Lista de obras -

A metaphyseal defect model of the femur for studies of murine bone healing

artículo científico publicado en 2001

Abnormal craniofacial development and expression patterns of extracellular matrix components in transgenic Del1 mice harboring a deletion mutation in the type II collagen gene

artículo científico publicado en 2004

Abnormal craniofacial growth and early mandibular osteoarthritis in mice harbouring a mutant type II collagen transgene

scientific journal article

Abnormal craniofacial morphology and cartilage structure in transgenic mice harboring a Gly --> Cys mutation in the cartilage-specific type II collagen gene

scientific article published on 01 July 1993

Abnormalities in secondary cartilages in four lines of transgenic mice harboring two different types of mutations in the cartilage-specific type II collagen gene

scientific article published on 01 July 1996

Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing

artículo científico publicado en 2001

Activation of chondrogenesis in response to injury in normal and transgenic mice with cartilage collagen mutations

artículo científico publicado el 1 de enero de 2001

Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice

artículo científico publicado en 2004

Age-dependent changes in the expression of matrix components in the mouse eye

scientific journal article

Altered expression of genes involved in the production and degradation of endometrial extracellular matrix in patients with unexplained infertility and recurrent miscarriages

artículo científico publicado en 2002

Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes

artículo científico publicado en 1994

Analysis of arthritic lesions in the Del1 mouse: a model for osteoarthritis

scientific article published on 01 January 2007

Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells

artículo científico publicado en 2000

Assembly of cartilage collagen fibrils is disrupted by overexpression of normal type II collagen in transgenic mice

artículo científico publicado en 1993

Cathepsin K deficiency aggravates lung injury in hyperoxia-exposed newborn mice ⬇️

artículo científico publicado el 1 de julio de 2011

Cathepsin expression during skeletal development

artículo científico publicado en 1999

Characterization of primary cultures of chondrocytes from type II collagen/beta-galactosidase transgenic mice

artículo científico publicado en 1994

Characterization of the murine Timp4 gene, localization within intron 5 of the synapsin 2 gene and tissue distribution of the mRNA.

artículo científico publicado en 2002

Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain

artículo científico publicado en 1992

Collagens and collagen-related matrix components in the human and mouse eye.

artículo científico publicado en 2004

Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1).

artículo científico publicado en 1995

Coordinate patterns of expression of type I and III collagens during mouse development

artículo científico publicado en 1995

Cysteine proteinases in chondrosarcomas

artículo científico publicado en 2001

Developmental expression of a type II collagen/beta-galactosidase fusion gene in transgenic mice

artículo científico publicado en 1995

Developmental regulation of mRNA species for types II, IX and XI collagens during mouse embryogenesis

artículo científico publicado en 1997

Differential turnover of cortical and trabecular bone in transgenic mice overexpressing cathepsin K.

artículo científico publicado en 2005

Effect of radiosynovectomy with holmium-166 ferric hydroxide macroaggregate on adult equine cartilage.

artículo científico publicado en 2004

Effect of zoledronic acid on incorporation of a bioceramic bone graft substitute

artículo científico publicado en 2005

Evidence for insufficient chondrocytic differentiation during repair of full-thickness defects of articular cartilage

artículo científico publicado en 1996

Exclusion of the COL2A1 gene as the mutation site in diastrophic dysplasia.

artículo científico publicado en 1989

Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus

artículo científico publicado en 2000

Expression of type II and IX collagen isoforms during normal and pathological cartilage and eye development ⬇️

artículo científico publicado el 1 de agosto de 1998

Expression of type VI, IX and XI collagen genes and alternative splicing of type II collagen transcripts in fracture callus tissue in mice

scientific article published on 01 May 1995

Expression patterns of cartilage collagens and Sox9 during mouse heart development

artículo científico publicado en 2003

Expression patterns of cathepsins B, H, K, L and S in the human endometrium

artículo científico publicado en 2001

Generation and use of transgenic mice as models of osteoarthritis

scientific article published on 01 January 2004

Growth retardation in transgenic mice harboring a type II collagen mutation

scientific article published on 01 June 1996

Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio

artículo científico publicado en 2004

Incorporation of cortical bone allografts and autografts in rats: expression patterns of mRNAs for the TGF-betas

artículo científico publicado en 1998

Individual Timp deficiencies differentially impact pro-MMP-2 activation

artículo científico publicado en 2006

Lifelong voluntary joint loading increases osteoarthritis in mice housing a deletion mutation in type II procollagen gene, and slightly also in non-transgenic mice

artículo científico publicado en 2002

Localization of osteonectin expression in human fetal skeletal tissues by in situ hybridization

artículo científico publicado en 1989

Localization of type II collagen mRNA isoforms in the developing eyes of normal and transgenic mice with a mutation in type II collagen gene.

artículo científico publicado en 1997

Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture

scientific journal article

Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.

