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"What makes some rats live so long?" The mitochondrial contribution to longevity through balance of mitochondrial dynamics and mtDNA content

artículo científico publicado en 2016

A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged

artículo científico publicado en 2015

A better understanding of why murine models of trauma do not recapitulate the human syndrome

artículo científico publicado en 2014

A comparison among the tissue-specific effects of aging and calorie restriction on TFAM amount and TFAM-binding activity to mtDNA in rat.

artículo científico publicado en 2014

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

artículo científico publicado en 2008

A method to determine RNA and DNA oxidation simultaneously by HPLC-ECD: greater RNA than DNA oxidation in rat liver after doxorubicin administration

artículo científico publicado en 2006

Active muscle regeneration following eccentric contraction-induced injury is similar between healthy young and older adults

artículo científico publicado en 2013

Administration of Enalapril Started Late in Life Attenuates Hypertrophy and Oxidative Stress Burden, Increases Mitochondrial Mass, and Modulates Mitochondrial Quality Control Signaling in the Rat Heart

scientific article published on 17 December 2018

Advanced Age Is Associated with Iron Dyshomeostasis and Mitochondrial DNA Damage in Human Skeletal Muscle ⬇️

scientific article published on 27 November 2019

Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.

artículo científico publicado en 2015

Age- and calorie restriction-related changes in rat brain mitochondrial DNA and TFAM binding.

artículo científico publicado en 2012

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

artículo científico publicado en 2008

Age-related cellular changes in the long-lived bivalve A. islandica

artículo científico publicado en 2015

Age-related differences in apoptosis with disuse atrophy in soleus muscle

scientific journal article

Age-related differences in lower extremity tissue compartments and associations with physical function in older adults

artículo científico publicado en 2011

Age-related hearing loss in C57BL/6J mice is mediated by Bak-dependent mitochondrial apoptosis.

artículo científico publicado en 2009

Aged mice are unable to mount an effective myeloid response to sepsis

artículo científico publicado en 2013

Aging and calorie restriction oppositely affect mitochondrial biogenesis through TFAM binding at both origins of mitochondrial DNA replication in rat liver.

artículo científico publicado en 2013

Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12

scientific article published on 01 January 2004

Altered Expression of Mitoferrin and Frataxin, Larger Labile Iron Pool and Greater Mitochondrial DNA Damage in the Skeletal Muscle of Older Adults

artículo científico publicado en 2020

Anabolic effects of testosterone are preserved during inhibition of 5alpha-reductase

scientific article published on 08 May 2007

Apoptosis in skeletal myocytes: a potential target for interventions against sarcopenia and physical frailty - a mini-review

artículo científico

Associations of Weight Change With Changes in Calf Muscle Characteristics and Functional Decline in Peripheral Artery Disease

scientific article published on 29 June 2019

Autophagy Suppresses Age-Dependent Ischemia and Reperfusion Injury in Livers of Mice ⬇️

artículo científico publicado el 18 de agosto de 2011

Autophagy and leucine promote chronological longevity and respiration proficiency during calorie restriction in yeast.

artículo científico publicado en 2013

Autophagy in the liver: cell's cannibalism and beyond

artículo científico publicado en 2016

Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.

artículo científico publicado en 2017

Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats

artículo científico publicado en 2010

Beneficial effects of exercise on age-related mitochondrial dysfunction and oxidative stress in skeletal muscle

artículo científico publicado en 2015

Bioenergetics and permeability transition pore opening in heart subsarcolemmal and interfibrillar mitochondria: effects of aging and lifelong calorie restriction.

artículo científico publicado en 2009

Brown adipose tissue and the cold war against obesity

artículo científico publicado en 2014

Caloric Restriction to Moderate Senescence: Mechanisms and Clinical Utility

scientific article published on December 2013

Caloric restriction in humans: potential pitfalls and health concerns

artículo científico publicado en 2005

Calorie restriction combined with resveratrol induces autophagy and protects 26-month-old rat hearts from doxorubicin-induced toxicity

artículo científico publicado en 2014

Calorie restriction for optimal cardiovascular aging: the weight of evidence

artículo científico publicado en 2010

Cellular mechanisms of cardioprotection by calorie restriction: state of the science and future perspectives

artículo científico publicado en 2009

Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction

scientific journal article

Changes in lipid distribution during aging and its modulation by calorie restriction

artículo científico publicado en 2009

Chronic pain, perceived stress, and cellular aging: an exploratory study

artículo científico publicado en 2012

Circulating Mitochondrial DNA at the Crossroads of Mitochondrial Dysfunction and Inflammation During Aging and Muscle Wasting Disorders.

artículo científico publicado en 2017

Clinical Characteristics and Response to Supervised Exercise Therapy in People with Lower Extremity Peripheral Artery Disease

artículo científico publicado en 2020

Cocoa to Improve Walking Performance in Older People With Peripheral Artery Disease: The COCOA-PAD Pilot Randomized Clinical Trial

artículo científico publicado en 2020

Comparing 6-minute walk versus treadmill walking distance as outcomes in randomized trials of peripheral artery disease

artículo científico publicado en 2019

Comparison of lifelong and late life exercise on oxidative stress in the cerebellum

artículo científico publicado en 2007

Contribution of impaired mitochondrial autophagy to cardiac aging: mechanisms and therapeutic opportunities

artículo científico publicado en 2012

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

Correction: A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice.

artículo científico publicado en 2008

Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease

artículo científico publicado en 2020

Critical role of autophagy in ischemia/reperfusion injury to aged livers ⬇️

artículo científico publicado el 1 de enero de 2012

Current nutritional recommendations and novel dietary strategies to manage sarcopenia

artículo científico publicado en 2013

Device-Measured Physical Activity As a Predictor of Disability in Mobility-Limited Older Adults

artículo científico

Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats.

artículo científico publicado en 2019

Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2:Bax ratio.

artículo científico publicado en 2002

Dysregulation of mitochondrial quality control processes contribute to sarcopenia in a mouse model of premature aging

artículo científico publicado en 2013

ENabling Reduction of Low-grade Inflammation in SEniors Pilot Study: Concept, Rationale, and Design

artículo científico publicado en 2017

Effect of Resveratrol on Walking Performance in Older People With Peripheral Artery Disease: The RESTORE Randomized Clinical Trial

artículo científico

Effect of losartan and fish oil on plasma IL-6 and mobility in older persons. The ENRGISE Pilot randomized clinical trial

article

Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice.

artículo científico publicado en 2016

Effects of Popular Diets without Specific Calorie Targets on Weight Loss Outcomes: Systematic Review of Findings from Clinical Trials.

artículo científico publicado en 2017

Effects of a weight loss plus exercise program on physical function in overweight, older women: a randomized controlled trial ⬇️

artículo científico publicado el 15 de junio de 2011

Effects of age and caloric restriction on brain neuronal cell death/survival

artículo científico publicado en 2004

Effects of age and sedentary lifestyle on skeletal muscle NF-kappaB signaling in men

artículo científico publicado en 2010

Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6

artículo científico publicado en 2006

Effects of life-long caloric restriction and voluntary exercise on age-related changes in levels of catecholamine biosynthetic enzymes and angiotensin II receptors in the rat adrenal medulla and hypothalamus

artículo científico publicado en 2007

Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats

artículo científico publicado en 2007

Evaluation of sex differences on mitochondrial bioenergetics and apoptosis in mice.

artículo científico publicado en 2006

Exercise-Induced Autophagy in Fatty Liver Disease

artículo científico publicado en 2017

Exploring the Predictive Ability of Dysfunctional High-Density Lipoprotein for Adverse Outcomes in Emergency Department Patients with Sepsis: A Preliminary Investigation

artículo científico publicado en 2017

Expression of key regulators of mitochondrial biogenesis in growth hormone receptor knockout (GHRKO) mice is enhanced but is not further improved by other potential life-extending interventions.

artículo científico publicado en 2011

Fasting or caloric restriction for Healthy Aging ⬇️

artículo científico publicado el 29 de abril de 2013

Frailty syndrome and skeletal muscle: results from the Invecchiare in Chianti study

artículo científico publicado en 2006

Fueling Inflamm-Aging through Mitochondrial Dysfunction: Mechanisms and Molecular Targets.

artículo científico publicado en 2017

Guidelines for the use and interpretation of assays for monitoring autophagy

artículo científico publicado en 2012

HDL Cholesterol Efflux is Impaired in Older Patients with Early Sepsis: A Subanalysis of a Prospective Pilot Study ⬇️

artículo científico publicado en 2017

HDL inflammatory index correlates with and predicts severity of organ failure in patients with sepsis and septic shock

artículo científico publicado en 2018

Hepatic oxidative stress during aging: effects of 8% long-term calorie restriction and lifelong exercise

scientific article published on 01 March 2006

Host responses to sepsis vary in different low-lethality murine models

artículo científico publicado en 2014

Idiopathic chronic fatigue in older adults is linked to impaired mitochondrial content and biogenesis signaling in skeletal muscle

scientific article published on 18 July 2016

Impact of chemotherapy on medium-term physical function and activity of older breast cancer survivors, and associated biomarkers.

