Lista de obras - J.J.P. Kastelein - Dominio Público Uruguay

1.W05.3 Common mutations in the lipoprotein lipase gene influence plasma lipids and prevalence of coronary heart disease

article

20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia

scientific article published on 01 October 2019

2P-0452 A genetic, biochemical and proteomic approach to dissection of inherited HDL phenotypes in humans

2P-0589 Influence of apolipoprotein E polymorphisms on coronary artery disease and on the efficacy of HMG-CoA reductase inhibitors in men

scholarly article by A.H. Maitland-van der Zee et al published January 2003 in Atherosclerosis. Supplements

4P-1046 Restoration of endothelial function by increasing HDL in subjects with isolated low-HDL

4WS26-2 Functional effects of tissue-specific expression of ATP-cassette transporter A1(ABCA1) provide multiple mechanisms for protection against against atherosclerosis

5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia

artículo científico publicado en 2009

A Functional Polymorphism in the Glucocorticoid Receptor Gene and Its Relation to Cardiovascular Disease Risk in Familial Hypercholesterolemia

article

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

artículo científico publicado en 2004

A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies.

artículo científico publicado en 2003

A randomized trial of rosuvastatin in the prevention of venous thromboembolism

artículo científico publicado en 2009

A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis

artículo científico publicado en 2015

A review of CETP and its relation to atherosclerosis

artículo científico publicado en 2004

A single Ser259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in Moroccans of Berber ancestry

article

A single bolus infusion of C-reactive protein increases gluconeogenesis and plasma glucose concentration in humans

artículo científico publicado en 2007

A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations

artículo científico

AAV1-LPL(S447X) gene therapy reduces hypertriglyceridemia in apoE2 knock in mice

artículo científico publicado en 2006

ABCA1 gene mutations, HDL cholesterol levels, and risk of ischemic heart disease

artículo científico publicado en 2008

ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention setting

artículo científico publicado en 2011

ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden

artículo científico publicado en 2012

ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels.

artículo científico publicado en 2002

ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis

artículo científico publicado en 2010

ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia

artículo científico publicado en 2008

ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial.

artículo científico

Achieved LDL cholesterol levels in patients with heterozygous familial hypercholesterolemia: A model that explores the efficacy of conventional and novel lipid-lowering therapy

artículo científico publicado en 2018

Achieving lipid goals in real life: the Dutch DISCOVERY study

artículo científico publicado en 2005

Activation of inflammation and coagulation after infusion of C-reactive protein in humans

artículo científico publicado en 2005

Adeno-associated virus LPL(S447X) gene therapy in LDL receptor knockout mice

artículo científico publicado en 2006

Adherence to and dosing of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes

artículo científico publicado en 2003

Adherence to and dosing of statins differs according to apolipoprotein E-genotypes.

artículo científico publicado en 2002

Adherence to evidence-based statin guidelines reduces the risk of hospitalizations for acute myocardial infarction by 40%: a cohort study

scientific article published on 07 December 2006

Adherence-adjusted efficacy with intensive versus standard statin therapy in patients with acute myocardial infarction in the IDEAL study

artículo científico publicado en 2009

Adiponectin and risk of coronary heart disease in apparently healthy men and women (from the EPIC-Norfolk Prospective Population Study)

artículo científico publicado en 2011

Advanced method for the identification of patients with inherited hypercholesterolemia

artículo científico publicado en 2004

Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia ⬇️

artículo científico publicado el 8 de marzo de 2012

Age at repair and left ventricular mass in patients after repair of aortic coarctation

scientific article published on 01 September 2005

Air pollution as noxious environmental factor in the development of cardiovascular disease.

scientific article published on April 2009

Alirocumab efficacy in patients with double heterozygous, compound heterozygous, or homozygous familial hypercholesterolemia

artículo científico publicado en 2017

An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men.

artículo científico publicado en 2004

Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study

artículo científico publicado en 2015

Anacetrapib: new hope for cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia

artículo científico publicado en 2008

And then there were acyl coenzyme A:cholesterol acyl transferase inhibitors

artículo científico publicado en 2006

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

artículo científico

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia

artículo científico publicado en 2015

Antisense apolipoprotein B therapy: where do we stand?

artículo científico publicado en 2007

Antisense oligonucleotides for the treatment of dyslipidaemia ⬇️

artículo científico publicado el 24 de mayo de 2012

ApoA-I induction as a potential cardioprotective strategy: rationale for the SUSTAIN and ASSURE studies.

artículo científico publicado en 2012

Apolipoprotein A-I mimetic peptides

artículo científico publicado en 2010

Apolipoprotein A-II is inversely associated with risk of future coronary artery disease

artículo científico publicado en 2007

Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study

artículo científico publicado en 2006

Apolipoprotein B synthesis inhibition: results from clinical trials

artículo científico publicado en 2010

Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study

artículo científico publicado en 2017

Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations

artículo científico publicado en 2011

Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS).

artículo científico publicado en 2006

Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia

artículo científico publicado en 2008

Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia

artículo científico publicado en 2004

Arterial stiffness, endothelial function and microcirculatory reactivity in healthy young males

artículo científico publicado en 2008

Assessment of Carotid Atherosclerosis in Normocholesterolemic Individuals With Proven Mutations in the Low-Density Lipoprotein Receptor or Apolipoprotein B Genes ⬇️

artículo científico publicado el 4 de junio de 2011

Assessment of atherosclerosis: the role of flow-mediated dilatation

artículo científico publicado en 2010

Assessment of omega-3 carboxylic acids in statin-treated patients with high levels of triglycerides and low levels of high-density lipoprotein cholesterol: Rationale and design of the STRENGTH trial

artículo científico publicado en 2018

Association between familial hypercholesterolemia and prevalence of type 2 diabetes mellitus

artículo científico publicado en 2015

Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study

artículo científico publicado en 2002

Association between statin use and plasma D-dimer levels. A systematic review and meta-analysis of randomised controlled trials.

artículo científico publicado en 2015

Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk

artículo científico publicado en 2017

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study

artículo científico publicado en 2015

Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study

artículo científico publicado en 2017

Association of Initial and Serial C-Reactive Protein Levels With Adverse Cardiovascular Events and Death After Acute Coronary Syndrome: A Secondary Analysis of the VISTA-16 Trial

scientific article published on 01 April 2019

Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis

artículo científico publicado en 2012

Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease

scientific article published on 01 January 2019

Asymptomatic individuals with a positive family history for premature coronary artery disease and elevated coronary calcium scores benefit from statin treatment: a post hoc analysis from the St. Francis Heart Study

artículo científico publicado en 2012

Atherogenesis in rheumatology

artículo científico publicado en 2006

Atherogenic lipoprotein particle size and concentrations and the effect of pravastatin in children with familial hypercholesterolemia

artículo científico publicado en 2008

Atherosclerosis imaging as a benchmark in the development of novel cardiovasular drugs

artículo científico publicado en 2007

Atherosclerosis measured by B-mode ultrasonography: effect of statin therapy on disease progression

artículo científico publicado en 2004

Atherosclerotic vascular disease in HIV: it is not just antiretroviral therapy that hurts the heart!

scientific article published on July 2007

Atorvastatin

Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein

artículo científico

Baseline cholesterol absorption and the response to ezetimibe/simvastatin therapy: a post-hoc analysis of the ENHANCE trial

artículo científico publicado en 2009

Baseline lipid values partly determine the response to high-dose simvastatin in patients with familial hypercholesterolemia. The examination of probands and relatives in Statin studies with familial hypercholesterolemia (ExPRESS FH).

artículo científico publicado en 2002

Beyond low-density lipoprotein cholesterol: respective contributions of non-high-density lipoprotein cholesterol levels, triglycerides, and the total cholesterol/high-density lipoprotein cholesterol ratio to coronary heart disease risk in apparently

artículo científico publicado en 2009

Biological, clinical and population relevance of 95 loci for blood lipids

artículo científico publicado en 2010

Both paraoxonase-1 genotype and activity do not predict the risk of future coronary artery disease; the EPIC-Norfolk Prospective Population Study

artículo científico publicado en 2009

C-reactive protein and atherogenesis: from fatty streak to clinical event

artículo científico publicado en 2007

C-reactive protein and cardiovascular risk: more fuel to the fire

artículo científico publicado en 2009

C-reactive protein and cholesterol are equally strong predictors of cardiovascular risk and both are important for quality clinical care

artículo científico publicado en 2013

C-reactive protein elicits white blood cell activation in humans

artículo científico publicado en 2009

C-reactive protein in the Heart Protection Study ⬇️

artículo científico publicado el 4 de junio de 2011

C-reactive protein is a mediator of cardiovascular disease ⬇️

artículo científico publicado el 3 de agosto de 2010

C-reactive protein levels and coronary artery disease incidence and mortality in apparently healthy men and women: the EPIC-Norfolk prospective population study 1993-2003.

artículo científico publicado en 2005

C-reactive protein, fatal and nonfatal coronary artery disease, stroke, and peripheral artery disease in the prospective EPIC-Norfolk cohort study

artículo científico publicado en 2013

CETP gene variation: relation to lipid parameters and cardiovascular risk

artículo científico publicado en 2004

CETP genotype predicts increased mortality in statin-treated men with proven cardiovascular disease: an adverse pharmacogenetic interaction

artículo científico publicado en 2008

Can we afford not to screen for FH?

scientific article published on 01 June 2017

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

artículo científico

Cardiovascular disease in systemic lupus erythematosus: has the time for action come?

artículo científico publicado en 2005

Cardiovascular event reduction versus new-onset diabetes during atorvastatin therapy: effect of baseline risk factors for diabetes

artículo científico publicado en 2012

Cardiovascular event reduction with PCSK9 inhibition among 1578 patients with familial hypercholesterolemia: Results from the SPIRE randomized trials of bococizumab

artículo científico publicado en 2018

Cardiovascular outcomes and their relationships to lipoprotein components in patients with and without chronic kidney disease: results from the IDEAL trial

artículo científico publicado en 2009

Cardiovascular risk in relation to functionality of sequence variants in the gene coding for the low-density lipoprotein receptor: a study among 29,365 individuals tested for 64 specific low-density lipoprotein-receptor sequence variants

artículo científico publicado en 2012

Cardiovascular risk--through the ages

artículo científico publicado en 2004

Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk: Meta-Analysis of 119 Clinical Trials Involving 100,667 Patients

artículo científico publicado en 2020

Carotid atherosclerosis progression in familial hypercholesterolemia patients: a pooled analysis of the ASAP, ENHANCE, RADIANCE 1, and CAPTIVATE studies

artículo científico publicado en 2010

Carotid intima-media thickness in children with familial hypercholesterolemia

artículo científico publicado en 2013

Carotid intima-media thickness in post-coarctectomy patients with exercise induced hypertension

artículo científico publicado en 2005

Carriers of lecithin cholesterol acyltransferase gene mutations have accelerated atherogenesis as assessed by carotid 3.0-T magnetic resonance imaging [corrected]

artículo científico publicado en 2011

Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction

artículo científico publicado en 2010

Carriers of the PCSK9 R46L Variant Are Characterized by an Antiatherogenic Lipoprotein Profile Assessed by Nuclear Magnetic Resonance Spectroscopy-Brief Report.

artículo científico publicado en 2016

Carriers of the frequent lipoprotein lipase S447X variant exhibit enhanced postprandial apoprotein B-48 clearance

scientific article published on 01 November 2005

Changes in mipomersen dosing regimen provide similar exposure with improved tolerability in randomized placebo-controlled study of healthy volunteers

artículo científico publicado en 2014

Chemokine ligand 2 genetic variants, serum monocyte chemoattractant protein-1 levels, and the risk of coronary artery disease

artículo científico publicado en 2010

Children with hypercholesterolemia of unknown cause: Value of genetic risk scores

artículo científico publicado en 2016

Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial

artículo científico publicado en 2015

Cholesterol levels in small LDL particles predict the risk of coronary heart disease in the EPIC-Norfolk prospective population study

artículo científico publicado en 2007

Cholesteryl ester transfer protein (CETP) inhibition beyond raising high-density lipoprotein cholesterol levels: pathways by which modulation of CETP activity may alter atherogenesis

artículo científico publicado en 2006

Cholesteryl ester transfer protein and hyperalphalipoproteinemia in Caucasians

scientific article published on 27 December 2006

Cholesteryl ester transfer protein inhibitor torcetrapib and off-target toxicity: a pooled analysis of the rating atherosclerotic disease change by imaging with a new CETP inhibitor (RADIANCE) trials

artículo científico publicado en 2008

Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase

artículo científico publicado en 2009

Chylomicronemia with low postheparin lipoprotein lipase levels in the setting of GPIHBP1 defects

artículo científico publicado en 2010

Clinical implications of JUPITER in a contemporary European population: the EPIC-Norfolk prospective population study

artículo científico

Clinical phenotype in relation to the distance-to-index-patient in familial hypercholesterolemia

artículo científico publicado en 2015

Clinical, diagnostic, and therapeutic aspects of familial hypercholesterolemia

artículo científico publicado en 2004

Colesevelam added to combination therapy with a statin and ezetimibe in patients with familial hypercholesterolemia: a 12-week, multicenter, randomized, double-blind, controlled trial

artículo científico publicado en 2010

Combination statin-fibrate therapy: safety aspects

artículo científico publicado en 2008

Common variants associated with plasma triglycerides and risk for coronary artery disease

artículo científico publicado en 2013

Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels

article

Comparative effect of atorvastatin (80 mg) versus simvastatin (20 to 40 mg) in preventing hospitalizations for heart failure in patients with previous myocardial infarction.

artículo científico publicado en 2009

Comparison between gradient gel electrophoresis and nuclear magnetic resonance spectroscopy in estimating coronary heart disease risk associated with LDL and HDL particle size

artículo científico publicado en 2010

Comparison of atorvastatin 80 mg/day versus simvastatin 20 to 40 mg/day on frequency of cardiovascular events late (five years) after acute myocardial infarction (from the Incremental Decrease in End Points through Aggressive Lipid Lowering [IDEAL]

artículo científico publicado en 2010

Comparison of efficacy and safety of atorvastatin (80 mg) to simvastatin (20 to 40 mg) in patients aged <65 versus >or=65 years with coronary heart disease (from the Incremental DEcrease through Aggressive Lipid Lowering [IDEAL] study).

artículo científico publicado en 2009

Comparison of ezetimibe plus simvastatin versus simvastatin monotherapy on atherosclerosis progression in familial hypercholesterolemia. Design and rationale of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regressio

artículo científico publicado en 2005

Comparison of in vivo carotid 3.0-T magnetic resonance to B-mode ultrasound imaging and histology in a porcine model

artículo científico publicado en 2009

Complement factor H Y402H decreases cardiovascular disease risk in patients with familial hypercholesterolaemia

artículo científico publicado en 2008

Completeness of carotid intima media thickness measurements depends on body composition: the RADIANCE 1 and 2 trials.

artículo científico publicado en 2010

Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort

artículo científico publicado en 2009

Compromised LCAT function is associated with increased atherosclerosis

artículo científico publicado en 2005

Congestive heart failure is associated with lipoprotein components in statin-treated patients with coronary heart disease Insights from the Incremental Decrease in End points Through Aggressive Lipid Lowering Trial (IDEAL).

artículo científico publicado en 2009

Consequences of cholesteryl ester transfer protein inhibition in patients with familial hypoalphalipoproteinemia

artículo científico publicado en 2005

Consumption of tall oil-derived phytosterols in a chocolate matrix significantly decreases plasma total and low-density lipoprotein-cholesterol levels

artículo científico publicado en 2002

Contemporary data on low-density lipoprotein cholesterol target value attainment and distance to target in a cohort of 57,885 statin-treated patients by country and region across the world

artículo científico publicado en 2016

Correction of feline lipoprotein lipase deficiency with adeno-associated virus serotype 1-mediated gene transfer of the lipoprotein lipase S447X beneficial mutation

artículo científico publicado en 2006

Corrigendum to "Efficacy of alirocumab in 1191 patients with a wide spectrum of mutations in genes causative for familial hypercholesterolemia" J Clin Lipidol 11 (2017) 1338-1346

scientific article published on 01 September 2020

Cost-effectiveness analysis of the genetic screening program for familial hypercholesterolemia in The Netherlands

artículo científico publicado en 2004

Cox proportional hazards models have more statistical power than logistic regression models in cross-sectional genetic association studies

article

Current and future pharmacologic options for the management of patients unable to achieve low-density lipoprotein-cholesterol goals with statins

scientific article published on January 2008

Dalcetrapib: no off-target toxicity on blood pressure or on genes related to the renin-angiotensin-aldosterone system in rats

artículo científico publicado en 2009

De-risking the clinical development of cholesteryl ester transfer protein inhibitors: how much is good enough? ⬇️

artículo científico publicado el 31 de octubre de 2011

Decade in review--dyslipidaemia: Resurgence of targets and compounds to treat dyslipidaemia

artículo científico

Declaring war on undertreatment: rationale for an aggressive approach to lowering cholesterol

artículo científico publicado en 2002

Defining the role of common variation in the genomic and biological architecture of adult human height

artículo científico publicado en 2014

Design and baseline characteristics of the Incremental Decrease in End Points through Aggressive Lipid Lowering study

artículo científico publicado en 2004

Designs of RADIANCE 1 and 2: carotid ultrasound studies comparing the effects of torcetrapib/atorvastatin with atorvastatin alone on atherosclerosis

artículo científico publicado en 2007

Detection of liquid phase cholesteryl ester in carotid atherosclerosis by 1H-MR spectroscopy in humans.

artículo científico publicado en 2013

Determinants of residual risk in secondary prevention patients treated with high- versus low-dose statin therapy: the Treating to New Targets (TNT) study

artículo científico publicado en 2012

Determining When to Add Nonstatin Therapy: A Quantitative Approach

artículo científico publicado en 2016

Diagnosing familial hypercholesterolaemia: the relevance of genetic testing

artículo científico publicado en 2006

Diagnosis and Management of Individuals With Heterozygous Familial Hypercholesterolemia: Too Late and Too Little

artículo científico publicado en 2016

Diagnosis and treatment of familial hypercholesterolaemia

artículo científico publicado en 2013

Differential effect of the rs4149056 variant in SLCO1B1 on myopathy associated with simvastatin and atorvastatin.

artículo científico publicado en 2011

Differential hs-CRP reduction in patients with familial hypercholesterolemia treated with aggressive or conventional statin therapy

artículo científico publicado en 2002

Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study

artículo científico publicado en 2007

Differentiating Familial Chylomicronemia Syndrome From Multifactorial Severe Hypertriglyceridemia by Clinical Profiles

scientific article published on 11 October 2019

Discovery and refinement of loci associated with lipid levels

artículo científico publicado en 2013

Discriminative ability of LDL-cholesterol to identify patients with familial hypercholesterolemia: a cross-sectional study in 26,406 individuals tested for genetic FH.

artículo científico publicado en 2012

Distribution of Estimated 10-Year Risk of Recurrent Vascular Events and Residual Risk in a Secondary Prevention Population.

artículo científico publicado en 2016

Dual targeting of hepatic fibrosis and atherogenesis by icosabutate, an engineered eicosapentaenoic acid derivative

scientific article published on 25 August 2020

Dyslipidaemia as predictor of progressive renal failure and the impact of treatment with atorvastatin

scientific article published on 08 March 2007

Dyslipidaemia in perspective

artículo científico publicado en 2014

Dyslipidaemia: Statin-associated muscle symptoms - really all in the mind?

artículo científico publicado en 2017

Dyslipidemia of Mothers With Familial Hypercholesterolemia Deteriorates Lipids in Adult Offspring ⬇️

artículo científico publicado el 23 de septiembre de 2010

Early statin therapy restores endothelial function in children with familial hypercholesterolemia

artículo científico publicado en 2002

Effect of 1 or 2 Doses of Inclisiran on Low-Density Lipoprotein Cholesterol Levels: One-Year Follow-up of the ORION-1 Randomized Clinical Trial

artículo científico publicado en 2019

Effect of Evolocumab on Coronary Plaque Composition

article

Effect of Evolocumab on Progression of Coronary Disease in Statin-Treated Patients: The GLAGOV Randomized Clinical Trial

artículo científico publicado en 2016

Effect of High-Dose Omega-3 Fatty Acids vs Corn Oil on Major Adverse Cardiovascular Events in Patients at High Cardiovascular Risk: The STRENGTH Randomized Clinical Trial

artículo científico publicado en 2020

Effect of Infusion of High-Density Lipoprotein Mimetic Containing Recombinant Apolipoprotein A-I Milano on Coronary Disease in Patients With an Acute Coronary Syndrome in the MILANO-PILOT Trial: A Randomized Clinical Trial

artículo científico publicado en 2018

Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking Rosuvastatin Open Label).

artículo científico

Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial: A Randomized Clinica

artículo científico publicado en 2018

Effect of Torcetrapib on Glucose, Insulin, and Hemoglobin A 1c in Subjects in the Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events (ILLUMINATE) Trial ⬇️

artículo científico publicado el 18 de julio de 2011

Effect of alirocumab dose increase on LDL lowering and lipid goal attainment in patients with dyslipidemia

artículo científico publicado en 2016

Effect of aliskiren on progression of coronary disease in patients with prehypertension: the AQUARIUS randomized clinical trial.

artículo científico

Effect of an siRNA Therapeutic Targeting PCSK9 on Atherogenic Lipoproteins: Pre-Specified Secondary End Points in ORION 1

scientific article published on 01 September 2018

Effect of apolipoprotein-B synthesis inhibition on liver triglyceride content in patients with familial hypercholesterolemia

artículo científico publicado en 2009

Effect of atorvastatin (80 mg) and simvastatin (40 mg) on plasma fibrinogen levels and on carotid intima media thickness in patients with familial hypercholesterolemia

artículo científico publicado en 2003

Effect of atorvastatin, cholesterol ester transfer protein inhibition, and diabetes mellitus on circulating proprotein subtilisin kexin type 9 and lipoprotein(a) levels in patients at high cardiovascular risk.

artículo científico publicado en 2017

Effect of high-dose atorvastatin on hospitalizations for heart failure: subgroup analysis of the Treating to New Targets (TNT) study

artículo científico publicado en 2007

Effect of inclisiran, the siRNA against PCSK9, on platelets, immune cells and immunological biomarkers - a pre-specified analysis from ORION-1

artículo científico publicado en 2020

Effect of intensive lipid lowering with atorvastatin on renal function in patients with coronary heart disease: the Treating to New Targets (TNT) study

artículo científico publicado en 2007

Effect of low-density lipoprotein receptor mutation on lipoproteins and cardiovascular disease risk: a parent-offspring study

artículo científico publicado en 2004

Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia

artículo científico publicado en 2010

Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

artículo científico publicado en 2015

Effect of rimonabant on carotid intima-media thickness (CIMT) progression in patients with abdominal obesity and metabolic syndrome: the AUDITOR Trial ⬇️

artículo científico publicado el 24 de mayo de 2011

Effect of rimonabant on progression of atherosclerosis in patients with abdominal obesity and coronary artery disease: the STRADIVARIUS randomized controlled trial

artículo científico

Effect of serial infusions of reconstituted high-density lipoprotein (CER-001) on coronary atherosclerosis: rationale and design of the CARAT study.

artículo científico publicado en 2017

Effect of statin withdrawal on frequency of cardiac events after vascular surgery

scientific article published on 22 May 2007

Effect of the BET Protein Inhibitor, RVX-208, on Progression of Coronary Atherosclerosis: Results of the Phase 2b, Randomized, Double-Blind, Multicenter, ASSURE Trial.

artículo científico

Effect of torcetrapib on carotid atherosclerosis in familial hypercholesterolemia

artículo científico publicado en 2007

Effectiveness of HMG-CoA reductase inhibitors is modified by the ACE insertion deletion polymorphism

artículo científico publicado en 2004

Effectiveness of inhibition of cholesteryl ester transfer protein by JTT-705 in combination with pravastatin in type II dyslipidemia

artículo científico publicado en 2005

Effects of CRP infusion on endothelial function and coagulation in normocholesterolemic and hypercholesterolemic subjects

scientific article published on 26 January 2007

Effects of Renal Impairment on the Pharmacokinetics, Efficacy, and Safety of Inclisiran: An Analysis of the ORION-7 and ORION-1 Studies

scientific article published on 17 October 2019

Effects of Supra-Physiological Levothyroxine Dosages on Liver Parameters, Lipids and Lipoproteins in Healthy Volunteers: A Randomized Controlled Crossover Study

artículo científico publicado en 2017

Effects of aliskiren in diabetic and non-diabetic patients with coronary artery disease: Insights from AQUARIUS.

artículo científico publicado en 2015

Effects of atorvastatin and simvastatin on low-density lipoprotein subfraction profile, low-density lipoprotein oxidizability, and antibodies to oxidized low-density lipoprotein in relation to carotid intima media thickness in familial hypercholeste

artículo científico publicado en 2004

Effects of high-dose atorvastatin on cerebrovascular events in patients with stable coronary disease in the TNT (treating to new targets) study

artículo científico publicado en 2006

Effects of short-term and long-term danazol treatment on lipoproteins, coagulation, and progression of atherosclerosis: two clinical trials in healthy volunteers and patients with hereditary angioedema.

artículo científico publicado en 2008

Effects of six APOA5 variants, identified in patients with severe hypertriglyceridemia, on in vitro lipoprotein lipase activity and receptor binding

artículo científico publicado en 2008

Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial.

artículo científico publicado en 2011

Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses

artículo científico publicado en 2016

Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial

artículo científico publicado en 2014

Efficacy and Safety of Alirocumab in Adults With Homozygous Familial Hypercholesterolemia: The ODYSSEY HoFH Trial

scientific article published on 01 July 2020

Efficacy and Safety of Pitavastatin in Children and Adolescents at High Future Cardiovascular Risk

artículo científico publicado en 2015

Efficacy and Safety of Pitavastatin in Children and Adolescents with Familial Hypercholesterolemia in Japan and Europe.

artículo científico publicado en 2017

Efficacy and safety of a novel cholesteryl ester transfer protein inhibitor, JTT-705, in humans: a randomized phase II dose-response study

artículo científico publicado en 2002

Efficacy and safety of a novel oral inducer of apolipoprotein a-I synthesis in statin-treated patients with stable coronary artery disease a randomized controlled trial

artículo científico publicado en 2011

Efficacy and safety of alirocumab in patients with heterozygous familial hypercholesterolemia not adequately controlled with current lipid-lowering therapy: design and rationale of the ODYSSEY FH studies

artículo científico publicado en 2014

Efficacy and safety of alirocumab in reducing lipids and cardiovascular events

artículo científico publicado en 2015

Efficacy and safety of coadministration of ezetimibe and simvastatin in adolescents with heterozygous familial hypercholesterolemia

artículo científico publicado en 2008

Efficacy and safety of disodium ascorbyl phytostanol phosphates in men with moderate dyslipidemia

artículo científico publicado en 2008

Efficacy and safety of ezetimibe monotherapy in children with heterozygous familial or nonfamilial hypercholesterolemia

scientific article published on 01 April 2015

Efficacy and safety of high-density lipoprotein cholesterol-increasing compounds: a meta-analysis of randomized controlled trials

artículo científico publicado en 2005

Efficacy and safety of mipomersen sodium (Kynamro).

artículo científico

Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy

artículo científico publicado en 2010

Efficacy and safety of rosuvastatin therapy for children with familial hypercholesterolemia

artículo científico publicado en 2010

Efficacy and safety of rosuvastatin therapy in children and adolescents with familial hypercholesterolemia: Results from the CHARON study

artículo científico publicado en 2015

Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized controlled trial

artículo científico publicado en 2004

Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized, double-blind, placebo-controlled trial with simvastatin

artículo científico publicado en 2002

Efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody alirocumab vs placebo in patients with heterozygous familial hypercholesterolemia

artículo científico publicado en 2016

Efficacy of Rosuvastatin in Children With Homozygous Familial Hypercholesterolemia and Association With Underlying Genetic Mutations

artículo científico publicado en 2017

Efficacy of alirocumab in 1191 patients with a wide spectrum of mutations in genes causative for familial hypercholesterolemia

artículo científico publicado en 2017

Efficacy of apolipoprotein B synthesis inhibition in subjects with mild-to-moderate hyperlipidaemia ⬇️

artículo científico publicado el 18 de mayo de 2011

Efficacy of statins in familial hypercholesterolaemia: a long term cohort study

artículo científico publicado en 2008

Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene

artículo científico publicado en 2003

Elevated remnant-like particles in heterozygous familial hypercholesterolemia and response to statin therapy

artículo científico publicado en 2002

Emerging Cardiovascular Disease Biomarkers and Incident Diabetes Mellitus Risk in Statin-Treated Patients With Coronary Artery Disease (from the Treating to New Targets [TNT] Study).

artículo científico publicado en 2016

Endothelial glycocalyx as potential diagnostic and therapeutic target in cardiovascular disease

artículo científico publicado en 2009

Endothelial glycocalyx damage coincides with microalbuminuria in type 1 diabetes

artículo científico publicado en 2006

Endothelial shear stress: a critical determinant of arterial remodeling and arterial stiffness in humans--a carotid 3.0-T MRI study

artículo científico publicado en 2010

Enhanced apoB48 metabolism in lipoprotein lipase X447 homozygotes

artículo científico publicado en 2006

Enhanced atherogenesis and altered high density lipoprotein in patients with Crohn's disease

artículo científico publicado en 2007

Enhanced conversion of triglyceride-rich lipoproteins and increased low-density lipoprotein removal in LPLS447X carriers

artículo científico publicado en 2005

Enhancing reverse cholesterol transport/raising HDL cholesterol: new options for prevention and treatment of cardiovascular disease

artículo científico publicado en 2004

Eprotirome in patients with familial hypercholesterolaemia (the AKKA trial): a randomised, double-blind, placebo-controlled phase 3 study

artículo científico publicado en 2014

Erratum: Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance

scholarly article published in European Journal of Human Genetics

Estimated individual lifetime benefit from PCSK9 inhibition in statin-treated patients with coronary artery disease.

artículo científico publicado en 2018

Evaluating bococizumab, a monoclonal antibody to PCSK9, on lipid levels and clinical events in broad patient groups with and without prior cardiovascular events: Rationale and design of the Studies of PCSK9 Inhibition and the Reduction of vascular E

artículo científico publicado en 2016

Evaluation of cholesterol lowering treatment of patients with familial hypercholesterolemia: a large cross-sectional study in The Netherlands.

artículo científico publicado en 2009

Evinacumab for Homozygous Familial Hypercholesterolemia

artículo científico publicado en 2020

Evolocumab in Pediatric Heterozygous Familial Hypercholesterolemia

scientific article published on 29 August 2020

Exome sequencing and directed clinical phenotyping diagnose cholesterol ester storage disease presenting as autosomal recessive hypercholesterolemia

artículo científico publicado en 2013

Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction

artículo científico publicado en 2014

Exome sequencing in suspected monogenic dyslipidemias

artículo científico publicado en 2015

Expression of type III hyperlipoproteinemia in apolipoprotein E2 (Arg158 --> Cys) homozygotes is associated with hyperinsulinemia

artículo científico publicado en 2002

Ext1 heterozygosity causes a modest effect on postprandial lipid clearance in humans

artículo científico publicado en 2015

Extreme xanthomatosis in patients with both familial hypercholesterolemia and cerebrotendinous xanthomatosis

scientific article published on 16 October 2011

Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice

artículo científico publicado en 2010

FISHing for the Miracle of Eicosapentaenoic Acid

artículo científico publicado en 2018

Familial Hypercholesterolemia: Present and Future Management ⬇️

artículo científico publicado el 1 de diciembre de 2011

Familial Hypercholesterolemia: The Most Common Monogenic Disorder in Humans

scientific article published on 01 May 2020

Familial defective apolipoprotein B and familial hypobetalipoproteinemia in one family: two neutralizing mutations

scientific article published on 01 May 2008

Familial defective apolipoprotein B versus familial hypercholesterolemia: an assessment of risk.

