Lista de obras -

Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.

artículo científico publicado en 2003

Aminopeptidase N (CD13) as a target for cancer chemotherapy

artículo científico publicado en 2011

Antitumor activity of the alkylating oligopeptides J1 (L-melphalanyl-p-L-fluorophenylalanine ethyl ester) and P2 (L-prolyl-m-L-sarcolysyl-p-L-fluorophenylalanine ethyl ester): comparison with melphalan ⬇️

artículo científico publicado el 1 de septiembre de 2003

Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-L-melphalanyl-p-L-fluorophenylalanine ethyl ester): comparison with its m-L-sarcolysin analogue P2.

artículo científico publicado en 2003

Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo

artículo científico publicado en 2004

Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells

artículo científico publicado en 2010

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguanidine CHS 828.

artículo científico publicado en 2004

Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice

artículo científico publicado en 2010

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

artículo científico publicado en 2011

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

artículo científico publicado en 2014

Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram

artículo científico publicado en 2006

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

artículo científico publicado en 2017

Melflufen - a peptidase-potentiated alkylating agent in clinical trials

artículo científico publicado en 2017

Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells

artículo científico publicado en 2002

Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index

artículo científico publicado en 2010

Novel activity of acriflavine against colorectal cancer tumor cells

artículo científico publicado en 2011

Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

artículo científico publicado en 2007

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

artículo científico publicado en 2011

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

artículo científico publicado en 2006

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

artículo científico publicado en 2013

Preclinical activity of melflufen (J1) in ovarian cancer

scientific article published on 09 August 2016

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

artículo científico publicado en 2013

Structure-activity relationship for alkylating dipeptide nitrogen mustard derivatives.

artículo científico publicado en 2003

The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

artículo científico publicado en 2008

The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

artículo científico publicado en 2007

Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects

artículo científico publicado en 2017

Lista de obras de

Activity of hydrolytic enzymes in tumour cells is a determinant for anti-tumour efficacy of the melphalan containing prodrug J1.

Aminopeptidase N (CD13) as a target for cancer chemotherapy

Antitumor activity of the alkylating oligopeptides J1 (L-melphalanyl-p-L-fluorophenylalanine ethyl ester) and P2 (L-prolyl-m-L-sarcolysyl-p-L-fluorophenylalanine ethyl ester): comparison with melphalan ⬇️

Antitumor activity of the novel melphalan containing tripeptide J3 (L-prolyl-L-melphalanyl-p-L-fluorophenylalanine ethyl ester): comparison with its m-L-sarcolysin analogue P2.

Antitumor efficacy and acute toxicity of the novel dipeptide melphalanyl-p-L-fluorophenylalanine ethyl ester (J1) in vivo

Characterization of the cytotoxic properties of the benzimidazole fungicides, benomyl and carbendazim, in human tumour cell lines and primary cultures of patient tumour cells

Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguanidine CHS 828.

Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice

In vitro evaluation of clinical activity and toxicity of anticancer drugs using tumor cells from patients and cells representing normal tissues

Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

Melflufen - a peptidase-potentiated alkylating agent in clinical trials

Modulation of pyridyl cyanoguanidine (CHS 828) induced cytotoxicity by 3-aminobenzamide in U-937 GTB cells

Nanoparticulate Quillaja saponin induces apoptosis in human leukemia cell lines with a high therapeutic index

Novel activity of acriflavine against colorectal cancer tumor cells

Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

Preclinical activity of melflufen (J1) in ovarian cancer

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

Structure-activity relationship for alkylating dipeptide nitrogen mustard derivatives.

The alpine violet, Viola biflora, is a rich source of cyclotides with potent cytotoxicity

The novel alkylating prodrug J1: diagnosis directed activity profile ex vivo and combination analyses in vitro

Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects