Lista de obras -

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.

artículo científico publicado en 2011

A novel role for P2X7 receptor signalling in the survival of mouse embryonic stem cells.

artículo científico publicado en 2011

A single point mutation has pleiotropic effects on pp60v-src function

artículo científico publicado en 1988

Autophosphorylation of p110δ phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo

artículo científico publicado en 1999

Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs

artículo científico publicado en 2009

Characterization of the phosphoinositide 3-kinase-dependent transcriptome in murine embryonic stem cells: identification of novel regulators of pluripotency

artículo científico

Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling ⬇️

artículo científico publicado el 1 de abril de 2011

Correction: Formation of a Polarised Primitive Endoderm Layer in Embryoid Bodies Requires Fgfr/Erk Signalling

artículo científico publicado en 2015

Correction: IL-2 stimulation of T lymphocytes induces sequential activation of mitogen-activated protein kinases and phosphorylation of p56lck at serine-59

correction of a scholarly article

Cytokine-induced protein kinase B activation and Bad phosphorylation do not correlate with cell survival of hemopoietic cells.

artículo científico publicado en 1999

Differential coupling of self-renewal signaling pathways in murine induced pluripotent stem cells

artículo científico publicado en 2012

Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing

artículo científico publicado en 2005

Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling

artículo científico publicado en 1999

Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells

artículo científico publicado en 2009

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

artículo científico publicado en 2006

Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling

artículo científico publicado en 2014

Genetic basis of hypo-responsiveness of A/J mice to interleukin-3

scientific article published on 01 April 1996

Glycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic stem cell self-renewal

artículo científico publicado en 2013

High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells

artículo científico publicado en 2012

IL-2 stimulation of T lymphocytes induces sequential activation of mitogen-activated protein kinases and phosphorylation of p56lck at serine-59

scientific article published on 01 December 1993

Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells

artículo científico publicado en 1997

Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase ⬇️

artículo científico publicado el 23 de septiembre de 1994

Interleukin-13 signal transduction in lymphohemopoietic cells. Similarities and differences in signal transduction with interleukin-4 and insulin

artículo científico publicado en 1995

Interleukin-3 Induces Association of the Protein-tyrosine Phosphatase SHP2 and Phosphatidylinositol 3-Kinase with a 100-kDa Tyrosine-phosphorylated Protein in Hemopoietic Cells ⬇️

artículo científico publicado el 14 de noviembre de 1997

Interleukin-4-dependent proliferation dissociates p44erk-1, p42erk-2, and p21ras activation from cell growth

scientific article published on 01 February 1994

Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides

artículo científico publicado en 2009

Isolation of C15: a novel antibody generated by phage display against mesenchymal stem cell-enriched fractions of adult human marrow

artículo científico publicado en 2005

Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the g

artículo científico publicado en 2006

MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.

artículo científico publicado en 2014

Mitogenesis induced by pp60v-src is not accompanied by increased expression of immediate early response genes

artículo científico publicado en 1990

Modulation of c-kit mRNA and protein by hemopoietic growth factors ⬇️

artículo científico publicado el 1 de mayo de 1991

Molecular interactions of SHP1 and SHP2 in IL-3-signalling

artículo científico publicado en 2002

Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members ⬇️

artículo científico publicado el 1 de septiembre de 1992

Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation

scientific article published on 01 August 1994

Novel octavalent cross-linker displays efficient trapping of protein-protein interactions.

artículo científico publicado en 2007

PI3K comes of age

artículo científico publicado en 2003

Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis

artículo científico publicado en 2007

Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.

artículo científico publicado en 2001

Phosphoinositide 3-kinases and regulation of embryonic stem cell fate

artículo científico publicado en 2007

Phosphoinositide 3-kinases can act independently of p27Kip1 to regulate optimal IL-3-dependent cell cycle progression and proliferation

artículo científico publicado en 2005

Regulation of Nanog Expression by Phosphoinositide 3-Kinase-dependent Signaling in Murine Embryonic Stem Cells

scientific article published in Journal of Biological Chemistry

Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling.

artículo científico publicado en 2004

Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).

artículo científico publicado en 2003

Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling

artículo científico publicado en 2002

SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates

scientific journal article

Shc associates with the IL-3 receptor β subunit, SHIP and Gab2 following IL-3 stimulation

artículo científico publicado en 2000

Spray-dried insulin particles retain biological activity in rapid in-vitro assay

artículo científico

Steel factor-induced tyrosine phosphorylation in murine mast cells. Common elements with IL-3-induced signal transduction pathways ⬇️

artículo científico publicado el 15 de octubre de 1992

Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells

artículo científico publicado en 2008

The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation

artículo científico publicado en 2009

The PI3K inhibitor arsenal: choose your weapon!

artículo científico publicado en 2007

The coupling of TEL/PDGFbetaR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases.

artículo científico publicado en 2003

The pleckstrin homology domain of Gab-2 is required for optimal interleukin-3 signalsome-mediated responses

artículo científico publicado en 2005

Three-dimensional culture systems for the expansion of pluripotent embryonic stem cells

artículo científico publicado en 2010

Tyrosine phosphatase SHP-1 acts at different stages of development to regulate hematopoiesis

artículo científico publicado en 2005

Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells

artículo científico publicado en 2014

p110δ, a novel phosphoinositide 3-kinase in leukocytes

artículo científico publicado en 1997

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein

artículo científico publicado en 1992

Lista de obras de

A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3.