artículo científico publicado en 2004

Familial hypercholesterolaemia: A global call to arms

artículo científico publicado en 2015

Familial hypercholesterolemia in children

artículo científico publicado en 2004

Familial hypercholesterolemia: current treatment and advances in management

artículo científico publicado en 2008

Family history and cardiovascular risk in familial hypercholesterolemia: data in more than 1000 children

artículo científico publicado en 2003

Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia

artículo científico publicado en 2002

Family history of premature coronary heart disease and risk prediction in the EPIC-Norfolk prospective population study

artículo científico publicado en 2010

Follow-up of children diagnosed with familial hypercholesterolemia in a national genetic screening program

scientific article published on 28 January 2012

Founder mutations in the Netherlands: geographical distribution of the most prevalent mutations in the low-density lipoprotein receptor and apolipoprotein B genes ⬇️

artículo científico publicado el 27 de enero de 2011

Frequent mutation in the ABCC6 gene (R1141X) is associated with a strong increase in the prevalence of coronary artery disease

artículo científico publicado en 2002

From mutation identification to therapy: discovery and origins of the first approved gene therapy in the Western world

artículo científico publicado en 2013

Functional interaction between -629C/A, -971G/A and -1337C/T polymorphisms in the CETP gene is a major determinant of promoter activity and plasma CETP concentration in the REGRESS Study.

artículo científico publicado en 2005

Functionality of sequence variants in the genes coding for the low-density lipoprotein receptor and apolipoprotein B in individuals with inherited hypercholesterolemia

artículo científico publicado en 2010

Future strategies in the management of dyslipidemia

artículo científico publicado en 2005

Gene therapy for lipoprotein lipase deficiency ⬇️

artículo científico publicado el 1 de agosto de 2012

Gene therapy for lipoprotein lipase deficiency: working toward clinical application

artículo científico publicado en 2005

Gene therapy in disorders of lipoprotein metabolism

artículo científico publicado en 2007

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci

artículo científico publicado en 2014

Gene-load score of the renin–angiotensin–aldosterone system is associated with coronary heart disease in familial hypercholesterolaemia

article

Genetic determinants of cardiovascular disease risk in familial hypercholesterolemia

artículo científico publicado en 2005

Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia

artículo científico publicado en 2005

Genetic polymorphisms: importance for response to HMG-CoA reductase inhibitors

artículo científico publicado en 2002

Genetic studies of body mass index yield new insights for obesity biology

artículo científico publicado en 2015

Genetic variant of the scavenger receptor BI in humans

artículo científico publicado en 2011

Genetic variation at the phospholipid transfer protein locus affects its activity and high-density lipoprotein size and is a novel marker of cardiovascular disease susceptibility

artículo científico publicado en 2010

Genetic variation inAPOB,PCSK9, andANGPTL3in carriers of pathogenic autosomal dominant hypercholesterolemic mutations with unexpected low LDL-Cl Levels ⬇️

artículo científico publicado el 22 de diciembre de 2011

Genetics of HDL-C: a causal link to atherosclerosis?

artículo científico

Genome-Wide Association Studies in Atherosclerosis ⬇️

artículo científico publicado el 1 de junio de 2011

Gonadal steroids, gonadotropins and DHEAS in young adults with familial hypercholesterolemia who had initiated statin therapy in childhood

artículo científico publicado en 2015

Guidelines were developed for data collection from medical records for use in retrospective analyses

artículo científico publicado en 2005

HDL cholesterol and residual risk of first cardiovascular events after treatment with potent statin therapy: an analysis from the JUPITER trial

artículo científico

HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events

artículo científico publicado en 2007

HDL particle size and the risk of coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study

artículo científico publicado en 2009

Haplotype analysis of the CETP gene: not TaqIB, but the closely linked -629C-->A polymorphism and a novel promoter variant are independently associated with CETP concentration

artículo científico publicado en 2003

Hepatic and cardiovascular consequences of familial hypobetalipoproteinemia

artículo científico publicado en 2005

Heterozygosity for ABCA1 gene mutations: effects on enzymes, apolipoproteins and lipoprotein particle size

artículo científico publicado en 2003

Heterozygosity for a loss-of-function mutation in GALNT2 improves plasma triglyceride clearance in man.

artículo científico publicado en 2011

Heterozygous familial hypercholesterolaemia in childhood: cardiovascular risk prevention

artículo científico publicado en 2009

High HDL cholesterol does not protect against coronary artery disease when associated with combined cholesteryl ester transfer protein and hepatic lipase gene variants

artículo científico publicado en 2007

High density lipoproteins (HDLs) and atherosclerosis; the unanswered questions

artículo científico publicado en 2003

High prevalence of mutations in LCAT in patients with low HDL cholesterol levels in The Netherlands: identification and characterization of eight novel mutations

artículo científico publicado en 2011

High-density lipoprotein attenuates inflammation and coagulation response on endotoxin challenge in humans

scientific article published on 15 February 2007

High-density lipoprotein cholesterol, high-density lipoprotein particle size, and apolipoprotein A-I: significance for cardiovascular risk: the IDEAL and EPIC-Norfolk studies

artículo científico publicado en 2008

High-density lipoprotein particle size and concentration and coronary risk

artículo científico publicado en 2009

High-density lipoprotein: a fall from grace?

artículo científico publicado en 2008

High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial

artículo científico publicado en 2005

High-dose statin monotherapy versus low-dose statin/ezetimibe combination on fasting and postprandial lipids and endothelial function in obese patients with the metabolic syndrome: The PANACEA study.

artículo científico publicado en 2012

High-dose statin therapy in patients with stable coronary artery disease: treating the right patients based on individualized prediction of treatment effect.

artículo científico

Homozygous autosomal dominant hypercholesterolaemia in the Netherlands: prevalence, genotype-phenotype relationship, and clinical outcome

artículo científico publicado en 2014

Homozygous autosomal dominant hypercholesterolaemia: prevalence, diagnosis, and current and future treatment perspectives

Homozygous autosomal dominant hypercholesterolemia: prevalence, diagnosis, and current and future treatment perspectives

artículo científico

Homozygous familial hypercholesterolaemia: light at the end of the tunnel

artículo científico publicado en 2017

Hormones and cardiovascular disease: a shift in paradigm with clinical consequences?

artículo científico publicado en 2009

IP-0038 A novel apoA-I mutation (Leu178Pro), identified by whole genome linkage approach, predisposes to endothelial dysfunction, increased arterial wall thickness and premature coronary artery disese

Icosabutate for the treatment of very high triglycerides: A placebo-controlled, randomized, double-blind, 12-week clinical trial

artículo científico publicado en 2015

Icosabutate, a Structurally Engineered Fatty Acid, Improves the Cardiovascular Risk Profile in Statin-Treated Patients with Residual Hypertriglyceridemia

artículo científico publicado en 2016

Identification and functional analysis of a naturally occurring E89K mutation in the ABCA1 gene of the WHAM chicken.

artículo científico publicado en 2002

Identification of a loss-of-function inducible degrader of the low-density lipoprotein receptor variant in individuals with low circulating low-density lipoprotein.

artículo científico publicado en 2013

Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach

artículo científico publicado en 2014

Impact of PCSK9 inhibition on coronary atheroma progression: Rationale and design of Global Assessment of Plaque Regression with a PCSK9 Antibody as Measured by Intravascular Ultrasound (GLAGOV).

artículo científico

Impact of statin therapy on coronary plaque composition: a systematic review and meta-analysis of virtual histology intravascular ultrasound studies

artículo científico publicado en 2015

Improved access to life insurance after genetic diagnosis of familial hypercholesterolaemia: cross-sectional postal questionnaire study

artículo científico publicado en 2012

In response to van den Berg et al: on the direct actions of CRP in humans.

artículo científico publicado en 2005

In vivo effects of C-reactive protein (CRP)-infusion into humans

scientific article published on 01 December 2005

In vivo quantification of carotid artery wall dimensions: 3.0-Tesla MRI versus B-mode ultrasound imaging.

artículo científico publicado en 2009

In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1.

artículo científico publicado en 2013

Inclisiran Lowers LDL-C and PCSK9 Irrespective of Diabetes Status: The ORION-1 Randomized Clinical Trial

scientific article published on 28 November 2018

Inclisiran for the Treatment of Heterozygous Familial Hypercholesterolemia

scientific article published on 18 March 2020

Inclisiran for the treatment of hypercholesterolaemia: implications and unanswered questions

artículo científico publicado en 2020

Inclisiran in Patients at High Cardiovascular Risk with Elevated LDL Cholesterol

artículo científico publicado en 2017

Increased carotid and femoral intima-media thickness in patients after repair of aortic coarctation: influence of early repair

scientific article published on 01 January 2006

Increased carotid intima-media thickness in HIV patients treated with protease inhibitors as compared to non-nucleoside reverse transcriptase inhibitors

artículo científico publicado en 2008

Increased coagulation factor VIII activity in patients with familial hypercholesterolemia

scientific article published on 01 December 2011

Increased inflammatory markers in children with familial hypercholesterolaemia

artículo científico publicado en 2006

Increased prevalence of risk factors for cardiovascular disease in long-term survivors of acute lymphoblastic leukemia and Wilms tumor treated with radiotherapy

scientific article published on 01 October 2010

Increased risk of coronary artery disease in Caucasians with extremely low HDL cholesterol due to mutations in ABCA1, APOA1, and LCAT.

artículo científico publicado en 2011

Increasing high-density lipoprotein cholesterol by cholesteryl ester transfer protein-inhibition: a rocky road and lessons learned? The early demise of the dal-HEART programme

artículo científico publicado en 2012

Increasing spatial resolution of 3T MRI scanning improves reproducibility of carotid arterial wall dimension measurements

artículo científico publicado en 2013

Increasing the Spatial Resolution of 3T Carotid MRI Has No Beneficial Effect for Plaque Component Measurement Reproducibility

artículo científico publicado en 2015

Indications that paraoxonase-1 contributes to plasma high density lipoprotein levels in familial hypercholesterolemia

artículo científico publicado en 2004

Inflammatory biomarkers and the prediction of coronary events among people at intermediate risk: the EPIC-Norfolk prospective population study

artículo científico publicado en 2009

Inflammatory biomarkers, physical activity, waist circumference, and risk of future coronary heart disease in healthy men and women

artículo científico publicado en 2009

Influence of LDL-receptor mutation type on age at first cardiovascular event in patients with familial hypercholesterolaemia

artículo científico publicado en 2006

Infusion of a lipid emulsion in healthy men decreases the serotonergic response

scientific article published on 07 February 2012

Inherited disorders of HDL metabolism and atherosclerosis

artículo científico publicado en 2005

Inhibition of cholesterol absorption by the combination of dietary plant sterols and ezetimibe: effects on plasma lipid levels

artículo científico publicado en 2005

Inhibition of lipoprotein-associated phospholipase activity by darapladib: shifting gears in cardiovascular drug development: are antiinflammatory drugs the next frontier?

artículo científico publicado en 2008

Inhibition of secretory phospholipase A(2) in patients with acute coronary syndromes: rationale and design of the vascular inflammation suppression to treat acute coronary syndrome for 16 weeks (VISTA-16) trial

scientific article published on 01 February 2012

Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation

artículo científico publicado en 2013

Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation

article

Integrated guidance on the care of familial hypercholesterolaemia from the International FH Foundation: executive summary.

artículo científico publicado en 2014

Integrated guidance on the care of familial hypercholesterolemia from the International FH Foundation

artículo científico publicado en 2014

Intensive lipid lowering with atorvastatin in patients with coronary heart disease and chronic kidney disease: the TNT (Treating to New Targets) study

artículo científico publicado en 2008

Intensive lipid lowering with atorvastatin in patients with stable coronary disease

artículo científico publicado en 2005

Intensive lipid-lowering with atorvastatin for secondary prevention in patients after coronary artery bypass surgery

artículo científico publicado en 2008

Interaction between a genetic variant of the platelet fibrinogen receptor and fibrinogen levels in determining the risk of cardiovascular events

artículo científico publicado en 2004

Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies

artículo científico publicado en 2012

Intervention to Improve Adherence to Lipid-Lowering Medication and Lipid-Levels in Patients With an Increased Cardiovascular Risk

article

Is Cholesteryl Ester Transfer Protein Inhibition an Effective Strategy to Reduce Cardiovascular Risk? CETP Inhibition as a Strategy to Reduce Cardiovascular Risk: The Pro Case

artículo científico publicado en 2015

Is insulin the preferred compound in lowering glucose levels in patients after a myocardial infarction?

artículo científico publicado en 2009

LDL cholesterol goals and cardiovascular risk during statin treatment: the IDEAL study ⬇️

artículo científico publicado el 8 de febrero de 2011

LDL cholesterol goals in high-risk patients: how low do we go and how do we get there?

artículo científico publicado en 2013

LDL-C-lowering therapy: current and future therapeutic targets

artículo científico publicado en 2008

LOWER, a registry of lomitapide-treated patients with homozygous familial hypercholesterolemia: Rationale and design

artículo científico publicado en 2015

Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT.

artículo científico publicado en 2010

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

artículo científico publicado en 2011

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci

artículo científico publicado en 2012

Levels and changes of HDL cholesterol and apolipoprotein A-I in relation to risk of cardiovascular events among statin-treated patients: a meta-analysis

artículo científico publicado en 2013

Lipid assessment, metabolic syndrome and coronary heart disease risk

artículo científico publicado en 2010

Lipid measures and cardiovascular disease prediction

artículo científico publicado en 2009

Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations

artículo científico publicado en 2012

Lipid parameters for measuring risk of cardiovascular disease ⬇️

artículo científico publicado el 1 de febrero de 2011

Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab

artículo científico publicado en 2017

Lipid-lowering medications

artículo científico publicado en 2004

Lipids and Lipoproteins in 2020

artículo científico publicado en 2020

Lipids, apolipoproteins, and their ratios in relation to cardiovascular events with statin treatment

artículo científico publicado en 2008

Lipoprotein Lipase Gene Polymorphisms and the Risk of Target Vessel Revascularization After Percutaneous Coronary Intervention

article

Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation

artículo científico publicado en 2006

Lipoprotein lipase deficiency--rare or common?

artículo científico publicado en 2002

Lipoprotein predictors of cardiovascular events in statin-treated patients with coronary heart disease. Insights from the Incremental Decrease In End-points Through Aggressive Lipid-lowering Trial (IDEAL).

artículo científico publicado en 2008

Lipoprotein(a) Improves Cardiovascular Risk Prediction Based on Established Risk Algorithms

artículo científico publicado en 2017

Lipoprotein(a) improves cardiovascular risk prediction based on the ACC/AHA and score algorithms in intermediate risk patients; the EPIC-Norfolk prospective population study

artículo científico publicado en 2017

Lipoprotein-associated phospholipase A2 mass and activity in children with heterozygous familial hypercholesterolemia and unaffected siblings: effect of pravastatin

artículo científico publicado en 2010

Local overexpression of C-type natriuretic peptide ameliorates vascular adaptation of porcine hemodialysis grafts

artículo científico publicado en 2004

Loci influencing blood pressure identified using a cardiovascular gene-centric array

artículo científico publicado en 2013

Loci influencing blood pressure identified using a cardiovascular gene-centric array.

artículo científico publicado en 2013

Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia

artículo científico publicado en 2014

Long term efficacy and safety of atorvastatin in the treatment of severe type III and combined dyslipidaemia

artículo científico publicado en 2002

Long term statin treatment reduces lipoprotein(a) concentrations in heterozygous familial hypercholesterolaemia

artículo científico publicado en 2003

Long-term LDL-c lowering in heterozygous familial hypercholesterolemia normalizes carotid intima-media thickness

artículo científico publicado en 2010

Long-term compliance with lipid-lowering medication after genetic screening for familial hypercholesterolemia

artículo científico publicado en 2003

Long-term correction of murine lipoprotein lipase deficiency with AAV1-mediated gene transfer of the naturally occurring LPL(S447X) beneficial mutation

artículo científico publicado en 2004

Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia

artículo científico publicado en 2016

Long-term safety and efficacy of high-dose atorvastatin treatment in patients with familial hypercholesterolemia

artículo científico publicado en 2005

Long-term statin treatment in children with familial hypercholesterolemia: more insight into tolerability and adherence

artículo científico publicado en 2015

Loss of endothelial glycocalyx during acute hyperglycemia coincides with endothelial dysfunction and coagulation activation in vivo.

artículo científico publicado en 2006

Loss of function in heparan sulfate elongation genes EXT1 and EXT 2 results in improved nitric oxide bioavailability and endothelial function

artículo científico publicado en 2014

Low HDL cholesterol levels in type I Gaucher disease do not lead to an increased risk of cardiovascular disease.

artículo científico publicado en 2008

Low-density lipoprotein cholesterol in a global cohort of 57,885 statin-treated patients

artículo científico publicado en 2016

Low-density lipoprotein receptor gene mutations and cardiovascular risk in a large genetic cascade screening population

artículo científico publicado en 2002

Low-density lipoprotein receptor genotype and response to pravastatin in children with familial hypercholesterolemia: substudy of an intima-media thickness trial

artículo científico publicado en 2005

Low-density lipoprotein receptor mutations generate synthetic genome-wide associations

artículo científico publicado en 2012

Management of hereditary dyslipidaemia; the paradigm of autosomal dominant hypercholesterolaemia

artículo científico publicado en 2005

Management of hypercholesterolemia in children

artículo científico publicado en 2014

Maternal inheritance of familial hypercholesterolemia caused by the V408M low-density lipoprotein receptor mutation increases mortality

artículo científico publicado en 2011

Measurement of arterial wall thickness as a surrogate marker for atherosclerosis

artículo científico publicado en 2004

Measurement of subclinical atherosclerosis: beyond risk factor assessment

artículo científico publicado en 2002

Measuring endothelial glycocalyx dimensions in humans: a potential novel tool to monitor vascular vulnerability

artículo científico publicado en 2007

Mendelian Randomization Study of ACLY and Cardiovascular Disease

artículo científico publicado en 2019

Meta-analysis of genome-wide association studies of HDL cholesterol response to statins

artículo científico publicado en 2016

Metabolic and cardiovascular disease: complications and consequences

scientific article published on 01 May 2005

Metabolic dyslipidemia and risk of future coronary heart disease in apparently healthy men and women: the EPIC-Norfolk prospective population study

artículo científico publicado en 2009

Metabolic syndrome and risk of coronary, cerebral, and peripheral vascular disease in a large Dutch population with familial hypercholesterolemia

artículo científico publicado en 2006

Metabolic syndrome and risk of restenosis in patients undergoing percutaneous coronary intervention.

artículo científico publicado en 2005

Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-controlled trial.

artículo científico publicado en 2012

Mo-P6:420 Two novel APOA5 missense mutations in patients with severe hypertriglyceridemia

Mo-W5:2 A gene therapy approach to treat human lipoprotein lipase deficiency

article

Modifying plasma low-density lipoprotein and high-density lipoprotein cholesterol: what combinations are available in the future?

artículo científico publicado en 2005

Molecular basis of autosomal dominant hypercholesterolemia: assessment in a large cohort of hypercholesterolemic children

artículo científico publicado en 2011

Molecular basis of familial hypercholesterolemia

artículo científico publicado en 2017

Molecular screening for familial hypercholesterolaemia: consequences for life and disability insurance

article

Molecular variation at the apolipoprotein B gene locus in relation to lipids and cardiovascular disease: a systematic meta-analysis

artículo científico publicado en 2003

Monocyte gene expression signature of patients with early onset coronary artery disease

artículo científico publicado en 2012

Monotherapy with the PCSK9 inhibitor alirocumab versus ezetimibe in patients with hypercholesterolemia: Results of a 24week, double-blind, randomized Phase 3 trial

article

Moving Targets: Recent Advances in Lipid-Lowering Therapies

artículo científico publicado en 2019

Mutation in KERA identified by linkage analysis and targeted resequencing in a pedigree with premature atherosclerosis

artículo científico publicado en 2014

Mutations in LPL, APOC2, APOA5, GPIHBP1 and LMF1 in patients with severe hypertriglyceridaemia ⬇️

artículo científico publicado el 13 de febrero de 2012

Mutations in STAP1 are associated with autosomal dominant hypercholesterolemia

artículo científico publicado en 2014

Mycophenolate mofetil (MMF): firing at the atherosclerotic plaque from different angles?

artículo científico publicado en 2005

Mycophenolate mofetil attenuates plaque inflammation in patients with symptomatic carotid artery stenosis

artículo científico publicado en 2010

Myeloperoxidase levels are not associated with carotid atherosclerosis progression in patients with familial hypercholesterolemia

scientific article published on 17 September 2007

Nevirapine and efavirenz elicit different changes in lipid profiles in antiretroviral-therapy-naive patients infected with HIV-1

artículo científico publicado en 2004

Nevirapine-containing antiretroviral therapy in HIV-1 infected patients results in an anti-atherogenic lipid profile

artículo científico publicado en 2001

New risk factors for atherosclerosis and patient risk assessment

artículo científico publicado en 2004

New strategies in the treatment of hypercholesterolemia

artículo científico publicado en 2005

Non-HDL cholesterol vs. apo B for risk of coronary heart disease in healthy individuals: the EPIC-Norfolk prospective population study

artículo científico publicado en 2013

Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia.

artículo científico publicado en 2014

Normalization of metabolic syndrome using fenofibrate, metformin or their combination

artículo científico publicado en 2007

Novel lipid modifying drugs to lower LDL cholesterol.

artículo científico publicado en 2017

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

artículo científico publicado en 2012

Novel mutations in scavenger receptor BI associated with high HDL cholesterol in humans

artículo científico publicado en 2011

Number needed to treat with rosuvastatin to prevent first cardiovascular events and death among men and women with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein: justification for the use of statins in prev

artículo científico

ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia

artículo científico publicado en 2015

Obesity and dyslipidemia

artículo científico publicado en 2011

Obesity and dyslipidemia

artículo científico publicado en 2008

Omega-3 free fatty acids for the treatment of severe hypertriglyceridemia: the EpanoVa fOr Lowering Very high triglyceridEs (EVOLVE) trial

artículo científico publicado en 2013

On-treatment lipoprotein components and risk of cerebrovascular events in the Treating to New Targets study ⬇️

artículo científico publicado el 27 de septiembre de 2010

On-treatment non-high-density lipoprotein cholesterol, apolipoprotein B, triglycerides, and lipid ratios in relation to residual vascular risk after treatment with potent statin therapy: JUPITER (justification for the use of statins in prevention: a

artículo científico publicado en 2012

Osteoprotegerin and soluble receptor activator of nuclear factor-kappaB ligand and risk for coronary events: a nested case-control approach in the prospective EPIC-Norfolk population study 1993-2003.

artículo científico publicado en 2009

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC) ⬇️

artículo científico publicado en 2018

Oxidation-specific biomarkers, lipoprotein(a), and risk of fatal and nonfatal coronary events

artículo científico publicado en 2010

Oxidized low-density lipoprotein in children with familial hypercholesterolemia and unaffected siblings: effect of pravastatin

artículo científico publicado en 2006

PCSK9 Inhibitors and Cardiovascular Events

artículo científico publicado en 2015

PCSK9 and resistin at the crossroads of the atherogenic dyslipidemia

artículo científico publicado en 2013

PCSK9 inhibition: the way forward in the treatment of dyslipidemia

artículo científico publicado en 2015

Paraoxonase genotype and carotid intima-media thickness in children with familial hypercholesterolemia

scientific article published on 01 June 2006

Partial recovery of the endothelial glycocalyx upon rosuvastatin therapy in patients with heterozygous familial hypercholesterolemia

artículo científico publicado en 2008

Particulate air pollution, coronary heart disease and individual risk assessment: a general overview

artículo científico publicado en 2009

Patients with low HDL-cholesterol caused by mutations in LCAT have increased arterial stiffness ⬇️

artículo científico publicado el 27 de septiembre de 2012

Patients with premature coronary artery disease who carry the ABCC6 R1141X mutation have no Pseudoxanthoma Elasticum phenotype

scientific article published on 01 April 2005

Persistent lipid abnormalities in statin-treated patients and predictors of LDL-cholesterol goal achievement in clinical practice in Europe and Canada.

artículo científico publicado en 2011

Perturbation of hyaluronan metabolism predisposes patients with type 1 diabetes mellitus to atherosclerosis

artículo científico publicado en 2007

Pharmacodynamic relationship between PCSK9, alirocumab, and LDL-C lowering in the ODYSSEY CHOICE I trial

scientific article published on 25 July 2020

Pharmacoeconomic evaluation of testing for angiotensin-converting enzyme genotype before starting beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor therapy in men.

artículo científico publicado en 2004

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins

artículo científico publicado en 2014

Pharmacogenetics of the CD14 endotoxin receptor polymorphism and progression of coronary atherosclerosis

artículo científico publicado en 2004

Phenotypic variability in familial hypercholesterolaemia: an update

artículo científico publicado en 2002

Physical activity, metabolic syndrome, and coronary risk: the EPIC-Norfolk prospective population study

artículo científico publicado en 2011

Physical activity, the Framingham risk score and risk of coronary heart disease in men and women of the EPIC-Norfolk study

artículo científico publicado en 2009

Physical inactivity, abdominal obesity and risk of coronary heart disease in apparently healthy men and women

artículo científico publicado en 2009

Pink-creamy whole blood in a 3-month-old infant with a homozygous deletion in the lipoprotein lipase gene

scientific article published on 04 January 2010

Plant stanols do not restore endothelial function in pre-pubertal children with familial hypercholesterolemia despite reduction of low-density lipoprotein cholesterol levels

artículo científico publicado en 2006

Plant sterols lower LDL cholesterol without improving endothelial function in prepubertal children with familial hypercholesterolaemia

artículo científico publicado en 2003

Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) trial: a nested case-control study

article

Plasma levels of PCSK9 and phenotypic variability in familial hypercholesterolemia

artículo científico publicado en 2012

Plasma levels of cholesteryl ester transfer protein and the risk of future coronary artery disease in apparently healthy men and women: the prospective EPIC (European Prospective Investigation into Cancer and nutrition)-Norfolk population study

artículo científico publicado en 2004

Plasma levels of lecithin:cholesterol acyltransferase and risk of future coronary artery disease in apparently healthy men and women: a prospective case-control analysis nested in the EPIC-Norfolk population study

artículo científico publicado en 2009

Plasma levels of plant sterols and the risk of coronary artery disease: the prospective EPIC-Norfolk Population Study

artículo científico publicado en 2006

Plasma lipoprotein(a) levels in patients with homozygous autosomal dominant hypercholesterolemia

artículo científico publicado en 2017

Plasma triglycerides and cardiovascular events in the Treating to New Targets and Incremental Decrease in End-Points through Aggressive Lipid Lowering trials of statins in patients with coronary artery disease

artículo científico publicado en 2009

Pleiotropic effects of statins: stabilization of the vulnerable atherosclerotic plaque?

artículo científico publicado en 2007

Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration

artículo científico publicado en 2016

Population pharmacokinetics of rosuvastatin in pediatric patients with heterozygous familial hypercholesterolemia

artículo científico publicado en 2015

Potent reduction of apolipoprotein B and low-density lipoprotein cholesterol by short-term administration of an antisense inhibitor of apolipoprotein B.

artículo científico publicado en 2006

Pre-procedural levels of erythrocyte sedimentation rate (ESR) and risk of clinical restenosis in patients with percutaneous coronary intervention and coronary stent placement.

artículo científico publicado en 2005

Prediction of cardiovascular events in statin-treated stable coronary patients of the treating to new targets randomized controlled trial by lipid and non-lipid biomarkers

artículo científico publicado en 2014

Predictive value of mild, residual descending aortic narrowing for blood pressure and vascular damage in patients after repair of aortic coarctation

scientific article published on 30 November 2004

Pregnancy in women suffering from familial hypercholesterolemia: a harmful period for both mother and newborn?

artículo científico publicado en 2009

Premature atherosclerosis, extremely low HDL-cholesterol and concurrent defects in APOA1 and ABCA1 genes: a family case report

artículo científico publicado en 2014

Premature cardiovascular disease in young women with heterozygous familial hypercholesterolemia

artículo científico publicado en 2006

Prevalence and management of familial hypercholesterolaemia in coronary patients: An analysis of EUROASPIRE IV, a study of the European Society of Cardiology

artículo científico publicado en 2015

Prolactin does not affect human platelet aggregation or secretion

artículo científico publicado en 2009

Prolactin fragmentation by trophoblastic matrix metalloproteinases as a possible contributor to peripartum cardiomyopathy and pre-eclampsia

artículo científico publicado en 2009

Prolactin levels and the risk of future coronary artery disease in apparently healthy men and women

artículo científico publicado en 2009

Proprotein convertase subtilisin/kexin type 9: from genetics to clinical trials

artículo científico publicado en 2018

Proteinuria in early childhood due to familial LCAT deficiency caused by loss of a disulfide bond in lecithin:cholesterol acyl transferase ⬇️

artículo científico publicado el 21 de enero de 2011

Quality assessment of the genetic test for familial hypercholesterolemia in the Netherlands

artículo científico publicado en 2013

RETRACTED: Prediction of Cardiovascular Events in Statin-Treated Stable Coronary Patients by Lipid and Nonlipid Biomarkers ⬇️

artículo científico publicado el 4 de enero de 2011

Raised serum levels of soluble CD40 ligand in patients with familial hypercholesterolemia: downregulatory effect of statin therapy

artículo científico publicado en 2003

Rate of change in carotid intima-media thickness and vascular events: meta-analyses can not solve all the issues. A point of view

artículo científico publicado en 2012

Rationale and design of Apo-I Event Reduction in Ischemic Syndromes I (AEGIS-I): A phase 2b, randomized, placebo-controlled, dose-ranging trial to investigate the safety and tolerability of CSL112, a reconstituted, infusible, human apoA-I, after acu

artículo científico publicado en 2016

Rationale and design of ApoA-I event reducing in ischemic syndromes II (AEGIS-II): A phase 3, multicenter, double-blind, randomized, placebo-controlled, parallel-group study to investigate the efficacy and safety of CSL112 in subjects after acute my

artículo científico publicado en 2020

Rationale and design of dal-VESSEL: a study to assess the safety and efficacy of dalcetrapib on endothelial function using brachial artery flow-mediated vasodilatation

artículo científico

Recent failures in antiatherosclerotic drug development: examples from the thyroxin receptor agonist, the secretory phospholipase A2 antagonist, and the acyl coenzyme A: cholesterol acyltransferase inhibitor programs

artículo científico

Reconstituted HDL infusion restores endothelial function in patients with type 2 diabetes mellitus

artículo científico publicado en 2008

Reduced fecal sterol excretion in subjects with familial hypoalphalipoproteinemia.

artículo científico publicado en 2009

Reducing cardiovascular disease risk in patients with type 2 diabetes and concomitant macrovascular disease: can insulin be too much of a good thing? ⬇️

artículo científico publicado el 1 de diciembre de 2011

Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial

artículo científico

Reduction of low-density lipoprotein cholesterol in patients with coronary heart disease and metabolic syndrome: analysis of the Treating to New Targets study.

artículo científico publicado en 2006

Reduction of monocyte chemoattractant protein 1 and macrophage migration inhibitory factor by a polyphenol-rich extract in subjects with clustered cardiometabolic risk factors

artículo científico publicado en 2011

Refocusing on use of cholesteryl ester transfer protein inhibitors

artículo científico publicado en 2007

Regression of carotid and femoral artery intima-media thickness in familial hypercholesterolemia: treatment with simvastatin

artículo científico publicado en 2003

Relation of Variability of Low-Density Lipoprotein Cholesterol and Blood Pressure to Events in Patients With Previous Myocardial Infarction from the IDEAL Trial

artículo científico publicado en 2016

Relationship between alirocumab, PCSK9, and LDL-C levels in four phase 3 ODYSSEY trials using 75 and 150 mg doses

scientific article published on 14 October 2019

Relationship between atorvastatin dose and the harm caused by torcetrapib ⬇️

artículo científico publicado el 2 de septiembre de 2012

Relationship of IgG and IgM autoantibodies and immune complexes to oxidized LDL with markers of oxidation and inflammation and cardiovascular events: results from the EPIC-Norfolk Study

artículo científico publicado en 2011

Relationship of lipoprotein-associated apolipoprotein C-III with lipid variables and coronary artery disease risk: The EPIC-Norfolk prospective population study

scientific article published on 29 August 2018

Relative risk for cardiovascular atherosclerotic events after smoking cessation: 6-9 years excess risk in individuals with familial hypercholesterolemia

artículo científico publicado en 2006

Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia

artículo científico publicado en 2008

Reply: statin-induced low low-density lipoprotein cholesterol level: is lower better?

