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2-12-08 Lipoprotein(a) and dementia in an elderly population

scholarly article

2001-2011: A Decade of the LADIS (Leukoaraiosis And DISability) Study: What Have We Learned about White Matter Changes and Small-Vessel Disease?

artículo científico publicado en 2011

A critical review of aspirin in the secondary prevention of noncardioembolic ischaemic stroke.

scientific article published on August 2010

A pathogenic mutation on exon 21 of the NOTCH3 gene causing CADASIL in an octogenarian paucisymptomatic patient

artículo científico publicado en 2007

A prospective community-based study of stroke in Southern Italy: the Vibo Valentia incidence of stroke study (VISS). Methodology, incidence and case fatality at 28 days, 3 and 12 months

artículo científico publicado en 2003

Acetazolamide for the prophylaxis of migraine in CADASIL: a preliminary experience

artículo científico publicado en 2012

Acute inflammatory events and ischemic stroke subtypes.

artículo científico publicado en 2003

Additive Role of a Potentially Reversible Cognitive Frailty Model and Inflammatory State on the Risk of Disability: The Italian Longitudinal Study on Aging

artículo científico publicado en 2017

Administrative data underestimate acute ischemic stroke events and thrombolysis treatments: Data from a multicenter validation survey in Italy.

artículo científico publicado en 2018

Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study

artículo científico publicado en 2006

Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging

artículo científico publicado en 2011

Aphasia predicts unfavorable outcome in mild ischemic stroke patients and prompts thrombolytic treatment.

artículo científico publicado en 2013

Application of the DSM-5 Criteria for Major Neurocognitive Disorder to Vascular MCI Patients.

artículo científico publicado en 2018

Association between diabetes and stroke subtype on survival and functional outcome 3 months after stroke: data from the European BIOMED Stroke Project

artículo científico publicado en 2003

Atrial Fibrillation and Cognition: Epidemiological Data and Possible Mechanisms

artículo científico publicado en 2015

Behavioral and psychological symptoms in Alzheimer's disease: frequency and relationship with duration and severity of the disease.

artículo científico publicado en 2005

Biopsychosocial frailty and the risk of incident dementia: The Italian longitudinal study on aging

scientific article published on 02 July 2019

Blood markers of inflammation and endothelial dysfunction in cardioembolic stroke: systematic review and meta-analysis.

artículo científico publicado en 2017

Blood-brain barrier leakage increases with small vessel disease in acute ischemic stroke

artículo científico publicado en 2017

Bone Marrow-Derived Progenitor Cells in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy

scientific article published on 24 December 2009

Bone Marrow-Derived Progenitor Cells in the Early Phase of Ischemic Stroke: Relation with Stroke Severity and Discharge Outcome

artículo científico publicado en 2009

Branch Atheromatous Disease: A Clinically Meaningful, Yet Unproven Concept

artículo científico publicado en 2016

CADASIL in central Italy: a retrospective clinical and genetic study in 229 patients

article

Calcium channel blockers and stroke.

artículo científico publicado en 2005

Callosal tissue loss parallels subtle decline in psychomotor speed. a longitudinal quantitative MRI study. The LADIS Study

artículo científico publicado en 2012

Carotid artery stenting: first consensus document of the ICCS-SPREAD Joint Committee

artículo científico publicado en 2006

Carotid artery stenting: second consensus document of the ICCS/ISO-SPREAD joint committee.

artículo científico

Cerebral White Matter Hypoperfusion Increases with Small-Vessel Disease Burden. Data From the Third International Stroke Trial

artículo científico publicado en 2017

Cerebral hemorrhages in CADASIL: report of four cases and a brief review

artículo científico publicado en 2013

Cerebral microbleeds in patients with mild cognitive impairment and small vessel disease: The Vascular Mild Cognitive Impairment (VMCI)-Tuscany study

artículo científico

Cerebral white matter changes are associated with abnormalities on neurological examination in non-disabled elderly: the LADIS study

artículo científico publicado en 2012

Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort

scientific article published on 06 July 2009

Circulating Biomarkers in Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Patients.

artículo científico publicado en 2016

Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review

artículo científico publicado en 2015

Coffee Consumption Habits and the Risk of Mild Cognitive Impairment: The Italian Longitudinal Study on Aging

artículo científico publicado en 2015

Cognitive decline and dementia related to cerebrovascular diseases: some evidence and concepts

artículo científico publicado en 2009

Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models

artículo científico publicado en 2002

Cognitive reserve moderates long-term cognitive and functional outcome in cerebral small vessel disease

artículo científico publicado en 2016

Combined intravenous and endovascular treatment versus primary mechanical thrombectomy. The Italian Registry of Endovascular Treatment in Acute Stroke

artículo científico publicado en 2019

Comparison of the Alzheimer's Disease Assessment Scale Cognitive Subscale and the Vascular Dementia Assessment Scale in differentiating elderly individuals with different degrees of white matter changes. The LADIS Study

artículo científico publicado en 2007

Confirmatory factor analysis of the Neuropsychological Assessment Battery of the LADIS study: a longitudinal analysis.

