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5-aminosalicylic acid given in the remission stage of colitis suppresses colitis-associated cancer in a mouse colitis model

artículo científico publicado en 2007

A novel aromatic mutagen, 5-amino-6-hydroxy-8H-benzo[6,7]azepino[5,4,3-de]quinolin-7-one (ABAQ), induces colonic preneoplastic lesions in mice

artículo científico publicado en 2014

A rare polymorphic variant of NBS1 reduces DNA repair activity and elevates chromosomal instability

artículo científico publicado en 2014

A rat colon cancer model induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP.

artículo científico publicado en 2002

A roadmap toward total elimination of cancer

artículo científico publicado en 2015

A tobacco-specific carcinogen, NNK, enhances AOM/DSS-induced colon carcinogenesis in male A/J mice

artículo científico publicado en 2008

AKT is critically involved in cooperation between obesity and the dietary carcinogen amino-1-methyl-6-phenylimidazo [4,5-b] (PhIP) toward colon carcinogenesis in rats

artículo científico publicado en 2013

ATM and SIRT6/SNF2H Mediate Transient H2AX Stabilization When DSBs Form by Blocking HUWE1 to Allow Efficient γH2AX Foci Formation

artículo científico publicado en 2015

Adiponectin inhibits colorectal cancer cell growth through the AMPK/mTOR pathway

artículo científico publicado en 2009

Amino acids C-terminal to the 14-3-3 binding motif in CDC25B affect the efficiency of 14-3-3 binding

artículo científico publicado en 2006

Association of pancreatic Fatty infiltration with pancreatic ductal adenocarcinoma.

artículo científico publicado en 2014

Association of visceral fat accumulation and plasma adiponectin with rectal dysplastic aberrant crypt foci in a clinical population

artículo científico publicado en 2008

Bcl11b SWI/SNF-complex subunit modulates intestinal adenoma and regeneration after γ-irradiation through Wnt/β-catenin pathway

artículo científico publicado en 2015

Binding of 14-3-3beta but not 14-3-3sigma controls the cytoplasmic localization of CDC25B: binding site preferences of 14-3-3 subtypes and the subcellular localization of CDC25B.

artículo científico publicado en 2004

Brain metastatic cancer cells release microRNA-181c-containing extracellular vesicles capable of destructing blood-brain barrier

artículo científico publicado en 2015

Cancer genetics and genomics of human FOX family genes ⬇️

artículo científico publicado el 27 de septiembre de 2012

Characterization of Dysplastic Aberrant Crypt Foci in the Rat Colon Induced by 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine ⬇️

artículo científico publicado el 1 de octubre de 2003

Chemoprevention of colorectal cancer: Past, present, and future

scientific article published on 17 September 2019

Chemoprevention of precursors to colon cancer by dehydroepiandrosterone (DHEA).

artículo científico publicado en 2002

Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway

artículo científico publicado en 2007

Circulating exosomal microRNAs as biomarkers of colon cancer.

artículo científico publicado en 2014

Clinical utility of circulating tumor DNA for molecular assessment in pancreatic cancer

artículo científico publicado en 2015

Comprehensive DNA adduct analysis reveals pulmonary inflammatory response contributes to genotoxic action of magnetite nanoparticles

artículo científico publicado en 2015

Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane

scientific article published on 01 January 2020

Conditional knockout of the leptin receptor in the colonic epithelium revealed the local effects of leptin receptor signaling in the progression of colonic tumors in mice

artículo científico publicado en 2014

Correlation of the plasma level of insulin-like growth factor-1 with the number of aberrant crypt foci in male individuals ⬇️

artículo científico publicado el 1 de mayo de 2009

Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.

artículo científico publicado en 2009

DNA Adductome Analysis Identifies N-Nitrosopiperidine Involved in the Etiology of Esophageal Cancer in Cixian, China

scientific article published on 09 July 2019

Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma

artículo científico publicado en 2012

Destruction of quadruplex by proteins, and its biological implications in replication and telomere maintenance ⬇️

artículo científico publicado el 1 de enero de 2003

Development of cancer-initiating cells and immortalized cells with genomic instability

artículo científico publicado en 2015

Differential expression of nanog1 and nanogp8 in colon cancer cells

artículo científico publicado en 2011

Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat.

artículo científico publicado en 2003

Differential staining of dysplastic aberrant crypt foci in the colon facilitates prediction of carcinogenic potentials of chemicals in rats

artículo científico publicado en 2005

Differentiation Therapy by Epigenetic Reconditioning Exerts Antitumor Effects on Liver Cancer Cells

artículo científico publicado en 2018

Effects of soy protein isolate on LEC rats, a model of Wilson disease: mechanisms underlying enhancement of liver cell damage

artículo científico publicado en 2003

Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet ⬇️

artículo científico publicado el 1 de enero de 2002

Efficient method for mapping and characterizing structures of deletion mutations in gpt delta mice using Southern blot analysis with oligo DNA probes

artículo científico publicado en 2004

Elucidation of the mode of interaction in the UP1-telomerase RNA-telomeric DNA ternary complex which serves to recruit telomerase to telomeric DNA and to enhance the telomerase activity

artículo científico publicado en 2008

Enhanced colon carcinogenesis induced by azoxymethane in min mice occurs via a mechanism independent of beta-catenin mutation

artículo científico publicado en 2002

Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells

artículo científico publicado en 2018

Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity.

artículo científico publicado en 2015

Evaluation of the degree of pancreatic fatty infiltration by area-based assessment of CT images: comparison with histopathology-based and CT attenuation index-based assessments.

artículo científico publicado en 2016

Experimental animal models of pancreatic carcinogenesis for prevention studies and their relevance to human disease.

artículo científico publicado en 2011

Expression of adiponectin receptors, AdipoR1 and AdipoR2, in normal colon epithelium and colon cancer tissue.

artículo científico publicado en 2008

FGF receptors: cancer biology and therapeutics

artículo científico publicado en 2014

Fatty pancreas: A possible risk factor for pancreatic cancer in animals and humans

scientific article published on 05 September 2018

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer

artículo científico publicado en 2012

Frequent and multiple mutations at minisatellite loci in sporadic human colorectal and gastric cancers--possible mechanistic differences from microsatellite instability in cancer cells

artículo científico publicado en 2002

Frequent inactivation of A20 in B-cell lymphomas

artículo científico publicado en 2009

Frequent inactivation of A20 through gene mutation in B-cell lymphomas

artículo científico publicado el 1 de junio de 2011

Functional screening using a microRNA virus library and microarrays: a new high-throughput assay to identify tumor-suppressive microRNAs

artículo científico publicado en 2010

Genetic alteration of poly(ADP-ribose) polymerase-1 in human germ cell tumors

artículo científico publicado en 2005

Genetic reconstitution of tumorigenesis in primary intestinal cells

artículo científico publicado en 2013

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype

artículo científico publicado en 2016

Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma

artículo científico publicado en 2016

Global gene expression analysis of rat colon cancers induced by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

artículo científico publicado en 2004

Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish

artículo científico publicado en 2004

HnRNP A3 binds to and protects mammalian telomeric repeats in vitro.

artículo científico publicado en 2007

Human DNA glycosylase enzyme TDG repairs thymine mispaired with exocyclic etheno-DNA adducts

artículo científico publicado en 2014

Hypermutation and unique mutational signatures of occupational cholangiocarcinoma in printing workers exposed to haloalkanes

artículo científico publicado en 2016

IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis

scientific journal article

In vivo genotoxicity of a novel heterocyclic amine, aminobenzoazepinoquinolinone-derivative (ABAQ), produced by the Maillard reaction between glucose and l-tryptophan

artículo científico publicado en 2013

Increased tumor necrosis factor receptor 1 expression in human colorectal adenomas ⬇️

artículo científico publicado el 14 de octubre de 2012

Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer.

artículo científico publicado en 2012

Induction of abnormal nuclear shapes in two distinct modes by overexpression of serine/threonine protein phosphatase 5 in Hela cells.

artículo científico publicado en 2007

Induction of intestinal tumors and lymphomas in C57BL/6N mice by a food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

artículo científico publicado en 2002

Induction of multinucleated cells and apoptosis in the PC-3 prostate cancer cell line by low concentrations of polyethylene glycol 1000.

artículo científico publicado en 2008

Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells

artículo científico publicado en 2012

Inhibition of peroxisome proliferator-activated receptor gamma activity in esophageal carcinoma cells results in a drastic decrease of invasive properties.

artículo científico publicado en 2006

Inhibition of peroxisome proliferator-activated receptor gamma activity suppresses pancreatic cancer cell motility

artículo científico publicado en 2008

Inhibition of peroxisome proliferator-activated receptor gamma promotes tumorigenesis through activation of the beta-catenin / T cell factor (TCF) pathway in the mouse intestine

artículo científico publicado en 2008

Interactions with RNA/DNA of proteins involved in the regulation of transcription, translation and telomere elongation

artículo científico publicado en 2007

Invasive ductal carcinoma developing in pancreas with severe Fatty infiltration

scientific article published on 01 October 2012

LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1

scientific journal article

LRP130, a single-stranded DNA/RNA-binding protein, localizes at the outer nuclear and endoplasmic reticulum membrane, and interacts with mRNA in vivo

artículo científico publicado en 2004

Leptin acts as a growth factor for colorectal tumours at stages subsequent to tumour initiation in murine colon carcinogenesis ⬇️

artículo científico publicado el 15 de marzo de 2011

Life style-related diseases of the digestive system: colorectal cancer as a life style-related disease: from carcinogenesis to medical treatment

artículo científico publicado en 2007

Lipoprotein Lipase as a Candidate Target for Cancer Prevention/Therapy ⬇️

artículo científico publicado el 19 de octubre de 2011

Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells

artículo científico publicado en 2007

Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells

article

Loss of p53 induces M-phase retardation following G2 DNA damage checkpoint abrogation.

artículo científico publicado en 2003

MEG3-derived miR-493-5p overcomes the oncogenic feature of IGF2-miR-483 loss of imprinting in hepatic cancer cells

artículo científico publicado en 2019

MKK7 mediates miR-493-dependent suppression of liver metastasis of colon cancer cells

artículo científico publicado en 2014

Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase

artículo científico publicado en 2009

Mesenchymal stem cell-derived extracellular vesicles: a glimmer of hope in treating Alzheimer's disease

artículo científico publicado en 2017

Metabolic syndrome and carcinogenesis

artículo científico publicado el 1 de enero de 2011

Metabolic syndrome: a novel high-risk state for colorectal cancer.

artículo científico publicado en 2012

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer

scientific article published on 06 June 2019

Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial ⬇️

artículo científico publicado el 1 de septiembre de 2010

Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase

artículo científico publicado en 2010

Metformin suppresses intestinal polyp growth in ApcMin/+ mice

artículo científico publicado en 2008

MicroRNA, SND1, and alterations in translational regulation in colon carcinogenesis

artículo científico publicado en 2010

MicroRNA-124a inhibits endoderm lineage commitment by targeting Sox17 and Gata6 in mouse embryonic stem cells

scientific article published on 30 December 2019

MicroRNA-493-5p-mediated repression of the MYCN oncogene inhibits hepatic cancer cell growth and invasion

artículo científico publicado en 2020

Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP.

artículo científico publicado en 2005

Molecular mechanisms for maintenance of G-rich short tandem repeats capable of adopting G4 DNA structures

artículo científico publicado en 2006

Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP-induced large bowel carcinogenesis

artículo científico publicado en 2007

Multifocal origin of occupational cholangiocarcinoma revealed by comparison of multilesion mutational profiles

scientific article published on 20 June 2019

NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).

artículo científico publicado en 2010

NEK9-dependent proliferation of cancer cells lacking functional p53

artículo científico publicado en 2014

NOX1-Dependent mTORC1 Activation via S100A9 Oxidation in Cancer Stem-like Cells Leads to Colon Cancer Progression

artículo científico publicado en 2019

Newly defined aberrant crypt foci as a marker for dysplasia in the rat colon.

artículo científico publicado en 2014

Novel p53 target gene FUCA1 encodes a fucosidase and regulates growth and survival of cancer cells

artículo científico publicado en 2016

NuMA is required for the selective induction of p53 target genes

artículo científico publicado en 2013

Nuclear export signal in CDC25B.

artículo científico publicado en 2004

Nucleotide sequence and chromosomal localization of the gene for pierisin-1, a DNA ADP-ribosylating protein, in the cabbage butterfly Pieris rapae ⬇️

artículo científico publicado el 12 de enero de 2012

Number of aberrant crypt foci in the rectum is a useful surrogate marker of colorectal adenoma recurrence ⬇️

artículo científico publicado el 2 de abril de 2012

Onset of Quiescence Following p53 Mediated Down-Regulation of H2AX in Normal Cells ⬇️

artículo científico publicado el 12 de agosto de 2011

Origins of Albino and Hooded Rats: Implications from Molecular Genetic Analysis across Modern Laboratory Rat Strains ⬇️

artículo científico publicado el 16 de agosto de 2012

PHLDA3 is a novel tumor suppressor of pancreatic neuroendocrine tumors

artículo científico publicado en 2014

PPARgamma Ligand as a Promising Candidate for Colorectal Cancer Chemoprevention: A Pilot Study

artículo científico publicado en 2010

Parp-1 deficiency causes an increase of deletion mutations and insertions/rearrangements in vivo after treatment with an alkylating agent

artículo científico publicado en 2005

Parp-1 deficiency does not enhance liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline in mice

artículo científico publicado en 2005

Parp-1 deficiency does not increase the frequency of tumors in the oral cavity and esophagus of ICR/129Sv mice by 4-nitroquinoline 1-oxide, a carcinogen producing bulky adducts

artículo científico publicado en 2005

Parp-1 deficiency implicated in colon and liver tumorigenesis induced by azoxymethane

artículo científico publicado en 2003

Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives

artículo científico publicado en 2003

Peripheral opioid antagonist enhances the effect of anti-tumor drug by blocking a cell growth-suppressive pathway in vivo

artículo científico publicado en 2015

Peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses colonic epithelial cell turnover and colon carcinogenesis through inhibition of the beta-catenin/T cell factor (TCF) pathway

artículo científico publicado en 2008

Peroxisome proliferator-activated receptor gamma ligands suppress colon carcinogenesis induced by azoxymethane in mice

artículo científico publicado en 2003

Poly(ADP‐ribose) and carcinogenesis ⬇️

artículo científico publicado el 1 de diciembre de 2003

Poly(etheno ADP-ribose) blocks poly(ADP-ribose) glycohydrolase activity.

artículo científico publicado en 2007

Predominant T helper type 2-inflammatory responses promote murine colon cancers

artículo científico publicado en 2006

Present status of support for adolescent and young adult cancer patients in member hospitals of Japanese Association of Clinical Cancer Centers

artículo científico publicado en 2020

Promotion of the Warburg effect is associated with poor benefit from adjuvant chemotherapy in colorectal cancer

scientific article published on 09 January 2020

Protective versus promotional effects of white tea and caffeine on PhIP-induced tumorigenesis and beta-catenin expression in the rat.

scientific article published on 17 February 2008

Protein hnRNP A1 and its derivative Up1 unfold quadruplex DNA in the human KRAS promoter: implications for transcription

artículo científico publicado en 2009

RPN2-mediated glycosylation of tetraspanin CD63 regulates breast cancer cell malignancy

artículo científico publicado en 2014

Real-time in vivo cellular imaging of graft-versus-host disease and its reaction to immunomodulatory reagents ⬇️

artículo científico publicado el 15 de marzo de 2012

Report of the JDS/JCA Joint Committee on Diabetes and Cancer

Report of the Japan Diabetes Society (JDS)/Japanese Cancer Association (JCA) Joint Committee on Diabetes and Cancer, Second Report

artículo científico publicado en 2016

Report of the Japan Diabetes Society/Japanese Cancer Association Joint Committee on Diabetes and Cancer

artículo científico publicado en 2013

Report of the Japan diabetes society/Japanese cancer association joint committee on diabetes and cancer, Second report

artículo científico publicado en 2016

Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age.

