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5-Imino-1,2-4-thiadiazoles and quinazolines derivatives as glycogen synthase kinase 3β (GSK-3β) and phosphodiesterase 7 (PDE7) inhibitors: determination of blood-brain barrier penetration and binding to human serum albumin.

artículo científico publicado en 2012

Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders

artículo científico publicado en 2014

Effect of phosphodiesterase 7 (PDE7) inhibitors in experimental autoimmune encephalomyelitis mice. Discovery of a new chemically diverse family of compounds

artículo científico publicado en 2012

Identification in silico and experimental validation of novel phosphodiesterase 7 inhibitors with efficacy in experimental autoimmune encephalomyelitis mice

artículo científico publicado en 2012

Neuroprotective efficacy of quinazoline type phosphodiesterase 7 inhibitors in cellular cultures and experimental stroke model

artículo científico publicado en 2011

Phosphodiesterase 7 inhibition preserves dopaminergic neurons in cellular and rodent models of Parkinson disease

artículo científico publicado en 2011

Phosphodiesterase 7 inhibitor reduced cognitive impairment and pathological hallmarks in a mouse model of Alzheimer's disease

artículo científico publicado en 2013

Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis

artículo científico publicado en 2014

Unraveling phosphodiesterase surfaces. Identification of phosphodiesterase 7 allosteric modulation cavities

artículo científico publicado en 2013

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