artículo científico publicado en 2013

Corpus Callosum Atrophy in Alzheimer's Disease and Subcortical Vascular Dementia : The LADIS Study

artículo científico publicado en 2010

Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study

artículo científico publicado en 2006

Corpus callosum tissue loss and development of motor and global cognitive impairment: the LADIS study

artículo científico publicado en 2011

Correction to: "When should primary angiitis of the central nervous system (PACNS) be suspected?": literature review and proposal of a preliminary screening algorithm

artículo científico publicado en 2020

DTI-derived indexes of brain WM correlate with cognitive performance in vascular MCI and small-vessel disease. A TBSS study

scientific article published on 01 June 2019

Daily Function as Predictor of Dementia in Cognitive Impairment, No Dementia (CIND) and Mild Cognitive Impairment (MCI): An 8-Year Follow-Up in the ILSA Study.

artículo científico publicado en 2016

Depressive symptoms predict cognitive decline and dementia in older people independently of cerebral white matter changes: the LADIS study

artículo científico publicado en 2013

Deterioration of gait and balance over time: the effects of age-related white matter change--the LADIS study

artículo científico publicado en 2013

Development and psychometric properties of a neuropsychological battery for mild cognitive impairment with small vessel disease: the VMCI-Tuscany Study

artículo científico publicado en 2015

Development of a neuropsychological battery for the Leukoaraiosis and Disability in the Elderly Study (LADIS): experience and baseline data

artículo científico publicado en 2006

Differential impact of cerebral white matter changes, diabetes, hypertension and stroke on cognitive performance among non-disabled elderly. The LADIS study

artículo científico publicado en 2007

Diffusion Tensor Imaging to Map Brain Microstructural Changes in CADASIL.

artículo científico publicado en 2016

Diffusion changes predict cognitive and functional outcome: the LADIS study

artículo científico publicado en 2013

Diffusion-weighted imaging and cognition in the leukoariosis and disability in the elderly study

artículo científico publicado en 2010

Direct thrombectomy for stroke in the presence of absolute exclusion criteria for thrombolysis

artículo científico publicado en 2020

Early-Stage White Matter Lesions Detected by Multispectral MRI Segmentation Predict Progressive Cognitive Decline

artículo científico publicado en 2015

Effect of Attention Training in Mild Cognitive Impairment Patients with Subcortical Vascular Changes: The RehAtt Study

artículo científico publicado en 2017

Effect of the Interaction between Recanalization and Collateral Circulation on Functional Outcome in Acute Ischaemic Stroke

artículo científico publicado en 2014

Effects of Age-Related White Matter Changes on Loss of Corpus Callosum Tissue: The Ladis Study

artículo científico publicado en 2010

Effects of sapropterin on endothelium-dependent vasodilation in patients with CADASIL: a randomized controlled trial

artículo científico

Efficacy and safety of nimodipine in subcortical vascular dementia: a randomized placebo-controlled trial

artículo científico publicado en 2005

Endovascular Thrombectomy for Acute Ischemic Stroke Beyond 6 Hours From Onset: A Real-World Experience

artículo científico publicado en 2020

Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack

artículo científico publicado en 2016

Erratum to: Monitoring the implementation of the State-Regional Council agreement 03/02/2005 as to the management of acute stroke events: a comparison of the Italian regional legislations

article

Erratum to: The Italian Registry of Endovascular Treatment in Acute Stroke: rationale, design and baseline features of patients

artículo científico publicado en 2015

Facial affect recognition in CADASIL patients

artículo científico publicado en 2012

Factors predicting the Montreal cognitive assessment (MoCA) applicability and performances in a stroke unit

artículo científico publicado en 2013

Familial cerebral cavernous malformation: report of a further Italian family

artículo científico publicado en 2009

First report of a pathogenic mutation on exon 24 of the NOTCH3 gene in a CADASIL family

artículo científico publicado en 2011

Fractal dimension of cerebral white matter: A consistent feature for prediction of the cognitive performance in patients with small vessel disease and mild cognitive impairment

scientific article published on 22 August 2019

Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on Aging

artículo científico publicado en 2011

Frailty syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Aging

artículo científico publicado en 2012

Functional and radiological outcomes after bridging therapy versus direct thrombectomy in stroke patients with unknown onset

artículo científico publicado en 2020

Functional magnetic resonance imaging with encoding task in patients with mild cognitive impairment and different severity of leukoaraiosis

artículo científico publicado en 2018

General Anesthesia Versus Conscious Sedation and Local Anesthesia During Thrombectomy for Acute Ischemic Stroke

artículo científico publicado en 2020

Global Burden of Small Vessel Disease-Related Brain Changes on MRI Predicts Cognitive and Functional Decline

scientific article published on 08 November 2019

Heterozygous mutations of HTRA1 gene in patients with familial cerebral small vessel disease.

