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Design and Discovery of N-(2-Methyl-5'-morpholino-6'-((tetrahydro-2H-pyran-4-yl)oxy)-[3,3'-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers.

artículo científico publicado en 2017

Design and Discovery of N-(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic

scientific article published on 16 May 2019

Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model

artículo científico publicado en 2016

Expression, purification and characterization of inactive and active forms of ERK2 from insect expression system

artículo científico publicado en 2015

Identification and structure–activity relationship of 2-morpholino 6-(3-hydroxyphenyl) pyrimidines, a class of potent and selective PI3 kinase inhibitors ⬇️

artículo científico publicado el 13 de octubre de 2010

Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer

artículo científico publicado en 2011

Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.

artículo científico publicado en 2017

RAF inhibitors activate the MAPK pathway by relieving inhibitory autophosphorylation

artículo científico publicado en 2013

Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K

artículo científico publicado en 2013

Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis

scientific article published on 17 February 2020

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