Lista de obras -

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

artículo científico publicado en 2016

A WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptide

artículo científico publicado en 2014

A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.

artículo científico publicado en 2010

A dramatic lung cancer course in a patient with a rare EGFR germline mutation exon 21 V843I: Is EGFR TKI resistance predictable?

artículo científico publicado en 2013

A natural structural variant of the mouse TCR beta-chain displays intrinsic receptor function and antigen specificity.

artículo científico publicado en 2006

A novel population of human melanoma-specific CD8 T cells recognizes Melan-AMART-1 immunodominant nonapeptide but not the corresponding decapeptide

artículo científico publicado en 2007

Access of extracellular cations to their binding sites in Na,K-ATPase: role of the second extracellular loop of the alpha subunit

artículo científico publicado en 2006

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

artículo científico publicado en 2014

Attracting cavities for docking. Replacing the rough energy landscape of the protein by a smooth attracting landscape

artículo científico publicado en 2015

BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination

artículo científico publicado en 2010

Blind docking of 260 protein-ligand complexes with EADock 2.0.

artículo científico publicado en 2009

CD3 delta establishes a functional link between the T cell receptor and CD8

artículo científico publicado en 2003

CD73 expression and clinical significance in human metastatic melanoma.

artículo científico publicado en 2018

CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers

artículo científico publicado en 2005

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

artículo científico

Combined Simulation and Mutagenesis Analyses Reveal the Involvement of Key Residues for Peroxisome Proliferator-activated Receptorα Helix 12 Dynamic Behavior

artículo científico publicado en 2007

Combining talimogene laherparepvec with immunotherapies in melanoma and other solid tumors

artículo científico publicado en 2017

Comparison between computational alanine scanning and per-residue binding free energy decomposition for protein-protein association using MM-GBSA: application to the TCR-p-MHC complex

artículo científico publicado en 2007

Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies.

artículo científico publicado en 2016

Design of short peptides to block BTLA/HVEM interactions for promoting anticancer T-cell responses

artículo científico publicado en 2017

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

artículo científico publicado en 2014

Distinct sets of alphabeta TCRs confer similar recognition of tumor antigen NY-ESO-1157-165 by interacting with its central Met/Trp residues

artículo científico publicado en 2008

Disulfide-Linked Peptides for Blocking BTLA/HVEM Binding

scientific article published on 18 January 2020

Docking to heme proteins.

artículo científico publicado en 2009

Docking, virtual high throughput screening and in silico fragment-based drug design

artículo científico publicado en 2009

Dramatic response of vemurafenib-induced cutaneous lesions upon switch to dual BRAF/MEK inhibition in a metastatic melanoma patient.

artículo científico publicado en 2014

Drug Design Workshop: A Web-Based Educational Tool To Introduce Computer-Aided Drug Design to the General Public

article by Antoine Daina et al published 27 February 2017 in Journal of Chemical Education

EADock: docking of small molecules into protein active sites with a multiobjective evolutionary optimization.

artículo científico publicado en 2007

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

artículo científico publicado en 2011

Expanding molecular modeling and design tools to non-natural sidechains

artículo científico publicado en 2012

Fast docking using the CHARMM force field with EADock DSS.

artículo científico publicado en 2011

Fifteen years SIB Swiss Institute of Bioinformatics: life science databases, tools and support

artículo científico publicado en 2014

Fourier transform convolution integrals applied to generalized Born molecular volume

artículo científico publicado en 2010

Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab

artículo científico publicado en 2013

Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition.

artículo científico publicado en 2009

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

artículo científico publicado en 2016

Guillain-Barré syndrome after adoptive cell therapy with tumor-infiltrating lymphocytes

artículo científico publicado en 2020

Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

artículo científico publicado en 2010

How T cell receptors interact with peptide‐MHCs: A multiple steered molecular dynamics study ⬇️

artículo científico publicado el 30 de agosto de 2011

Identification of human IKK-2 inhibitors of natural origin (Part II): in Silico prediction of IKK-2 inhibitors in natural extracts with known anti-inflammatory activity

scientific article published on 22 September 2011

Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays

artículo científico publicado en 2011

Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression

artículo científico publicado en 2013

Immunogenicity of the carcinoembryonic antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma patients

artículo científico publicado en 2007

Impact of orthologous melan-A peptide immunizations on the anti-self melan-A/HLA-A2 T cell cross-reactivity

artículo científico publicado en 2006

Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids

artículo científico publicado en 2013

In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1.

artículo científico publicado en 2008

In-Vivo Detection and Tracking of T Cells in Various Organs in a Melanoma Tumor Model by 19F-Fluorine MRS/MRI.

artículo científico publicado en 2016

Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+ T Cell Responsiveness ⬇️

artículo científico publicado el 29 de junio de 2012

Intratumoural immunotherapies for unresectable and metastatic melanoma: current status and future perspectives

artículo científico publicado en 2020

Local alignment refinement using structural assessment

artículo científico publicado en 2008

Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib.

artículo científico publicado en 2013

MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial

artículo científico publicado en 2014

MedCo: Enabling Secure and Privacy-Preserving Exploration of Distributed Clinical and Genomic Data

artículo científico publicado en 2018

Multiple nivolumab-induced CNS demyelination with spontaneous resolution in an asymptomatic metastatic melanoma patient

scientific article published on 02 December 2019

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

artículo científico publicado en 2017

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patients

artículo científico publicado en 2012

Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators.

artículo científico publicado en 2007

Persistence of EBV antigen-specific CD8 T cell clonotypes during homeostatic immune reconstitution in cancer patients

artículo científico publicado en 2013

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.

artículo científico publicado en 2018

Phase I, open-label study of pasireotide in patients with BRAF-wild type and NRAS-wild type, unresectable and/or metastatic melanoma

scientific article published on 23 July 2018

Prediction of cross-recognition of peptide-HLA A2 by Melan-A-specific cytotoxic T lymphocytes using three-dimensional quantitative structure-activity relationships

artículo científico publicado en 2013

Predictive value of the MGMT promoter methylation status in metastatic melanoma patients receiving first-line temozolomide plus bevacizumab in the trial SAKK 50/07 ⬇️

artículo científico publicado el 18 de mayo de 2012

Pulmonary sarcoid-like granulomatosis induced by ipilimumab.

artículo científico publicado en 2012

Quantification of the next-generation oral anti-tumor drugs dabrafenib, trametinib, vemurafenib, cobimetinib, pazopanib, regorafenib and two metabolites in human plasma by liquid chromatography-tandem mass spectrometry.

artículo científico publicado en 2018

RNA pentaloop structures as effective targets of regulators belonging to the RsmA/CsrA protein family

artículo científico publicado en 2013

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.

artículo científico publicado en 2012

Rational design of indoleamine 2,3-dioxygenase inhibitors

artículo científico publicado en 2010

SHP-1 phosphatase activity counteracts increased T cell receptor affinity

artículo científico publicado en 2013

SPHN/PHRT - MedCo in Action: Empowering the Swiss Molecular Tumor Board with Privacy-Preserving and Real-Time Patient Discovery

artículo científico publicado en 2020

Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer

artículo científico publicado en 2018

Sequence determinants of a microtubule tip localization signal (MtLS).

artículo científico publicado en 2012

Shaping the interaction landscape of bioactive molecules.

artículo científico publicado en 2013

Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes ⬇️

artículo científico publicado el 29 de agosto de 2011

Structural and functional interaction sites between Na,K-ATPase and FXYD proteins.

artículo científico publicado en 2004

Structural prediction of peptides bound to MHC class I.

artículo científico publicado en 2005

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

artículo científico publicado en 2017

SwissDock, a protein-small molecule docking web service based on EADock DSS

artículo científico publicado en 2011

SwissParam: A fast force field generation tool for small organic molecules

artículo científico publicado en 2011

SwissSidechain: a molecular and structural database of non-natural sidechains

artículo científico publicado en 2012

SwissSimilarity: A Web Tool for Low to Ultra High Throughput Ligand-Based Virtual Screening

artículo científico publicado en 2016

SwissTargetPrediction: a web server for target prediction of bioactive small molecules

artículo científico publicado en 2014

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

artículo científico publicado en 2019

T-cell receptors binding orientation over peptide/MHC class I is driven by long-range interactions

artículo científico publicado en 2012

TCRep 3D: an automated in silico approach to study the structural properties of TCR repertoires

artículo científico publicado en 2011

The Binding Mode of N-Hydroxyamidines to Indoleamine 2,3-Dioxygenase 1 (IDO1).

artículo científico

The T-Cell Receptor Can Bind to the Peptide-Bound Major Histocompatibility Complex and Uncomplexed β2-Microglobulin through Distinct Binding Sites.

artículo científico publicado en 2017

The caveolin-binding motif of the pathogen-related yeast protein Pry1, a member of the CAP protein superfamily, is required for in vivo export of cholesteryl acetate.

