Lista de obras -

A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system.

artículo científico publicado en 2009

A modular approach to the ECVAM principles on test validity.

artículo científico publicado en 2004

A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine

artículo científico publicado en 2007

Acutoxbase, an innovative database for in vitro acute toxicity studies

artículo científico publicado en 2008

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

artículo científico publicado en 2018

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation

artículo científico publicado en 2012

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

artículo científico publicado en 2011

Assessment of an automated in vitro basal cytotoxicity test system based on metabolically-competent cells ⬇️

artículo científico publicado el 20 de diciembre de 2012

Automation of an in vitro cytotoxicity assay used to estimate starting doses in acute oral systemic toxicity tests ⬇️

artículo científico publicado el 21 de marzo de 2012

Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data

artículo científico publicado en 2014

Blood-brain barrier in vitro models and their application in toxicology. The report and recommendations of ECVAM Workshop 49.

artículo científico publicado en 2004

Capturing the applicability of in vitro-in silico membrane transporter data in chemical risk assessment and biomedical research

artículo científico publicado en 2018

Comparison of metabolic stability and metabolite identification of 55 ECVAM/ICCVAM validation compounds between human and rat liver homogenates and microsomes - a preliminary analysis.

artículo científico publicado en 2009

Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics

artículo científico publicado en 2018

Dedication to Dr José-Manuel Zaldívar Comenges (1958-2012).

artículo científico publicado en 2017

Detection of the embryotoxic potential of cyclophosphamide by using a combined system of metabolic competent cells and embryonic stem cells

artículo científico publicado en 2002

Development of a mechanistically-based genetically engineered PC12 cell system to detect p53-mediated cytotoxicity

artículo científico publicado en 2006

Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals.

artículo científico publicado en 2011

Differentiation-Promoting Medium Additives for Hepatocyte Cultivation and Cryopreservation

artículo científico

ECVAM and New Technologies for Toxicity Testing ⬇️

artículo científico publicado el 1 de enero de 2012

ECVAM's response to the changing political environment for alternatives: consequences of the European Union chemicals and cosmetics policies

scientific article published on 01 November 2003

Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects.

artículo científico publicado en 2007

Ensuring the Quality of Stem Cell-Derived In Vitro Models for Toxicity Testing

artículo científico publicado en 2016

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

artículo científico publicado en 2020

Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance

scientific article published on 09 August 2018

Establishment of a Human 3D Tissue-Based Assay for Upper Respiratory Tract Absorption

Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release

artículo científico publicado en 2002

Finding opportunities in the area of Alternative Methods to Animal Testing for Romania and inauguration of the Romanian Center for Alternative Test Methods (ROCAM).

artículo científico publicado en 2015

Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides

artículo científico publicado en 2008

Generation of functional neural artificial tissue from human umbilical cord blood stem cells

artículo científico publicado en 2009

Good Cell Culture Practice for stem cells and stem-cell-derived models.

artículo científico publicado en 2016

Good Cell Culture Practice. ECVAM Good Cell Culture Practice Task Force Report 1

scientific article published on 01 July 2002

Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0) - Draft for stakeholder discussion and call for action

artículo científico publicado en 2020

Good cell culture practices &in vitro toxicology.

artículo científico publicado en 2017

Guidance on good cell culture practice. a report of the second ECVAM task force on good cell culture practice

artículo científico publicado en 2005

Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide

artículo científico publicado en 2006

Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation

artículo científico publicado en 2005

Inter-laboratory evaluation of the response of primary human hepatocyte cultures to model CYP inducers - a European Centre for Validation of Alternative Methods (ECVAM) - funded pre-validation study.

artículo científico publicado en 2009

International Harmonization and Cooperation in the Validation of Alternative Methods

artículo científico publicado en 2016

International validation of novel pyrogen tests based on human monocytoid cells.

artículo científico publicado en 2005

Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.

artículo científico publicado en 2006

Metabolism-mediated neurotoxicity: the significance of genetically engineered cell lines and new three-dimensional cell cultures

artículo científico publicado en 2002

Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54

artículo científico publicado en 2006

Micro-stamped surfaces for the patterned growth of neural stem cells.