artículo científico publicado en 2009

Roles of the PDZ-binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes

artículo científico publicado en 2017

SCFβ(TrCP) mediates stress-activated MAPK-induced Cdc25B degradation.

artículo científico publicado en 2011

SND1, a component of RNA-induced silencing complex, is up-regulated in human colon cancers and implicated in early stage colon carcinogenesis

artículo científico publicado en 2007

Semaphorin 4D, a lymphocyte semaphorin, enhances tumor cell motility through binding its receptor, plexinB1, in pancreatic cancer ⬇️

artículo científico publicado el 13 de septiembre de 2011

Significance of inflammation-associated regenerative mucosa characterized by Paneth cell metaplasia and beta-catenin accumulation for the onset of colorectal carcinogenesis in rats initiated with 1,2-dimethylhydrazine

artículo científico publicado en 2007

Slow-cycling cancer stem cells regulate progression and chemoresistance in colon cancer

scientific article published on 19 August 2020

Soy Protein Isolate Enhances Hepatic Copper Accumulation and Cell Damage in LEC Rats ⬇️

artículo científico publicado el 1 de mayo de 2003

Spontaneous mutations in the Helicobacter pylori rpsL gene

artículo científico publicado en 2003

Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice

scientific article published on 04 August 2005

Stress-activated mitogen-activated protein kinases c-Jun NH2-terminal kinase and p38 target Cdc25B for degradation.

artículo científico publicado en 2009

Studies on mammary carcinogenesis induced by a heterocyclic amine, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, in mice and rats

artículo científico publicado en 2002

Systematic exploration of cancer-associated microRNA through functional screening assays

artículo científico publicado en 2011

TSPAN12 is a critical factor for cancer-fibroblast cell contact-mediated cancer invasion

artículo científico publicado en 2014

TSPAN2 is involved in cell invasion and motility during lung cancer progression.

artículo científico publicado en 2014

The Arf/p53 Protein Module, Which Induces Apoptosis, Down-regulates Histone H2AX to Allow Normal Cells to Survive in the Presence of Anti-cancer Drugs ⬇️

artículo científico publicado el 27 de marzo de 2013

The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells

artículo científico publicado en 2017

The p53 activator overcomes resistance to ALK inhibitors by regulating p53-target selectivity in ALK-driven neuroblastomas.

artículo científico publicado en 2018

Translesional DNA synthesis through a C8-guanyl adduct of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in Vitro: REV1 inserts dC opposite the lesion, and DNA polymerase kappa potentially catalyzes extension reaction from the 3'-dC terminus

scientific article published on 23 July 2009

Tumor suppressor miR-22 determines p53-dependent cellular fate through post-transcriptional regulation of p21.

artículo científico publicado en 2011

Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

artículo científico publicado en 2007

Unfolding of higher DNA structures formed by the d(CGG) triplet repeat by UP1 protein

artículo científico publicado en 2005

Unfolding of quadruplex structure in the G-rich strand of the minisatellite repeat by the binding protein UP1.

artículo científico publicado en 2002

Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers.

artículo científico publicado en 2005

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

artículo científico publicado en 2012

[A Multi-Stakeholder Dialogue on Universal Health Coverage for Cancer in Asia - Seeking an Approach to Asia Health and Wellbeing Initiative]

scientific article published on 01 September 2018

[Decreased PPARs activity mediated induction of anoikis and inability of cell adhesion and invasion in colorectal carcinoma cells]

artículo científico publicado en 2006

[Oncogenes and tumor-suppressor genes]

scientific article published on 01 April 2011

[PPARgamma and cancer]

scientific article published on 01 February 2010

[Risk factors for non-hereditary colonic cancers]

scientific article published on 01 February 2007

[The 2nd Japan Public-Private Dialogue Forum-A Multi-Stakeholder Dialogue on Universal Health Coverage for Cancer in Asia-Seeking an Approach to Asia Health and Wellbeing Initiative]

scientific article published on 01 April 2019

beta-catenin is strongly elevated in rat colonic epithelium following short-term intermittent treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and a high-fat diet

artículo científico publicado en 2008

miR-493 induction during carcinogenesis blocks metastatic settlement of colon cancer cells in liver

artículo científico publicado en 2012

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