artículo científico publicado en 2016

Impaired Iron Status in Aging Research ⬇️

artículo científico publicado el 22 de febrero de 2012

Increased TFAM binding to mtDNA damage hot spots is associated with mtDNA loss in aged rat heart

scientific article published on 30 June 2018

Increased inflammation but similar physical composition and function in older-aged, HIV-1 infected subjects

artículo científico publicado en 2015

Increased iron content and RNA oxidative damage in skeletal muscle with aging and disuse atrophy

scientific journal article

Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity

scientific article published on 06 May 2009

Inhibition of NF-κB-induced inflammatory responses by angiotensin II antagonists in aged rat kidney ⬇️

artículo científico publicado el 3 de marzo de 2011

Innovations in Geroscience to enhance mobility in older adults

artículo científico publicado en 2020

Integrated control of brown adipose tissue

artículo científico publicado en 2016

Intraoperative hemidiaphragm electrical stimulation reduces oxidative stress and upregulates autophagy in surgery patients undergoing mechanical ventilation: exploratory study

artículo científico publicado en 2016

Investigations of botanicals on food intake, satiety, weight loss and oxidative stress: study protocol of a double-blind, placebo-controlled, crossover study ⬇️

artículo científico publicado el 1 de noviembre de 2011

Iron accumulation with age, oxidative stress and functional decline

artículo científico publicado en 2008

LIPid Intensive Drug therapy for Sepsis Pilot (LIPIDS-P): Phase I/II clinical trial protocol of lipid emulsion therapy for stabilising cholesterol levels in sepsis and septic shock

scientific article published on 18 September 2019

Life long calorie restriction increases heat shock proteins and proteasome activity in soleus muscles of Fisher 344 rats

scientific article published on 01 January 2005

Lifelong exercise and mild (8%) caloric restriction attenuate age-induced alterations in plantaris muscle morphology, oxidative stress and IGF-1 in the Fischer-344 rat.

artículo científico publicado en 2008

Lipid intensive drug therapy for sepsis pilot: A Bayesian phase I clinical trial

artículo científico publicado en 2020

Long-term effects of caloric restriction or exercise on DNA and RNA oxidation levels in white blood cells and urine in humans

artículo científico publicado en 2008

Long-term perturbation of muscle iron homeostasis following hindlimb suspension in old rats is associated with high levels of oxidative stress and impaired recovery from atrophy.

artículo científico publicado en 2011

Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers

scientific article published on 17 May 2018

MEANINGFUL CHANGE IN SIX-MINUTE WALK IN PEOPLE WITH PERIPHERAL ARTERY DISEASE

artículo científico publicado en 2020

Mitochondria and aging

artículo científico publicado en 2011

Mitochondrial DNA mutations and apoptosis in mammalian aging.

artículo científico publicado en 2006

Mitochondrial DNA mutations induce mitochondrial dysfunction, apoptosis and sarcopenia in skeletal muscle of mitochondrial DNA mutator mice

artículo científico publicado en 2010

Mitochondrial DNA mutations, energy metabolism and apoptosis in aging muscle

artículo científico publicado en 2006

Mitochondrial death effectors: relevance to sarcopenia and disuse muscle atrophy.

artículo científico publicado en 2009

Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

artículo científico publicado en 2013

Mitochondrial iron accumulation with age and functional consequences

artículo científico publicado en 2008

Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy.

artículo científico publicado en 2013

Mitochondrial quality control mechanisms as molecular targets in cardiac ageing

artículo científico publicado en 2018

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy

artículo científico publicado en 2010

Moderate caloric restriction increases diaphragmatic antioxidant enzyme mRNA, but not when combined with lifelong exercise

artículo científico publicado en 2006

Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults

artículo científico publicado en 2008

Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle.

artículo científico publicado en 2007

Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging

scientific article published on 23 February 2009

Molecular inflammation: underpinnings of aging and age-related diseases

artículo científico publicado en 2008

Molecular mechanism of PPAR in the regulation of age-related inflammation

artículo científico publicado en 2008

Multiple pathways to the same end: mechanisms of myonuclear apoptosis in sarcopenia of aging

artículo científico publicado en 2010

Muscle fiber specific apoptosis and TNF-alpha signaling in sarcopenia are attenuated by life-long calorie restriction

scientific article published on 21 January 2005

Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis

scientific article published on 13 November 2019

Myeloperoxidase levels and mortality in frail community-living elderly individuals.

artículo científico publicado en 2010

New insights into the role of mitochondria in aging: mitochondrial dynamics and more ⬇️

artículo científico publicado el 1 de agosto de 2010

Old Mice Demonstrate Organ Dysfunction as well as Prolonged Inflammation, Immunosuppression, and Weight Loss in a Modified Surgical Sepsis Model

artículo científico publicado en 2019

Older Sepsis Survivors Suffer Persistent Disability Burden and Poor Long-Term Survival

artículo científico publicado en 2020

Patterns of circulating inflammatory biomarkers in older persons with varying levels of physical performance: a partial least squares-discriminant analysis approach

artículo científico publicado en 2014

Peripheral artery disease, calf skeletal muscle mitochondrial DNA copy number, and functional performance

artículo científico publicado en 2018

Persistent inflammation and anemia among critically ill septic patients

scientific article published on 01 February 2019

Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery

artículo científico publicado en 2018

Persistent inflammation, immunosuppression, and catabolism syndrome after severe blunt trauma

artículo científico publicado en 2014

Persistent injury-associated anemia and aging: Novel insights.

