficacy of interferon monotherapy in young adult patients with chronic hepatitis C virus infection.

Efficacy of interferon monotherapy to 394 consecutive naive cases infected with hepatitis C virus genotype 2a in Japan: therapy efficacy as consequence of tripartite interaction of viral, host and interferon treatment-related factors

Efficacy of interferon retreatment after relapse for chronic hepatitis C patients with biochemical response after first interferon therapy

Efficacy of interferon therapy in elderly patients with chronic hepatitis C.

Efficacy of lamivudine therapy and factors associated with emergence of resistance in chronic hepatitis B virus infection in Japan.

Efficacy of lamivudine treatment in Japanese patients with hepatitis B virus-related cirrhosis

Efficacy of prolonged interferon therapy for patients with chronic hepatitis C with HCV-genotype 1b and high virus load

Factors associated with the virological response of lamivudine-resistant hepatitis B virus during combination therapy with adefovir dipivoxil plus lamivudine.

Factors contributing to ribavirin dose reduction due to anemia during interferon alfa2b and ribavirin combination therapy for chronic hepatitis C.

Favorable efficacy of long-term lamivudine therapy in patients with chronic hepatitis B: an 8-year follow-up study.

HBe antigen loss during lamivudine therapy is not caused by mutations in precore and core promoter genes in patients with chronic hepatitis B.

Hepatitis B virus-related hepatocellular carcinogenesis and its prevention

Hepatocellular carcinoma in noncirrhotic young adult patients with chronic hepatitis B viral infection

Hepatocyte steatosis is an important predictor of response to interferon (IFN) monotherapy in Japanese patients infected with HCV genotype 2a: Virological features of IFN-resistant cases with hepatocyte steatosis

High-dose interferon alpha-2b induction therapy in combination with ribavirin for Japanese patients infected with hepatitis C virus genotype 1b with a high baseline viral load.

Histological improvements after a three-year lamivudine therapy in patients with chronic hepatitis B in whom YMDD mutants did not or did develop

Infection with hepatitis B virus genotype A in Tokyo, Japan during 1976 through 2001.

Influence of hepatitis C virus subtype on hepatocellular carcinogenesis: a multivariate analysis of a retrospective cohort of 593 patients with cirrhosis

Inhibitory effect of branched-chain amino acid granules on progression of compensated liver cirrhosis due to hepatitis C virus

Interferon for treatment of breakthrough infection with hepatitis B virus mutants developing during long-term lamivudine therapy

Interferon lowers tumor recurrence rate after surgical resection or ablation of hepatocellular carcinoma: a pilot study of patients with hepatitis B virus-related cirrhosis.

Interferon monotherapy for patients with chronic hepatitis C and normal serum aminotransferase levels at commencement of treatment.

Interferon therapy for 2 years or longer reduces the incidence of hepatocarcinogenesis in patients with chronic hepatitis C viral infection.

Interferon-alpha for reinfection with hepatitis C virus in two patients with chronic hepatitis C who had responded to previous therapies

Lamivudine monotherapy for spontaneous severe acute exacerbation of chronic hepatitis B.

Long-term clinical remission induced by corticosteroid withdrawal therapy (CSWT) in patients with chronic hepatitis B infection: a prospective randomized controlled trial--CSWT with and without follow-up interferon-alpha therapy

Long-term follow-up of HBeAg-positive young adult Japanese patients treated with corticosteroid withdrawal therapy for chronic hepatitis B

Long-term follow-up of interferon monotherapy in 454 consecutive naive patients infected with hepatitis C virus: multi-course interferon therapy may reduce the risk of hepatocellular carcinoma and increase survival

Long-term outcome after hepatitis B surface antigen seroclearance in patients with chronic hepatitis B.

Long-term outcome after interferon therapy in elderly patients with chronic hepatitis C.

Long-term outcome of HBV carriers with negative HBe antigen and normal aminotransferase.

Long-term presence of HBV in the sera of chronic hepatitis B patients with HBsAg seroclearance.

Long-term prognosis by lamivudine monotherapy for severe acute exacerbation in chronic hepatitis B infection: emergence of YMDD motif mutant and risk of breakthrough hepatitis -- an open-cohort study

Low rate of YMDD motif mutations in polymerase gene of hepatitis B virus in chronically infected patients not treated with lamivudine.

Mutations of polymerase, precore and core promoter gene in hepatitis B virus during 5-year lamivudine therapy

Natural history of compensated cirrhosis in the Child-Pugh class A compared between 490 patients with hepatitis C and 167 with B virus infections.

Origin of neovascular structure in an early stage of hepatocellular carcinoma: study of alpha-smooth muscle actin immunohistochemistry in serial thin sections of surgically resected cancer

Peripheral CD8+/CD25+ lymphocytes may be implicated in hepatocellular injuries in patients with acute-onset autoimmune hepatitis

Persistence of acute infection with hepatitis B virus genotype A and treatment in Japan

Precore wild-type hepatitis B virus with G1896 in the resolution of persistent hepatitis B virus infection.

Prediction model of hepatocarcinogenesis for patients with hepatitis C virus-related cirrhosis. Validation with internal and external cohorts

Predictive factors of virological non-response to interferon-ribavirin combination therapy for patients infected with hepatitis C virus of genotype 1b and high viral load.

Randomized trial of prolonged interferon retreatment for chronic hepatitis C patients with HCV-genotype 1b and high virus load ⬇️

Randomized, controlled trial of natural interferon-alpha therapy for e-antigen-positive chronic hepatitis B patients

Recurrence rate and prognosis of patients with hepatocellular carcinoma that developed after elimination of hepatitis C virus RNA by interferon therapy. A closed cohort study including matched control patients

Serum levels of gamma-globulin and total bilirubin influence the prevalence of multiple extrahepatic complication in patients with hepatitis C virus infection

Severe acute exacerbation of liver disease may reduce or delay emergence of YMDD motif mutants in long-term lamivudine therapy for hepatitis B e antigen-positive chronic hepatitis B.

Significance of hepatitis B virus DNA clearance and early prediction of hepatocellular carcinogenesis in patients with cirrhosis undergoing interferon therapy: long-term follow up of a pilot study

Significance of multicentric cancer recurrence after potentially curative ablation of hepatocellular carcinoma: a longterm cohort study of 892 patients with viral cirrhosis.

Significance of serum ribavirin concentration in combination therapy of interferon and ribavirin for chronic hepatitis C.

Stepwise hook extension technique for radiofrequency ablation therapy of hepatocellular carcinoma

Successful control of ruptured hepatocellular carcinoma with radiofrequency ablation.

Sustained negativity for HCV-RNA over 24 or more months by long-term interferon therapy correlates with eradication of HCV in patients with hepatitis C virus genotype 1b and high viral load

The influence of hepatitis B virus genotype on the development of lamivudine resistance during long-term treatment.

Type C-chronic hepatitis patients who had autoimmune phenomenon and developed jaundice during interferon therapy

Usefulness of serum KL-6 for early diagnosis of idiopathic pulmonary fibrosis in patients with hepatitis C virus.

Usefulness of the serum KL-6 assay in patients with hepatitis C virus

Viral genotypes and response to interferon in patients with acute prolonged hepatitis B virus infection of adulthood in Japan

Virological and biochemical relapse according to YMDD motif mutant type during long‐term lamivudine monotherapy ⬇️