Lista de obras -

5-(tryptophylamino)-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based cholecystokinin receptor antagonists: reversal of CCK1 receptor subtype selectivity toward CCK2 receptors

artículo científico publicado en 2004

A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.

artículo científico publicado en 2005

A switch of G protein-coupled receptor binding preference from phosphoinositide 3-kinase (PI3K)-p85 to filamin A negatively controls the PI3K pathway

artículo científico publicado en 2011

An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway

artículo científico publicado en 2006

Analysis of the interactions of sulfur-containing amino acids in membrane proteins

artículo científico publicado en 2016

Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor

artículo científico publicado en 2006

Cholecystokinin and gastrin receptors

artículo científico publicado en 2006

Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.

artículo científico publicado en 2005

Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity

artículo científico publicado en 2018

Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway

artículo científico publicado en 2006

Distinct CCK-2 receptor conformations associated with β-arrestin-2 recruitment or phospholipase-C activation revealed by a biased antagonist

artículo científico publicado en 2013

Evidence for a direct and functional interaction between the regulators of G protein signaling-2 and phosphorylated C terminus of cholecystokinin-2 receptor.

artículo científico publicado en 2008

Evidence that interspecies polymorphism in the human and rat cholecystokinin receptor-2 affects structure of the binding site for the endogenous agonist cholecystokinin.

artículo científico publicado en 2005

Expression of cholecystokinin-2/gastrin receptor in the murine pancreas modulates cell adhesion and cell differentiation in vivo

artículo científico publicado en 2004

Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors

artículo científico publicado en 2015

GIP receptor: Expression in neuroendocrine tumours, internalization, signalling from endosomes and structure-function relationship studies

artículo científico publicado en 2019

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.

artículo científico publicado en 2015

Gastrin mediated cholecystokinin-2 receptor activation induces loss of cell adhesion and scattering in epithelial MDCK cells

artículo científico publicado en 2002

Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients

artículo científico publicado en 2002

Glucose-dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors

artículo científico publicado en 2011

Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells

artículo científico publicado en 2006

Gut hormone GPCRs: structure, function, drug discovery

artículo científico publicado en 2016

High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor.

artículo científico publicado en 2003

Identification of determinants of glucose-dependent insulinotropic polypeptide receptor that interact with N-terminal biologically active region of the natural ligand.

artículo científico publicado en 2010

Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies

artículo científico publicado en 2003

Insights into the binding and activation sites of the receptors for cholecystokinin and gastrin

artículo científico publicado en 2007

Internalization and desensitization of the human glucose-dependent-insulinotropic receptor is affected by N-terminal acetylation of the agonist

artículo científico publicado en 2015

Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes

artículo científico publicado en 2016

Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin

scientific journal article

Linking non-peptide ligand binding mode to activity at the human cholecystokinin-2 receptor

artículo científico publicado en 2008

Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas

artículo científico publicado en 2006

Mechanism of activation of a G protein-coupled receptor, the human cholecystokinin-2 receptor

scientific article published on 28 June 2007

Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor

artículo científico publicado en 2005

Modeled structure of the whole regulator G-protein signaling-2

artículo científico publicado en 2006

Molecular mechanism underlying partial and full agonism mediated by the human cholecystokinin-1 receptor

artículo científico publicado en 2005

New Anthranilic Acid Based Antagonists with High Affinity and Selectivity for the Human Cholecystokinin Receptor 1 (hCCK1-R) ⬇️

artículo científico publicado el 20 de julio de 2011

Partial agonism, neutral antagonism, and inverse agonism at the human wild-type and constitutively active cholecystokinin-2 receptors

artículo científico publicado en 2005

Peptide/benzodiazepine hybrids as ligands of CCKA and CCKB receptors

artículo científico publicado en 2000

Probing a model of a GPCR/ligand complex in an explicit membrane environment: the human cholecystokinin-1 receptor.

artículo científico publicado en 2005

Real-Time Analysis of Magnetic Hyperthermia Experiments on Living Cells under a Confocal Microscope

artículo científico publicado en 2015

Regulation of membrane cholecystokinin-2 receptor by agonists enables classification of partial agonists as biased agonists.

artículo científico publicado en 2010

Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors?

artículo científico publicado en 2003

Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors.

artículo científico publicado en 2005

Structure of cholecystokinin receptor binding sites and mechanism of activation/inactivation by agonists/antagonists.

artículo científico publicado en 2002

Sulfur-containing amino acids in 7TMRs: molecular gears for pharmacology and function

artículo científico

Targeted Magnetic Intra-Lysosomal Hyperthermia produces lysosomal reactive oxygen species and causes Caspase-1 dependent cell death.

artículo científico publicado en 2017

Targeted nanoscale magnetic hyperthermia: challenges and potentials of peptide-based targeting

artículo científico publicado en 2015

Targeting a G-protein-coupled receptor overexpressed in endocrine tumors by magnetic nanoparticles to induce cell death

artículo científico publicado en 2014

The Family of G Protein-Coupled Receptors: An Example of Membrane Proteins ⬇️

artículo científico publicado el 1 de enero de 2010

The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1.

artículo científico publicado en 2004

The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process

artículo científico publicado en 2001

Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen-induced preneoplastic lesions formation

artículo científico publicado en 2005

Transgenic mice expressing cholecystokinin 2 receptors in the pancreas

artículo científico publicado en 2002

Understanding Peptide Binding in Class A G Protein-Coupled Receptors

scientific article published on 10 July 2019

Validated ligand binding sites in CCK receptors. next step: computer-aided design of novel CCK ligands

artículo científico publicado en 2007

[Internalized receptor for glucose-dependent insulinotropic peptide stimulates adenylyl cyclase on early endosomes]

artículo científico publicado en 2018

c-Jun NH(2)-terminal kinase pathway in growth-promoting effect of the G protein-coupled receptor cholecystokinin B receptor: a protein kinase C/Src-dependent-mechanism.

artículo científico publicado en 2002

Lista de obras de

5-(tryptophylamino)-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-based cholecystokinin receptor antagonists: reversal of CCK1 receptor subtype selectivity toward CCK2 receptors

A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.

A switch of G protein-coupled receptor binding preference from phosphoinositide 3-kinase (PI3K)-p85 to filamin A negatively controls the PI3K pathway

An ITIM-like motif within the CCK2 receptor sequence required for interaction with SHP-2 and the activation of the AKT pathway

Analysis of the interactions of sulfur-containing amino acids in membrane proteins

Cholecystokinin 1 receptor modulates the MEKK1-induced c-Jun trans-activation: structural requirements of the receptor

Cholecystokinin and gastrin receptors

Combination of molecular modeling, site-directed mutagenesis, and SAR studies to delineate the binding site of pyridopyrimidine antagonists on the human CCK1 receptor.

Combined Treatments of Magnetic Intra-Lysosomal Hyperthermia with Doxorubicin Promotes Synergistic Anti-Tumoral Activity

Direct binding of p85 to sst2 somatostatin receptor reveals a novel mechanism for inhibiting PI3K pathway

Distinct CCK-2 receptor conformations associated with β-arrestin-2 recruitment or phospholipase-C activation revealed by a biased antagonist

Evidence for a direct and functional interaction between the regulators of G protein signaling-2 and phosphorylated C terminus of cholecystokinin-2 receptor.

Evidence that interspecies polymorphism in the human and rat cholecystokinin receptor-2 affects structure of the binding site for the endogenous agonist cholecystokinin.

Expression of cholecystokinin-2/gastrin receptor in the murine pancreas modulates cell adhesion and cell differentiation in vivo

Functional elements of the gastric inhibitory polypeptide receptor: Comparison between secretin- and rhodopsin-like G protein-coupled receptors

GIP receptor: Expression in neuroendocrine tumours, internalization, signalling from endosomes and structure-function relationship studies

GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014.

