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ATM alters the otherwise robust chromatin mobility at sites of DNA double-strand breaks (DSBs) in human cells.

artículo científico publicado en 2014

ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control

artículo científico publicado en 2011

ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through Exonuclease 1.

artículo científico publicado en 2015

Application of fluorescence lifetime imaging microscopy of DNA binding dyes to assess radiation-induced chromatin compaction changes

scholarly article by Elham Abdollahi published in August 2018

Aprataxin, a novel protein that protects against genotoxic stress

artículo científico publicado en 2004

Aprataxin, poly-ADP ribose polymerase 1 (PARP-1) and apurinic endonuclease 1 (APE1) function together to protect the genome against oxidative damage.

artículo científico publicado en 2009

Autophosphorylation and ATM activation: additional sites add to the complexity

artículo científico publicado en 2010

Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

artículo científico publicado en 2007

Biophysical modeling of fragment length distributions of DNA plasmids after X and heavy-ion irradiation analyzed by atomic force microscopy

artículo científico publicado en 2008

CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response

artículo científico publicado en 2010

Carbon ion radiotherapy of human lung cancer attenuates HIF-1 signaling and acts with considerably enhanced therapeutic efficiency

artículo científico publicado en 2013

Clustered DNA damage concentrated in particle trajectories causes persistent large-scale rearrangements in chromatin architecture

artículo científico publicado en 2018

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA-PK

artículo científico publicado en 2013

Clustered double-strand breaks in heterochromatin perturb DNA repair after high linear energy transfer irradiation

artículo científico publicado en 2016

Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells.

artículo científico publicado en 2011

DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

artículo científico publicado el 21 de abril de 2011

DNA end resection is needed for the repair of complex lesions in G1-phase human cells

artículo científico publicado en 2014

Different mechanisms of cell death in radiosensitive and radioresistant p53 mutated head and neck squamous cell carcinoma cell lines exposed to carbon ions and x-rays

artículo científico publicado en 2009

Differential Repair Protein Recruitment at Sites of Clustered and Isolated DNA Double-Strand Breaks Produced by High-Energy Heavy Ions

scientific article published on 29 January 2020

Direct visualisation of heavy ion induced DNA fragmentation using atomic force microscopy

artículo científico publicado en 2004

Efficient Rejoining of DNA Double-Strand Breaks despite Increased Cell-Killing Effectiveness following Spread-Out Bragg Peak Carbon-Ion Irradiation

artículo científico

Factors determining DNA double-strand break repair pathway choice in G2 phase

scientific journal article

Genome-wide multi-parametric analysis of H2AX or γH2AX distributions during ionizing radiation-induced DNA damage response.

artículo científico publicado en 2013

Identification of the elementary structural units of the DNA damage response.

artículo científico publicado en 2017

Impact of Charged Particle Exposure on Homologous DNA Double-Strand Break Repair in Human Blood-Derived Cells.

artículo científico publicado en 2015

Impact of carbon ion irradiation on epidermal growth factor receptor signaling and glioma cell migration in comparison to conventional photon irradiation

artículo científico publicado el 21 de febrero de 2013

Increased effectiveness of carbon ions in the production of reactive oxygen species in normal human fibroblasts.

artículo científico publicado en 2014

Live Cell Imaging to Study Real-Time ATM-Mediated Recruitment of DNA Repair Complexes to Sites of Ionizing Radiation-Induced DNA Damage

artículo científico publicado en 2017

Nanolesions induced by heavy ions in human tissues: Experimental and theoretical studies

artículo científico publicado en 2012

Nanoscale analysis of clustered DNA damage after high-LET irradiation by quantitative electron microscopy--the heavy burden to repair

artículo científico publicado en 2015

Nucleolar localization of aprataxin is dependent on interaction with nucleolin and on active ribosomal DNA transcription

artículo científico publicado en 2006

Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments.

artículo científico publicado en 2013

PCNA-dependent accumulation of CDKN1A into nuclear foci after ionizing irradiation.

artículo científico publicado en 2012

Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase

artículo científico publicado en 2015

Quantification of chemiluminescent signals using photon-sensitive films or a CCD camera

artículo científico publicado en 2003

Reduced contribution of thermally labile sugar lesions to DNA double strand break formation after exposure to heavy ions

artículo científico publicado en 2013

SFM studies of carbon ion induced damages in plasmid DNA

scientific article published on 01 November 2007

Spatiotemporal dynamics of early DNA damage response proteins on complex DNA lesions

artículo científico publicado en 2013

Species conserved DNA damage response at the inactive human X chromosome

artículo científico publicado en 2013

Targeted irradiation of Mammalian cells using a heavy-ion microprobe.

artículo científico publicado en 2006

The absence of an early calcium response to heavy-ion radiation in Mammalian cells.

artículo científico publicado en 2008

The link between cell-cycle dependent radiosensitivity and repair pathways: a model based on the local, sister-chromatid conformation dependent switch between NHEJ and HR.

artículo científico publicado en 2015

Three-dimensional invasion of human glioblastoma cells remains unchanged by X-ray and carbon ion irradiation in vitro

artículo científico publicado en 2012

Tissue slice cultures from humans or rodents: a new tool to evaluate biological effects of heavy ions

artículo científico publicado en 2010

Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or (12)C heavy ions.

artículo científico publicado en 2010

Upgrading the GSI beamline microscope with a confocal fluorescence lifetime scanner to monitor charged particle induced chromatin decondensation in living cells

article

p53-independent early and late apoptosis is mediated by ceramide after exposure of tumor cells to photon or carbon ion irradiation

artículo científico publicado el 25 de marzo de 2013