Lista de obras -

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat

artículo científico publicado en 2011

A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

scientific article published on 01 November 2020

ATRT-16. CONGENITAL RHABDOID TUMORS AS A MAJOR CLINICAL CHALLENGE - A COLLABORATIVE EUROPEAN EFFORT

Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups

Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data

artículo científico publicado en 2020

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

artículo científico publicado en 2011

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

artículo científico publicado en 2009

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

artículo científico publicado en 2016

Author Correction: The landscape of genomic alterations across childhood cancers

artículo científico publicado en 2018

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience

artículo científico publicado en 2019

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology

artículo científico publicado en 2017

Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins

artículo científico publicado en 2008

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

scientific article published on 27 December 2018

Corrigendum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

artículo científico publicado en 2012

DNA methylation-based classification of central nervous system tumours

artículo científico publicado en 2018

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

artículo científico publicado en 2014

Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma

artículo científico publicado en 2011

Dissecting the genomic complexity underlying medulloblastoma

artículo científico publicado en 2012

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

artículo científico publicado en 2012

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

artículo científico publicado en 2014

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

artículo científico publicado en 2016

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes.

artículo científico publicado en 2010

GENE-12. ANAPLASTIC NEUROEPITHELIAL TUMOR WITH CONDENSED NUCLEI (ANTCON): A NOVEL BRAIN TUMOR ENTITY WITH RECURRENT NTRK FUSION

Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas

artículo científico publicado en 2011

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

artículo científico publicado en 2014

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

artículo científico publicado en 2012

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

scientific article published on 01 April 2020

HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.

artículo científico publicado en 2012

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth

artículo científico publicado en 2010

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

artículo científico publicado en 2012

INFORM2 NivEnt: The first trial of the INFORM2 biomarker driven phase I/II trial series: the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies

artículo científico publicado en 2020

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

scientific article published on 01 April 2020

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

artículo científico publicado en 2015

LGG-11. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA.

artículo científico publicado en 2018

Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma

artículo científico publicado en 2016

MB-57INTERACTION OF HDAC2 AND MYC IN GROUP 3 MEDULLOBLASTOMA - A NOVEL THERAPEUTIC TARGET.

artículo científico publicado en 2016

MEDU-20. TARGETING OF MYC BY HDAC INHIBITION IN MYC AMPLIFIED GROUP 3 MEDULLOBLASTOMA.

artículo científico publicado en 2017

MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma

artículo científico publicado en 2011

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

artículo científico publicado en 2015

Molecular staging of intracranial ependymoma in children and adults

artículo científico publicado en 2010

Nestin expression identifies ependymoma patients with poor outcome

artículo científico publicado en 2012

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study

artículo científico publicado en 2016

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

artículo científico publicado en 2015

No correlation between NF1 mutation position and risk of optic pathway glioma in 77 unrelated NF1 patients

artículo científico publicado en 2016

Novel oncogene amplifications in tumors from a family with Li-Fraumeni syndrome

artículo científico publicado en 2009

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

artículo científico publicado en 2011

PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH

PCM-16MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS.

artículo científico publicado en 2016

PDTM-47. CHARACTERIZATION OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA AND ITS ROLE IN ONCOGENE-INDUCED SENESCENCE

Pediatric Low-Grade Gliomas: Next Biologically Driven Steps

artículo científico publicado en 2017

Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors

artículo científico publicado en 2015

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.

artículo científico publicado en 2018

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

artículo científico publicado en 2021

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

artículo científico publicado en 2013

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

artículo científico publicado en 2013

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

artículo científico publicado en 2020

Reply to J.C. Lindsey et al

Response to trametinib treatment in progressive pediatric low-grade glioma patients

artículo científico publicado en 2020

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

artículo científico publicado en 2016

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions

scientific article published on 05 July 2019

Sarcoma classification by DNA methylation profiling

artículo científico publicado en 2021

TMOD-05. MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS AND THEIR USE IN PRECLINICAL EXPERIMENTS.

artículo científico publicado en 2017

TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.

artículo científico publicado en 2010

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

artículo científico publicado en 2015

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

artículo científico publicado en 2018

The landscape of genomic alterations across childhood cancers

artículo científico publicado en 2018

The molecular landscape of ETMR at diagnosis and relapse

scientific article published on 04 December 2019

The whole-genome landscape of medulloblastoma subtypes

artículo científico publicado en 2017

Lista de obras de

A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat

A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR

ATRT-16. CONGENITAL RHABDOID TUMORS AS A MAJOR CLINICAL CHALLENGE - A COLLABORATIVE EUROPEAN EFFORT

Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups

Accurate calling of KIAA1549-BRAF fusions from DNA of human brain tumours using methylation array-based copy number and gene panel sequencing data

An activated mutant BRAF kinase domain is sufficient to induce pilocytic astrocytoma in mice

Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines

Atypical Teratoid/Rhabdoid Tumors Are Comprised of Three Epigenetic Subgroups with Distinct Enhancer Landscapes

