Lista de obras -

2-Aminobenzimidazoles as potent Aurora kinase inhibitors.

artículo científico publicado en 2009

4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase

artículo científico publicado en 2016

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

artículo científico publicado en 2014

A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma

artículo científico publicado en 2012

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

artículo científico publicado en 2003

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation

artículo científico publicado en 2005

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice

artículo científico publicado en 2016

Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

artículo científico publicado en 2016

Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability

artículo científico publicado en 2019

Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors

artículo científico publicado en 2008

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors

artículo científico publicado en 2008

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma

artículo científico publicado en 2019

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

artículo científico publicado en 2005

Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors

artículo científico publicado en 2010

Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)

article

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system

artículo científico publicado en 2014

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor

artículo científico publicado en 2016

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

artículo científico publicado en 2014

Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation

artículo científico publicado en 2014

Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

artículo científico publicado en 2018

Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity

artículo científico publicado en 2004

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

artículo científico publicado en 2014

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

artículo científico publicado en 2013

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

artículo científico publicado en 2014

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

artículo científico publicado en 2016

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

artículo científico publicado en 2015

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

artículo científico publicado en 2015

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state

artículo científico publicado en 2005

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

artículo científico publicado en 2015

Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry

artículo científico publicado en 2002

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species

artículo científico publicado en 2013

Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity

scientific article published on 13 July 2020

Structural analysis of caspase-1 inhibitors derived from Tethering.

artículo científico publicado en 2005

Structural basis for dual-mode inhibition of the ABC transporter MsbA

artículo científico publicado en 2018

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors

artículo científico publicado en 2014

Tethering identifies fragment that yields potent inhibitors of human caspase-1

artículo científico publicado en 2005

Lista de obras de

2-Aminobenzimidazoles as potent Aurora kinase inhibitors.

4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

A multivalent approach towards linked dual-pharmacology prostaglandin F receptor agonist/carbonic anhydrase-II inhibitors for the treatment of glaucoma

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation

Cell Active Hydroxylactam Inhibitors of Human Lactate Dehydrogenase with Oral Bioavailability in Mice

Correction to Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability

Design and synthesis of 2-amino-isoxazolopyridines as Polo-like kinase inhibitors

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors

Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma

Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors

Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors

Diethylaminosulfur trifluoride-mediated intramolecular cyclization of 2-hydroxycycloalkylureas to fused bicyclic aminooxazoline compounds and evaluation of their biochemical activity against β-secretase-1 (BACE-1)

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor

Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity

Discovery of selective and noncovalent diaminopyrimidine-based inhibitors of epidermal growth factor receptor containing the T790M resistance mutation

Disrupting Gram-Negative Bacterial Outer Membrane Biosynthesis through Inhibition of the Lipopolysaccharide Transporter MsbA

Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity

Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase

Identification of substituted 2-thio-6-oxo-1,6-dihydropyrimidines as inhibitors of human lactate dehydrogenase

Identification of substituted 3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study

Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species

Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity

Structural analysis of caspase-1 inhibitors derived from Tethering.

Structural basis for dual-mode inhibition of the ABC transporter MsbA

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors

Tethering identifies fragment that yields potent inhibitors of human caspase-1