artículo científico

High lipoprotein(a) serum levels in three CADASIL families

IER-SICH Nomogram to Predict Symptomatic Intracerebral Hemorrhage After Thrombectomy for Stroke

artículo científico publicado en 2019

IER-START nomogram for prediction of three-month unfavorable outcome after thrombectomy for stroke

scientific article published on 25 March 2019

Impact of acute-phase complications and interventions on 6-month survival after stroke. A prospective observational study.

artículo científico publicado en 2018

Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology.

artículo científico publicado en 2005

Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study

artículo científico publicado en 2006

Impaired attention predicts motor performance decline in older community-dwellers with normal baseline mobility: results from the Italian Longitudinal Study on Aging (ILSA).

artículo científico publicado en 2007

Impaired vasoreactivity in mildly disabled CADASIL patients

artículo científico publicado en 2011

Incidence of Dementia, Alzheimer's Disease, and Vascular Dementia in Italy. The ILSA Study

artículo científico publicado en 2002

Infections and Chlamydia pneumoniae antibodies influence the functional outcome in thrombolysed strokes

artículo científico publicado en 2017

Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis.

artículo científico publicado en 2017

Influence of Different Screening Procedures on the Stroke Prevalence Estimates: The Italian Longitudinal Study on Aging

article

Intravenous glycoprotein IIb/IIIa inhibitor (tirofiban) followed by intra-arterial urokinase and mechanical thrombolysis in stroke.

artículo científico publicado en 2005

Intravenous thrombolysis and intra-arterial interventions in acute ischemic stroke: Italian Stroke Organisation (ISO)-SPREAD guidelines.

artículo científico publicado en 2015

Intravenous thrombolysis for acute ischemic stroke associated to extracranial internal carotid artery occlusion: the ICARO-2 study.

artículo científico publicado en 2012

Intravenous thrombolysis or endovascular therapy for acute ischemic stroke associated with cervical internal carotid artery occlusion: the ICARO-3 study.

artículo científico publicado en 2014

Intravenous tirofiban with intra-arterial urokinase and mechanical thrombolysis in stroke: preliminary experience in 11 cases

artículo científico publicado en 2005

Is the oxidant/antioxidant status altered in CADASIL patients?

artículo científico publicado en 2013

Italian Project on Epidemiology of Alzheimer's disease (I.PR.E.A.): study design and methodology of cross-sectional survey

artículo científico publicado en 2005

Lacunar Infarcts, Depression, and Anxiety Symptoms One Year after Stroke.

artículo científico publicado en 2016

Leukoaraiosis and lacunes are associated with poor clinical outcomes in ischemic stroke patients treated with intravenous thrombolysis.

artículo científico publicado en 2016

Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study

artículo científico publicado en 2006

Liver fibrosis score, physical frailty, and the risk of dementia in older adults: The Italian Longitudinal Study on Aging

scientific article published on 24 August 2020

Location, number and factors associated with cerebral microbleeds in an Italian-British cohort of CADASIL patients.

artículo científico publicado en 2018

Longitudinal Study on Low-Dose Aspirin versus Placebo Administration in Silent Brain Infarcts: The Silence Study

artículo científico publicado en 2018

Longitudinal cognitive decline in subcortical ischemic vascular disease--the LADIS Study

artículo científico publicado en 2009

Loss of corpus callosum tissue is associated with subjective memory complaints: The LADIS study

artículo científico publicado en 2010

Low total cholesterol and increased risk of dying: are low levels clinical warning signs in the elderly? Results from the Italian Longitudinal Study on Aging

artículo científico publicado en 2003

MMP9 variation after thrombolysis is associated with hemorrhagic transformation of lesion and death

artículo científico publicado en 2013

MRI-defined subcortical ischemic vascular disease: baseline clinical and neuropsychological findings. The LADIS Study

artículo científico publicado en 2009

Mechanical thrombectomy in patients with proximal occlusions and low NIHSS: Results from a large prospective registry

artículo científico publicado en 2020

Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing

artículo científico publicado en 2009

Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging

artículo científico publicado en 2009

Methods of Implementation of Evidence-Based Stroke Care in Europe: European Implementation Score Collaboration

artículo científico publicado en 2015

Monitoring the implementation of the State-Regional Council agreement 03/02/2005 as to the management of acute stroke events: a comparison of the Italian regional legislations

artículo científico publicado en 2013

Multimodal MRI classification in vascular mild cognitive impairment.

