Lista de obras -

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

artículo científico publicado en 2015

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

artículo científico publicado en 2018

Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains

scientific article published on 01 November 2020

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

artículo científico publicado en 2012

CD4-binding-Site Recognition by VH1-46 Germline-derived HIV-1 Neutralizers.

artículo científico publicado en 2014

Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

article

Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies

Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies

artículo científico publicado en 2011

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

scientific article published on 11 December 2019

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1

artículo científico publicado en 2011

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

artículo científico publicado en 2010

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

artículo científico publicado en 2015

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

artículo científico publicado en 2011

Development of a 3Mut-Apex-Stabilized Envelope Trimer that Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses

scientific article published on 15 April 2020

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8

artículo científico publicado en 2016

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

artículo científico publicado en 2014

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape

artículo científico publicado en 2012

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

artículo científico publicado en 2014

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

artículo científico publicado en 2018

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

artículo científico publicado en 2011

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

artículo científico publicado en 2016

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

artículo científico publicado en 2013

Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies

artículo científico publicado en 2011

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.

scientific article published on August 2016

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

artículo científico publicado en 2019

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

artículo científico publicado en 2015

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

artículo científico publicado en 2013

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

artículo científico publicado en 2013

N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function

artículo científico publicado en 2013

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses

artículo científico publicado en 2021

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

artículo científico publicado en 2016

Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04

artículo científico publicado en 2013

Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera

artículo científico publicado en 2015

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine

artículo científico publicado en 2019

Protection of calves by a prefusion-stabilized bovine RSV F vaccine

artículo científico publicado en 2017

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

artículo científico publicado en 2017

Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region

artículo científico publicado en 2009

Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains

artículo científico publicado en 2013

Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

artículo científico publicado en 2021

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.

artículo científico publicado en 2015

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

artículo científico publicado en 2017

Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies

artículo científico publicado en 2016

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

artículo científico publicado en 2010

Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6

artículo científico publicado en 2014

Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1

artículo científico publicado en 2013

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

artículo científico publicado en 2014

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

artículo científico publicado en 2015

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

artículo científico publicado en 2013

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

artículo científico publicado en 2021

Structural basis of respiratory syncytial virus neutralization by motavizumab

artículo científico publicado en 2010

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

artículo científico publicado en 2014

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

artículo científico publicado en 2011

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

artículo científico publicado en 2013

Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

artículo científico publicado en 2011

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

scientific article published on 01 April 2020

Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F

artículo científico publicado en 2010

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

artículo científico publicado en 2013

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

artículo científico publicado en 2017

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structure-based design of head-only fusion glycoprotein immunogens for respiratory syncytial virus

artículo científico publicado en 2016

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

artículo científico publicado en 2016

Transplanting supersites of HIV-1 vulnerability

artículo científico publicado en 2014

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

artículo científico publicado en 2016

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

artículo científico publicado en 2018

Uncleaved Soluble gp140 Constructs with Retained Native-like Trimer Conformation and Antigenicity.

artículo científico publicado en 2014

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

artículo científico publicado en 2012

Lista de obras de

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

CD4-binding-Site Recognition by VH1-46 Germline-derived HIV-1 Neutralizers.

Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies

Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

Development of a 3Mut-Apex-Stabilized Envelope Trimer that Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04

Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine

Protection of calves by a prefusion-stabilized bovine RSV F vaccine

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region

Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains

Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6

Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

Structural basis of respiratory syncytial virus neutralization by motavizumab

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4

Structure-based design of head-only fusion glycoprotein immunogens for respiratory syncytial virus

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

Transplanting supersites of HIV-1 vulnerability

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

Uncleaved Soluble gp140 Constructs with Retained Native-like Trimer Conformation and Antigenicity.

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops