Lista de obras -

A CD4-derived peptide carrier blocks acute HIV-1 infection in vitro and binds to gp120 in the presence of Walter-Reed stage 1-6 HIV+ sera

artículo científico publicado el 1 de noviembre de 1992

A Phase I study with an anti-CD30 ricin A-chain immunotoxin (Ki-4.dgA) in patients with refractory CD30+ Hodgkin's and non-Hodgkin's lymphoma

scientific article published on 01 June 2002

A novel recombinant vaccine which protects mice against ricin intoxication.

artículo científico publicado en 2002

A phase 1 study of Combotox in pediatric patients with refractory B-lineage acute lymphoblastic leukemia

artículo científico publicado en 2009

A phase I study of a combination of anti‐CD19 and anti‐CD22 immunotoxins (Combotox) in adult patients with refractory B‐lineage acute lymphoblastic leukaemia ⬇️

artículo científico publicado el 7 de julio de 2011

A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy.

artículo científico publicado en 1993

A phase I study of bolus versus continuous infusion of the anti-CD19 immunotoxin, IgG-HD37-dgA, in patients with B-cell lymphoma.

artículo científico publicado en 1996

A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19(+), CD22(+) B cell lymphoma

artículo científico publicado en 2000

A phase-I study of an anti-CD25 ricin A-chain immunotoxin (RFT5-SMPT-dgA) in patients with refractory Hodgkin's lymphoma

artículo científico publicado en 1997

Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation

artículo científico publicado en 2006

An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive persons

artículo científico publicado en 2002

Anti-CD19 antibodies inhibit the function of the P-gp pump in multidrug-resistant B lymphoma cells.

artículo científico publicado en 1999

Anti-CD19 immunotoxin enhances the activity of chemotherapy in severe combined immunodeficient mice with human pre-B acute lymphoblastic leukemia

artículo científico publicado en 2006

Binding of cytophilic rabbit IgG to homologous hepatocytes ⬇️

artículo científico publicado el 15 de junio de 1979

CD4 peptide-protein conjugates, but not recombinant human CD4, bind to recombinant gp120 from the human immunodeficiency virus in the presence of serum from AIDS patients

artículo científico publicado en 1991

Chemical Construction of Immunotoxins

artículo científico publicado el 1 de enero de 2000

Chemical construction of immunotoxins

artículo científico publicado en 2001

Clinical Trials with an Anti-CD25 Ricin A-Chain Experimental and Immunotoxin (RFT5-SMPT-dgA) in Hodgkin's Lymphoma ⬇️

artículo científico publicado el 1 de agosto de 1998

Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin’s lymphoma ⬇️

artículo científico publicado el 1 de mayo de 2003

Complete sustained response of a refractory, post-transplantation, large B-cell lymphoma to an anti-CD22 immunotoxin

artículo científico publicado en 1997

Design and In Vivo Characterization of Immunoconjugates Targeting HIV gp160.

artículo científico publicado en 2016

Evaluation of a CD25-specific immunotoxin for prevention of graft-versus-host disease after unrelated marrow transplantation

artículo científico publicado en 2004

Evaluation of four CD22 antibodies as ricin A chain-containing immunotoxins for the in vivo therapy of human B-cell leukemias and lymphomas

artículo científico publicado en 1988

Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy

artículo científico publicado en 1988

Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome

artículo científico publicado en 1999

Fibronectin inhibits the cytotoxic effect of ricin A chain on endothelial cells

artículo científico publicado en 1996

Generation and characterization of a novel tetravalent anti-CD22 antibody with improved antitumor activity and pharmacokinetics

scientific article published on 22 December 2005

Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice

scientific article published on 10 March 2003

HIV-infected cells are killed by rCD4-ricin A chain

artículo científico publicado en 1988

Identification of Human Anti-HIV gp160 Monoclonal Antibodies That Make Effective Immunotoxins

artículo científico publicado en 2016

Immunoconjugates containing ricin A chain and either human anti-gp41 or CD4 kill H9 cells infected with different isolates of HIV, but do not inhibit normal T or B cell function

artículo científico publicado en 1990

Immunology. Considering therapeutic antibodies

artículo científico publicado en 2006

Immunotoxins for the Treatment of B-Cell Lymphomas ⬇️

artículo científico publicado el 1 de julio de 1997

Interaction between rabbit IgG immune complexes and Ricinus agglutinin

artículo científico publicado en 1986

Isolation of a rabbit IgG fraction with cytophilic properties ⬇️

artículo científico publicado el 13 de mayo de 1983

Large scale preparation of an immunoconjugate constructed with human recombinant CD4 and deglycosylated ricin A chain

artículo científico publicado en 1990

Large scale preparation of immunotoxins constructed with the Fab' fragment of IgG1 murine monoclonal antibodies and chemically deglycosylated ricin A chain

artículo científico publicado en 1988

Optimized clinical-scale culture conditions for ex vivo selective depletion of host-reactive donor lymphocytes: a strategy for GvHD prophylaxis in allogeneic PBSC transplantation

artículo científico publicado en 2002

Partial reduction of human FOXP3+ CD4 T cells in vivo after CD25-directed recombinant immunotoxin administration

artículo científico publicado en 2008

Phase I trial of an anti-CD19 deglycosylated ricin A chain immunotoxin in non-Hodgkin's lymphoma: effect of an intensive schedule of administration

artículo científico publicado en 1995

Preparation and characterization of conjugates of recombinant CD4 and deglycosylated ricin A chain using different cross-linkers

artículo científico publicado en 1990

Purification and properties of immunotoxins containing one vs. two deglycosylated ricin A chains.

artículo científico publicado en 1993

Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantation in elderly patients and association with acute graft-versus-host disease.

artículo científico publicado en 2007

Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation

artículo científico publicado en 2005

Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses

artículo científico publicado en 2003

The GLP large scale preparation of immunotoxins containing deglycosylated ricin A chain and a hindered disulfide bond

artículo científico publicado en 1991

The effect of a monoclonal antibody coupled to ricin A chain-derived peptides on endothelial cells in vitro: insights into toxin-mediated vascular damage

artículo científico publicado en 2000

The epitope specificity and tissue reactivity of four murine monoclonal anti-CD22 antibodies

scientific article published on 01 January 1989

The evaluation of recombinant, chimeric, tetravalent antihuman CD22 antibodies

artículo científico publicado en 2004

The generation of immunotoxins using chimeric anti-CD22 antibodies containing mutations which alter their serum half-life

artículo científico publicado en 2005

The in vivo anti-tumor activity of immunotoxins containing two versus one deglycosylated ricin A chains

artículo científico publicado en 1995

Treatment of SCID/human B cell precursor ALL with anti-CD19 and anti-CD22 immunotoxins

artículo científico publicado en 2003

Treatment of refractory Hodgkin's lymphoma patients with an anti-CD25 ricin A-chain immunotoxin

scientific article published on 01 January 2000

Lista de obras de

A CD4-derived peptide carrier blocks acute HIV-1 infection in vitro and binds to gp120 in the presence of Walter-Reed stage 1-6 HIV+ sera

A Phase I study with an anti-CD30 ricin A-chain immunotoxin (Ki-4.dgA) in patients with refractory CD30+ Hodgkin's and non-Hodgkin's lymphoma

A novel recombinant vaccine which protects mice against ricin intoxication.

A phase 1 study of Combotox in pediatric patients with refractory B-lineage acute lymphoblastic leukemia

A phase I study of a combination of anti‐CD19 and anti‐CD22 immunotoxins (Combotox) in adult patients with refractory B‐lineage acute lymphoblastic leukaemia ⬇️

A phase I study of an anti-CD22-deglycosylated ricin A chain immunotoxin in the treatment of B-cell lymphomas resistant to conventional therapy.

A phase I study of bolus versus continuous infusion of the anti-CD19 immunotoxin, IgG-HD37-dgA, in patients with B-cell lymphoma.

A phase I study of combination therapy with immunotoxins IgG-HD37-deglycosylated ricin A chain (dgA) and IgG-RFB4-dgA (Combotox) in patients with refractory CD19(+), CD22(+) B cell lymphoma

A phase-I study of an anti-CD25 ricin A-chain immunotoxin (RFT5-SMPT-dgA) in patients with refractory Hodgkin's lymphoma

Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation

An anti-CD45RO immunotoxin kills latently infected human immunodeficiency virus (HIV) CD4 T cells in the blood of HIV-positive persons

Anti-CD19 antibodies inhibit the function of the P-gp pump in multidrug-resistant B lymphoma cells.

