Lista de obras -

5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

artículo científico publicado en 2016

A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens

artículo científico publicado en 2015

A general protocol for the generation of Nanobodies for structural biology

artículo científico publicado en 2014

Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite

artículo científico publicado en 2007

An improved crystal form of Plasmodium falciparum peptide deformylase

artículo científico publicado en 2004

An improved protocol for rapid freezing of protein samples for long-term storage

artículo científico publicado en 2003

Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei

artículo científico publicado en 2003

Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target

artículo científico publicado en 2004

Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands

artículo científico publicado en 2009

Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins

artículo científico publicado en 2003

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

artículo científico publicado en 2008

Cholera holotoxin assembly requires a hydrophobic domain at the A-B5 interface: mutational analysis and development of an in vitro assembly system

artículo científico publicado en 2003

Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.

artículo científico publicado en 2014

Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody

artículo científico publicado en 2009

Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs

artículo científico publicado en 2010

Crystal Structures of the Response Regulator DosR from Mycobacterium tuberculosis Suggest a Helix Rearrangement Mechanism for Phosphorylation Activation

artículo científico publicado en 2008

Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum ⬇️

artículo científico publicado en 2012

Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody

artículo científico publicado en 2012

Crystal structure of an IdeR-DNA complex reveals a conformational change in activated IdeR for base-specific interactions

artículo científico publicado en 2004

Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.

artículo científico publicado en 2006

Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica

artículo científico publicado en 2010

Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily.

artículo científico publicado en 2005

Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design

artículo científico publicado en 2013

Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase

artículo científico publicado en 2011

Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis

artículo científico publicado en 2007

Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design

artículo científico publicado en 2002

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

scientific article published on 16 June 2016

Development of methionyl-tRNA synthetase inhibitors as antibiotics for Gram-positive bacterial infections.

artículo científico publicado en 2017

Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei

artículo científico publicado en 2008

Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

artículo científico publicado en 2012

Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry

artículo científico publicado en 2018

Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium

artículo científico publicado en 2009

From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.

artículo científico publicado en 2017

Functional studies of the Mycobacterium tuberculosis iron-dependent regulator

scientific journal article

GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides

artículo científico publicado en 2002

Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes

artículo científico publicado en 2006

High-Affinity Pentavalent Ligands of <i>Escherichia coli</i> Heat-Labile Enterotoxin by Modular Structure-Based Design

artículo científico publicado en 2000

Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.

artículo científico publicado en 2014

Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.

artículo científico publicado en 2013

Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites

artículo científico publicado en 2015

KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei

artículo científico publicado en 2007

Large cyclic peptides as cores of multivalent ligands: application to inhibitors of receptor binding by cholera toxin

artículo científico publicado en 2004

Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts

artículo científico publicado en 2017

Modeling the interaction between aldolase and the thrombospondin-related anonymous protein, a key connection of the malaria parasite invasion machinery

artículo científico publicado en 2007

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

artículo científico publicado en 2012

NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design

scientific article published on 12 May 2006

Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus

artículo científico publicado en 2009

Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy

artículo científico publicado en 2014

Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer

artículo científico publicado en 2004

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

artículo científico publicado en 2019

Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.

artículo científico publicado en 2017

Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

artículo científico publicado en 2014

Prediction of protein crystallization outcome using a hybrid method

artículo científico publicado en 2010

Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets

artículo científico publicado en 2005

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.

artículo científico publicado en 2015

Screening a fragment cocktail library using ultrafiltration

artículo científico publicado en 2011

Secretins: dynamic channels for protein transport across membranes

artículo científico publicado en 2011

Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice

artículo científico publicado en 2011

Sites of interaction between aldolase and thrombospondin-related anonymous protein in plasmodium

artículo científico publicado en 2003

Solution- and solid-phase syntheses of guanidine-bridged, water-soluble linkers for multivalent ligand design

scientific article published on 01 April 2004

Structural and Functional Studies on the Interaction of GspC and GspD in the Type II Secretion System

artículo científico publicado en 2011

Structural and functional studies of EpsC, a crucial component of the type 2 secretion system from Vibrio cholerae

artículo científico publicado en 2006

Structural basis for UTP specificity of RNA editing TUTases from Trypanosoma brucei

artículo científico publicado en 2005

Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin

artículo científico publicado en 2004

Structural genomics of pathogenic protozoa: an overview

artículo científico publicado en 2008

Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5

artículo científico publicado en 2008

Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure–activity relationships with Trypanosoma brucei GSK-3 ⬇️