artículo científico publicado en 2010

Molecular biological evaluation of bioactive glass microspheres and adjunct bone morphogenetic protein 2 gene transfer in the enhancement of new bone formation

artículo científico publicado en 2005

Molecular cloning of the human alpha 2(IX) collagen cDNA and assignment of the human COL9A2 gene to chromosome 1

artículo científico publicado en 1993

Molecular profiling of human chondrosarcomas for matrix production and cancer markers

scientific article published on 01 July 2002

Molecular profiling of polycystic ovaries for markers of cell invasion and matrix turnover.

artículo científico publicado en 2005

Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing

artículo científico publicado en 1991

Mutation in type II collagen gene disturbs spinal development and gene expression patterns in transgenic Del1 mice

artículo científico publicado el 1 de diciembre de 1997

No improvement in the overall survival of 194 patients with chondrosarcoma in Finland in 1971-1990

scientific article published on 01 June 2003

Normal long bone growth and development in type X collagen-null mice

artículo científico publicado en 1994

Ocular abnormalities in transgenic mice harboring mutations in the type II collagen gene

artículo científico publicado en 1996

Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene

artículo científico publicado en 2000

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation

artículo científico publicado en 2013

Overexpression of cathepsin K accelerates the resorption cycle and osteoblast differentiation in vitro

artículo científico publicado en 2008

Prepublication data sharing

artículo científico publicado en 2009

Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor

scientific journal article

Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene

artículo científico publicado en 1991

Retarded chondrogenesis in transgenic mice with a type II collagen defect results in fracture healing abnormalities

scientific article published on 01 August 1994

Roadmap for a precision-medicine initiative in the Nordic region

artículo científico publicado en 2019

Sequence analysis of regulatory regions of the human collagen X gene

article

Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs.

artículo científico publicado en 1992

Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs

artículo científico publicado en 1991

Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K

scientific article published on 01 December 2005

Structural analysis of the regulatory elements of the type-II procollagen gene. Conservation of promoter and first intron sequences between human and mouse

artículo científico publicado en 1992

Temporospatial expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in mouse antigen-induced arthritis

scientific article published on 27 August 2005

The B subunit of a rat heteromeric CCAAT-binding transcription factor shows a striking sequence identity with the yeast Hap2 transcription factor

artículo científico publicado en 1990

The exon structure of the mouse alpha 2(IX) collagen gene shows unexpected divergence from the chick gene

artículo científico publicado en 1994

The genes encoding alpha 2(IX) collagen (COL9A2) map to human chromosome 1p32.3-p33 and mouse chromosome 4

artículo científico publicado en 1994

The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern

artículo científico publicado en 1993

Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology

artículo científico publicado en 2006

Transcriptional control mechanisms for the expression of type I collagen genes ⬇️

artículo científico publicado el 1 de noviembre de 1991

Transgenic Mice as Models for Heritable Diseases ⬇️

artículo científico publicado el 1 de abril de 1992

Transgenic mice with deficiencies in cartilage collagens: possible models for gene therapy.

artículo científico publicado en 1995

Tutkimusetiikka Suomessa 1980-luvulta tähän päivään ⬇️

artículo científico

Ultrastructural characterization of developmental and degenerative vitreo-retinal changes in the eyes of transgenic mice with a deletion mutation in type II collagen gene

artículo científico publicado en 2002

Variability in the upstream promoter and intron sequences of the human, mouse and chick type X collagen genes

artículo científico publicado en 1996

Lista de obras de

A metaphyseal defect model of the femur for studies of murine bone healing

Abnormal craniofacial development and expression patterns of extracellular matrix components in transgenic Del1 mice harboring a deletion mutation in the type II collagen gene

Abnormal craniofacial growth and early mandibular osteoarthritis in mice harbouring a mutant type II collagen transgene

Abnormal craniofacial morphology and cartilage structure in transgenic mice harboring a Gly --> Cys mutation in the cartilage-specific type II collagen gene

Abnormalities in secondary cartilages in four lines of transgenic mice harboring two different types of mutations in the cartilage-specific type II collagen gene

Accelerated up-regulation of L-Sox5, Sox6, and Sox9 by BMP-2 gene transfer during murine fracture healing

Activation of chondrogenesis in response to injury in normal and transgenic mice with cartilage collagen mutations

Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice

Age-dependent changes in the expression of matrix components in the mouse eye

Altered expression of genes involved in the production and degradation of endometrial extracellular matrix in patients with unexplained infertility and recurrent miscarriages

Analysis of aggrecan and tenascin gene expression in mouse skeletal tissues by northern and in situ hybridization using species specific cDNA probes

Analysis of arthritic lesions in the Del1 mouse: a model for osteoarthritis

Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cells

Assembly of cartilage collagen fibrils is disrupted by overexpression of normal type II collagen in transgenic mice

Cathepsin K deficiency aggravates lung injury in hyperoxia-exposed newborn mice ⬇️

Cathepsin expression during skeletal development

Characterization of primary cultures of chondrocytes from type II collagen/beta-galactosidase transgenic mice

Characterization of the murine Timp4 gene, localization within intron 5 of the synapsin 2 gene and tissue distribution of the mRNA.

Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain

Collagens and collagen-related matrix components in the human and mouse eye.

Conservation of the sizes of 53 introns and over 100 intronic sequences for the binding of common transcription factors in the human and mouse genes for type II procollagen (COL2A1).

Coordinate patterns of expression of type I and III collagens during mouse development

Cysteine proteinases in chondrosarcomas

Developmental expression of a type II collagen/beta-galactosidase fusion gene in transgenic mice

Developmental regulation of mRNA species for types II, IX and XI collagens during mouse embryogenesis

Differential turnover of cortical and trabecular bone in transgenic mice overexpressing cathepsin K.

Effect of radiosynovectomy with holmium-166 ferric hydroxide macroaggregate on adult equine cartilage.

Effect of zoledronic acid on incorporation of a bioceramic bone graft substitute

Evidence for insufficient chondrocytic differentiation during repair of full-thickness defects of articular cartilage

Exclusion of the COL2A1 gene as the mutation site in diastrophic dysplasia.

Expression of cathepsins B, H, K, L, and S and matrix metalloproteinases 9 and 13 during chondrocyte hypertrophy and endochondral ossification in mouse fracture callus

Expression of type II and IX collagen isoforms during normal and pathological cartilage and eye development ⬇️

Expression of type VI, IX and XI collagen genes and alternative splicing of type II collagen transcripts in fracture callus tissue in mice

Expression patterns of cartilage collagens and Sox9 during mouse heart development

Expression patterns of cathepsins B, H, K, L and S in the human endometrium

Generation and use of transgenic mice as models of osteoarthritis

Growth retardation in transgenic mice harboring a type II collagen mutation

Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio

Incorporation of cortical bone allografts and autografts in rats: expression patterns of mRNAs for the TGF-betas

Individual Timp deficiencies differentially impact pro-MMP-2 activation

Lifelong voluntary joint loading increases osteoarthritis in mice housing a deletion mutation in type II procollagen gene, and slightly also in non-transgenic mice

Localization of osteonectin expression in human fetal skeletal tissues by in situ hybridization

Localization of type II collagen mRNA isoforms in the developing eyes of normal and transgenic mice with a mutation in type II collagen gene.

Mice with a deletion in the first intron of the Col1a1 gene develop age-dependent aortic dissection and rupture

Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload.

Molecular biological evaluation of bioactive glass microspheres and adjunct bone morphogenetic protein 2 gene transfer in the enhancement of new bone formation

Molecular cloning of the human alpha 2(IX) collagen cDNA and assignment of the human COL9A2 gene to chromosome 1

Molecular profiling of human chondrosarcomas for matrix production and cancer markers

Molecular profiling of polycystic ovaries for markers of cell invasion and matrix turnover.

Mouse type II collagen gene. Complete nucleotide sequence, exon structure, and alternative splicing

Mutation in type II collagen gene disturbs spinal development and gene expression patterns in transgenic Del1 mice

No improvement in the overall survival of 194 patients with chondrosarcoma in Finland in 1971-1990

Normal long bone growth and development in type X collagen-null mice

Ocular abnormalities in transgenic mice harboring mutations in the type II collagen gene

Osteoarthritis-like lesions in transgenic mice harboring a small deletion mutation in type II collagen gene

Osteoclast-specific cathepsin K deletion stimulates S1P-dependent bone formation

Overexpression of cathepsin K accelerates the resorption cycle and osteoblast differentiation in vitro

Prepublication data sharing

Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor

Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene

Retarded chondrogenesis in transgenic mice with a type II collagen defect results in fracture healing abnormalities

Roadmap for a precision-medicine initiative in the Nordic region

Sequence analysis of regulatory regions of the human collagen X gene

Specific hybridization probes for mouse alpha 2(IX) and alpha 1(X) collagen mRNAs.

Specific hybridization probes for mouse type I, II, III and IX collagen mRNAs

Spontaneous development of synovitis and cartilage degeneration in transgenic mice overexpressing cathepsin K

Structural analysis of the regulatory elements of the type-II procollagen gene. Conservation of promoter and first intron sequences between human and mouse

Temporospatial expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in mouse antigen-induced arthritis

The B subunit of a rat heteromeric CCAAT-binding transcription factor shows a striking sequence identity with the yeast Hap2 transcription factor

The exon structure of the mouse alpha 2(IX) collagen gene shows unexpected divergence from the chick gene

The genes encoding alpha 2(IX) collagen (COL9A2) map to human chromosome 1p32.3-p33 and mouse chromosome 4

The mouse collagen X gene: complete nucleotide sequence, exon structure and expression pattern

Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology

Transcriptional control mechanisms for the expression of type I collagen genes ⬇️

Transgenic Mice as Models for Heritable Diseases ⬇️

Transgenic mice with deficiencies in cartilage collagens: possible models for gene therapy.

Tutkimusetiikka Suomessa 1980-luvulta tähän päivään ⬇️

Ultrastructural characterization of developmental and degenerative vitreo-retinal changes in the eyes of transgenic mice with a deletion mutation in type II collagen gene

Variability in the upstream promoter and intron sequences of the human, mouse and chick type X collagen genes