Author Correction: The landscape of genomic alterations across childhood cancers

Brainstem biopsy in pediatric diffuse intrinsic pontine glioma in the era of precision medicine: the INFORM study experience

Childhood cancer predisposition syndromes-A concise review and recommendations by the Cancer Predisposition Working Group of the Society for Pediatric Oncology and Hematology

Cisplatin-resistant neuroblastoma cells express enhanced levels of epidermal growth factor receptor (EGFR) and are sensitive to treatment with EGFR-specific toxins

Comprehensive Analysis of Chromatin States in Atypical Teratoid/Rhabdoid Tumor Identifies Diverging Roles for SWI/SNF and Polycomb in Gene Regulation

Corrigendum: Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

DNA methylation-based classification of central nervous system tumours

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

Delineation of two clinically and molecularly distinct subgroups of posterior fossa ependymoma

Dissecting the genomic complexity underlying medulloblastoma

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes.

GENE-12. ANAPLASTIC NEUROEPITHELIAL TUMOR WITH CONDENSED NUCLEI (ANTCON): A NOVEL BRAIN TUMOR ENTITY WITH RECURRENT NTRK FUSION

Genetic aberrations leading to MAPK pathway activation mediate oncogene-induced senescence in sporadic pilocytic astrocytomas

Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

Germline Elongator mutations in Sonic Hedgehog medulloblastoma

HD-MB03 is a novel Group 3 medulloblastoma model demonstrating sensitivity to histone deacetylase inhibitor treatment.

HDAC5 and HDAC9 in medulloblastoma: novel markers for risk stratification and role in tumor cell growth

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma

INFORM2 NivEnt: The first trial of the INFORM2 biomarker driven phase I/II trial series: the combination of nivolumab and entinostat in children and adolescents with refractory high-risk malignancies

Infant high grade gliomas comprise multiple subgroups characterized by novel targetable gene fusions and favorable outcomes

Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers

LGG-11. REGULATION OF ONCOGENE-INDUCED SENESCENCE IN PILOCYTIC ASTROCYTOMA.

Low-dose Actinomycin-D treatment re-establishes the tumoursuppressive function of P53 in RELA-positive ependymoma

MB-57INTERACTION OF HDAC2 AND MYC IN GROUP 3 MEDULLOBLASTOMA - A NOVEL THERAPEUTIC TARGET.

MEDU-20. TARGETING OF MYC BY HDAC INHIBITION IN MYC AMPLIFIED GROUP 3 MEDULLOBLASTOMA.

MicroRNA-182 promotes leptomeningeal spread of non-sonic hedgehog-medulloblastoma

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups

Molecular staging of intracranial ependymoma in children and adults

Nestin expression identifies ependymoma patients with poor outcome

Next-generation personalised medicine for high-risk paediatric cancer patients - The INFORM pilot study

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets

No correlation between NF1 mutation position and risk of optic pathway glioma in 77 unrelated NF1 patients

Novel oncogene amplifications in tumors from a family with Li-Fraumeni syndrome

Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

PCLN-05. A BIOBANK OF PATIENT-DERIVED MOLECULARLY CHARACTERIZED ORTHOTOPIC PEDIATRIC BRAIN TUMOR MODELS FOR PRECLINICAL RESEARCH

PCM-16MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS.

PDTM-47. CHARACTERIZATION OF THE SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE IN PILOCYTIC ASTROCYTOMA AND ITS ROLE IN ONCOGENE-INDUCED SENESCENCE

Pediatric Low-Grade Gliomas: Next Biologically Driven Steps

Pediatric Targeted Therapy: Clinical Feasibility of Personalized Diagnostics in Children with Relapsed and Progressive Tumors

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience.

Radiation-induced gliomas represent H3-/IDH-wild type pediatric gliomas with recurrent PDGFRA amplification and loss of CDKN2A/B

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

Reduced chromatin binding of MYC is a key effect of HDAC inhibition in MYC amplified medulloblastoma

Reply to J.C. Lindsey et al

Response to trametinib treatment in progressive pediatric low-grade glioma patients

Risk stratification of childhood medulloblastoma in the molecular era: the current consensus

Routine RNA sequencing of formalin-fixed paraffin-embedded specimens in neuropathology diagnostics identifies diagnostically and therapeutically relevant gene fusions

Sarcoma classification by DNA methylation profiling

TMOD-05. MOLECULAR CHARACTERIZATION OF ORTHOTOPIC PATIENT-DERIVED XENOGRAFT MODELS OF PEDIATRIC BRAIN TUMORS AND THEIR USE IN PRECLINICAL EXPERIMENTS.

TP53 mutation is frequently associated with CTNNB1 mutation or MYCN amplification and is compatible with long-term survival in medulloblastoma.

Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma

The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

The landscape of genomic alterations across childhood cancers

The molecular landscape of ETMR at diagnosis and relapse

The whole-genome landscape of medulloblastoma subtypes