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2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Disrupts Control of Cell Proliferation and Apoptosis in a Human Model of Adult Liver Progenitors

artículo científico publicado en 2019

5-Lipoxygenase inhibitors potentiate 1alpha,25-dihydroxyvitamin D3-induced monocytic differentiation by activating p38 MAPK pathway.

artículo científico publicado en 2009

7H-Dibenzo[c,g]carbazole and 5,9-dimethyldibenzo[c,g]carbazole exert multiple toxic events contributing to tumor promotion in rat liver epithelial 'stem-like' cells.

artículo científico publicado en 2006

Activation of ERK1/2 and p38 kinases by polycyclic aromatic hydrocarbons in rat liver epithelial cells is associated with induction of apoptosis.

artículo científico publicado en 2005

Activation of autophagy and PPARγ protect colon cancer cells against apoptosis induced by interactive effects of butyrate and DHA in a cell type-dependent manner: The role of cell differentiation.

artículo científico publicado en 2016

Activation of the aryl hydrocarbon receptor is the major toxic mode of action of an organic extract of a reference urban dust particulate matter mixture: the role of polycyclic aromatic hydrocarbons.

artículo científico publicado en 2011

Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage

artículo científico publicado en 2008

Androgen depletion induces senescence in prostate cancer cells through down-regulation of Skp2

artículo científico publicado en 2011

Apoptosis and inhibition of gap-junctional intercellular communication induced by LA-12, a novel hydrophobic platinum(IV) complex

scientific journal article

Apoptosis inhibitor 5 (API-5; AAC-11; FIF) is upregulated in human carcinomas in vivo.

artículo científico publicado en 2012

Aryl hydrocarbon receptor negatively regulates expression of the plakoglobin gene (jup).

artículo científico

Aryl hydrocarbon receptor-activating polychlorinated biphenyls and their hydroxylated metabolites induce cell proliferation in contact-inhibited rat liver epithelial cells.

artículo científico publicado en 2004

Aryl hydrocarbon receptor-mediated disruption of contact inhibition is associated with connexin43 downregulation and inhibition of gap junctional intercellular communication

artículo científico publicado en 2012

Autocrine Signaling by Wnt-5a Deregulates Chemotaxis of Leukemic Cells and Predicts Clinical Outcome in Chronic Lymphocytic Leukemia

artículo científico publicado en 2015

Automatic cell cloning assay for determining the clonogenic capacity of cancer and cancer stem-like cells.

artículo científico publicado en 2013

Benzo[a]pyrene and tumor necrosis factor-α coordinately increase genotoxic damage and the production of proinflammatory mediators in alveolar epithelial type II cells.

artículo científico publicado en 2011

Breast cancer-specific mutations in CK1epsilon inhibit Wnt/beta-catenin and activate the Wnt/Rac1/JNK and NFAT pathways to decrease cell adhesion and promote cell migration.

artículo científico publicado en 2010

Butyrate alters expression of cytochrome P450 1A1 and metabolism of benzo[a]pyrene via its histone deacetylase activity in colon epithelial cell models.

artículo científico publicado en 2016

Butyrate and docosahexaenoic acid interact in alterations of specific lipid classes in differentiating colon cancer cells

artículo científico publicado en 2017

Butyrate interacts with benzo[a]pyrene to alter expression and activities of xenobiotic metabolizing enzymes involved in metabolism of carcinogens within colon epithelial cell models

scientific article published on 13 November 2018

Changes in telomerase activity, expression and splicing in response to differentiation of normal and carcinoma colon cells

artículo científico publicado en 2003

Chk1 Inhibitor SCH900776 Effectively Potentiates the Cytotoxic Effects of Platinum-Based Chemotherapeutic Drugs in Human Colon Cancer Cells

artículo científico publicado en 2017

Cisplatin and a potent platinum(IV) complex-mediated enhancement of TRAIL-induced cancer cells killing is associated with modulation of upstream events in the extrinsic apoptotic pathway.

artículo científico publicado en 2010

Cisplatin or LA-12 enhance killing effects of TRAIL in prostate cancer cells through Bid-dependent stimulation of mitochondrial apoptotic pathway but not caspase-10.

artículo científico publicado en 2017

Colon Cancer and Perturbations of the Sphingolipid Metabolism

artículo científico publicado en 2019

Concentrations of methylated naphthalenes, anthracenes, and phenanthrenes occurring in Czech river sediments and their effects on toxic events associated with carcinogenesis in rat liver cell lines.

artículo científico publicado en 2007

DHA-mediated enhancement of TRAIL-induced apoptosis in colon cancer cells is associated with engagement of mitochondria and specific alterations in sphingolipid metabolism

artículo científico publicado en 2014

Decreased WNT3 expression in chronic lymphocytic leukaemia is a hallmark of disease progression and identifies patients with worse prognosis in the subgroup with mutated IGHV.

artículo científico publicado en 2016

Detachment-mediated resistance to TRAIL-induced apoptosis is associated with stimulation of the PI3K/Akt pathway in fetal and adenocarcinoma epithelial colon cells

artículo científico publicado el 8 de abril de 2011

Dietary fatty acids specifically modulate phospholipid pattern in colon cells with distinct differentiation capacities

artículo científico publicado en 2016

Differences in TRAIL-induced changes of Mcl-1 expression among distinct human colon epithelial cell lines

artículo científico publicado en 2009

Different cell cycle modulation following treatment of human ovarian carcinoma cells with a new platinum(IV) complex vs cisplatin.

artículo científico publicado en 2007

Different modulation of TRAIL-induced apoptosis by inhibition of pro-survival pathways in TRAIL-sensitive and TRAIL-resistant colon cancer cells

artículo científico publicado en 2006

Differential effects of indirubin and 2,3,7,8-tetrachlorodibenzo-p-dioxin on the aryl hydrocarbon receptor (AhR) signalling in liver progenitor cells.

artículo científico publicado en 2010

Differentiation-specific association of HP1alpha and HP1beta with chromocentres is correlated with clustering of TIF1beta at these sites

artículo científico publicado en 2007

Drug efflux transporters, MRP1 and BCRP, affect the outcome of hypericin-mediated photodynamic therapy in HT-29 adenocarcinoma cells.

artículo científico publicado en 2009

Dynamic Monitoring of Cellular Remodeling Induced by the Transforming Growth Factor-β1.

artículo científico publicado en 2009

Effect of acetazolamide on hypericin photocytotoxicity

artículo científico publicado en 2002

Effect of adenosine on the growth of human T-lymphocyte leukemia cell line MOLT-4.

artículo científico publicado en 2007

Expression of FGF19 in human embryonic stem cells.

artículo científico publicado en 2013

FGFR3 signaling induces a reversible senescence phenotype in chondrocytes similar to oncogene-induced premature senescence

scientific journal article

Fetal colon cell line FHC exhibits tumorigenic phenotype, complex karyotype, and TP53 gene mutation.

artículo científico publicado en 2010

Fibroblast growth factor and canonical WNT/β-catenin signaling cooperate in suppression of chondrocyte differentiation in experimental models of FGFR signaling in cartilage.

artículo científico publicado en 2015

Fibroblast growth factor inhibits interferon gamma-STAT1 and interleukin 6-STAT3 signaling in chondrocytes

artículo científico publicado en 2008

Growth/differentiation factor-15 inhibits differentiation into osteoclasts--a novel factor involved in control of osteoclast differentiation.

artículo científico publicado en 2009

Growth/differentiation factor-15 is an abundant cytokine in human seminal plasma.

artículo científico publicado en 2010

Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs

artículo científico publicado en 2009

Hypericin affects cancer side populations via competitive inhibition of BCRP.

artículo científico publicado en 2018

In vitro proliferation of fibrosarcoma cells depends on intact functions of lipoxygenases and cytochrome P-450-monooxygenase

artículo científico publicado en 2004

Inflammatory mediators accelerate metabolism of benzo[a]pyrene in rat alveolar type II cells: the role of enhanced cytochrome P450 1B1 expression

scientific journal article

Inhibition of β-catenin signalling promotes DNA damage elicited by benzo[a]pyrene in a model of human colon cancer cells via CYP1 deregulation

artículo científico publicado en 2015

Instability restricts signaling of multiple fibroblast growth factors.

artículo científico publicado en 2015

Interaction of dietary fatty acids with tumour necrosis factor family cytokines during colon inflammation and cancer

artículo científico publicado en 2014

Interactive effects of inflammatory cytokine and abundant low-molecular-weight PAHs on inhibition of gap junctional intercellular communication, disruption of cell proliferation control, and the AhR-dependent transcription

artículo científico publicado en 2014

LA-12 overcomes confluence-dependent resistance of HT-29 colon cancer cells to Pt (II) compounds

artículo científico publicado en 2010

Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids

artículo científico publicado en 2011

Lipoxygenase inhibitors enhance tumor suppressive effects of jun proteins on v-myb-transformed monoblasts BM2.

artículo científico publicado en 2003

Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells

artículo científico publicado en 2015

Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin

artículo científico publicado el 4 de febrero de 2011

MAC'09, Otto and us…

artículo científico publicado en 2010

MK-886 enhances tumour necrosis factor-alpha-induced differentiation and apoptosis.

artículo científico publicado en 2005

Mechanisms involved in the cell cycle and apoptosis of HT-29 cells pre-treated with MK-886 prior to photodynamic therapy with hypericin

artículo científico publicado en 2008

Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

artículo científico publicado en 2010

Modulation of estrogen receptor-dependent reporter construct activation and G0/G1-S-phase transition by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells.

artículo científico publicado en 2002

Modulation of hypericin photodynamic therapy by pretreatment with 12 various inhibitors of arachidonic acid metabolism in colon adenocarcinoma HT-29 cells

artículo científico publicado en 2007

Molecular adjuvants based on nonpyrogenic lipophilic derivatives of norAbuMDP/GMDP formulated in nanoliposomes: stimulation of innate and adaptive immunity

scientific article published on 30 January 2015

Molecular pathology of the fibroblast growth factor family

artículo científico publicado en 2009

Monocytic differentiation of leukemic HL-60 cells induced by co-treatment with TNF-alpha and MK886 requires activation of pro-apoptotic machinery

artículo científico publicado en 2009

Multikinase activity of fibroblast growth factor receptor (FGFR) inhibitors SU5402, PD173074, AZD1480, AZD4547 and BGJ398 compromises the use of small chemicals targeting FGFR catalytic activity for therapy of short-stature syndromes.

artículo científico publicado en 2015

Multiple biological effects of inhibitors of arachidonic acid metabolism on human keratinocytes

artículo científico publicado en 2002

Multiple defects in negative regulation of the PKB/Akt pathway sensitise human cancer cells to the antiproliferative effect of non-steroidal anti-inflammatory drugs

artículo científico publicado en 2009

NF449 is a novel inhibitor of fibroblast growth factor receptor 3 (FGFR3) signaling active in chondrocytes and multiple myeloma cells

artículo científico publicado en 2010

Necrosis predominates in the cell death of human colon adenocarcinoma HT-29 cells treated under variable conditions of photodynamic therapy with hypericin

artículo científico publicado en 2007

Novel Anticancer Platinum(IV) Complexes with Adamantylamine: Their Efficiency and Innovative Chemotherapy Strategies Modifying Lipid Metabolism

scientific article published on January 2008

Opposite regulation of MDM2 and MDMX expression in acquisition of mesenchymal phenotype in benign and cancer cells.

artículo científico publicado en 2015

Phospholipid profiling enables to discriminate tumor- and non-tumor-derived human colon epithelial cells: Phospholipidome similarities and differences in colon cancer cell lines and in patient-derived cell samples

scientific article published on 30 January 2020

Platinum(IV) complex LA-12 exerts higher ability than cisplatin to enhance TRAIL-induced cancer cell apoptosis via stimulation of mitochondrial pathway

artículo científico publicado en 2014

Platinum(IV) complex with adamantylamine as nonleaving amine group: synthesis, characterization, and in vitro antitumor activity against a panel of cisplatin-resistant cancer cell lines.