artículo científico publicado en 2015

Response by Kusters et al to Letter Regarding Article, "Effect of Rosuvastatin on Carotid Intima-Media Thickness in Children With Heterozygous Familial Hypercholesterolemia: The CHARON Study (Hypercholesterolemia in Children and Adolescents Taking R

artículo científico publicado en 2018

Response to micronized fenofibrate treatment is associated with the peroxisome-proliferator-activated receptors alpha G/C intron7 polymorphism in subjects with type 2 diabetes

artículo científico publicado en 2004

Restoration of endothelial function by increasing high-density lipoprotein in subjects with isolated low high-density lipoprotein

artículo científico publicado en 2003

Results from a rosuvastatin historical cohort study in more than 45 000 Dutch statin users, a PHARMO study

article

Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis

artículo científico publicado en 2011

Risk of new-onset diabetes and cardiovascular risk reduction from high-dose statin therapy in pre-diabetics and non-pre-diabetics: an analysis from TNT and IDEAL

scientific article published on 01 February 2015

Role of plasma adiponectin on the HDL-cholesterol raising effect of atorvastatin in patients with type 2 diabetes

article

Role of the apolipoprotein B-apolipoprotein A-I ratio in cardiovascular risk assessment: a case-control analysis in EPIC-Norfolk

artículo científico publicado en 2007

Rosuvastatin for primary prevention among individuals with elevated high-sensitivity c-reactive protein and 5% to 10% and 10% to 20% 10-year risk. Implications of the Justification for Use of Statins in Prevention: an Intervention Trial Evaluating R

artículo científico

Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial Infarction: The AEGIS-I Trial (ApoA-I Event Reducing in Ischemic Syndromes I).

artículo científico publicado en 2016

Safety and efficacy of Atorvastatin-induced very low-density lipoprotein cholesterol levels in Patients with coronary heart disease (a post hoc analysis of the treating to new targets [TNT] study)

artículo científico publicado en 2007

Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study

artículo científico publicado en 2016

Safety and efficacy of mipomersen in patients with heterozygous familial hypercholesterolemia

scientific article published on 10 November 2018

Safety and tolerability of dalcetrapib

artículo científico publicado en 2009

Safety and tolerability of prolonged-release nicotinic acid in statin-treated patients

artículo científico publicado en 2007

Safety of Very Low Low-Density Lipoprotein Cholesterol Levels With Alirocumab: Pooled Data From Randomized Trials

artículo científico publicado en 2017

Safety of rosuvastatin

artículo científico publicado en 2004

Screening and treatment of familial hypercholesterolemia - Lessons from the past and opportunities for the future (based on the Anitschkow Lecture 2014)

artículo científico publicado en 2015

Segregation of LIPG, CETP, and GALNT2 mutations in Caucasian families with extremely high HDL cholesterol

artículo científico publicado en 2012

Selection of individuals for genetic testing for familial hypercholesterolaemia: development and external validation of a prediction model for the presence of a mutation causing familial hypercholesterolaemia

artículo científico publicado en 2016

Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms

artículo científico publicado en 2009

Serum bilirubin levels in familial hypercholesterolemia: a new risk marker for cardiovascular disease? ⬇️

artículo científico publicado el 23 de junio de 2011

Serum levels of type II secretory phospholipase A2 and the risk of future coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study.

artículo científico publicado en 2005

Serum lipoprotein lipase concentration and risk for future coronary artery disease: the EPIC-Norfolk prospective population study

artículo científico publicado en 2005

Serum myeloperoxidase levels are associated with the future risk of coronary artery disease in apparently healthy individuals: the EPIC-Norfolk Prospective Population Study

artículo científico publicado en 2007

Seven lipoprotein lipase gene polymorphisms, lipid fractions, and coronary disease: a HuGE association review and meta-analysis

artículo científico publicado en 2008

Severe heterozygous familial hypercholesterolemia and risk for cardiovascular disease: a study of a cohort of 14,000 mutation carriers

artículo científico publicado en 2014

Should rosuvastatin be withdrawn from the market?

artículo científico publicado en 2004

Simvastatin with or without ezetimibe in familial hypercholesterolemia

artículo científico publicado en 2008

Statin Initiation During Childhood in Patients With Familial Hypercholesterolemia: Consequences for Cardiovascular Risk

artículo científico publicado en 2016

Statin therapy and secretory phospholipase A₂ in children with heterozygous familial hypercholesterolemia

artículo científico publicado en 2013

Statin therapy with ezetimibe or niacin in high-risk patients

artículo científico publicado en 2009

Statin treatment in children with familial hypercholesterolemia: the younger, the better

artículo científico publicado en 2007

Statin use during pregnancy: a systematic review and meta-analysis

artículo científico publicado en 2012

Statins in Familial Hypercholesterolemia: Consequences for Coronary Artery Disease and All-Cause Mortality

artículo científico publicado en 2016

Steady-state pharmacokinetics of pravastatin in children with familial hypercholesterolaemia

scientific article published on 01 January 2004

Subclinical atherosclerosis as a target of therapy: potential role of statins

artículo científico publicado en 2004

Surrogate markers for atherosclerotic disease

artículo científico publicado en 2005

Surrogate markers in clinical trials--challenges and opportunities

scientific article published on 14 December 2008

Surrogate markers of atherosclerosis: impact of statins

artículo científico publicado en 2003

Sustained changes in lipid profile and macrophage migration inhibitory factor levels after anti-tumour necrosis factor therapy in rheumatoid arthritis

artículo científico publicado en 2008

Targeted exonic sequencing of GWAS loci in the high extremes of the plasma lipids distribution

artículo científico publicado en 2016

Targeting cardiovascular risk in rheumatoid arthritis: a dual role for statins

artículo científico publicado en 2010

Targeting cholesteryl ester transfer protein for the prevention and management of cardiovascular disease

artículo científico publicado en 2006

Ten-year follow-up after initiation of statin therapy in children with familial hypercholesterolemia

artículo científico publicado en 2014

The 719Arg Variant of KIF6 and Cardiovascular Outcomes in Statin-Treated, Stable Coronary Patients of the Treating to New Targets and Incremental Decrease in End Points Through Aggressive Lipid-Lowering Prospective Studies ⬇️

artículo científico publicado el 1 de febrero de 2012

The ACC/AHA 2013 guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: the good the bad and the uncertain: a comparison with ESC/EAS guidelines for the management of dyslipidaemias 2011.

artículo científico publicado en 2014

The CSL112-2001 trial: Safety and tolerability of multiple doses of CSL112 (apolipoprotein A-I [human]), an intravenous formulation of plasma-derived apolipoprotein A-I, among subjects with moderate renal impairment after acute myocardial infarction

artículo científico publicado en 2018

The ENHANCE study and marketing ezetimibe

artículo científico publicado en 2008

The HDL hypothesis: does high-density lipoprotein protect from atherosclerosis?

artículo científico publicado en 2010

The PCSK9 decade ⬇️

artículo científico publicado el 17 de julio de 2012

The Role of Non-HDL Cholesterol in Risk Stratification for Coronary Artery Disease ⬇️

artículo científico publicado el 1 de abril de 2012

The apolipoprotein epsilon4 allele confers additional risk in children with familial hypercholesterolemia

artículo científico publicado en 2003

The cholesteryl ester transfer protein (CETP) TaqIB polymorphism in the cholesterol and recurrent events study: no interaction with the response to pravastatin therapy and no effects on cardiovascular outcome: a prospective analysis of the CETP TaqI

artículo científico publicado en 2004

The contribution of classical risk factors to cardiovascular disease in familial hypercholesterolaemia: data in 2400 patients

artículo científico publicado en 2004

The dyslipidemia of chronic renal disease: effects of statin therapy

artículo científico publicado en 2006

The effect of an apolipoprotein A-I-containing high-density lipoprotein-mimetic particle (CER-001) on carotid artery wall thickness in patients with homozygous familial hypercholesterolemia: The Modifying Orphan Disease Evaluation (MODE) study.

artículo científico publicado en 2015

The effect of statins on cardiovascular outcomes by smoking status: A systematic review and meta-analysis of randomized controlled trials

artículo científico publicado en 2017

The effectiveness of HMG-CoA reductase inhibitors in an elderly population is independent of apolipoprotein E-genotypes.

artículo científico publicado en 2002

The endothelial glycocalyx: a potential barrier between health and vascular disease

artículo científico publicado en 2005

The expression of type III hyperlipoproteinemia: involvement of lipolysis genes

artículo científico publicado en 2008

The genetics of high-density lipoprotein metabolism: clinical relevance for therapeutic approaches

artículo científico publicado en 2009

The hypertriglyceridemic-waist phenotype and the risk of coronary artery disease: results from the EPIC-Norfolk prospective population study

artículo científico publicado en 2010

The impact of statin therapy on plasma levels of von Willebrand factor antigen. Systematic review and meta-analysis of randomised placebo-controlled trials.

artículo científico publicado en 2015

The metabolism of triglyceride-rich lipoproteins revisited: new players, new insight

artículo científico publicado en 2009

The pharmacokinetics and pharmacokinetic/pharmacodynamic relationships of evacetrapib administered as monotherapy or in combination with statins

artículo científico publicado en 2014

The prolactin receptor is expressed in macrophages within human carotid atherosclerotic plaques: a role for prolactin in atherogenesis?

artículo científico publicado en 2010

The relationship between cholesteryl ester transfer protein levels and risk factor profile in patients with familial hypercholesterolemia

artículo científico publicado en 2004

The risk of tendon xanthomas in familial hypercholesterolaemia is influenced by variation in genes of the reverse cholesterol transport pathway and the low-density lipoprotein oxidation pathway

artículo científico publicado en 2009

The role of CETP inhibition in dyslipidemia

artículo científico publicado en 2007

The role of the ABCA1 transporter and cholesterol efflux in familial hypoalphalipoproteinemia

artículo científico publicado en 2003

The significance of femoral intima-media thickness and plaque scoring in the Atorvastatin versus Simvastatin on Atherosclerosis Progression (ASAP) study

artículo científico publicado en 2003

The use of lipid-lowering drug therapy in children and adolescents.

scientific article published on March 2009

The use of statins in people at risk of developing diabetes mellitus: evidence and guidance for clinical practice.

artículo científico

The year in cardiology 2014: prevention

artículo científico publicado en 2015

Thrombospondin-2 polymorphism is associated with a reduced risk of premature myocardial infarction

artículo científico publicado en 2002

Thyroid Hormone Mimetics: the Past, Current Status and Future Challenges

artículo científico publicado en 2016

Time to change the SCORE?

artículo científico publicado en 2017

Tolerability, pharmacokinetics and pharmacodynamics of TA-8995, a selective cholesteryl ester transfer protein (CETP) inhibitor, in healthy subjects

artículo científico publicado en 2014

Total cardiovascular disease burden: comparing intensive with moderate statin therapy insights from the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering) trial

artículo científico publicado en 2009

Treatment of dyslipidaemia in childhood

scientific article published on April 2010

Treatment of low HDL-C subjects with the CETP modulator dalcetrapib increases plasma campesterol only in those without ABCA1 and/or ApoA1 mutations

artículo científico publicado en 2014

Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis

artículo científico

Triglycerides and Cardiovascular Risk ⬇️

artículo científico publicado el 1 de agosto de 2009

Truncation mutations in ABCA1 suppress normal upregulation of full-length ABCA1 by 9-cis-retinoic acid and 22-R-hydroxycholesterol

artículo científico publicado en 2002

Tumor necrosis factor-alpha inhibition protects against endotoxin-induced endothelial glycocalyx perturbation.

artículo científico publicado en 2008

Two Common Haplotypes of the Glucocorticoid Receptor Gene Are Associated with Increased Susceptibility to Cardiovascular Disease in Men with Familial Hypercholesterolemia

article

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol

scientific article published on 18 March 2020

Two novel mutations in apolipoprotein C3 underlie atheroprotective lipid profiles in families

artículo científico publicado en 2013

Two years after molecular diagnosis of familial hypercholesterolemia: majority on cholesterol-lowering treatment but a minority reaches treatment goal

artículo científico publicado en 2010

Two-year efficacy and safety of simvastatin 80 mg in familial hypercholesterolemia (the Examination of Probands and Relatives in Statin Studies With Familial Hypercholesterolemia [ExPRESS FH]).

artículo científico publicado en 2002

Ultrasound imaging techniques for the evaluation of cardiovascular therapies

artículo científico publicado en 2008

Ultrasound protocols to measure carotid intima-media thickness in trials; comparison of reproducibility, rate of progression, and effect of intervention in subjects with familial hypercholesterolemia and subjects with mixed dyslipidemia

artículo científico publicado en 2010

Update of the molecular basis of familial hypercholesterolemia in The Netherlands

artículo científico publicado en 2005

Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia

artículo científico publicado en 2009

Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study

artículo científico publicado en 2007

Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial

artículo científico

Varespladib: targeting the inflammatory face of atherosclerosis ⬇️

artículo científico publicado el 25 de noviembre de 2010

Variants of toll-like receptor 4 modify the efficacy of statin therapy and the risk of cardiovascular events

artículo científico publicado en 2003

Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia

artículo científico publicado en 2005

Vascular disease: meta-regression of CIMT trials-data in, garbage out.

artículo científico publicado en 2011

Vascular effects and safety of dalcetrapib in patients with or at risk of coronary heart disease: the dal-VESSEL randomized clinical trial

artículo científico publicado en 2012

Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials

artículo científico publicado en 2014

What does the future hold for cholesteryl ester transfer protein inhibition?

artículo científico publicado en 2015

What future for combination therapies?

artículo científico publicado en 2003

What promise does PCSK9 hold?

artículo científico publicado en 2005

[Gene Therapy Office; the Potemkin village of the Ministry of Infrastructure and Water Management]

scientific article published on 05 December 2019

Lista de obras de J.J.P. Kastelein

1.W05.3 Common mutations in the lipoprotein lipase gene influence plasma lipids and prevalence of coronary heart disease

20-Year Follow-up of Statins in Children with Familial Hypercholesterolemia

2P-0452 A genetic, biochemical and proteomic approach to dissection of inherited HDL phenotypes in humans

2P-0589 Influence of apolipoprotein E polymorphisms on coronary artery disease and on the efficacy of HMG-CoA reductase inhibitors in men

4P-1046 Restoration of endothelial function by increasing HDL in subjects with isolated low-HDL

4WS26-2 Functional effects of tissue-specific expression of ATP-cassette transporter A1(ABCA1) provide multiple mechanisms for protection against against atherosclerosis

5-Lipoxygenase activating protein (ALOX5AP) gene variants associate with the presence of xanthomas in familial hypercholesterolemia

A Functional Polymorphism in the Glucocorticoid Receptor Gene and Its Relation to Cardiovascular Disease Risk in Familial Hypercholesterolemia

A novel apoA-I mutation (L178P) leads to endothelial dysfunction, increased arterial wall thickness, and premature coronary artery disease

A novel functional polymorphism in the PECAM-1 gene (53G>A) is associated with progression of atherosclerosis in the LOCAT and REGRESS studies.

A randomized trial of rosuvastatin in the prevention of venous thromboembolism

A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis

A review of CETP and its relation to atherosclerosis

A single Ser259Arg mutation in the gene for lipoprotein lipase causes chylomicronemia in Moroccans of Berber ancestry

A single bolus infusion of C-reactive protein increases gluconeogenesis and plasma glucose concentration in humans

A systematic review and meta-analysis of the effect of statins on plasma asymmetric dimethylarginine concentrations

AAV1-LPL(S447X) gene therapy reduces hypertriglyceridemia in apoE2 knock in mice

ABCA1 gene mutations, HDL cholesterol levels, and risk of ischemic heart disease

ABCA1 impacts athero-thrombotic risk and 10-year survival in a contemporary secondary prevention setting

ABCA1 mutation carriers with low high-density lipoprotein cholesterol are characterized by a larger atherosclerotic burden

ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels.

ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis

ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia

ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia: the CAPTIVATE randomized trial.

Achieved LDL cholesterol levels in patients with heterozygous familial hypercholesterolemia: A model that explores the efficacy of conventional and novel lipid-lowering therapy

Achieving lipid goals in real life: the Dutch DISCOVERY study

Activation of inflammation and coagulation after infusion of C-reactive protein in humans

Adeno-associated virus LPL(S447X) gene therapy in LDL receptor knockout mice

Adherence to and dosing of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitors in the general population differs according to apolipoprotein E-genotypes

Adherence to and dosing of statins differs according to apolipoprotein E-genotypes.

Adherence to evidence-based statin guidelines reduces the risk of hospitalizations for acute myocardial infarction by 40%: a cohort study

Adherence-adjusted efficacy with intensive versus standard statin therapy in patients with acute myocardial infarction in the IDEAL study

Adiponectin and risk of coronary heart disease in apparently healthy men and women (from the EPIC-Norfolk Prospective Population Study)

Advanced method for the identification of patients with inherited hypercholesterolemia

Advances in genetics show the need for extending screening strategies for autosomal dominant hypercholesterolaemia ⬇️

Age at repair and left ventricular mass in patients after repair of aortic coarctation

Air pollution as noxious environmental factor in the development of cardiovascular disease.

Alirocumab efficacy in patients with double heterozygous, compound heterozygous, or homozygous familial hypercholesterolemia

An integrated evaluation of endothelial constitutive nitric oxide synthase polymorphisms and coronary artery disease in men.

Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study

Anacetrapib: new hope for cholesteryl ester transfer protein inhibitors in the treatment of dyslipidemia

And then there were acyl coenzyme A:cholesterol acyl transferase inhibitors

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia

Antisense apolipoprotein B therapy: where do we stand?

Antisense oligonucleotides for the treatment of dyslipidaemia ⬇️

ApoA-I induction as a potential cardioprotective strategy: rationale for the SUSTAIN and ASSURE studies.

Apolipoprotein A-I mimetic peptides

Apolipoprotein A-II is inversely associated with risk of future coronary artery disease

Apolipoprotein A-V, triglycerides and risk of coronary artery disease: the prospective Epic-Norfolk Population Study

Apolipoprotein B synthesis inhibition: results from clinical trials

Apolipoprotein C-III Levels and Incident Coronary Artery Disease Risk: The EPIC-Norfolk Prospective Population Study

Apolipoprotein isoform E4 does not increase coronary heart disease risk in carriers of low-density lipoprotein receptor mutations

Apolipoprotein-E polymorphism and response to pravastatin in men with coronary artery disease (REGRESS).

Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and coronary heart disease risk in familial hypercholesterolemia

Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia

Arterial stiffness, endothelial function and microcirculatory reactivity in healthy young males

Assessment of Carotid Atherosclerosis in Normocholesterolemic Individuals With Proven Mutations in the Low-Density Lipoprotein Receptor or Apolipoprotein B Genes ⬇️

Assessment of atherosclerosis: the role of flow-mediated dilatation

Assessment of omega-3 carboxylic acids in statin-treated patients with high levels of triglycerides and low levels of high-density lipoprotein cholesterol: Rationale and design of the STRENGTH trial

Association between familial hypercholesterolemia and prevalence of type 2 diabetes mellitus

Association between increased arterial-wall thickness and impairment in ABCA1-driven cholesterol efflux: an observational study

Association between statin use and plasma D-dimer levels. A systematic review and meta-analysis of randomised controlled trials.

Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk

Association of HDL cholesterol efflux capacity with incident coronary heart disease events: a prospective case-control study

Association of High-Density Lipoprotein-Cholesterol Versus Apolipoprotein A-I With Risk of Coronary Heart Disease: The European Prospective Investigation Into Cancer-Norfolk Prospective Population Study, the Atherosclerosis Risk in Communities Study

Association of Initial and Serial C-Reactive Protein Levels With Adverse Cardiovascular Events and Death After Acute Coronary Syndrome: A Secondary Analysis of the VISTA-16 Trial

Association of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis

Association of Triglyceride-Lowering LPL Variants and LDL-C-Lowering LDLR Variants With Risk of Coronary Heart Disease

Asymptomatic individuals with a positive family history for premature coronary artery disease and elevated coronary calcium scores benefit from statin treatment: a post hoc analysis from the St. Francis Heart Study

Atherogenesis in rheumatology

Atherogenic lipoprotein particle size and concentrations and the effect of pravastatin in children with familial hypercholesterolemia

Atherosclerosis imaging as a benchmark in the development of novel cardiovasular drugs

Atherosclerosis measured by B-mode ultrasonography: effect of statin therapy on disease progression

Atherosclerotic vascular disease in HIV: it is not just antiretroviral therapy that hurts the heart!

Atorvastatin

Baseline characteristics of participants in the JUPITER trial, a randomized placebo-controlled primary prevention trial of statin therapy among individuals with low low-density lipoprotein cholesterol and elevated high-sensitivity C-reactive protein

Baseline cholesterol absorption and the response to ezetimibe/simvastatin therapy: a post-hoc analysis of the ENHANCE trial

Baseline lipid values partly determine the response to high-dose simvastatin in patients with familial hypercholesterolemia. The examination of probands and relatives in Statin studies with familial hypercholesterolemia (ExPRESS FH).