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Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments

artículo científico publicado en 2014

Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

artículo científico publicado en 2016

Loss of cancer drug activity in colon cancer HCT-116 cells during spheroid formation in a new 3-D spheroid cell culture system

artículo científico publicado en 2012

Mebendazole-induced M1 polarisation of THP-1 macrophages may involve DYRK1B inhibition

Mechanistic characterization of a copper containing thiosemicarbazone with potent antitumor activity

artículo científico publicado en 2017

Novel activity of acriflavine against colorectal cancer tumor cells

artículo científico publicado en 2011

Phenotype-based drug screening in primary ovarian carcinoma cultures identifies intracellular iron depletion as a promising strategy for cancer treatment

artículo científico publicado en 2011

Phenotype-based screening of mechanistically annotated compounds in combination with gene expression and pathway analysis identifies candidate drug targets in a human squamous carcinoma cell model

artículo científico publicado en 2006

Piperlongumine induces inhibition of the ubiquitin-proteasome system in cancer cells

artículo científico publicado en 2013

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer

artículo científico publicado en 2013

STAT1 signaling is associated with acquired crossresistance to doxorubicin and radiation in myeloma cell lines

artículo científico publicado en 2007

Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance

artículo científico publicado en 2013

Screening of an annotated compound library for drug activity in a resistant myeloma cell line

artículo científico publicado en 2006

Targeting tumor cells based on Phosphodiesterase 3A expression

artículo científico publicado en 2017

The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation

artículo científico publicado en 2017

Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer

artículo científico publicado en 2015

Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects

artículo científico publicado en 2017