Lista de obras -

A novel multiple-stage antimalarial agent that inhibits protein synthesis

artículo científico publicado en 2015

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

artículo científico publicado en 2012

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis

artículo científico publicado en 2009

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

artículo científico publicado en 2013

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

artículo científico publicado en 2016

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors

artículo científico publicado en 2011

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

artículo científico publicado en 2010

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

artículo científico publicado en 2010

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

artículo científico publicado en 2011

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

artículo científico publicado en 2015

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

artículo científico publicado en 2015

Discovery of a Novel Class of Orally Active Trypanocidal N -Myristoyltransferase Inhibitors

artículo científico publicado en 2012

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

artículo científico publicado en 2016

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

scholarly article published in Antimicrobial Agents and Chemotherapy

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

artículo científico publicado en 2010

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei

artículo científico publicado en 2009

Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis

artículo científico publicado en 2014

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

artículo científico publicado en 2010

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

artículo científico publicado en 2009

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488

artículo científico publicado en 2011

Quinol derivatives as potential trypanocidal agents

artículo científico publicado en 2011

Screening a protein kinase inhibitor library against Plasmodium falciparum

artículo científico publicado en 2017

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase

artículo científico publicado en 2009

Target assessment for antiparasitic drug discovery

artículo científico publicado en 2007

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

scientific article published on 17 June 2016

Lista de obras de

A novel multiple-stage antimalarial agent that inhibits protein synthesis

Chemical proteomic analysis reveals the drugability of the kinome of Trypanosoma brucei.

Chemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasis

Comparison of a high-throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis

Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

Dihydroquinazolines as a Novel Class of Trypanosoma brucei Trypanothione Reductase Inhibitors: Discovery, Synthesis, and Characterization of their Binding Mode by Protein Crystallography

Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei

Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library

Discovery of a Novel Class of Orally Active Trypanocidal N -Myristoyltransferase Inhibitors

Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy

Erratum for De Rycker et al., Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis

Investigation of trypanothione reductase as a drug target in Trypanosoma brucei

Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Optimisation of the anti-Trypanosoma brucei activity of the opioid agonist U50488

Quinol derivatives as potential trypanocidal agents

Screening a protein kinase inhibitor library against Plasmodium falciparum

Synthesis and evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) analogues as inhibitors of trypanothione reductase

Target assessment for antiparasitic drug discovery

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials