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A novel monoclonal antibody DC63 reveals that inhibitor 1 of protein phosphatase 2A is preferentially nuclearly localised in human brain.

artículo científico publicado en 2007

A simple and rapid LC-MS/MS and CE-MS/MS analytical strategy for the determination of therapeutic peptides in modern immunotherapeutics and biopharmaceutics

artículo científico publicado en 2020

CSF phospho-tau correlates with behavioural decline and brain insoluble phospho-tau levels in a rat model of tauopathy

artículo científico publicado en 2010

Capillary electrophoresis and ultra-high performance liquid chromatography methods in clinical monitoring of creatinine in human urine: a comparative study

artículo científico publicado en 2020

Comparison of Different Matrices as Potential Quality Control Samples for Neurochemical Dementia Diagnostics

artículo científico publicado en 2016

Crystallization and preliminary X-ray diffraction analysis of tau protein microtubule-binding motifs in complex with Tau5 and DC25 antibody Fab fragments.

artículo científico publicado en 2012

Determination of immunogenic proteins in biopharmaceuticals by UHPLC-MS amino acid analysis

scientific article published on 10 May 2019

Environmental Enrichment Rescues Functional Deficit and Alters Neuroinflammation in a Transgenic Model of Tauopathy

artículo científico publicado en 2020

Evaluation of a novel immunoassay to detect p-Tau Thr127 in the CSF to distinguish Alzheimer disease from other dementias

scientific article published on 24 September 2020

FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer's disease

artículo científico publicado en 2018

First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model

artículo científico publicado en 2014

Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease ⬇️

artículo científico publicado el 12 de octubre de 2010

Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation

artículo científico publicado en 2020

Hyperphosphorylated Truncated Protein Tau Induces Caspase-3 Independent Apoptosis-Like Pathway in the Alzheimer's Disease Cellular Model ⬇️

artículo científico publicado el 1 de enero de 2011

Identification of structural determinants on tau protein essential for its pathological function: novel therapeutic target for tau immunotherapy in Alzheimer's disease.

artículo científico publicado en 2014

Immunomodulation of memory-impairing protein tau in Alzheimer's disease

artículo científico publicado en 2012

Intraneuronal accumulation of misfolded tau protein induces overexpression of Hsp27 in activated astrocytes.

artículo científico publicado en 2015

Microglia display modest phagocytic capacity for extracellular tau oligomers

artículo científico publicado en 2014

N-terminal truncation of microtubule associated protein tau dysregulates its cellular localization

artículo científico publicado en 2015

Neuronal Expression of Truncated Tau Efficiently Promotes Neurodegeneration in Animal Models: Pitfalls of Toxic Oligomer Analysis.

artículo científico publicado en 2017

New age of neuroproteomics in Alzheimer's disease research

artículo científico publicado en 2009

Preparation, crystallization and preliminary X-ray analysis of the Fab fragment of monoclonal antibody MN423, revealing the structural aspects of Alzheimer's paired helical filaments.

artículo científico publicado en 2006

Profiling of Amino Acids in Urine Samples of Patients Suffering from Inflammatory Bowel Disease by Capillary Electrophoresis-Mass Spectrometry

scientific article published on 14 September 2019

Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial

artículo científico publicado en 2016

The Distance between N and C Termini of Tau and of FTDP-17 Mutants Is Modulated by Microtubule Interactions in Living Cells.

artículo científico publicado en 2017

The self-perpetuating tau truncation circle

artículo científico publicado en 2012

Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans

artículo científico publicado en 2019

Transition of tau protein from disordered to misordered in Alzheimer's disease.

artículo científico publicado en 2010

Truncated tau expression levels determine life span of a rat model of tauopathy without causing neuronal loss or correlating with terminal neurofibrillary tangle load

artículo científico publicado en 2008

Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study

artículo científico publicado en 2015

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