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A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning

artículo científico publicado en 2009

Accelerating Precision Drug Development and Drug Repurposing by Leveraging Human Genetics

artículo científico publicado en 2017

An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission

artículo científico publicado en 2007

Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats

artículo científico publicado en 2008

Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals multiple modes of activity

artículo científico publicado en 2008

Leveraging Human Genetics to Identify Safety Signals Prior to Drug Marketing Approval and Clinical Use

artículo científico publicado en 2020

Mining 100 million notes to find homelessness and adverse childhood experiences: 2 case studies of rare and severe social determinants of health in electronic health records

artículo científico publicado en 2017

Reply to Ward and Colleagues' Comment on "Using Human Experiments of Nature to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors"

artículo científico publicado en 2018

Synthesis and structure-activity relationships of allosteric potentiators of the m(4) muscarinic acetylcholine receptor

artículo científico publicado en 2009

Systematically Prioritizing Candidates in Genome-Based Drug Repurposing

artículo científico publicado en 2019

Using Human 'Experiments of Nature' to Predict Drug Safety Issues: An Example with PCSK9 Inhibitors

artículo científico publicado en 2017

Using What We Already Have: Uncovering New Drug Repurposing Strategies in Existing Omics Data

artículo científico publicado en 2019

When Enough Is Enough: Decision Criteria for Moving a Known Drug into Clinical Testing for a New Indication in the Absence of Preclinical Efficacy Data

artículo científico publicado en 2017

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