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A class of sterol 14-demethylase inhibitors as anti-Trypanosoma cruzi agents.

artículo científico publicado en 2003

Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation.

artículo científico publicado en 2003

Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone.

scientific article published on 28 January 2009

C-terminal proteolysis of prenylated proteins in trypanosomatids and RNA interference of enzymes required for the post-translational processing pathway of farnesylated proteins

artículo científico publicado en 2007

Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents.

artículo científico publicado en 2004

Efficacy, Pharmacokinetics, and Metabolism of Tetrahydroquinoline Inhibitors of Plasmodium falciparum Protein Farnesyltransferase

artículo científico publicado en 2007

In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability

artículo científico publicado en 2004

Isothiazole dioxide derivative 6n inhibits vascular smooth muscle cell proliferation and protein farnesylation

scientific journal article

Isothiazole dioxides: synthesis and inhibition of Trypanosoma brucei protein farnesyltransferase.

artículo científico publicado en 2002

Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics.

artículo científico publicado en 2003

Protein farnesyl transferase inhibitors for the treatment of malaria and African trypanosomiasis.

artículo científico publicado en 2005

Protein farnesyltransferase inhibitors exhibit potent antimalarial activity

artículo científico publicado en 2005

Protein geranylgeranyltransferase-I of Trypanosoma cruzi

artículo científico publicado en 2007

Second generation tetrahydroquinoline-based protein farnesyltransferase inhibitors as antimalarials

artículo científico publicado en 2007

Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites

artículo científico publicado en 2005

Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites

scientific article published on September 2006

Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation

artículo científico publicado en 2006