Lista de obras -

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

artículo científico publicado en 2019

A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly

artículo científico publicado en 2012

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

scientific article published on 28 September 2009

Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir

artículo científico publicado en 2014

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.

artículo científico publicado en 2017

Clinical targeting of HIV capsid protein with a long-acting small molecule

artículo científico publicado en 2020

Development and application of a fast, reproducible assay to measure HCV NS3 protease activity using Escherichia coli lysate

artículo científico publicado en 2015

Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).

artículo científico publicado en 2017

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation

artículo científico publicado en 2011

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly

artículo científico publicado en 2015

GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein

artículo científico publicado en 2015

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

artículo científico publicado en 2007

Large-scale functional purification of recombinant HIV-1 capsid

artículo científico publicado en 2013

Lipid-sensing high-throughput ApoA-I assays

scientific article published on 17 July 2012

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.

artículo científico publicado en 2013

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action ⬇️

artículo científico publicado el 25 de abril de 2012

PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy

scientific article published on 22 October 2019

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH

artículo científico publicado en 2006

Preparation of HCV NS3 and NS5B proteins to support small-molecule drug discovery

artículo científico publicado en 2011

Screening and Identification of a Novel Class of TGF-β Type 1 Receptor Kinase Inhibitor ⬇️

artículo científico publicado el 26 de abril de 2011

Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes

scientific article published on 30 July 2019

Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors

artículo científico publicado en 2014

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor

scientific article published on 15 November 2018

The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function

artículo científico publicado en 2012

The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.

artículo científico publicado en 2007

The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties

artículo científico

Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

artículo científico publicado en 2020

Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex

artículo científico publicado en 2010

Lista de obras de

A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model

A trimer of dimers is the basic building block for human immunodeficiency virus-1 capsid assembly

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex

Binding kinetics, potency, and selectivity of the hepatitis C virus NS3 protease inhibitors GS-9256 and vedroprevir

Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.

Clinical targeting of HIV capsid protein with a long-acting small molecule

Development and application of a fast, reproducible assay to measure HCV NS3 protease activity using Escherichia coli lysate

Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII).

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation

Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly

GS-5806 inhibits pre- to postfusion conformational changes of the respiratory syncytial virus fusion protein

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

Large-scale functional purification of recombinant HIV-1 capsid

Lipid-sensing high-throughput ApoA-I assays

Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.

New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action ⬇️

PD-1 Blockade and TLR7 Activation Lack Therapeutic Benefit in Chronic Simian Immunodeficiency Virus-Infected Macaques on Antiretroviral Therapy

Phosphonic acid-containing analogues of mycophenolic acid as inhibitors of IMPDH

Preparation of HCV NS3 and NS5B proteins to support small-molecule drug discovery

Screening and Identification of a Novel Class of TGF-β Type 1 Receptor Kinase Inhibitor ⬇️

Spatiotemporal Analysis of Hepatitis B Virus X Protein in Primary Human Hepatocytes

Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors

Structure-guided discovery of a novel, potent, and orally bioavailable 3,5-dimethylisoxazole aryl-benzimidazole BET bromodomain inhibitor

The HCV non-nucleoside inhibitor Tegobuvir utilizes a novel mechanism of action to inhibit NS5B polymerase function

The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.

The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties

Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B

Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex