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A Genetic Risk Score Associated with Chronic Obstructive Pulmonary Disease Susceptibility and Lung Structure on Computed Tomography

scientific article published on 01 September 2019

A Transcriptomic Method to Determine Airway Immune Dysfunction in T2-High and T2-Low Asthma

scientific article published on 01 February 2019

A combined pulmonary-radiology workshop for visual evaluation of COPD: study design, chest CT findings and concordance with quantitative evaluation

artículo científico publicado en 2012

A distinctive alveolar macrophage activation state induced by cigarette smoking

artículo científico publicado en 2005

A microRNA upregulated in asthma airway T cells promotes TH2 cytokine production

artículo científico publicado en 2014

A qPCR-based metric of Th2 airway inflammation in asthma.

artículo científico publicado en 2013

A randomised, placebo-controlled trial evaluating effects of lebrikizumab on airway eosinophilic inflammation and remodelling in uncontrolled asthma (CLAVIER)

scientific article published on 10 September 2020

A role for neutrophils in asthma?

artículo científico publicado en 2002

Accumulation of BDCA1⁺ dendritic cells in interstitial fibrotic lung diseases and Th2-high asthma

artículo científico publicado en 2014

Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high asthma

artículo científico publicado en 2010

Age and Small Airway Imaging Abnormalities in Subjects with and without Airflow Obstruction in SPIROMICS.

artículo científico publicado en 2016

Airway Mucin Concentration as a Marker of Chronic Bronchitis

artículo científico publicado en 2017

Airway epithelial miRNA expression is altered in asthma.

artículo científico publicado en 2012

Airway smooth muscle in bronchial tone, inflammation, and remodeling: basic knowledge to clinical relevance

artículo científico publicado en 2007

Altered microRNA profiles in bronchoalveolar lavage fluid exosomes in asthmatic patients

artículo científico publicado en 2013

Alternative splicing of interleukin-33 and type 2 inflammation in asthma.

artículo científico publicado en 2016

Alveolar eosinophilia in current smokers with chronic obstructive pulmonary disease in the SPIROMICS cohort.

artículo científico publicado en 2017

Alveolar macrophage recruitment and activation by chronic second hand smoke exposure in mice

artículo científico publicado en 2009

American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report

artículo científico publicado en 2017

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup

article

An integrated nano-scale approach to profile miRNAs in limited clinical samples

artículo científico publicado en 2012

Applying stereology to measure thickness of the basement membrane zone in bronchial biopsy specimens

artículo científico publicado en 2003

Association between Emphysema and COPD Outcomes in COPDGene and SPIROMICS Cohorts.

artículo científico publicado en 2018

Association of Dysanapsis With Chronic Obstructive Pulmonary Disease Among Older Adults

artículo científico publicado en 2020

Association of Long-term Ambient Ozone Exposure With Respiratory Morbidity in Smokers

scientific article published on 09 December 2019

Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort

artículo científico publicado en 2017

Association of urine mitochondrial DNA with clinical measures of COPD in the SPIROMICS cohort

artículo científico publicado en 2020

Associations Among 25-Hydroxyvitamin D Levels, Lung Function, and Exacerbation Outcomes in COPD: An Analysis of the SPIROMICS Cohort

scientific article published on 17 January 2020

Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease

artículo científico publicado en 2015

At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.

artículo científico publicado en 2018

Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

scientific article published on 01 June 2019

Azithromycin and risk of COPD exacerbations in patients with and without Helicobacter pylori

artículo científico publicado en 2017

Azithromycin for prevention of exacerbations of COPD.

artículo científico publicado en 2011

Biomarkers Predictive of Exacerbations in the SPIROMICS and COPDGene Cohorts.

artículo científico publicado en 2017

Bronchoalveolar Lavage Fluid from COPD Patients Reveals More Compounds Associated with Disease than Matched Plasma

artículo científico publicado en 2019

COPD Exacerbation Biomarkers Validated Using Multiple Reaction Monitoring Mass Spectrometry

artículo científico publicado en 2016

COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone

COVID-19 Related Genes in Sputum Cells in Asthma: Relationship to Demographic Features and Corticosteroids

scientific article published on 29 April 2020

CXCL9 and CXCL10 are differentially associated with systemic organ involvement and pulmonary disease severity in sarcoidosis

scientific article published on 20 November 2019

Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction

artículo científico publicado en 2012

Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort

scientific article published on 18 December 2018

Chitotriosidase is the primary active chitinase in the human lung and is modulated by genotype and smoking habit.

scientific article published on 09 October 2008

Chronic Respiratory Symptoms with Normal Spirometry. A Reliable Clinical Entity?

artículo científico publicado en 2016

Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis

artículo científico publicado en 2019

Clinical Significance of Symptoms in Smokers with Preserved Pulmonary Function

scientific article published on May 2016

Clinical phenotypes of atopy and asthma in COPD: a meta-analysis of SPIROMICS and COPDGene

artículo científico publicado en 2020

Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD.

artículo científico publicado en 2016

Comparison of serum, EDTA plasma and P100 plasma for luminex-based biomarker multiplex assays in patients with chronic obstructive pulmonary disease in the SPIROMICS study

artículo científico publicado en 2014

Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling

scientific article published on 16 July 2018

Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management.

artículo científico publicado en 2015

Current smoking with or without chronic bronchitis is independently associated with goblet cell hyperplasia in healthy smokers and COPD subjects

scientific article published on 18 November 2020

DAP12 is required for macrophage recruitment to the lung in response to cigarette smoke and chemotaxis toward CCL2

artículo científico publicado en 2010

Defining Chronic Mucus Hypersecretion Using the CAT in the SPIROMICS Cohort

artículo científico publicado en 2020

Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

artículo científico publicado en 2015

Design of the Redefining Therapy in Early COPD Study

scientific article published on 28 September 2020

Design of the Subpopulations and Intermediate Outcome Measures in COPD (SPIROMICS) AIR Study

artículo científico publicado en 2017

Design of the Subpopulations and Intermediate Outcomes in COPD Study (SPIROMICS).

artículo científico publicado en 2013

Differentiation of quantitative CT imaging phenotypes in asthma versus COPD.

artículo científico publicado en 2017

Dissecting asthma using focused transgenic modeling and functional genomics

artículo científico publicado en 2005

Distinct roles of FOXA2 and FOXA3 in allergic airway disease and asthma.

artículo científico publicado en 2009

Effect of beta-blockers on exacerbation rate and lung function in chronic obstructive pulmonary disease (COPD).

artículo científico publicado en 2017

Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma

artículo científico publicado en 2016

Efficient RNP-directed Human Gene Targeting Reveals SPDEF Is Required for IL-13-induced Mucostasis

artículo científico publicado en 2020

Electronic Cigarette Use in US Adults at Risk for or with COPD: Analysis from Two Observational Cohorts.

artículo científico publicado en 2017

Elevated circulating MMP-9 is linked to increased COPD exacerbation risk in SPIROMICS and COPDGene.

artículo científico publicado en 2018

Epithelial mucin stores are increased in the large airways of smokers with airflow obstruction

artículo científico publicado en 2006

Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function

artículo científico publicado en 2012

Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling

artículo científico publicado en 2018

Erratum: Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers

scientific article published on 01 January 2020

Extracellular DNA, Neutrophil Extracellular Traps, and Inflammasome Activation in Severe Asthma

scientific article published on 01 May 2019

Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment

artículo científico publicado en 2016

Frequency of exacerbations in patients with chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort

artículo científico publicado en 2017

Gene expression patterns of Th2 inflammation and intercellular communication in asthmatic airways

artículo científico publicado en 2010

Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways

scientific article published on 11 August 2020

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

artículo científico publicado en 2017

Genome-wide association study of lung function and clinical implication in heavy smokers

Genome-wide profiling identifies epithelial cell genes associated with asthma and with treatment response to corticosteroids

artículo científico publicado en 2007

Global Absence and Targeting of Protective Immune States in Severe COVID-19

artículo científico publicado en 2020

Global Absence and Targeting of Protective Immune States in Severe COVID-19

artículo científico publicado en 2020

Global absence and targeting of protective immune states in severe COVID-19

artículo científico publicado en 2021

Human airway branch variation and chronic obstructive pulmonary disease

artículo científico publicado en 2018

Human asthma phenotypes: from the clinic, to cytokines, and back again ⬇️

artículo científico publicado el 1 de julio de 2011

Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression

artículo científico publicado en 2004

IFN-γ-Producing T-Helper 17.1 Cells Are Increased in Sarcoidosis and Are More Prevalent than T-Helper Type 1 Cells

artículo científico publicado en 2016

Imaging-based clusters in current smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS)

scientific article published on 18 September 2018

Imaging-based clusters in former smokers of the COPD cohort associate with clinical characteristics: the SubPopulations and intermediate outcome measures in COPD study (SPIROMICS)

articulo cientifico publicado en 2019

Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS

artículo científico publicado en 2020

Increased expression of neutrophil-related genes in patients with early sepsis-induced ARDS.

artículo científico publicado en 2015

Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations

artículo científico publicado en 2016

Influence of Lightweight Ambulatory Oxygen on Oxygen Use and Activity Patterns of COPD Patients Receiving Long-Term Oxygen Therapy ⬇️

artículo científico publicado el 1 de febrero de 2012

Interferon-inducible chemokines reflect severity and progression in sarcoidosis

artículo científico publicado en 2013

Interferon-stimulated Gene Expression, Type-2 Inflammation and Endoplasmic Reticulum Stress in Asthma.

artículo científico publicado en 2017

Large Differences in Small RNA Composition Between Human Biofluids

article

Long-term Sequelae of Nonobstructive Chronic Bronchitis-Is Airflow Obstruction Important?

artículo científico publicado en 2020

Long-term comparative immunogenicity of protein conjugate and free polysaccharide pneumococcal vaccines in chronic obstructive pulmonary disease

artículo científico publicado en 2012

Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes

artículo científico publicado en 2014

Lower serum IgA is associated with COPD exacerbation risk in SPIROMICS.

artículo científico publicado en 2018

Mannose-binding lectin deficiency and acute exacerbations of chronic obstructive pulmonary disease

artículo científico publicado en 2012

Marijuana Use Associations with Pulmonary Symptoms and Function in Tobacco Smokers Enrolled in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS).

artículo científico publicado en 2018

Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma.

artículo científico publicado en 2013

Methodologic advancements in the study of airway smooth muscle

artículo científico publicado en 2004

Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction

artículo científico publicado en 2012

Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level

scientific article published on 19 May 2019

Muc5b is required for airway defence

scientific journal article

Mucus Plugs and Emphysema in the Pathophysiology of Airflow Obstruction and Hypoxemia in Smokers

artículo científico publicado en 2020

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.

artículo científico publicado en 2018

NT-proBNP in stable COPD and future exacerbation risk: Analysis of the SPIROMICS cohort

scientific article published on 05 June 2018

Nasal gene expression changes with inhaled corticosteroid treatment in asthma

scientific article published on 15 July 2019

Network analysis identifies a putative role for the PPAR and type 1 interferon pathways in glucocorticoid actions in asthmatics

artículo científico publicado en 2012

New Spirometry Indices for Detecting Mild Airflow Obstruction

artículo científico publicado en 2018

New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries

scholarly article published 12 June 2018

Novel Respiratory Disability Score Predicts COPD Exacerbations and Mortality in the SPIROMICS Cohort

artículo científico publicado en 2020

Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients

artículo científico publicado en 2012

Phenotypes of disease severity in a cohort of hospitalized COVID-19 patients: Results from the IMPACC study

artículo científico publicado en 2022

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts

artículo científico publicado en 2016

Precision Medicine: The New Frontier in Idiopathic Pulmonary Fibrosis

artículo científico publicado en 2016

Predictors of chronic obstructive pulmonary disease exacerbation reduction in response to daily azithromycin therapy

artículo científico publicado en 2014

ROP: dumpster diving in RNA-sequencing to find the source of 1 trillion reads across diverse adult human tissues

artículo científico publicado en 2018

Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis.

artículo científico publicado en 2013

Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS

scientific article published on 31 October 2019

Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization

artículo científico publicado en 2011

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids

artículo científico publicado en 2018

Relationship of Absolute Telomere Length With Quality of Life, Exacerbations, and Mortality in COPD

scientific article published on 12 July 2018

Respiratory Symptoms Items from the COPD Assessment Test Identify Ever-Smokers with Preserved Lung Function at Higher Risk for Poor Respiratory Outcomes. An Analysis of the Subpopulations and Intermediate Outcome Measures in COPD Study Cohort

artículo científico publicado en 2017

Responsiveness to Parenteral Corticosteroids and Lung Function Trajectory in Adults with Moderate to Severe Asthma

scientific article published on 08 December 2020

Roles of epithelial cell-derived periostin in TGF-beta activation, collagen production, and collagen gel elasticity in asthma

artículo científico publicado en 2010

Rural Residence and COPD Exacerbations: Analysis of the SPIROMICS Cohort

artículo científico publicado en 2018

SPIROMICS Protocol for Multicenter Quantitative Computed Tomography to Phenotype the Lungs.

artículo científico publicado en 2016

Safety and Tolerability of Comprehensive Research Bronchoscopy in Chronic Obstructive Pulmonary Disease. Results from the SPIROMICS Bronchoscopy Substudy

artículo científico publicado en 2019

Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease

artículo científico publicado en 2009

Sarcoidosis Blood Transcriptome Reflects Lung Inflammation and Overlaps with Tuberculosis ⬇️

artículo científico publicado el 18 de agosto de 2011

Serum CXCL11 correlates with pulmonary outcomes and disease burden in sarcoidosis

artículo científico publicado en 2019

Serum IgE clearance is facilitated by human FcεRI internalization

artículo científico publicado en 2014

Serum IgG Levels and Risk of COPD Hospitalization: A Pooled Meta-Analysis

scientific article published on 18 May 2020

Serum IgG and risk of exacerbations and hospitalizations in chronic obstructive pulmonary disease

artículo científico publicado en 2017

Serum IgG subclass levels and risk of exacerbations and hospitalizations in patients with COPD.

artículo científico publicado en 2018

Serum amino acid concentrations and clinical outcomes in smokers: SPIROMICS metabolomics study

artículo científico publicado en 2019

Simvastatin for the prevention of exacerbations in moderate-to-severe COPD

artículo científico publicado en 2014

Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease.

artículo científico publicado en 2017

Structural and Functional Features on Quantitative Chest Computed Tomography in the Korean Asian versus the White American Healthy Non-Smokers

scientific article published on 01 July 2019

Superior immune response to protein-conjugate versus free pneumococcal polysaccharide vaccine in chronic obstructive pulmonary disease.

artículo científico publicado en 2009

Symptoms in Smokers with Preserved Pulmonary Function.

artículo científico publicado en 2016

Systemic Markers of Inflammation in Smokers With Symptoms Despite Preserved Spirometry in SPIROMICS

scientific article published on 23 January 2019

T-bet Expression in Peripheral Th17.0 Cells Is Associated With Pulmonary Function Changes in Sarcoidosis

artículo científico publicado en 2020

T-helper type 2-driven inflammation defines major subphenotypes of asthma.

scientific article published on 29 May 2009

T2-"Low" Asthma: Overview and Management Strategies

scientific article published on 01 February 2020

Targeting Chronic Obstructive Pulmonary Disease Phenotypes, Endotypes, and Biomarkers

scientific article published on 01 December 2018

The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS

scientific article published on 01 March 2020

The H Antigen at Epithelial Surfaces Is Associated with Susceptibility to Asthma Exacerbation ⬇️

artículo científico publicado el 23 de agosto de 2010

The value of blood cytokines and chemokines in assessing COPD.

artículo científico publicado en 2017

Tumour necrosis factor receptor-75 and risk of COPD exacerbation in the azithromycin trial

artículo científico publicado en 2013

Understanding the impact of second-hand smoke exposure on clinical outcomes in participants with COPD in the SPIROMICS cohort

artículo científico publicado en 2016

Variability in objective and subjective measures affects baseline values in studies of patients with COPD.

artículo científico publicado en 2017

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