artículo científico publicado en 2014

The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis

artículo científico publicado en 2007

The fourth extracellular loop of the alpha subunit of Na,K-ATPase. Functional evidence for close proximity with the second extracellular loop

artículo científico publicado en 2008

The fourth transmembrane segment of the Na,K-ATPase alpha subunit: a systematic mutagenesis study

artículo científico publicado en 2004

The peroxisomal enzyme L-PBE is required to prevent the dietary toxicity of medium-chain fatty acids

artículo científico publicado en 2013

Trametinib Induces the Stabilization of a Dual GNAQ p.Gly48Leu- and FGFR4 p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology

scientific article published on 28 October 2020

Use of the FACTS solvation model for protein-ligand docking calculations. Application to EADock.

artículo científico publicado en 2010

Vaccination with LAG-3Ig (IMP321) and Peptides Induces Specific CD4 and CD8 T-Cell Responses in Metastatic Melanoma Patients--Report of a Phase I/IIa Clinical Trial

artículo científico publicado en 2015

Vaccination with long NY-ESO-1 79-108 peptide and CpG-B leads to robust activation of CD4 and CD8 T cell responses in stage III/IV melanoma patients, and a new HLA-DR7 epitope.

artículo científico publicado en 2015

Vaccination-induced functional competence of circulating human tumor-specific CD8 T-cells.

artículo científico publicado en 2011

[Advances in Oncology 2019]

scientific article published on 01 January 2020

[Cardiotoxicity of immune checkpoint inhibitors used in cancer treatment]

artículo científico publicado en 2020

[ENT management of head and neck cutaneous melanoma]

scientific article published on 01 October 2020

[Genomics medicine and oncology]

artículo científico publicado en 2014

[Locally advanced and metastatic melanoma : novelties]

artículo científico publicado en 2020

[New therapeutic weapons in stage IV melanoma]

[Oncology, what's new in 2018]

scientific article published on 01 January 2019

[Principles of adoptive cell therapy based on "Tumor Infiltrating Lymphocytes"].

artículo científico publicado en 2016

iLOGP: a simple, robust, and efficient description of n-octanol/water partition coefficient for drug design using the GB/SA approach

artículo científico publicado en 2014

Lista de obras de

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

A WXW motif is required for the anticancer activity of the TAT-RasGAP317-326 peptide

A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.

A dramatic lung cancer course in a patient with a rare EGFR germline mutation exon 21 V843I: Is EGFR TKI resistance predictable?

A natural structural variant of the mouse TCR beta-chain displays intrinsic receptor function and antigen specificity.

A novel population of human melanoma-specific CD8 T cells recognizes Melan-AMART-1 immunodominant nonapeptide but not the corresponding decapeptide

Access of extracellular cations to their binding sites in Na,K-ATPase: role of the second extracellular loop of the alpha subunit

Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response.

Attracting cavities for docking. Replacing the rough energy landscape of the protein by a smooth attracting landscape

BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination

Blind docking of 260 protein-ligand complexes with EADock 2.0.

CD3 delta establishes a functional link between the T cell receptor and CD8

CD73 expression and clinical significance in human metastatic melanoma.

CD8+ cytotoxic T lymphocyte activation by soluble major histocompatibility complex-peptide dimers

Challenges in the Discovery of Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Combined Simulation and Mutagenesis Analyses Reveal the Involvement of Key Residues for Peroxisome Proliferator-activated Receptorα Helix 12 Dynamic Behavior

Combining talimogene laherparepvec with immunotherapies in melanoma and other solid tumors

Comparison between computational alanine scanning and per-residue binding free energy decomposition for protein-protein association using MM-GBSA: application to the TCR-p-MHC complex

Design and Validation of a Novel Generic Platform for the Production of Tetravalent IgG1-like Bispecific Antibodies.

Design of short peptides to block BTLA/HVEM interactions for promoting anticancer T-cell responses

Detailed analysis and follow-up studies of a high-throughput screening for indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors.

Distinct sets of alphabeta TCRs confer similar recognition of tumor antigen NY-ESO-1157-165 by interacting with its central Met/Trp residues

Disulfide-Linked Peptides for Blocking BTLA/HVEM Binding

Docking to heme proteins.

Docking, virtual high throughput screening and in silico fragment-based drug design

Dramatic response of vemurafenib-induced cutaneous lesions upon switch to dual BRAF/MEK inhibition in a metastatic melanoma patient.

Drug Design Workshop: A Web-Based Educational Tool To Introduce Computer-Aided Drug Design to the General Public

EADock: docking of small molecules into protein active sites with a multiobjective evolutionary optimization.

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

Expanding molecular modeling and design tools to non-natural sidechains

Fast docking using the CHARMM force field with EADock DSS.

Fifteen years SIB Swiss Institute of Bioinformatics: life science databases, tools and support

Fourier transform convolution integrals applied to generalized Born molecular volume

Frequencies of circulating MDSC correlate with clinical outcome of melanoma patients treated with ipilimumab

Functional analysis and structural modeling of human APOBEC3G reveal the role of evolutionarily conserved elements in the inhibition of human immunodeficiency virus type 1 infection and Alu transposition.

Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma

Guillain-Barré syndrome after adoptive cell therapy with tumor-infiltrating lymphocytes

Homology-based identification of capsid determinants that protect HIV1 from human TRIM5α restriction

How T cell receptors interact with peptide‐MHCs: A multiple steered molecular dynamics study ⬇️

Identification of human IKK-2 inhibitors of natural origin (Part II): in Silico prediction of IKK-2 inhibitors in natural extracts with known anti-inflammatory activity

Identification of human IKK-2 inhibitors of natural origin (part I): modeling of the IKK-2 kinase domain, virtual screening and activity assays

Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression

Immunogenicity of the carcinoembryonic antigen derived peptide 694 in HLA-A2 healthy donors and colorectal carcinoma patients

Impact of orthologous melan-A peptide immunizations on the anti-self melan-A/HLA-A2 T cell cross-reactivity

Improving binding affinity and stability of peptide ligands by substituting glycines with D-amino acids

In vitro biotransformation of imatinib by the tumor expressed CYP1A1 and CYP1B1.

In-Vivo Detection and Tracking of T Cells in Various Organs in a Melanoma Tumor Model by 19F-Fluorine MRS/MRI.

Interplay between T Cell Receptor Binding Kinetics and the Level of Cognate Peptide Presented by Major Histocompatibility Complexes Governs CD8+ T Cell Responsiveness ⬇️

Intratumoural immunotherapies for unresectable and metastatic melanoma: current status and future perspectives

Local alignment refinement using structural assessment

Lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib.

MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial

MedCo: Enabling Secure and Privacy-Preserving Exploration of Distributed Clinical and Genomic Data

Multiple nivolumab-induced CNS demyelination with spontaneous resolution in an asymptomatic metastatic melanoma patient

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma

Nano-particle vaccination combined with TLR-7 and -9 ligands triggers memory and effector CD8⁺ T-cell responses in melanoma patients

Peroxisome proliferator-activated receptor structures: ligand specificity, molecular switch and interactions with regulators.

Persistence of EBV antigen-specific CD8 T cell clonotypes during homeostatic immune reconstitution in cancer patients

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer.

Phase I, open-label study of pasireotide in patients with BRAF-wild type and NRAS-wild type, unresectable and/or metastatic melanoma

Prediction of cross-recognition of peptide-HLA A2 by Melan-A-specific cytotoxic T lymphocytes using three-dimensional quantitative structure-activity relationships

Predictive value of the MGMT promoter methylation status in metastatic melanoma patients receiving first-line temozolomide plus bevacizumab in the trial SAKK 50/07 ⬇️

Pulmonary sarcoid-like granulomatosis induced by ipilimumab.

Quantification of the next-generation oral anti-tumor drugs dabrafenib, trametinib, vemurafenib, cobimetinib, pazopanib, regorafenib and two metabolites in human plasma by liquid chromatography-tandem mass spectrometry.

RNA pentaloop structures as effective targets of regulators belonging to the RsmA/CsrA protein family

Rational design of 4-aryl-1,2,3-triazoles for indoleamine 2,3-dioxygenase 1 inhibition.

Rational design of indoleamine 2,3-dioxygenase inhibitors

SHP-1 phosphatase activity counteracts increased T cell receptor affinity

SPHN/PHRT - MedCo in Action: Empowering the Swiss Molecular Tumor Board with Privacy-Preserving and Real-Time Patient Discovery

Sensitive and frequent identification of high avidity neo-epitope specific CD8 + T cells in immunotherapy-naive ovarian cancer

Sequence determinants of a microtubule tip localization signal (MtLS).

Shaping the interaction landscape of bioactive molecules.

Single cell analysis reveals similar functional competence of dominant and nondominant CD8 T-cell clonotypes ⬇️

Structural and functional interaction sites between Na,K-ATPase and FXYD proteins.

Structural prediction of peptides bound to MHC class I.

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

SwissDock, a protein-small molecule docking web service based on EADock DSS

SwissParam: A fast force field generation tool for small organic molecules

SwissSidechain: a molecular and structural database of non-natural sidechains