Gastrin mediated cholecystokinin-2 receptor activation induces loss of cell adhesion and scattering in epithelial MDCK cells

Genetic, pharmacological and functional analysis of cholecystokinin-1 and cholecystokinin-2 receptor polymorphism in type 2 diabetes and obese patients

Glucose-dependent insulinotropic polypeptide receptors in most gastroenteropancreatic and bronchial neuroendocrine tumors

Glycine-extended gastrin activates two independent tyrosine-kinases in upstream of p85/p110 phosphatidylinositol 3-kinase in human colonic tumour cells

Gut hormone GPCRs: structure, function, drug discovery

High tumorigenic potential of a constitutively active mutant of the cholecystokinin 2 receptor.

Identification of determinants of glucose-dependent insulinotropic polypeptide receptor that interact with N-terminal biologically active region of the natural ligand.

Identification of tyrosine 189 and asparagine 358 of the cholecystokinin 2 receptor in direct interaction with the crucial C-terminal amide of cholecystokinin by molecular modeling, site-directed mutagenesis, and structure/affinity studies

Insights into the binding and activation sites of the receptors for cholecystokinin and gastrin

Internalization and desensitization of the human glucose-dependent-insulinotropic receptor is affected by N-terminal acetylation of the agonist

Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes

Involvement of JAK2 upstream of the PI 3-kinase in cell-cell adhesion regulation by gastrin

Linking non-peptide ligand binding mode to activity at the human cholecystokinin-2 receptor

Mechanism for Src activation by the CCK2 receptor: Patho-physiological functions of this receptor in pancreas

Mechanism of activation of a G protein-coupled receptor, the human cholecystokinin-2 receptor

Modeled structure of a G-protein-coupled receptor: the cholecystokinin-1 receptor

Modeled structure of the whole regulator G-protein signaling-2

Molecular mechanism underlying partial and full agonism mediated by the human cholecystokinin-1 receptor

New Anthranilic Acid Based Antagonists with High Affinity and Selectivity for the Human Cholecystokinin Receptor 1 (hCCK1-R) ⬇️

Partial agonism, neutral antagonism, and inverse agonism at the human wild-type and constitutively active cholecystokinin-2 receptors

Peptide/benzodiazepine hybrids as ligands of CCKA and CCKB receptors

Probing a model of a GPCR/ligand complex in an explicit membrane environment: the human cholecystokinin-1 receptor.

Real-Time Analysis of Magnetic Hyperthermia Experiments on Living Cells under a Confocal Microscope

Regulation of membrane cholecystokinin-2 receptor by agonists enables classification of partial agonists as biased agonists.

Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors?

Signaling pathways associated with colonic mucosa hyperproliferation in mice overexpressing gastrin precursors.

Structure of cholecystokinin receptor binding sites and mechanism of activation/inactivation by agonists/antagonists.

Sulfur-containing amino acids in 7TMRs: molecular gears for pharmacology and function

Targeted Magnetic Intra-Lysosomal Hyperthermia produces lysosomal reactive oxygen species and causes Caspase-1 dependent cell death.

Targeted nanoscale magnetic hyperthermia: challenges and potentials of peptide-based targeting

Targeting a G-protein-coupled receptor overexpressed in endocrine tumors by magnetic nanoparticles to induce cell death

The Family of G Protein-Coupled Receptors: An Example of Membrane Proteins ⬇️

The G-protein-coupled CCK2 receptor associates with phospholipase Cgamma1.

The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process

Transgenic expression of CCK2 receptors sensitizes murine pancreatic acinar cells to carcinogen-induced preneoplastic lesions formation

Transgenic mice expressing cholecystokinin 2 receptors in the pancreas

Understanding Peptide Binding in Class A G Protein-Coupled Receptors

Validated ligand binding sites in CCK receptors. next step: computer-aided design of novel CCK ligands

[Internalized receptor for glucose-dependent insulinotropic peptide stimulates adenylyl cyclase on early endosomes]

c-Jun NH(2)-terminal kinase pathway in growth-promoting effect of the G protein-coupled receptor cholecystokinin B receptor: a protein kinase C/Src-dependent-mechanism.