A novel role for P2X7 receptor signalling in the survival of mouse embryonic stem cells.

A single point mutation has pleiotropic effects on pp60v-src function

Autophosphorylation of p110δ phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo

Blocking phosphoinositide 3-kinase activity in colorectal cancer cells reduces proliferation but does not increase apoptosis alone or in combination with cytotoxic drugs

Characterization of the phosphoinositide 3-kinase-dependent transcriptome in murine embryonic stem cells: identification of novel regulators of pluripotency

Controlling embryonic stem cell proliferation and pluripotency: the role of PI3K- and GSK-3-dependent signalling ⬇️

Correction: Formation of a Polarised Primitive Endoderm Layer in Embryoid Bodies Requires Fgfr/Erk Signalling

Correction: IL-2 stimulation of T lymphocytes induces sequential activation of mitogen-activated protein kinases and phosphorylation of p56lck at serine-59

Cytokine-induced protein kinase B activation and Bad phosphorylation do not correlate with cell survival of hemopoietic cells.

Differential coupling of self-renewal signaling pathways in murine induced pluripotent stem cells

Differential expression of cannabinoid receptors in the human colon: cannabinoids promote epithelial wound healing

Dissociation of apoptosis from proliferation, protein kinase B activation, and BAD phosphorylation in interleukin-3-mediated phosphoinositide 3-kinase signaling

Distinct roles for isoforms of the catalytic subunit of class-IA PI3K in the regulation of behaviour of murine embryonic stem cells

Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL).

Formation of a polarised primitive endoderm layer in embryoid bodies requires fgfr/erk signalling

Genetic basis of hypo-responsiveness of A/J mice to interleukin-3

Glycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic stem cell self-renewal

High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells

IL-2 stimulation of T lymphocytes induces sequential activation of mitogen-activated protein kinases and phosphorylation of p56lck at serine-59

Insulin receptor substrate-2 is the major 170-kDa protein phosphorylated on tyrosine in response to cytokines in murine lymphohemopoietic cells

Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase ⬇️

Interleukin-13 signal transduction in lymphohemopoietic cells. Similarities and differences in signal transduction with interleukin-4 and insulin

Interleukin-3 Induces Association of the Protein-tyrosine Phosphatase SHP2 and Phosphatidylinositol 3-Kinase with a 100-kDa Tyrosine-phosphorylated Protein in Hemopoietic Cells ⬇️

Interleukin-4-dependent proliferation dissociates p44erk-1, p42erk-2, and p21ras activation from cell growth

Involvement of GSK-3 in regulation of murine embryonic stem cell self-renewal revealed by a series of bisindolylmaleimides

Isolation of C15: a novel antibody generated by phage display against mesenchymal stem cell-enriched fractions of adult human marrow

Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the g

MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.

Mitogenesis induced by pp60v-src is not accompanied by increased expression of immediate early response genes

Modulation of c-kit mRNA and protein by hemopoietic growth factors ⬇️

Molecular interactions of SHP1 and SHP2 in IL-3-signalling

Multiple hemopoietic growth factors stimulate activation of mitogen-activated protein kinase family members ⬇️

Multiple hemopoietins, with the exception of interleukin-4, induce modification of Shc and mSos1, but not their translocation

Novel octavalent cross-linker displays efficient trapping of protein-protein interactions.

PI3K comes of age

Phosphoinositide 3-kinase signalling regulates early development and developmental haemopoiesis

Phosphoinositide 3-kinase-dependent regulation of interleukin-3-induced proliferation: involvement of mitogen-activated protein kinases, SHP2 and Gab2.

Phosphoinositide 3-kinases and regulation of embryonic stem cell fate

Phosphoinositide 3-kinases can act independently of p27Kip1 to regulate optimal IL-3-dependent cell cycle progression and proliferation

Regulation of Nanog Expression by Phosphoinositide 3-Kinase-dependent Signaling in Murine Embryonic Stem Cells

Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling.

Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2).

Role of the protein tyrosine phosphatase SHP-1 (Src homology phosphatase-1) in the regulation of interleukin-3-induced survival, proliferation and signalling

SHP1 and SHP2 protein-tyrosine phosphatases associate with betac after interleukin-3-induced receptor tyrosine phosphorylation. Identification of potential binding sites and substrates

Shc associates with the IL-3 receptor β subunit, SHIP and Gab2 following IL-3 stimulation

Spray-dried insulin particles retain biological activity in rapid in-vitro assay

Steel factor-induced tyrosine phosphorylation in murine mast cells. Common elements with IL-3-induced signal transduction pathways ⬇️

Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells

The FunGenES database: a genomics resource for mouse embryonic stem cell differentiation

The PI3K inhibitor arsenal: choose your weapon!

The coupling of TEL/PDGFbetaR to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases.

The pleckstrin homology domain of Gab-2 is required for optimal interleukin-3 signalsome-mediated responses

Three-dimensional culture systems for the expansion of pluripotent embryonic stem cells

Tyrosine phosphatase SHP-1 acts at different stages of development to regulate hematopoiesis

Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells

p110δ, a novel phosphoinositide 3-kinase in leukocytes

p21ras activation via hemopoietin receptors and c-kit requires tyrosine kinase activity but not tyrosine phosphorylation of p21ras GTPase-activating protein