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155. High Throughput screen for identifying small molecule modulators of alpha-glucosidase for the potential treatment of Pompe disease

5-(4-(4-Acetylphenyl)piperazin-1-ylsulfonyl)indolin-2-one Analogs as Inhibitors of Acid alpha-Glucosidase for Potential Chaperone Treatment of Pompe Disease or Intervention for Diabetes Mellitus Type 2

A high throughput glucocerebrosidase assay using the natural substrate glucosylceramide

artículo científico publicado en 2011

A new resorufin-based alpha-glucosidase assay for high-throughput screening

artículo científico publicado en 2009

Discovery of a novel noniminosugar acid α glucosidase chaperone series

artículo científico publicado en 2012

Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase

Discovery, SAR, and Biological Evaluation of a Non-Inhibitory Chaperone for Acid Alpha Glucosidase

Discovery, structure-activity relationship, and biological evaluation of noninhibitory small molecule chaperones of glucocerebrosidase

artículo científico publicado en 2012

Evaluation of 2-thioxo-2,3,5,6,7,8-hexahydropyrimido[4,5-d]pyrimidin-4(1H)-one analogues as GAA activators

artículo científico publicado en 2010

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity

artículo científico publicado en 2011

High throughput screening for inhibitors of alpha-galactosidase

artículo científico publicado en 2010

High throughput screening for small molecule therapy for Gaucher disease using patient tissue as the source of mutant glucocerebrosidase

artículo científico publicado en 2012

Macrophage models of Gaucher disease for evaluating disease pathogenesis and candidate drugs

artículo científico publicado en 2014

Non-iminosugar glucocerebrosidase small molecule chaperones

artículo científico publicado en 2011

Synthesis and characterization of a new fluorogenic substrate for alpha-galactosidase

artículo científico publicado en 2009

Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease

artículo científico publicado en 2007

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