artículo científico publicado en 2018

Persistent injury-associated anemia in aged rats.

artículo científico publicado en 2018

Phrenic nerve stimulation increases human diaphragm fiber force after cardiothoracic surgery

artículo científico publicado en 2014

Practicality of intermittent fasting in humans and its effect on oxidative stress and genes related to aging and metabolism

artículo científico publicado en 2015

Prognostic value of NT-proBNP levels in the acute phase of sepsis on lower long-term physical function and muscle strength in sepsis survivors

artículo científico publicado en 2019

Protective immunity and defects in the neonatal and elderly immune response to sepsis

artículo científico publicado en 2014

Resveratrol and exercise combined to treat functional limitations in late life: A pilot randomized controlled trial

artículo científico publicado en 2020

Resveratrol and exercise to treat functional limitations in late life: design of a randomized controlled trial

artículo científico publicado en 2017

Role of mitochondrial dysfunction and altered autophagy in cardiovascular aging and disease: from mechanisms to therapeutics.

artículo científico publicado en 2013

Safety and metabolic outcomes of resveratrol supplementation in older adults: results of a twelve-week, placebo-controlled pilot study

artículo científico publicado en 2014

Sarcopenia of aging: underlying cellular mechanisms and protection by calorie restriction

artículo científico publicado en 2009

Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients

artículo científico publicado en 2017

Septic Stability? Gut Microbiota in Young Adult MICE Maintains Overall Stability After Sepsis Compared to Old Adult MICE

scientific article published on 20 August 2020

Short-term caloric restriction, resveratrol, or combined treatment regimens initiated in late-life alter mitochondrial protein expression profiles in a fiber-type specific manner in aged animals ⬇️

artículo científico publicado el 7 de junio de 2013

Skeletal muscle apoptosis, sarcopenia and frailty at old age.

artículo científico publicado en 2006

Skeletal muscle apoptotic signaling predicts thigh muscle volume and gait speed in community-dwelling older persons: an exploratory study.

artículo científico publicado en 2012

Skeletal muscle autophagy and apoptosis during aging: effects of calorie restriction and life-long exercise

artículo científico publicado en 2009

Skeletal muscle mitochondrial energetics are associated with maximal aerobic capacity and walking speed in older adults

artículo científico publicado en 2012

Successful aging: Advancing the science of physical independence in older adults.

artículo científico publicado en 2015

Systemic inflammation, body composition, and physical performance in old community-dwellers.

scientific article published on 08 August 2016

Targeting mitochondrial quality control for treating sarcopenia: lessons from physical exercise

artículo científico publicado en 2018

The "BIOmarkers associated with Sarcopenia and PHysical frailty in EldeRly pErsons" (BIOSPHERE) study: Rationale, design and methods

artículo científico publicado en 2018

The Effect of Aging Physiology on Critical Care

artículo científico publicado en 2020

The Role of Genome Instability in Frailty: Mitochondria versus Nucleus

artículo científico publicado en 2015

The authors reply

The emerging role of iron dyshomeostasis in the mitochondrial decay of aging

artículo científico publicado en 2010

The impact of aging on mitochondrial function and biogenesis pathways in skeletal muscle of sedentary high- and low-functioning elderly individuals

artículo científico publicado en 2012

The impact of behavioral intervention on obesity mediated declines in mobility function: implications for longevity

artículo científico publicado en 2011

The role of apoptosis in age-related skeletal muscle atrophy

artículo científico publicado en 2005

The role of mitochondrial DNA mutations in aging and sarcopenia: implications for the mitochondrial vicious cycle theory of aging

artículo científico publicado en 2007

Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis

artículo científico publicado en 2020

Tumor necrosis factor alpha signaling in skeletal muscle: effects of age and caloric restriction

artículo científico publicado en 2005

Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity ⬇️

artículo científico publicado el 8 de enero de 2013

Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2'-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress

scientific article published on 17 August 2007

Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia

artículo científico publicado en 2011

Vascular dysfunction as a potential culprit of sarcopenia

artículo científico publicado en 2020

WITHDRAWN: Life-long caloric restriction counteracts apoptotic effects of aging in the brain and bolsters the action of apoptosis inhibitors

artículo científico publicado en 2005

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

artículo científico publicado en 2016

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