artículo científico publicado en 2004

Platinum(IV) complex with adamantylamine overcomes intrinsic resistance to cisplatin in ovarian cancer cells.

artículo científico publicado en 2005

Polycyclic aromatic hydrocarbons modulate cell proliferation in rat hepatic epithelial stem-like WB-F344 cells.

artículo científico publicado en 2004

Pre-treatment of HT-29 cells with 5-LOX inhibitor (MK-886) induces changes in cell cycle and increases apoptosis after photodynamic therapy with hypericin

artículo científico publicado en 2006

Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation

artículo científico publicado en 2012

Regulation of the Metabolism of Polyunsaturated Fatty Acids and Butyrate in Colon Cancer Cells

artículo científico publicado el 1 de enero de 2013

Response of normal and colon cancer epithelial cells to TNF-family apoptotic inducers

artículo científico publicado en 2008

Specific alterations of sphingolipid metabolism identified in EpCAM-positive cells isolated from human colon tumors

scientific article published on 21 May 2020

TGF-beta1 suppresses IL-6-induced STAT3 activation through regulation of Jak2 expression in prostate epithelial cells

artículo científico publicado en 2010

TGF-β1 signaling plays a dominant role in the crosstalk between TGF-β1 and the aryl hydrocarbon receptor ligand in prostate epithelial cells

artículo científico publicado en 2012

TGF-β1-induced EMT of non-transformed prostate hyperplasia cells is characterized by early induction of SNAI2/Slug.

artículo científico publicado en 2011

The 2,2',4,4',5,5'-hexachlorobiphenyl-enhanced degradation of connexin 43 involves both proteasomal and lysosomal activities.

artículo científico publicado en 2008

The aryl hydrocarbon receptor-dependent deregulation of cell cycle control induced by polycyclic aromatic hydrocarbons in rat liver epithelial cells

artículo científico publicado en 2006

The effect of nonsteroidal antiinflammatory drugs ibuprofen, flurbiprofen, and diclofenac on in vitro and in vivo growth of mouse fibrosarcoma

artículo científico publicado en 2002

The effects of TNF-alpha and inhibitors of arachidonic acid metabolism on human colon HT-29 cells depend on differentiation status

artículo científico publicado en 2004

The fibroblast surface markers FAP, anti-fibroblast, and FSP are expressed by cells of epithelial origin and may be altered during epithelial-to-mesenchymal transition.

artículo científico publicado en 2017

The interplay of the aryl hydrocarbon receptor and β-catenin alters both AhR-dependent transcription and Wnt/β-catenin signaling in liver progenitors

artículo científico publicado en 2011

The planar cell polarity pathway drives pathogenesis of chronic lymphocytic leukemia by the regulation of B-lymphocyte migration.

artículo científico publicado en 2013

The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells.

artículo científico publicado en 2009

The role of high cell density in the promotion of neuroendocrine transdifferentiation of prostate cancer cells.

artículo científico publicado en 2014

Transforming growth factor-beta1 inhibits all-trans retinoic acid-induced apoptosis

artículo científico publicado en 2005

Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver "stem-like" cells

artículo científico publicado en 2007

Tumor necrosis factor-alpha potentiates genotoxic effects of benzo[a]pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression

scientific journal article

beta-Naphthoflavone and 3'-methoxy-4'-nitroflavone exert ambiguous effects on Ah receptor-dependent cell proliferation and gene expression in rat liver 'stem-like' cells

scientific journal article

c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2.

artículo científico publicado en 2006

n-3 Polyunsaturated fatty acids alter benzo[a]pyrene metabolism and genotoxicity in human colon epithelial cell models

scientific article published on 17 December 2018

p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts

artículo científico publicado en 2007

β-arrestin promotes Wnt-induced low density lipoprotein receptor-related protein 6 (Lrp6) phosphorylation via increased membrane recruitment of Amer1 protein.

artículo científico publicado en 2013