Lista de obras -

Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity ⬇️

artículo científico publicado el 13 de diciembre de 2011

Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease ⬇️

artículo científico publicado el 1 de abril de 2012

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties

artículo científico publicado en 2017

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

artículo científico publicado en 2013

Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.

artículo científico publicado en 2014

Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.

artículo científico publicado en 2014

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

scientific article published on 01 January 2004

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

artículo científico publicado en 2004

Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease ⬇️

artículo científico publicado el 3 de mayo de 2011

Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment

scholarly article by Joy Y Feng et al published August 2018 in Antimicrobial Agents and Chemotherapy

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH

artículo científico publicado en 2006

Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs

artículo científico publicado en 2012

Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors

artículo científico publicado en 2014

Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives

artículo científico publicado en 2004

Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization

scientific article published on 27 February 2007

Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.

artículo científico publicado en 2004

Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546).

artículo científico publicado en 2003

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides

artículo científico publicado en 2012

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

artículo científico publicado en 2012

Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

artículo científico publicado en 2015

Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors

artículo científico publicado en 2012

Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors

artículo científico publicado en 2015

Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase

artículo científico publicado en 2015

Lista de obras de

Discovery of GS-9256: A novel phosphinic acid derived inhibitor of the hepatitis C virus NS3/4A protease with potent clinical activity ⬇️

Discovery of GS-9451: An acid inhibitor of the hepatitis C virus NS3/4A protease ⬇️

Discovery of a 2'-fluoro-2'-C-methyl C-nucleotide HCV polymerase inhibitor and a phosphoramidate prodrug with favorable properties

Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients.

Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug.

Metabolism and pharmacokinetics of the anti-hepatitis C virus nucleotide prodrug GS-6620.

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

Novel, potent, and orally bioavailable phosphinic acid inhibitors of the hepatitis C virus NS3 protease ⬇️

Nucleotide Prodrug Containing a Nonproteinogenic Amino Acid To Improve Oral Delivery of a Hepatitis C Virus Treatment

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH

Practical synthesis of 1′-substituted Tubercidin C-nucleoside analogs

Preparation and biological evaluation of 1'-cyano-2'-C-methyl pyrimidine nucleosides as HCV NS5B polymerase inhibitors

Quinazolinone fungal efflux pump inhibitors. Part 2: In vitro structure-activity relationships of (N-methyl-piperazinyl)-containing derivatives

Quinazolinone fungal efflux pump inhibitors. Part 3: (N-methyl)piperazine variants and pharmacokinetic optimization

Quinazolinone-based fungal efflux pump inhibitors. Part 1: Discovery of an (N-methylpiperazine)-containing derivative with activity in clinically relevant Candida spp.

Relationships between structure, antibacterial activity, serum stability, pharmacokinetics and efficacy in 3-(heteroarylthio)cephems. Discovery of RWJ-333441 (MC-04,546).

Sensitivity of mitochondrial transcription and resistance of RNA polymerase II dependent nuclear transcription to antiviral ribonucleosides

Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

Synthesis and characterization of 1'-C-cyano-2'-fluoro-2'-C-methyl pyrimidine nucleosides as HCV polymerase inhibitors.

Synthesis and characterization of 2'-C-Me branched C-nucleosides as HCV polymerase inhibitors

Synthesis of 1'-C-cyano pyrimidine nucleosides and characterization as HCV polymerase inhibitors

Viral replication. Structural basis for RNA replication by the hepatitis C virus polymerase