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A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877

artículo científico publicado en 2020

A laparoscopic knot-tying device for minimally invasive cardiac surgery.

artículo científico publicado en 2009

Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).

artículo científico publicado en 2017

Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies

scientific article published on 21 December 2018

Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure

artículo científico publicado en 2005

GPR68 Senses Flow and Is Essential for Vascular Physiology.

artículo científico publicado en 2018

Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

artículo científico publicado en 2020

Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.

artículo científico publicado en 2015

Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis

scientific article published on 05 February 2020

Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules

artículo científico publicado en 2016

Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth

scientific article published on December 2013

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non-Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers

scientific article published on 10 December 2019

Screening the mammalian extracellular proteome for regulators of embryonic human stem cell pluripotency

artículo científico publicado en 2010

Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133

artículo científico publicado en 2020

Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents

scientific article published on 17 May 2019