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Abstract 5347: SK053, a small molecule inhibitor of enzymes involved in allosteric disulfide bonds formation, shows potent anti-leukemic effects and induces differentiation of human AML cells

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML with activating FLT3 mutations

artículo científico publicado en 2020

Complexity of Blocking Bivalent Protein-Protein Interactions: Development of a Highly Potent Inhibitor of the Menin-Mixed-Lineage Leukemia Interaction

artículo científico publicado en 2018

Design and synthesis of triarylacrylonitrile analogues of tamoxifen with improved binding selectivity to protein kinase C.

artículo científico publicado en 2016

Dimeric peroxiredoxins are druggable targets in human Burkitt lymphoma.

artículo científico publicado en 2015

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity

artículo científico publicado en 2021

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

artículo científico publicado en 2020

Menin regulates the serine biosynthetic pathway in Ewing sarcoma.

artículo científico publicado en 2018

Pharmacologic Inhibition of the Menin-MLL Interaction Leads to Transcriptional Repression of PEG10 and Blocks Hepatocellular Carcinoma

artículo científico publicado en 2017

Synthesis of novel, peptidic kinase inhibitors with cytostatic/cytotoxic activity.

artículo científico publicado en 2014

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