artículo científico publicado en 2008

New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment

scientific article published on 08 June 2020

Overcoming barriers to validation of non-animal partial replacement methods/Integrated Testing Strategies: the report of an EPAA-ECVAM workshop.

artículo científico publicado en 2009

PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop

artículo científico publicado en 2013

Patterned growth and differentiation of human cord blood-derived neural stem cells on bio-functionalized surfaces

artículo científico publicado en 2009

Physiologically-based Kinetic Modelling (PBK Modelling): meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63

scientific article published on 01 December 2007

Practical Aspects of Designing and Conducting Validation Studies Involving Multi-study Trials

artículo científico publicado en 2016

Proposal for a Brazilian centre on alternative test methods.

artículo científico publicado en 2009

Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered

artículo científico publicado en 2008

Report of the EPAA-ECVAM workshop on the validation of Integrated Testing Strategies (ITS).

artículo científico publicado en 2012

Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model ⬇️

artículo científico publicado el 17 de noviembre de 2011

Stem cell-derived systems in toxicology assessment

artículo científico publicado en 2015

Strategies to replace in vivo acute systemic toxicity testing. The report and recommendations of ECVAM Workshop 50

artículo científico publicado en 2004

Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles

artículo científico publicado en 2005

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

scientific article published on 01 January 2019

Testing Methods and Toxicity Assessment (Including Alternatives)

article

The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58.

artículo científico publicado en 2006

The value of alternative testing for neurotoxicity in the context of regulatory needs ⬇️

artículo científico publicado el 24 de agosto de 2005

Three-dimensional HepaRG model as an attractive tool for toxicity testing

artículo científico publicado en 2012

Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project

artículo científico publicado en 2011

Towards harmonization of test methods for in vitro hepatic clearance studies

scientific article published on 20 November 2019

Toxicokinetics and metabolism

artículo científico publicado en 2005

Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches

artículo científico

Validation of Alternative In Vitro Methods to Animal Testing: Concepts, Challenges, Processes and Tools

artículo científico publicado en 2016

Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study

scientific article published on 31 May 2019

What is understood by "animal-free research"?

artículo científico publicado en 2019

Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies

artículo científico publicado en 2007

mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach

artículo científico publicado en 2009

Lista de obras de

A human stem cell-based model for identifying adverse effects of organic and inorganic chemicals on the developing nervous system.

A modular approach to the ECVAM principles on test validity.

A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine

Acutoxbase, an innovative database for in vitro acute toxicity studies

Advanced Good Cell Culture Practice for human primary, stem cell-derived and organoid models as well as microphysiological systems

Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation

Alternative (non-animal) methods for cosmetics testing: current status and future prospects-2010.

Assessment of an automated in vitro basal cytotoxicity test system based on metabolically-competent cells ⬇️

Automation of an in vitro cytotoxicity assay used to estimate starting doses in acute oral systemic toxicity tests ⬇️

Biotransformation in vitro: An essential consideration in the quantitative in vitro-to-in vivo extrapolation (QIVIVE) of toxicity data

Blood-brain barrier in vitro models and their application in toxicology. The report and recommendations of ECVAM Workshop 49.

Capturing the applicability of in vitro-in silico membrane transporter data in chemical risk assessment and biomedical research

Comparison of metabolic stability and metabolite identification of 55 ECVAM/ICCVAM validation compounds between human and rat liver homogenates and microsomes - a preliminary analysis.

Cytochrome P450 Induction and Xeno-Sensing Receptors Pregnane X Receptor, Constitutive Androstane Receptor, Aryl Hydrocarbon Receptor and Peroxisome Proliferator-Activated Receptor α at the Crossroads of Toxicokinetics and Toxicodynamics

Dedication to Dr José-Manuel Zaldívar Comenges (1958-2012).

Detection of the embryotoxic potential of cyclophosphamide by using a combined system of metabolic competent cells and embryonic stem cells

Development of a mechanistically-based genetically engineered PC12 cell system to detect p53-mediated cytotoxicity

Developmental neurotoxicity testing: recommendations for developing alternative methods for the screening and prioritization of chemicals.

Differentiation-Promoting Medium Additives for Hepatocyte Cultivation and Cryopreservation

ECVAM and New Technologies for Toxicity Testing ⬇️

ECVAM's response to the changing political environment for alternatives: consequences of the European Union chemicals and cosmetics policies

Electrophysiological recording of re-aggregating brain cell cultures on multi-electrode arrays to detect acute neurotoxic effects.

Ensuring the Quality of Stem Cell-Derived In Vitro Models for Toxicity Testing

Erratum to Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance

Establishment of a Human 3D Tissue-Based Assay for Upper Respiratory Tract Absorption

Evaluation and prevalidation of an immunotoxicity test based on human whole-blood cytokine release

Finding opportunities in the area of Alternative Methods to Animal Testing for Romania and inauguration of the Romanian Center for Alternative Test Methods (ROCAM).

Gene expression as a sensitive endpoint to evaluate cell differentiation and maturation of the developing central nervous system in primary cultures of rat cerebellar granule cells (CGCs) exposed to pesticides

Generation of functional neural artificial tissue from human umbilical cord blood stem cells

Good Cell Culture Practice for stem cells and stem-cell-derived models.

Good Cell Culture Practice. ECVAM Good Cell Culture Practice Task Force Report 1

Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0) - Draft for stakeholder discussion and call for action

Good cell culture practices &in vitro toxicology.

Guidance on good cell culture practice. a report of the second ECVAM task force on good cell culture practice

Highly purified lipoteichoic acid induced pro-inflammatory signalling in primary culture of rat microglia through Toll-like receptor 2: selective potentiation of nitric oxide production by muramyl dipeptide

Inflammatory neurodegeneration induced by lipoteichoic acid from Staphylococcus aureus is mediated by glia activation, nitrosative and oxidative stress, and caspase activation

Inter-laboratory evaluation of the response of primary human hepatocyte cultures to model CYP inducers - a European Centre for Validation of Alternative Methods (ECVAM) - funded pre-validation study.

International Harmonization and Cooperation in the Validation of Alternative Methods

International validation of novel pyrogen tests based on human monocytoid cells.

Meeting report: Validation of toxicogenomics-based test systems: ECVAM-ICCVAM/NICEATM considerations for regulatory use.

Metabolism-mediated neurotoxicity: the significance of genetically engineered cell lines and new three-dimensional cell cultures

Metabolism: a bottleneck in in vitro toxicological test development. The report and recommendations of ECVAM workshop 54

Micro-stamped surfaces for the patterned growth of neural stem cells.

New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment

Overcoming barriers to validation of non-animal partial replacement methods/Integrated Testing Strategies: the report of an EPAA-ECVAM workshop.

PBTK modelling platforms and parameter estimation tools to enable animal-free risk assessment: recommendations from a joint EPAA--EURL ECVAM ADME workshop

Patterned growth and differentiation of human cord blood-derived neural stem cells on bio-functionalized surfaces

Physiologically-based Kinetic Modelling (PBK Modelling): meeting the 3Rs agenda. The report and recommendations of ECVAM Workshop 63

Practical Aspects of Designing and Conducting Validation Studies Involving Multi-study Trials

Proposal for a Brazilian centre on alternative test methods.

Relevance of in vitro neurotoxicity testing for regulatory requirements: challenges to be considered

Report of the EPAA-ECVAM workshop on the validation of Integrated Testing Strategies (ITS).

Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model ⬇️

Stem cell-derived systems in toxicology assessment

Strategies to replace in vivo acute systemic toxicity testing. The report and recommendations of ECVAM Workshop 50

Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles

Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data

Testing Methods and Toxicity Assessment (Including Alternatives)

The principles of weight of evidence validation of test methods and testing strategies. The report and recommendations of ECVAM workshop 58.

The value of alternative testing for neurotoxicity in the context of regulatory needs ⬇️

Three-dimensional HepaRG model as an attractive tool for toxicity testing

Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project

Towards harmonization of test methods for in vitro hepatic clearance studies

Toxicokinetics and metabolism

Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches

Validation of Alternative In Vitro Methods to Animal Testing: Concepts, Challenges, Processes and Tools

Validation of in vitro methods for human cytochrome P450 enzyme induction: Outcome of a multi-laboratory study

What is understood by "animal-free research"?

Workgroup report: incorporating in vitro alternative methods for developmental neurotoxicity into international hazard and risk assessment strategies

mRNA expression is a relevant tool to identify developmental neurotoxicants using an in vitro approach