Lista de obras -

A Physiologically Based Pharmacokinetic Model for Strontium Exposure in Rat ⬇️

artículo científico publicado el 30 de marzo de 2013

Application of Item Response Theory to Model Disease Progression and Agomelatine Effect in Patients with Major Depressive Disorder

artículo científico publicado en 2019

Application of hematological toxicity modeling in clinical development of abexinostat (S-78454, PCI-24781), a new histone deacetylase inhibitor.

artículo científico publicado en 2013

Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates.

artículo científico publicado en 2015

Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology

artículo científico publicado en 2018

Development of a complex parent-metabolite joint population pharmacokinetic model.

artículo científico

Development of a physiologically-based pharmacokinetic model of the rat central nervous system.

artículo científico publicado en 2014

Dose ranging pharmacokinetics and brain distribution of norfloxacin using microdialysis in rats

artículo científico publicado en 2003

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 1: comparison of uniresponse and multiresponse designs using PopDes

artículo científico publicado en 2008

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results

artículo científico publicado en 2008

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use.

artículo científico publicado en 2018

Impact of Interleukin-6 on Drug-Metabolizing Enzymes and Transporters in Intestinal Cells

artículo científico publicado en 2019

Impact of hepatic CYP3A4 ontogeny functions on DDI risk in paediatric PBPK/PD modelling: critical literature review and ivabradine case study

artículo científico publicado en 2020

Impact of interleukin-6 on drug transporters and permeability in the hCMEC/D3 blood-brain barrier model

artículo científico publicado en 2020

Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: Handling Sacrifice Censoring and Error Caused by Experimental Measurement on Larger Tumor Sizes

artículo científico publicado en 2016

Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: a Novel Method to Handle the Interval Censoring Caused by Measurement of Smaller Tumors

artículo científico publicado en 2016

Influence of covariance between random effects in design for nonlinear mixed-effect models with an illustration in pediatric pharmacokinetics

artículo científico publicado en 2014

Influence of the Duration of Intravenous Drug Administration on Tumor Uptake ⬇️

artículo científico publicado el 25 de julio de 2013

Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART® Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity

artículo científico publicado en 2018

Model Description Language (MDL): A Standard for Modeling and Simulation

artículo científico publicado en 2017

Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology

artículo científico publicado en 2018

Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment

artículo científico publicado en 2015

Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment

artículo científico publicado en 2015

Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach

artículo científico publicado en 2021

Norfloxacin blood-brain barrier transport in rats is not affected by probenecid coadministration

artículo científico publicado en 2006

Norfloxacin-induced electroencephalogram alteration and seizures in rats are not triggered by enhanced levels of intracerebral glutamate

artículo científico publicado en 2003

Optimal blood sampling time windows for parameter estimation using a population approach: design of a phase II clinical trial

artículo científico publicado en 2005

Optimal sampling times for a drug and its metabolite using SIMCYP(®) simulations as prior information

artículo científico publicado en 2013

Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm

artículo científico publicado en 2009

Pharmacokinetic modeling of free amoxicillin concentrations in rat muscle extracellular fluids determined by microdialysis

artículo científico publicado en 2005

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of norfloxacin in rats.

artículo científico publicado en 2003

Pharmacokinetic/Pharmacodynamic modeling of abexinostat-induced thrombocytopenia across different patient populations: application for the determination of the maximum tolerated doses in both lymphoma and solid tumour patients

artículo científico publicado en 2014

Pharmacokinetic/pharmacodynamic modelling-based optimisation of administration schedule for the histone deacetylase inhibitor abexinostat (S78454/PCI-24781) in phase I.

artículo científico publicado en 2013

Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy

scientific article published on 02 April 2019

Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

artículo científico publicado en 2017

Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil.

artículo científico publicado en 2010

Quantitative Systems Pharmacology approaches for Immuno-oncology: adding virtual patients to the development paradigm

artículo científico publicado en 2020

Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method

scientific article published on 08 October 2020

Simultaneous central nervous system distribution and pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats.

artículo científico publicado en 2004

Some alternatives to asymptotic tests for the analysis of pharmacogenetic data using nonlinear mixed effects models

artículo científico publicado en 2011

Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development

scientific article published on 10 November 2019

Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation

scientific article published on 25 May 2020

Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice

artículo científico publicado en 2018

Lista de obras de

A Physiologically Based Pharmacokinetic Model for Strontium Exposure in Rat ⬇️

Application of Item Response Theory to Model Disease Progression and Agomelatine Effect in Patients with Major Depressive Disorder

Application of hematological toxicity modeling in clinical development of abexinostat (S-78454, PCI-24781), a new histone deacetylase inhibitor.