artículo científico publicado el 30 de diciembre de 2010

Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate

artículo científico publicado en 2011

Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major

artículo científico publicado en 2006

Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum

artículo científico publicado en 2006

Structure of aTrypanosoma bruceiα/β-hydrolase fold protein with unknown function

artículo científico publicado en 2008

Structure of ribose 5-phosphate isomerase from Plasmodium falciparum

artículo científico publicado en 2006

Structure of the GspK-GspI-GspJ complex from the enterotoxigenic Escherichia coli type 2 secretion system

artículo científico publicado en 2008

Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor ⬇️

artículo científico publicado en 2006

Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution

scientific journal article

Structure of the cholera toxin secretion channel in its closed state ⬇️

artículo científico publicado el 19 de septiembre de 2010

Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum

artículo científico publicado en 2006

Structure of the prolyl-tRNA synthetase from the eukaryotic pathogenGiardia lamblia

artículo científico publicado en 2012

Structure-based design of a macrocyclic inhibitor for peptide deformylase

artículo científico publicado en 2003

Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.

artículo científico publicado en 2016

Structures of Mycobacterium tuberculosis DosR and DosR-DNA complex involved in gene activation during adaptation to hypoxic latency

artículo científico publicado en 2005

Structures of Plasmodium falciparum purine nucleoside phosphorylase complexed with sulfate and its natural substrate inosine

artículo científico publicado en 2005

Structures of Substrate- and Inhibitor-Bound Adenosine Deaminase from a Human Malaria Parasite Show a Dramatic Conformational Change and Shed Light on Drug Selectivity

artículo científico publicado en 2008

Structures of Trypanosoma brucei methionyl-tRNA synthetase with urea-based inhibitors provide guidance for drug design against sleeping sickness

artículo científico publicado en 2014

Structures of a key interaction protein from the Trypanosoma brucei editosome in complex with single domain antibodies

artículo científico publicado en 2011

Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity

article published in 2001

The Crystal Structure and Activity of a Putative Trypanosomal Nucleoside Phosphorylase Reveal It to be a Homodimeric Uridine Phosphorylase

artículo científico publicado en 2010

The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer

artículo científico publicado en 2011

The Role of Medical Structural Genomics in Discovering New Drugs for Infectious Diseases

artículo científico publicado en 2009

The binding of cholera toxin to the periplasmic vestibule of the type II secretion channel ⬇️

artículo científico publicado el 1 de mayo de 2011

The closed MTIP-myosin A-tail complex from the malaria parasite invasion machinery ⬇️

artículo científico publicado en 2007

The compact conformation of the Plasmodium knowlesi myosin tail interacting protein MTIP in complex with the C-terminal helix of myosin A.

artículo científico publicado en 2013

The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.

artículo científico publicado en 2018

The crystal structure of the periplasmic domain of the type II secretion system protein EpsM from Vibrio cholerae: the simplest version of the ferredoxin fold

artículo científico publicado en 2004

The structure of Plasmodium vivax phosphatidylethanolamine-binding protein suggests a functional motif containing a left-handed helix

artículo científico publicado en 2007

The structure of the C-terminal domain of the largest editosome interaction protein and its role in promoting RNA binding by RNA-editing ligase L2

artículo científico publicado en 2012

The structure of the D3 domain of Plasmodium falciparum myosin tail interacting protein MTIP in complex with a nanobody

artículo científico publicado en 2013

The structure of tryptophanyl-tRNA synthetase from Giardia lamblia reveals divergence from eukaryotic homologs

artículo científico publicado en 2010

The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding

artículo científico publicado en 2002

Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors

artículo científico publicado en 2010

Two sensor kinases contribute to the hypoxic response of Mycobacterium tuberculosis

scientific journal article

Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.

artículo científico publicado en 2012

Use of thermal melt curves to assess the quality of enzyme preparations

artículo científico publicado en 2009

Using Fragment Cocktail Crystallography To Assist Inhibitor Design ofTrypanosoma bruceiNucleoside 2-Deoxyribosyltransferase†

artículo científico publicado en 2006

Lista de obras de

5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens

A general protocol for the generation of Nanobodies for structural biology

Aldolase provides an unusual binding site for thrombospondin-related anonymous protein in the invasion machinery of the malaria parasite

An improved crystal form of Plasmodium falciparum peptide deformylase

An improved protocol for rapid freezing of protein samples for long-term storage

Analysis of the sequence motifs responsible for the interactions of peroxins 14 and 5, which are involved in glycosome biogenesis in Trypanosoma brucei

Biogenesis of peroxisomes and glycosomes: trypanosomatid glycosome assembly is a promising new drug target

Buffer optimization of thermal melt assays of Plasmodium proteins for detection of small-molecule ligands

Characterization of Trypanosoma brucei PEX14 and its role in the import of glycosomal matrix proteins

Characterization of Trypanosoma brucei dihydroorotate dehydrogenase as a possible drug target; structural, kinetic and RNAi studies

Cholera holotoxin assembly requires a hydrophobic domain at the A-B5 interface: mutational analysis and development of an in vitro assembly system

Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases.

Crystal Structure of the N-Terminal Domain of the Secretin GspD from ETEC Determined with the Assistance of a Nanobody

Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs

Crystal Structures of the Response Regulator DosR from Mycobacterium tuberculosis Suggest a Helix Rearrangement Mechanism for Phosphorylation Activation

Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum ⬇️

Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody

Crystal structure of an IdeR-DNA complex reveals a conformational change in activated IdeR for base-specific interactions

Crystal structure of glyceraldehyde-3-phosphate dehydrogenase from Plasmodium falciparum at 2.25 A resolution reveals intriguing extra electron density in the active site.

Crystal structure of the aspartyl-tRNA synthetase from Entamoeba histolytica

Crystal structures and proposed structural/functional classification of three protozoan proteins from the isochorismatase superfamily.

Crystal structures of Plasmodium falciparum cytosolic tryptophanyl-tRNA synthetase and its potential as a target for structure-guided drug design

Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase

Crystal structures, metal activation, and DNA-binding properties of two-domain IdeR from Mycobacterium tuberculosis

Crystals of peptide deformylase from Plasmodium falciparum reveal critical characteristics of the active site for drug design

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis

Development of methionyl-tRNA synthetase inhibitors as antibiotics for Gram-positive bacterial infections.

Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei

Distinct States of Methionyl-tRNA Synthetase Indicate Inhibitor Binding by Conformational Selection

Fragment-Based Screening of a Natural Product Library against 62 Potential Malaria Drug Targets Employing Native Mass Spectrometry

Fragment-based cocktail crystallography by the medical structural genomics of pathogenic protozoa consortium

From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.

Functional studies of the Mycobacterium tuberculosis iron-dependent regulator

GAF domains: two-billion-year-old molecular switches that bind cyclic nucleotides

Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes

High-Affinity Pentavalent Ligands of <i>Escherichia coli</i> Heat-Labile Enterotoxin by Modular Structure-Based Design

Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening.

Induced resistance to methionyl-tRNA synthetase inhibitors in Trypanosoma brucei is due to overexpression of the target.

Inhibitors of methionyl-tRNA synthetase have potent activity against Giardia intestinalis trophozoites

KREPA6 is an RNA-binding protein essential for editosome integrity and survival of Trypanosoma brucei

Large cyclic peptides as cores of multivalent ligands: application to inhibitors of receptor binding by cholera toxin

Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts

Modeling the interaction between aldolase and the thrombospondin-related anonymous protein, a key connection of the malaria parasite invasion machinery

Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1

NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design

Nanobody-aided structure determination of the EpsI:EpsJ pseudopilin heterodimer from Vibrio vulnificus

Neospora caninum calcium-dependent protein kinase 1 is an effective drug target for neosporosis therapy

Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.

Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold

Prediction of protein crystallization outcome using a hybrid method

Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets

SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1.

Screening a fragment cocktail library using ultrafiltration

Secretins: dynamic channels for protein transport across membranes

Selective inhibitors of methionyl-tRNA synthetase have potent activity against Trypanosoma brucei Infection in Mice

Sites of interaction between aldolase and thrombospondin-related anonymous protein in plasmodium

Solution- and solid-phase syntheses of guanidine-bridged, water-soluble linkers for multivalent ligand design

Structural and Functional Studies on the Interaction of GspC and GspD in the Type II Secretion System

Structural and functional studies of EpsC, a crucial component of the type 2 secretion system from Vibrio cholerae

Structural basis for UTP specificity of RNA editing TUTases from Trypanosoma brucei

Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin

Structural genomics of pathogenic protozoa: an overview

Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5

Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure–activity relationships with Trypanosoma brucei GSK-3 ⬇️

Structure of Leishmania major methionyl-tRNA synthetase in complex with intermediate products methionyladenylate and pyrophosphate

Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major

Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum

Structure of aTrypanosoma bruceiα/β-hydrolase fold protein with unknown function

Structure of ribose 5-phosphate isomerase from Plasmodium falciparum

Structure of the GspK-GspI-GspJ complex from the enterotoxigenic Escherichia coli type 2 secretion system

Structure of the MTIP-MyoA complex, a key component of the malaria parasite invasion motor ⬇️

Structure of the Mycobacterium tuberculosis flavin dependent thymidylate synthase (MtbThyX) at 2.0A resolution

Structure of the cholera toxin secretion channel in its closed state ⬇️

Structure of the conserved hypothetical protein MAL13P1.257 from Plasmodium falciparum

Structure of the prolyl-tRNA synthetase from the eukaryotic pathogenGiardia lamblia

Structure-based design of a macrocyclic inhibitor for peptide deformylase