Anti-CD19 immunotoxin enhances the activity of chemotherapy in severe combined immunodeficient mice with human pre-B acute lymphoblastic leukemia

Binding of cytophilic rabbit IgG to homologous hepatocytes ⬇️

CD4 peptide-protein conjugates, but not recombinant human CD4, bind to recombinant gp120 from the human immunodeficiency virus in the presence of serum from AIDS patients

Chemical Construction of Immunotoxins

Chemical construction of immunotoxins

Clinical Trials with an Anti-CD25 Ricin A-Chain Experimental and Immunotoxin (RFT5-SMPT-dgA) in Hodgkin's Lymphoma ⬇️

Clinical evaluation of ricin A-chain immunotoxins in patients with Hodgkin’s lymphoma ⬇️

Complete sustained response of a refractory, post-transplantation, large B-cell lymphoma to an anti-CD22 immunotoxin

Design and In Vivo Characterization of Immunoconjugates Targeting HIV gp160.

Evaluation of a CD25-specific immunotoxin for prevention of graft-versus-host disease after unrelated marrow transplantation

Evaluation of four CD22 antibodies as ricin A chain-containing immunotoxins for the in vivo therapy of human B-cell leukemias and lymphomas

Evaluation of ricin A chain-containing immunotoxins directed against CD19 and CD22 antigens on normal and malignant human B-cells as potential reagents for in vivo therapy

Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome

Fibronectin inhibits the cytotoxic effect of ricin A chain on endothelial cells

Generation and characterization of a novel tetravalent anti-CD22 antibody with improved antitumor activity and pharmacokinetics

Genetic engineering of an immunotoxin to eliminate pulmonary vascular leak in mice

HIV-infected cells are killed by rCD4-ricin A chain

Identification of Human Anti-HIV gp160 Monoclonal Antibodies That Make Effective Immunotoxins

Immunoconjugates containing ricin A chain and either human anti-gp41 or CD4 kill H9 cells infected with different isolates of HIV, but do not inhibit normal T or B cell function

Immunology. Considering therapeutic antibodies

Immunotoxins for the Treatment of B-Cell Lymphomas ⬇️

Interaction between rabbit IgG immune complexes and Ricinus agglutinin

Isolation of a rabbit IgG fraction with cytophilic properties ⬇️

Large scale preparation of an immunoconjugate constructed with human recombinant CD4 and deglycosylated ricin A chain

Large scale preparation of immunotoxins constructed with the Fab' fragment of IgG1 murine monoclonal antibodies and chemically deglycosylated ricin A chain

Optimized clinical-scale culture conditions for ex vivo selective depletion of host-reactive donor lymphocytes: a strategy for GvHD prophylaxis in allogeneic PBSC transplantation

Partial reduction of human FOXP3+ CD4 T cells in vivo after CD25-directed recombinant immunotoxin administration

Phase I trial of an anti-CD19 deglycosylated ricin A chain immunotoxin in non-Hodgkin's lymphoma: effect of an intensive schedule of administration

Preparation and characterization of conjugates of recombinant CD4 and deglycosylated ricin A chain using different cross-linkers

Purification and properties of immunotoxins containing one vs. two deglycosylated ricin A chains.

Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantation in elderly patients and association with acute graft-versus-host disease.

Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation

Selective depletion of donor alloreactive T cells without loss of antiviral or antileukemic responses

The GLP large scale preparation of immunotoxins containing deglycosylated ricin A chain and a hindered disulfide bond

The effect of a monoclonal antibody coupled to ricin A chain-derived peptides on endothelial cells in vitro: insights into toxin-mediated vascular damage

The epitope specificity and tissue reactivity of four murine monoclonal anti-CD22 antibodies

The evaluation of recombinant, chimeric, tetravalent antihuman CD22 antibodies

The generation of immunotoxins using chimeric anti-CD22 antibodies containing mutations which alter their serum half-life

The in vivo anti-tumor activity of immunotoxins containing two versus one deglycosylated ricin A chains

Treatment of SCID/human B cell precursor ALL with anti-CD19 and anti-CD22 immunotoxins

Treatment of refractory Hodgkin's lymphoma patients with an anti-CD25 ricin A-chain immunotoxin