Comparison of Nonlinear Mixed Effects Models and Noncompartmental Approaches in Detecting Pharmacogenetic Covariates.

Correction to: Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology

Development of a complex parent-metabolite joint population pharmacokinetic model.

Development of a physiologically-based pharmacokinetic model of the rat central nervous system.

Dose ranging pharmacokinetics and brain distribution of norfloxacin using microdialysis in rats

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 1: comparison of uniresponse and multiresponse designs using PopDes

Drug-drug interaction predictions with PBPK models and optimal multiresponse sampling time designs: application to midazolam and a phase I compound. Part 2: clinical trial results

Getting Innovative Therapies Faster to Patients at the Right Dose: Impact of Quantitative Pharmacology Towards First Registration and Expanding Therapeutic Use.

Impact of Interleukin-6 on Drug-Metabolizing Enzymes and Transporters in Intestinal Cells

Impact of hepatic CYP3A4 ontogeny functions on DDI risk in paediatric PBPK/PD modelling: critical literature review and ivabradine case study

Impact of interleukin-6 on drug transporters and permeability in the hCMEC/D3 blood-brain barrier model

Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: Handling Sacrifice Censoring and Error Caused by Experimental Measurement on Larger Tumor Sizes

Improvement of Parameter Estimations in Tumor Growth Inhibition Models on Xenografted Animals: a Novel Method to Handle the Interval Censoring Caused by Measurement of Smaller Tumors

Influence of covariance between random effects in design for nonlinear mixed-effect models with an illustration in pediatric pharmacokinetics

Influence of the Duration of Intravenous Drug Administration on Tumor Uptake ⬇️

Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART® Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity

Model Description Language (MDL): A Standard for Modeling and Simulation

Model-Based Adaptive Optimal Design (MBAOD) Improves Combination Dose Finding Designs: an Example in Oncology

Model-based approaches for ivabradine development in paediatric population, part I: study preparation assessment

Model-based approaches for ivabradine development in paediatric population, part II: PK and PK/PD assessment

Modeling restoration of gefitinib efficacy by co‐administration of MET inhibitors in an EGFR inhibitor‐resistant NSCLC xenograft model: A tumor‐in‐host DEB‐based approach

Norfloxacin blood-brain barrier transport in rats is not affected by probenecid coadministration

Norfloxacin-induced electroencephalogram alteration and seizures in rats are not triggered by enhanced levels of intracerebral glutamate

Optimal blood sampling time windows for parameter estimation using a population approach: design of a phase II clinical trial

Optimal sampling times for a drug and its metabolite using SIMCYP(®) simulations as prior information

Pharmacogenetics and population pharmacokinetics: impact of the design on three tests using the SAEM algorithm

Pharmacokinetic modeling of free amoxicillin concentrations in rat muscle extracellular fluids determined by microdialysis

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of norfloxacin in rats.

Pharmacokinetic/Pharmacodynamic modeling of abexinostat-induced thrombocytopenia across different patient populations: application for the determination of the maximum tolerated doses in both lymphoma and solid tumour patients

Pharmacokinetic/pharmacodynamic modelling-based optimisation of administration schedule for the histone deacetylase inhibitor abexinostat (S78454/PCI-24781) in phase I.

Prediction of Human Nonlinear Pharmacokinetics of a New Bcl-2 Inhibitor Using PBPK Modeling and Interspecies Extrapolation Strategy

Prediction of renal transporter-mediated drug-drug interactions for a drug which is an OAT substrate and inhibitor using PBPK modelling

Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil.

Quantitative Systems Pharmacology approaches for Immuno-oncology: adding virtual patients to the development paradigm

Simultaneous Ivabradine Parent-Metabolite PBPK/PD Modelling Using a Bayesian Estimation Method

Simultaneous central nervous system distribution and pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats.

Some alternatives to asymptotic tests for the analysis of pharmacogenetic data using nonlinear mixed effects models

Transforming Translation Through Quantitative Pharmacology for High-Impact Decision Making in Drug Discovery and Development

Translational approach from preclinical to clinical: comparison of dose finding methods of a new Bcl2 inhibitor using PK-PD modeling and interspecies extrapolation

Tumor Growth Inhibition Modelling Based on Receptor Occupancy and Biomarker Activity of a New Bcl-2 Inhibitor in Mice