Lista de obras -

AMD3100 is a CXCR7 ligand with allosteric agonist properties

artículo científico publicado en 2009

Agonists for the Chemokine Receptor CXCR4.

artículo científico publicado en 2011

An engineered GM-CSF-CCL2 fusokine is a potent inhibitor of CCR2-driven inflammation as demonstrated in a murine model of inflammatory arthritis

artículo científico publicado en 2009

BRET analysis of GPCR oligomerization: newer does not mean better

artículo científico publicado en 2007

Biased antagonism of CXCR4 avoids antagonist tolerance

article

Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers.

artículo científico publicado en 2005

Decreasing the frameshift efficiency translates into an equivalent reduction of the replication of the human immunodeficiency virus type 1.

artículo científico publicado en 2005

Design, synthesis, and biological evaluation of CXCR4 ligands

artículo científico publicado en 2016

Development of Novel CXC Chemokine Receptor 7 (CXCR7) Ligands: Selectivity Switch from CXCR4 Antagonists with a Cyclic Pentapeptide Scaffold

article

Development of a novel noncompetitive antagonist of IL-1 receptor

scientific article published on 01 May 2008

Different Effects of the Different Natural CC Chemokine Receptor 2b Ligands on β-Arrestin Recruitment, GαiSignaling, and Receptor Internalization ⬇️

artículo científico publicado el 18 de noviembre de 2010

Different contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3.

artículo científico publicado en 2017

Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation.

artículo científico publicado en 2006

Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and Gαi activation.

artículo científico publicado en 2011

Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.

artículo científico publicado en 2009

G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm.

artículo científico publicado en 2006

HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165

artículo científico publicado en 2009

Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages

artículo científico publicado en 2002

Herpes Simplex Virus Type 1-induced FasL Expression in Human Monocytic Cells and Its Implications for Cell Death, Viral Replication, and Immune Evasion ⬇️

artículo científico publicado el 1 de febrero de 2011

Ligand-specific conformational transitions and intracellular transport required for atypical chemokine receptor 3-mediated chemokine scavenging.

artículo científico publicado en 2017

Medicinal chemistry applied to a synthetic protein: development of highly potent HIV entry inhibitors

artículo científico publicado en 2004

Mode of binding of the cyclic agonist peptide TC14012 to CXCR7: identification of receptor and compound determinants

artículo científico publicado en 2015

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

artículo científico publicado en 2011

Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12.

artículo científico publicado en 2016

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.

artículo científico publicado en 2018

Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry

artículo científico publicado en 2006

Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1.

artículo científico

Photolabeling identifies transmembrane domain 4 of CXCR4 as a T140 binding site

artículo científico publicado en 2009

Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway

artículo científico publicado en 2009

Positive regulation of insulin signaling by neuraminidase 1.

artículo científico publicado en 2013

Proangiogenic effects of protease-activated receptor 2 are tumor necrosis factor-alpha and consecutively Tie2 dependent

scientific journal article

Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure.

artículo científico publicado en 2012

Selection of peptides interfering with a ribosomal frameshift in the human immunodeficiency virus type 1

artículo científico publicado en 2008

Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation

artículo científico publicado en 2017

Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists

artículo científico publicado en 2016

Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4

artículo científico publicado en 2012

Structure–Activity Relationship Study of Cyclic Pentapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3)

artículo científico publicado en 2018

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment

scientific article published on 18 June 2019

The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element ⬇️

artículo científico publicado el 8 de octubre de 2010

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin.

artículo científico publicado en 2014

The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains

artículo científico publicado en 2010

The presence of the TAR RNA structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (HIV-1) by modifying the rate of translation initiation

artículo científico publicado en 2007

Virus-Cell Interactions

[Multiple talents of the chemokine receptor-CXCR4]

artículo científico publicado en 2007

[Mystery upon the origin for the selection of AIDS-protective CCR5Delta32]

artículo científico publicado en 2005

Lista de obras de

AMD3100 is a CXCR7 ligand with allosteric agonist properties

Agonists for the Chemokine Receptor CXCR4.

An engineered GM-CSF-CCL2 fusokine is a potent inhibitor of CCR2-driven inflammation as demonstrated in a murine model of inflammatory arthritis

BRET analysis of GPCR oligomerization: newer does not mean better

Biased antagonism of CXCR4 avoids antagonist tolerance

Bioluminescence resonance energy transfer reveals ligand-induced conformational changes in CXCR4 homo- and heterodimers.

Decreasing the frameshift efficiency translates into an equivalent reduction of the replication of the human immunodeficiency virus type 1.

Design, synthesis, and biological evaluation of CXCR4 ligands

Development of Novel CXC Chemokine Receptor 7 (CXCR7) Ligands: Selectivity Switch from CXCR4 Antagonists with a Cyclic Pentapeptide Scaffold

Development of a novel noncompetitive antagonist of IL-1 receptor

Different Effects of the Different Natural CC Chemokine Receptor 2b Ligands on β-Arrestin Recruitment, GαiSignaling, and Receptor Internalization ⬇️

Different contribution of chemokine N-terminal features attest a different ligand binding mode and a bias towards activation of the atypical chemokine receptor ACKR3/CXCR7 compared to CXCR4 and CXCR3.

Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation.

Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and Gαi activation.

Functional selectivity of natural and synthetic prostaglandin EP4 receptor ligands.

G-protein-coupled receptors signalling at the cell nucleus: an emerging paradigm.

HTLV-1 uses HSPG and neuropilin-1 for entry by molecular mimicry of VEGF165

Hemofiltrate CC chemokine 1[9-74] causes effective internalization of CCR5 and is a potent inhibitor of R5-tropic human immunodeficiency virus type 1 strains in primary T cells and macrophages

Herpes Simplex Virus Type 1-induced FasL Expression in Human Monocytic Cells and Its Implications for Cell Death, Viral Replication, and Immune Evasion ⬇️

Ligand-specific conformational transitions and intracellular transport required for atypical chemokine receptor 3-mediated chemokine scavenging.

Medicinal chemistry applied to a synthetic protein: development of highly potent HIV entry inhibitors

Mode of binding of the cyclic agonist peptide TC14012 to CXCR7: identification of receptor and compound determinants

Monomeric and dimeric CXCL12 inhibit metastasis through distinct CXCR4 interactions and signaling pathways

Mutational Analysis of Atypical Chemokine Receptor 3 (ACKR3/CXCR7) Interaction with Its Chemokine Ligands CXCL11 and CXCL12.

Neuraminidase 1 activates insulin receptor and reverses insulin resistance in obese mice.

Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry

Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1.

Photolabeling identifies transmembrane domain 4 of CXCR4 as a T140 binding site

Positive feedback activation of estrogen receptors by the CXCL12-CXCR4 pathway

Positive regulation of insulin signaling by neuraminidase 1.

Proangiogenic effects of protease-activated receptor 2 are tumor necrosis factor-alpha and consecutively Tie2 dependent

Restoration of renal function by a novel prostaglandin EP4 receptor-derived peptide in models of acute renal failure.

Selection of peptides interfering with a ribosomal frameshift in the human immunodeficiency virus type 1

Structural basis for chemokine recognition by a G protein-coupled receptor and implications for receptor activation

Structure-Activity Relationship and Signaling of New Chimeric CXCR4 Agonists

Structure-based ligand discovery for the protein-protein interface of chemokine receptor CXCR4

Structure–Activity Relationship Study of Cyclic Pentapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3)

The Distinct Roles of CXCR3 Variants and Their Ligands in the Tumor Microenvironment

The activity of the HIV-1 IRES is stimulated by oxidative stress and controlled by a negative regulatory element ⬇️

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin.

The peptidomimetic CXCR4 antagonist TC14012 recruits beta-arrestin to CXCR7: roles of receptor domains

The presence of the TAR RNA structure alters the programmed -1 ribosomal frameshift efficiency of the human immunodeficiency virus type 1 (HIV-1) by modifying the rate of translation initiation

Virus-Cell Interactions

[Multiple talents of the chemokine receptor-CXCR4]

[Mystery upon the origin for the selection of AIDS-protective CCR5Delta32]