artículo científico publicado en 2015

Neurological abnormalities predict disability: the LADIS (Leukoaraiosis And DISability) study

article

Neuropsychological predictors of dementia in a three-year follow-up period: data from the LADIS study

artículo científico publicado en 2010

On the etiology of incident brain lacunes: longitudinal observations from the LADIS study

artículo científico publicado en 2008

Operationalizing mild cognitive impairment criteria in small vessel disease: the VMCI-Tuscany Study

artículo científico publicado en 2015

Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat.

artículo científico publicado en 2002

Pesticide exposure might be a strong risk factor for Parkinson's disease

artículo científico publicado en 2008

Physical activity in the elderly is associated with improved executive function and processing speed: the LADIS Study

artículo científico publicado en 2014

Physical activity prevents progression for cognitive impairment and vascular dementia: results from the LADIS (Leukoaraiosis and Disability) study

artículo científico publicado en 2012

Postpartum psychiatric disturbances as an unrecognized onset of CADASIL.

artículo científico publicado en 2005

Prediction of Impaired Performance in Trail Making Test in MCI Patients With Small Vessel Disease Using DTI Data.

artículo científico publicado en 2016

Predictive value of MoCA in the acute phase of stroke on the diagnosis of mid-term cognitive impairment.

artículo científico publicado en 2013

Prevalence of Atrial Fibrillation Subtypes in Italy and Projections to 2060 for Italy and Europe

artículo científico publicado en 2020

Prevalence of Fabry disease and GLA variants in young patients with acute stroke: The challenge to widen the screening. The Fabry-Stroke Italian Registry

artículo científico publicado en 2024

Prevalence of aging-associated cognitive decline in an Italian elderly population: results from cross-sectional phase of Italian PRoject on Epidemiology of Alzheimer's disease (IPREA).

artículo científico publicado en 2010

Prevalence of atrial fibrillation in the Italian elderly population and projections from 2020 to 2060 for Italy and the European Union: the FAI Project

artículo científico publicado en 2019

Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study

artículo científico publicado en 2008

Progressive lacunar stroke: review of mechanisms, prognostic features, and putative treatments

artículo científico

Quality indicators in acute stroke care: a prospective observational survey in 13 Italian regions.

artículo científico publicado en 2013

Quantitation of brain tissue changes associated with white matter hyperintensities by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis and Disability in the Elderly) study

artículo científico publicado en 2009

Relationship between periventricular and deep white matter lesions and depressive symptoms in older people. The LADIS Study

artículo científico publicado en 2006

Relationship between progression of brain white matter changes and late-life depression: 3-year results from the LADIS study

artículo científico publicado en 2012

Relevance of brain lesion location for cognition in vascular mild cognitive impairment

artículo científico publicado en 2019

Relevance of prehospital stroke code activation for acute treatment measures in stroke care: a review

artículo científico publicado en 2012

Reperfusion Injury after ischemic Stroke Study (RISKS): single-centre (Florence, Italy), prospective observational protocol study.

artículo científico publicado en 2018

Resting state fMRI regional homogeneity correlates with cognition measures in subcortical vascular cognitive impairment.

artículo científico publicado en 2016

Reversible Cognitive Frailty, Dementia, and All-Cause Mortality. The Italian Longitudinal Study on Aging

artículo científico publicado en 2017

Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes: A Study of Clinical, Neuroimaging, and Biological Markers-The VMCI-Tuscany Study: Rationale, Design, and Methodology.

artículo científico publicado en 2012

Risk and predictors of motor-performance decline in a normally functioning population-based sample of elderly subjects: the Italian Longitudinal Study on Aging.

artículo científico publicado en 2006

Risk factors and health determinants in older Italians

artículo científico publicado en 2004

Risk factors and outcome of subtypes of ischemic stroke. Data from a multicenter multinational hospital-based registry. The European Community Stroke Project

artículo científico publicado en 2006

Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study

artículo científico publicado en 2007

Screening for CADASIL mutations

scientific article published on 01 January 2003

Segmentation of age-related white matter changes in a clinical multi-center study

artículo científico publicado en 2008

Selective risk factors profiles and outcomes among patients with stroke and history of prior myocardial infarction. The European Community Stroke Project

