Lista de obras -

Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.

artículo científico publicado en 2014

Alprazolam as an in vivo probe for studying induction of CYP3A in cynomolgus monkeys.

artículo científico publicado en 2010

Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies

artículo científico publicado en 2017

Cytochrome P450 metabolic activities in the small intestine of cynomolgus macaques bred in Cambodia, China, and Indonesia.

artículo científico publicado en 2013

Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice

artículo científico publicado en 2019

Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

artículo científico publicado en 2017

Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450

artículo científico publicado en 2014

Expression profile of hepatic genes in cynomolgus macaques bred in Cambodia, China, and Indonesia: implications for cytochrome P450 genes.

artículo científico publicado en 2011

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

artículo científico publicado en 2009

Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.

artículo científico publicado en 2016

Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.

artículo científico publicado en 2015

Identification and characterization of CYP2B6 cDNA in cynomolgus macaques (Macaca fascicularis).

artículo científico publicado en 2009

Identification and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis).

artículo científico publicado en 2009

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

artículo científico publicado en 2013

In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.

artículo científico publicado en 2016

Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers.

artículo científico publicado en 2016

Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation

scientific article published on 03 October 2012

Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline

artículo científico publicado en 2013

Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey

artículo científico publicado en 2011

Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets.

artículo científico publicado en 2016

Plasma and Hepatic Concentrations of Acetaminophen and Its Primary Conjugates after Oral Administrations Determined in Experimental Animals and Humans and Extrapolated by Pharmacokinetic Modeling

scientific article published on 12 November 2020

Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide.

artículo científico publicado en 2016

Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs

artículo científico publicado en 2012

Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus).

artículo científico publicado en 2015

Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo.

artículo científico publicado en 2015

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor

artículo científico publicado en 2014

Lista de obras de

Age-related changes of hepatic clearances of cytochrome P450 probes, midazolam and R-/S-warfarin in combination with caffeine, omeprazole and metoprolol in cynomolgus monkeys using in vitro-in vivo correlation.

Alprazolam as an in vivo probe for studying induction of CYP3A in cynomolgus monkeys.

Assessment of multiple cytochrome P450 activities in metabolically inactivated human liver microsomes and roles of P450 2C isoforms in reaction phenotyping studies

Cytochrome P450 metabolic activities in the small intestine of cynomolgus macaques bred in Cambodia, China, and Indonesia.

Different Roles of Human Cytochrome P450 2C9 and 3A Enzymes in Diclofenac 4'- and 5-Hydroxylations Mediated by Metabolically Inactivated Human Hepatocytes in Previously Transplanted Chimeric Mice

Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models

Evaluation of 23 Lots of Commercially Available Cryopreserved Hepatocytes for Induction Assays of Human Cytochromes P450

Expression profile of hepatic genes in cynomolgus macaques bred in Cambodia, China, and Indonesia: implications for cytochrome P450 genes.

Genetic variants of CYP3A4 and CYP3A5 in cynomolgus and rhesus macaques.

Human plasma concentrations of cytochrome P450 probe cocktails extrapolated from pharmacokinetics in mice transplanted with human hepatocytes and from pharmacokinetics in common marmosets using physiologically based pharmacokinetic modeling.

Human plasma concentrations of cytochrome P450 probes extrapolated from pharmacokinetics in cynomolgus monkeys using physiologically based pharmacokinetic modeling.

Identification and characterization of CYP2B6 cDNA in cynomolgus macaques (Macaca fascicularis).

Identification and characterization of CYP2C18 in the cynomolgus macaque (Macaca fascicularis).

In vivo drug interactions of the teratogen thalidomide with midazolam: heterotropic cooperativity of human cytochrome P450 in humanized TK-NOG mice.

In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.

Individual Differences in Metabolic Clearance of S-Warfarin Efficiently Mediated by Polymorphic Marmoset Cytochrome P450 2C19 in Livers.

Monkey liver cytochrome P450 2C19 is involved in R- and S-warfarin 7-hydroxylation

Monkey liver cytochrome P450 2C9 is involved in caffeine 7-N-demethylation to form theophylline

Newly identified CYP2C93 is a functional enzyme in rhesus monkey, but not in cynomolgus monkey

Oxidation of R- and S-omeprazole stereoselectively mediated by liver microsomal cytochrome P450 2C19 enzymes from cynomolgus monkeys and common marmosets.

Plasma and Hepatic Concentrations of Acetaminophen and Its Primary Conjugates after Oral Administrations Determined in Experimental Animals and Humans and Extrapolated by Pharmacokinetic Modeling

Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide.

Simultaneous pharmacokinetics assessment of caffeine, warfarin, omeprazole, metoprolol, and midazolam intravenously or orally administered to Microminipigs

Simultaneous pharmacokinetics evaluation of human cytochrome P450 probes, caffeine, warfarin, omeprazole, metoprolol and midazolam, in common marmosets (Callithrix jacchus).

Slow R-warfarin 7-hydroxylation mediated by P450 2C19 genetic variants in cynomolgus monkeys in vivo.

Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor