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Activation of an early feedback survival loop involving phospho-ErbB3 is a general response of melanoma cells to RAF/MEK inhibition and is abrogated by anti-ErbB3 antibodies.

artículo científico publicado en 2013

Activation of the ErbB3-AKT axis promotes melanoma cell survival and proliferation in response to RAF/MEK inhibition.

artículo científico publicado en 2014

Combination of antibodies directed against different ErbB3 surface epitopes prevents the establishment of resistance to BRAF/MEK inhibitors in melanoma.

artículo científico publicado en 2015

Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes

artículo científico publicado en 2007

ErbB3 plays a key role in the early phase of establishment of resistance to BRAF and/or MEK inhibitors

artículo científico publicado en 2015

Galpha13 regulation of proto-Dbl signaling

artículo científico publicado en 2007

Inhibition of PI3K induces Rac activation and membrane ruffling in proto-Dbl expressing cells

artículo científico publicado en 2006

Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma

artículo científico publicado en 2018

Phosphorylation-independent membrane relocalization of ezrin following association with Dbl in vivo

artículo científico publicado en 2004

Polarized endocytosis of the keratinocyte growth factor receptor in migrating cells: role of SRC-signaling and cortactin

artículo científico publicado en 2011

Regulation of proto-Dbl by intracellular membrane targeting and protein stability

artículo científico publicado en 2002

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