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AP39, A Mitochondrially Targeted Hydrogen Sulfide Donor, Exerts Protective Effects in Renal Epithelial Cells Subjected to Oxidative Stress in Vitro and in Acute Renal Injury in Vivo

artículo científico publicado en 2015

AP39, a mitochondrially targeted hydrogen sulfide donor, exerts protective effects in a rat model of renal ischemia–reperfusion

article published in 2015

AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

artículo científico publicado en 2014

Age-dependent deficiency in import of mitochondrial DNA glycosylases required for repair of oxidatively damaged bases

artículo científico publicado en 2003

Age-dependent modulation of DNA repair enzymes by covalent modification and subcellular distribution

artículo científico publicado en 2004

Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair

artículo científico publicado en 2011

Deficiency in repair of the mitochondrial genome sensitizes proliferating myoblasts to oxidative damage

artículo científico publicado en 2013

Effect of aging on intracellular distribution of abasic (AP) endonuclease 1 in the mouse liver

scientific article published on 01 October 2005

Effects of the Poly(ADP-Ribose) Polymerase Inhibitor Olaparib in Cerulein-Induced Pancreatitis

scientific article published on 02 July 2019

Hydrogen Sulfide Is an Endogenous Stimulator of Mitochondrial DNA Repair

Hydrogen sulfide attenuates cytokine production through the modulation of chromatin remodeling.

artículo científico publicado en 2015

Identification and characterization of mitochondrial abasic (AP)-endonuclease in mammalian cells

artículo científico publicado en 2006

Intracellular trafficking and regulation of mammalian AP-endonuclease 1 (APE1), an essential DNA repair protein.

artículo científico publicado en 2006

Long patch base excision repair in mammalian mitochondrial genomes

artículo científico publicado en 2008

Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells

artículo científico publicado en 2018

Mitochondrial poly(ADP-ribose) polymerase: The Wizard of Oz at work

artículo científico publicado en 2016

Novel Mitochondria-Targeted Hydrogen Sulfide (H2S) Donors AP39 and AP123 Attenuate Hyperglycaemia-Induced Oxidative Stress and Loss of Bioenergetics in Microvascular Endothelial Cells

Obesity and Hepatosteatosis in Mice with Enhanced Oxidative DNA Damage Processing in Mitochondria ⬇️

artículo científico publicado el 1 de abril de 2011

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function

artículo científico publicado en 2014

P21

scholarly article

P22

Regulation of mitochondrial poly(ADP-Ribose) polymerase activation by the β-adrenoceptor/cAMP/protein kinase A axis during oxidative stress

artículo científico publicado en 2014

Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3'-phosphatase in maintenance of mitochondrial genome

artículo científico publicado en 2011

The PARP inhibitor olaparib exerts beneficial effects in mice subjected to cecal ligature and puncture and in cells subjected to oxidative stress without impairing DNA integrity: A potential opportunity for repurposing a clinically used oncological

artículo científico publicado en 2019

Upregulation and mitochondrial sequestration of hemoglobins occurs in circulating leukocytes during critical illness, conferring a cytoprotective phenotype

artículo científico publicado en 2015

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