Self-perceived memory complaints predict progression to Alzheimer disease. The LADIS study

artículo científico publicado en 2011

Sex differences in the clinical presentation, resource use, and 3-month outcome of acute stroke in Europe: data from a multicenter multinational hospital-based registry

artículo científico publicado en 2003

Small Vessel Disease Is Associated with Tissue Inhibitor of Matrix Metalloproteinase-4 After Ischaemic Stroke

artículo científico publicado en 2018

Small vessel disease and biomarkers of endothelial dysfunction after ischaemic stroke

artículo científico publicado en 2018

Small vessel disease and clinical outcomes after endovascular treatment in acute ischemic stroke

scientific article published on 14 March 2019

Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study

artículo científico publicado en 2005

Sparse decomposition and modeling of anatomical shape variation.

artículo científico publicado en 2007

Stroke in Renaissance time: the case of Francesco I de' Medici

artículo científico

Stroke in an elderly population: incidence and impact on survival and daily function. The Italian Longitudinal Study on Aging

artículo científico publicado en 2003

Stroke knowledge in Italy

artículo científico publicado en 2014

Stroke recurrence in an elderly CADASIL patient on aspirin discontinuation due to severe auto-immune thrombocytopenia

artículo científico publicado en 2010

Systemic thrombolysis in patients with acute ischemic stroke and Internal Carotid ARtery Occlusion: the ICARO study

artículo científico publicado en 2011

Telemedicine for acute ischaemic stroke

artículo científico publicado en 2016

The Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Scale: a screening tool to select patients for NOTCH3 gene analysis.

artículo científico publicado en 2012

The Florence VAS-COG clinic: a model for the care of patients with cognitive and behavioral disturbances consequent to cerebrovascular diseases.

artículo científico publicado en 2014

The Italian Registry of Endovascular Treatment in Acute Stroke: rationale, design and baseline features of patients.

artículo científico publicado en 2015

The Italian stroke-app: ICTUS3R.

artículo científico publicado en 2016

The VAS-COG clinic: an out-patient service for patients with cognitive and behavioral consequences of cerebrovascular diseases

artículo científico publicado en 2012

The burden of microstructural damage modulates cortical activation in elderly subjects with MCI and leuko-araiosis. A DTI and fMRI study

artículo científico publicado en 2012

The coexistence of heart failure predicts short term mortality, but not disability, in patients with acute ischemic stroke treated with thrombolysis: the Florence area Registry.

artículo científico publicado en 2012

The influence of previous infections and antichlamydia pneumoniae seropositivity on functional outcome in ischemic stroke patients: results from the IN2 study

scientific article published on 26 March 2015

The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training-II. The RehAtt Study: rationale, design and methodology.

artículo científico

The relation between white-matter lesions and cognition

artículo científico publicado en 2007

Unbalanced Metalloproteinase-9 and Tissue Inhibitors of Metalloproteinases Ratios Predict Hemorrhagic Transformation of Lesion in Ischemic Stroke Patients Treated with Thrombolysis: Results from the MAGIC Study

artículo científico publicado en 2015

Urinary complaints in nondisabled elderly people with age-related white matter changes: the Leukoaraiosis And DISability (LADIS) Study.

artículo científico publicado en 2008

Use of rivaroxaban in patients with stroke

artículo científico publicado en 2017

Variation in risk factors for recent small subcortical infarcts with infarct size, shape, and location

artículo científico publicado en 2013

Vascular factors predict polyneuropathy in a non-diabetic elderly population

Visual rating scales for age-related white matter changes (leukoaraiosis): can the heterogeneity be reduced?

artículo científico publicado en 2002

Vitamin D levels in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

artículo científico publicado en 2017

White matter hyperintensities and depression--preliminary results from the LADIS study.

artículo científico publicado en 2005

White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study

artículo científico publicado en 2006

White matter lesion progression in LADIS: frequency, clinical effects, and sample size calculations

artículo científico publicado en 2012

White matter microstructural damage and depressive symptoms in patients with mild cognitive impairment and cerebral small vessel disease: the VMCI-Tuscany Study

artículo científico publicado en 2015

White matter microstructural damage in small vessel disease is associated with Montreal cognitive assessment but not with mini mental state examination performances: vascular mild cognitive impairment Tuscany study

artículo científico publicado en 2014

Whole brain apparent diffusion coefficient histogram: a new tool for evaluation of leukoaraiosis

artículo científico publicado en 2002

[Prevalence of dementia in Tuscany: results from four population-based epidemiological studies]

scientific article published on 01 July 2006